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The map label for this gene is fmt

Identifier: 186474807

GI number: 186474807

Start: 42691

End: 43674

Strand: Direct

Name: fmt

Synonym: Bphy_0036

Alternate gene names: 186474807

Gene position: 42691-43674 (Clockwise)

Preceding gene: 186474806

Following gene: 186474808

Centisome position: 1.23

GC content: 68.29

Gene sequence:

>984_bases
ATGAGTCACACCTTGCGCGTCATTTTTGCCGGTACGCCGGAGTTCGCCGCCGCCGCGTTGGCCGCCATTCACGAAGCGGG
CTTCCCGGTGCCGCTGGTGCTCACCCAGCCGGACCGCCCGGCGGGACGCGGCATGAAGCTGCAGGCCAGCCCCGTCAAGC
GTTACGCGCAAGAGCACGGCATCGAAGTGGCGCAGCCGCCTTCGCTGCGCCGTAACGGCAAGTATCCAGCGCAAGCCACT
GCCGCCATCGAGCAGCTGCGGGCGACACCGCACGACGTCATGGTCGTTGCCGCCTACGGGCTGTTGTTGCCGCAGGAAGT
GCTCGACATTGCGCCGCACGGCTGCATCAATATTCACGCGTCGCTGCTGCCGCGCTGGCGGGGCGCGGCGCCGATCCACC
GTGCAATCGAAGCAGGCGACGCCGAAACAGGCATCACGCTGATGCAGATGGACGCCGGCCTCGATACGGGCGCGATGATT
TCCGAGGTCCGCACCGCGATCGCCGGCACAGACACCACTGCGACGCTGCACGACCGGCTTGCCGAAGCGGGCGCAAAGCT
GATAGTCGACGCGCTAGTCGAACTGGAACGCAGCGGCAAGCTGGCGTCGATCCCGCAGCCGGCCGCAGGCGCGACCTACG
CCGAGAAAATCGCCAAGCACGAAGCGGCGCTCGACTGGCGACGCCCCGCGGCGGAACTGGCCCGTCAGGTTCGCGCGTTC
GACCCGTTCCCCGGCGGCGCCGCGACGCTCGACGGCGCGGTGCTCAAGCTCTGGTCCGCTGCCGCAGTCGACGCTTCGTG
CAAGGCAGAACCCGGCACGATTGTGGAGGTGTCGCCCGAAGGCGTTGTCGTGGCATGCGGCGATGGCGCATTGCGCATCA
CGCAACTCCAGAAGCCGGGCGGCAAGCGCCTGCCGGTGCGCGATTTTCTCGCCGGCTCGACGCTCGCGGCGGGCCAGCGC
TTCGAACTCGCACAGCCACAATAA

Upstream 100 bases:

>100_bases
TTCGTCGAATATCTGTCGCCGCTCAAGCAGACGCGCATCAAGAGCAAGATGAAGAAGCTCGCGCACGCAATGTGATGCGC
TTTAGAATAGCCATCAGCCT

Downstream 100 bases:

>100_bases
AGTCAGCCTTCGCGTTGCACCATATGCCGTTCGGCCGGGGCGCGCCGCGCTCGCGCGGCGCGTTAAAATCTTCGGTGCAA
CTTGCCTGAAGAGGACTCCA

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MSHTLRVIFAGTPEFAAAALAAIHEAGFPVPLVLTQPDRPAGRGMKLQASPVKRYAQEHGIEVAQPPSLRRNGKYPAQAT
AAIEQLRATPHDVMVVAAYGLLLPQEVLDIAPHGCINIHASLLPRWRGAAPIHRAIEAGDAETGITLMQMDAGLDTGAMI
SEVRTAIAGTDTTATLHDRLAEAGAKLIVDALVELERSGKLASIPQPAAGATYAEKIAKHEAALDWRRPAAELARQVRAF
DPFPGGAATLDGAVLKLWSAAAVDASCKAEPGTIVEVSPEGVVVACGDGALRITQLQKPGGKRLPVRDFLAGSTLAAGQR
FELAQPQ

Sequences:

>Translated_327_residues
MSHTLRVIFAGTPEFAAAALAAIHEAGFPVPLVLTQPDRPAGRGMKLQASPVKRYAQEHGIEVAQPPSLRRNGKYPAQAT
AAIEQLRATPHDVMVVAAYGLLLPQEVLDIAPHGCINIHASLLPRWRGAAPIHRAIEAGDAETGITLMQMDAGLDTGAMI
SEVRTAIAGTDTTATLHDRLAEAGAKLIVDALVELERSGKLASIPQPAAGATYAEKIAKHEAALDWRRPAAELARQVRAF
DPFPGGAATLDGAVLKLWSAAAVDASCKAEPGTIVEVSPEGVVVACGDGALRITQLQKPGGKRLPVRDFLAGSTLAAGQR
FELAQPQ
>Mature_326_residues
SHTLRVIFAGTPEFAAAALAAIHEAGFPVPLVLTQPDRPAGRGMKLQASPVKRYAQEHGIEVAQPPSLRRNGKYPAQATA
AIEQLRATPHDVMVVAAYGLLLPQEVLDIAPHGCINIHASLLPRWRGAAPIHRAIEAGDAETGITLMQMDAGLDTGAMIS
EVRTAIAGTDTTATLHDRLAEAGAKLIVDALVELERSGKLASIPQPAAGATYAEKIAKHEAALDWRRPAAELARQVRAFD
PFPGGAATLDGAVLKLWSAAAVDASCKAEPGTIVEVSPEGVVVACGDGALRITQLQKPGGKRLPVRDFLAGSTLAAGQRF
ELAQPQ

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI238814322, Length=322, Percent_Identity=28.2608695652174, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI164663775, Length=340, Percent_Identity=28.8235294117647, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI21614513, Length=335, Percent_Identity=26.2686567164179, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1789683, Length=310, Percent_Identity=49.0322580645161, Blast_Score=287, Evalue=5e-79,
Organism=Escherichia coli, GI1788589, Length=296, Percent_Identity=33.1081081081081, Blast_Score=149, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI133930964, Length=326, Percent_Identity=27.3006134969325, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6319458, Length=182, Percent_Identity=29.1208791208791, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45550868, Length=315, Percent_Identity=28.5714285714286, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28571984, Length=226, Percent_Identity=32.3008849557522, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24585660, Length=252, Percent_Identity=27.7777777777778, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_BURP8 (B2JJU4)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001856277.1
- ProteinModelPortal:   B2JJU4
- SMR:   B2JJU4
- GeneID:   6241540
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_0036
- HOGENOM:   HBG571560
- OMA:   IMQMDEG
- ProtClustDB:   PRK00005
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 34279; Mature: 34148

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHTLRVIFAGTPEFAAAALAAIHEAGFPVPLVLTQPDRPAGRGMKLQASPVKRYAQEHG
CCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEECHHHHHHHHHCC
IEVAQPPSLRRNGKYPAQATAAIEQLRATPHDVMVVAAYGLLLPQEVLDIAPHGCINIHA
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEHH
SLLPRWRGAAPIHRAIEAGDAETGITLMQMDAGLDTGAMISEVRTAIAGTDTTATLHDRL
HHCCCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHH
AEAGAKLIVDALVELERSGKLASIPQPAAGATYAEKIAKHEAALDWRRPAAELARQVRAF
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHC
DPFPGGAATLDGAVLKLWSAAAVDASCKAEPGTIVEVSPEGVVVACGDGALRITQLQKPG
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEECCCCEEEEEECCCC
GKRLPVRDFLAGSTLAAGQRFELAQPQ
CCCCCHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SHTLRVIFAGTPEFAAAALAAIHEAGFPVPLVLTQPDRPAGRGMKLQASPVKRYAQEHG
CCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEECHHHHHHHHHCC
IEVAQPPSLRRNGKYPAQATAAIEQLRATPHDVMVVAAYGLLLPQEVLDIAPHGCINIHA
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEHH
SLLPRWRGAAPIHRAIEAGDAETGITLMQMDAGLDTGAMISEVRTAIAGTDTTATLHDRL
HHCCCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHH
AEAGAKLIVDALVELERSGKLASIPQPAAGATYAEKIAKHEAALDWRRPAAELARQVRAF
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHC
DPFPGGAATLDGAVLKLWSAAAVDASCKAEPGTIVEVSPEGVVVACGDGALRITQLQKPG
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEECCCCEEEEEECCCC
GKRLPVRDFLAGSTLAAGQRFELAQPQ
CCCCCHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA