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The map label for this gene is norM [H]

Identifier: 183222687

GI number: 183222687

Start: 3449554

End: 3450945

Strand: Reverse

Name: norM [H]

Synonym: LEPBI_I3343

Alternate gene names: 183222687

Gene position: 3450945-3449554 (Counterclockwise)

Preceding gene: 183222688

Following gene: 183222686

Centisome position: 95.87

GC content: 37.86

Gene sequence:

>1392_bases
ATGACACGTGCAAGTTTATGGGATGATTTAAAAAAAGCCTTAGCTGGTTCCGAGGCTGATTATACAGAGGTGAGTTTACG
AAAGGCTATCTTTCTTTTATCGATACCTATGATTTTGGAATTAGTTTTGGAATCTGTATTTGCAGTAGTTGATATATATT
TTGTTGGTAAAATTGGAGCATCAGCAGTCGCAACTGTCGGATTGACCGAAACTTACCTTTTTCTACTTTATTCAGTAGCC
ATGGGACTTTCTTTTTCAGTGACTGCAATCGTTGCCCGAAGGATTGGTGAAAAAGAAAAAGATAAAGCGGCAATTGCTGC
CATCCAATCTATTTGGATTGCAATCATTTCTTCGATACCATTTGCTATCGCGGGTATTTTCTATTCGAAGGAACTACTAA
CATTAATGGGAGCAGACGAATGGGTTCTCAATGAAGGATTCCATTATATGCAATGGATGTTAGGTGGAAATTTAGTCATC
GTATTATTATTTCTAATCAATGCAGTTTTTCGCGGTGCAGGTGATGCCGCAATTTCAATGCGAGTCCTTTGGATTGCGAA
TGGTTTTAATATCATTTTGGATCCAATTTTTATTTTTGGTTGGGGTCCTATACCAGCGTTCGGTATCACAGGTGCTGCGA
TTGCAACAAATATTGGAAGAGGTATCGGTGTTTTGTTTCAACTTTGGTTGTTGTTTCAAGGTGGAAAACACATTAAGATA
CTAGTTAGTCATCTAAAAATTGAATGGGAGACGATATCGGGAATTCTAATCACTTCTCTTGGTGGAATTGGTCAAATGGT
CGTTGGTATGACTTCTTGGATTTTTATTATGAGAATTTTATCAGAGTTTGGAAGTCAGACAGTTGCGGGTGCTACTATCG
CACTTAGAACAATGATGTTTACATTGATGCCTTCCTGGGGAATGTCTAATGCGGTTGCAACTTTAGTTGGACAAAACTTA
GGCGCTGGTAAGCCTGATCGTGCAGAACAGTCTGTTTGGTACACTGGTTTCTGCAATATGGGTTATCTGATCATCGTATC
GATCATTTATTATTTCTTTAGTGAAAACATCATTGGAATTTTTACAGATGATCCATTGGTTATTAAGATTGGTTCCGAAT
GGTTAAGGATCGTATCGTATTCGTATTTTATCTATGCATGGTGGATGGCAGCAAGCCAAGCATTTAATGGAGCTGGCGAT
ACAATGACTCCAACAAAAATCAATGTTATCTTTTTTTGGATCATCCAAATTCCGTTAGCTTATACTTTAGGCAAGTATCT
TCATTTTGGTTATAGTGGAGTATTTTGGGCCATGATGCTGTCTGAAACTTCTGTCGGTGTTTACACTCTTTGGTTATTTA
CCAAGGGGAAATGGAAAGAAATGAAAGTATAA

Upstream 100 bases:

>100_bases
TGGTCGTTGGTTTTGGTGCCATCGAAGGTGCTCATCAAACTCTTAGTCGCTTAAACCAATATTTGAGATAAACATTAAGA
ATTTTATAGGATACGAATAT

Downstream 100 bases:

>100_bases
AAATTAGAAACTATGAATTCGCAAAAAAAAGTTTCCATTGATGAGTATATCCAATCCTTTCCAAAAGAGGTGCAAACAAT
TCTCTCAAAAGTGAGAAAAA

Product: drug/sodium antiporter

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MTRASLWDDLKKALAGSEADYTEVSLRKAIFLLSIPMILELVLESVFAVVDIYFVGKIGASAVATVGLTETYLFLLYSVA
MGLSFSVTAIVARRIGEKEKDKAAIAAIQSIWIAIISSIPFAIAGIFYSKELLTLMGADEWVLNEGFHYMQWMLGGNLVI
VLLFLINAVFRGAGDAAISMRVLWIANGFNIILDPIFIFGWGPIPAFGITGAAIATNIGRGIGVLFQLWLLFQGGKHIKI
LVSHLKIEWETISGILITSLGGIGQMVVGMTSWIFIMRILSEFGSQTVAGATIALRTMMFTLMPSWGMSNAVATLVGQNL
GAGKPDRAEQSVWYTGFCNMGYLIIVSIIYYFFSENIIGIFTDDPLVIKIGSEWLRIVSYSYFIYAWWMAASQAFNGAGD
TMTPTKINVIFFWIIQIPLAYTLGKYLHFGYSGVFWAMMLSETSVGVYTLWLFTKGKWKEMKV

Sequences:

>Translated_463_residues
MTRASLWDDLKKALAGSEADYTEVSLRKAIFLLSIPMILELVLESVFAVVDIYFVGKIGASAVATVGLTETYLFLLYSVA
MGLSFSVTAIVARRIGEKEKDKAAIAAIQSIWIAIISSIPFAIAGIFYSKELLTLMGADEWVLNEGFHYMQWMLGGNLVI
VLLFLINAVFRGAGDAAISMRVLWIANGFNIILDPIFIFGWGPIPAFGITGAAIATNIGRGIGVLFQLWLLFQGGKHIKI
LVSHLKIEWETISGILITSLGGIGQMVVGMTSWIFIMRILSEFGSQTVAGATIALRTMMFTLMPSWGMSNAVATLVGQNL
GAGKPDRAEQSVWYTGFCNMGYLIIVSIIYYFFSENIIGIFTDDPLVIKIGSEWLRIVSYSYFIYAWWMAASQAFNGAGD
TMTPTKINVIFFWIIQIPLAYTLGKYLHFGYSGVFWAMMLSETSVGVYTLWLFTKGKWKEMKV
>Mature_462_residues
TRASLWDDLKKALAGSEADYTEVSLRKAIFLLSIPMILELVLESVFAVVDIYFVGKIGASAVATVGLTETYLFLLYSVAM
GLSFSVTAIVARRIGEKEKDKAAIAAIQSIWIAIISSIPFAIAGIFYSKELLTLMGADEWVLNEGFHYMQWMLGGNLVIV
LLFLINAVFRGAGDAAISMRVLWIANGFNIILDPIFIFGWGPIPAFGITGAAIATNIGRGIGVLFQLWLLFQGGKHIKIL
VSHLKIEWETISGILITSLGGIGQMVVGMTSWIFIMRILSEFGSQTVAGATIALRTMMFTLMPSWGMSNAVATLVGQNLG
AGKPDRAEQSVWYTGFCNMGYLIIVSIIYYFFSENIIGIFTDDPLVIKIGSEWLRIVSYSYFIYAWWMAASQAFNGAGDT
MTPTKINVIFFWIIQIPLAYTLGKYLHFGYSGVFWAMMLSETSVGVYTLWLFTKGKWKEMKV

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=441, Percent_Identity=21.9954648526077, Blast_Score=92, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 51182; Mature: 51051

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRASLWDDLKKALAGSEADYTEVSLRKAIFLLSIPMILELVLESVFAVVDIYFVGKIGA
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SAVATVGLTETYLFLLYSVAMGLSFSVTAIVARRIGEKEKDKAAIAAIQSIWIAIISSIP
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
FAIAGIFYSKELLTLMGADEWVLNEGFHYMQWMLGGNLVIVLLFLINAVFRGAGDAAISM
HHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHEEE
RVLWIANGFNIILDPIFIFGWGPIPAFGITGAAIATNIGRGIGVLFQLWLLFQGGKHIKI
EEEEEECCCHHEECHHHEEECCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHCCCCHHEE
LVSHLKIEWETISGILITSLGGIGQMVVGMTSWIFIMRILSEFGSQTVAGATIALRTMMF
EEEHHEEEEHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
TLMPSWGMSNAVATLVGQNLGAGKPDRAEQSVWYTGFCNMGYLIIVSIIYYFFSENIIGI
HHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEE
FTDDPLVIKIGSEWLRIVSYSYFIYAWWMAASQAFNGAGDTMTPTKINVIFFWIIQIPLA
ECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
YTLGKYLHFGYSGVFWAMMLSETSVGVYTLWLFTKGKWKEMKV
HHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCC
>Mature Secondary Structure 
TRASLWDDLKKALAGSEADYTEVSLRKAIFLLSIPMILELVLESVFAVVDIYFVGKIGA
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SAVATVGLTETYLFLLYSVAMGLSFSVTAIVARRIGEKEKDKAAIAAIQSIWIAIISSIP
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
FAIAGIFYSKELLTLMGADEWVLNEGFHYMQWMLGGNLVIVLLFLINAVFRGAGDAAISM
HHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHEEE
RVLWIANGFNIILDPIFIFGWGPIPAFGITGAAIATNIGRGIGVLFQLWLLFQGGKHIKI
EEEEEECCCHHEECHHHEEECCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHCCCCHHEE
LVSHLKIEWETISGILITSLGGIGQMVVGMTSWIFIMRILSEFGSQTVAGATIALRTMMF
EEEHHEEEEHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
TLMPSWGMSNAVATLVGQNLGAGKPDRAEQSVWYTGFCNMGYLIIVSIIYYFFSENIIGI
HHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEE
FTDDPLVIKIGSEWLRIVSYSYFIYAWWMAASQAFNGAGDTMTPTKINVIFFWIIQIPLA
ECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
YTLGKYLHFGYSGVFWAMMLSETSVGVYTLWLFTKGKWKEMKV
HHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]