Click here to switch to the map view.

The map label for this gene is acdA3 [H]

Identifier: 183222662

GI number: 183222662

Start: 3429779

End: 3431455

Strand: Reverse

Name: acdA3 [H]

Synonym: LEPBI_I3317

Alternate gene names: 183222662

Gene position: 3431455-3429779 (Counterclockwise)

Preceding gene: 183222664

Following gene: 183222661

Centisome position: 95.33

GC content: 44.9

Gene sequence:

>1677_bases
ATGACCGCAACGGCAGTGAAACTCGAAAAATCCCAGGCGGAGAAGGCATTGAACGCCCAAGCCGCCCTCCTCAATGAAGT
TACGAAACGACTCGCACAGAAAAATTCCGATAACGGCAAAGTTTCCGTCAGCAAAATGGACAAAACGCAACATGTGTTTT
ACCAACTTGCTTGGATGACAGCACAACAACGTGTTGCTGAAAACTTTATCGTTTATGCTTGGGATGCTTCCAAAGGAACT
GGTGAATTGGAACAGAAAATGGCCCTCACTTTTGCGGCAGAAACTGTTTCCAACATTCGTTCTGAACTAGCAGCGCGTCC
TGCAGAATACGAACTTACGTATCAGGAATTATTCTCCAAATTGTTTTCCGACGAAATCAACAGTTTCGTGGAAGCGGCCT
CCAAAATGGAAAACTACGAAGCCATCGTTGATAAAATTGTCGACCTCGGACACTTCGGTGCTTACGGACTTTCTGAAGAC
CACGAAAATTTCCGTGGAATTTTCAAAGATTTCGCTGAAAATGTAGTCGTTCCACACGCAGAACATGTACACAGACATGA
TGACCTCATTCCTCAAGAAATCATCAATGGATTAAAAGACATGGGTTGTTTTGGTCTTTGTATCCCAGAACAGTTCGGTG
GGATCCAACCAGATGATCGTCCAGACAACATATCGATGTTAGTGGTTACTGAAGAACTATCGCGTGGTTCCCTTGGAGCT
GCAGGTTCCCTCATCACTCGTCCTGAAATCATGTCGAAGGCTCTCCTCAAAGGGGGAACTGAAGAACAAAAAAATAAATG
GTTACCACTCCTTGCATCCGGCGAAAAATTTGCGGGAATCATGGTGACAGAACCTAACTACGGTTCCGATGTTGCTGGTG
TCTCTGTCACTGCAAAAGAAGTGGAAGGTGGATTTGTCATCAATGGTGTGAAAACGTGGTGTACATTTGCAGGTTATGCG
AACCTCCTTCTCATCCTTTGCCGCACGGAAGCAGATCCAAGTTTGAAACACAGAGGTCTTTCCATCCTACTTGCTGAAAA
ACCATCCTTTGACGGTCATGAATTCAGTTACAAACAAGAAGGTGGTGGATCGATCCAAGGAAAAGCAATCGGAACCATCG
GTTACCGTGGAATGCACTCCTATGAAGTTTCTTTTGAAGACTACTTTGTTCCAAAAGAAAACCTTCTTGGTGGTGATGCA
GGCCGTGGAAAAGGTTTTTACTTCCAAATGGAAGGATTTGCTGGTGGAAGGATCCAAACTGCTGCTCGTGCCAATGGTGT
GATGCAAGCTGCTCTTGAAGCAGCACTTCGTTATTCACAAGAACGTAAAGTATTCGCAAAACCAATTTACGATTACACTT
TAACAAAGTTTAAAATTGCGAAGATGGCTATGATTGTGCAAGCAACTCGCCAATACACAAACTATGTAGCAACTCTCCTC
GATGACCACAAAGGCCAAATGGAAGCAACCCTTGTCAAATTGTATGCATCCAAAATTGCTGAATGGGTCACTCGGGAAGC
GATGCAAATCCATGGTGGCATGGGTTATGCGGAAGAATACCCAGTATCCCGTTACTTCGTTGATGCTCGCGTATTCTCTA
TCTTTGAAGGGGCAGAGGAAGTGATGGCTCTTCGCGTCGTAGCGAAAGACCTTCTTGACCAAGCACTCGCTTCGTAA

Upstream 100 bases:

>100_bases
TTTCGAAAGGCTCAACCCAAAACCTAGTCTAAAAATGAAAATGACAGGGTACTTTCCTTCCGTATAGTGGAAGAAAACCA
CCCGCAGGAACGTTAAACAC

Downstream 100 bases:

>100_bases
GATCACAAAAAATCTTTACCGATGGGAGAAACTCTTTCGGTAAAGATCCAATCCAAACGATGTCATTCTGTAATGAATCA
AATGACACAAACTGCAAGAA

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 558; Mature: 557

Protein sequence:

>558_residues
MTATAVKLEKSQAEKALNAQAALLNEVTKRLAQKNSDNGKVSVSKMDKTQHVFYQLAWMTAQQRVAENFIVYAWDASKGT
GELEQKMALTFAAETVSNIRSELAARPAEYELTYQELFSKLFSDEINSFVEAASKMENYEAIVDKIVDLGHFGAYGLSED
HENFRGIFKDFAENVVVPHAEHVHRHDDLIPQEIINGLKDMGCFGLCIPEQFGGIQPDDRPDNISMLVVTEELSRGSLGA
AGSLITRPEIMSKALLKGGTEEQKNKWLPLLASGEKFAGIMVTEPNYGSDVAGVSVTAKEVEGGFVINGVKTWCTFAGYA
NLLLILCRTEADPSLKHRGLSILLAEKPSFDGHEFSYKQEGGGSIQGKAIGTIGYRGMHSYEVSFEDYFVPKENLLGGDA
GRGKGFYFQMEGFAGGRIQTAARANGVMQAALEAALRYSQERKVFAKPIYDYTLTKFKIAKMAMIVQATRQYTNYVATLL
DDHKGQMEATLVKLYASKIAEWVTREAMQIHGGMGYAEEYPVSRYFVDARVFSIFEGAEEVMALRVVAKDLLDQALAS

Sequences:

>Translated_558_residues
MTATAVKLEKSQAEKALNAQAALLNEVTKRLAQKNSDNGKVSVSKMDKTQHVFYQLAWMTAQQRVAENFIVYAWDASKGT
GELEQKMALTFAAETVSNIRSELAARPAEYELTYQELFSKLFSDEINSFVEAASKMENYEAIVDKIVDLGHFGAYGLSED
HENFRGIFKDFAENVVVPHAEHVHRHDDLIPQEIINGLKDMGCFGLCIPEQFGGIQPDDRPDNISMLVVTEELSRGSLGA
AGSLITRPEIMSKALLKGGTEEQKNKWLPLLASGEKFAGIMVTEPNYGSDVAGVSVTAKEVEGGFVINGVKTWCTFAGYA
NLLLILCRTEADPSLKHRGLSILLAEKPSFDGHEFSYKQEGGGSIQGKAIGTIGYRGMHSYEVSFEDYFVPKENLLGGDA
GRGKGFYFQMEGFAGGRIQTAARANGVMQAALEAALRYSQERKVFAKPIYDYTLTKFKIAKMAMIVQATRQYTNYVATLL
DDHKGQMEATLVKLYASKIAEWVTREAMQIHGGMGYAEEYPVSRYFVDARVFSIFEGAEEVMALRVVAKDLLDQALAS
>Mature_557_residues
TATAVKLEKSQAEKALNAQAALLNEVTKRLAQKNSDNGKVSVSKMDKTQHVFYQLAWMTAQQRVAENFIVYAWDASKGTG
ELEQKMALTFAAETVSNIRSELAARPAEYELTYQELFSKLFSDEINSFVEAASKMENYEAIVDKIVDLGHFGAYGLSEDH
ENFRGIFKDFAENVVVPHAEHVHRHDDLIPQEIINGLKDMGCFGLCIPEQFGGIQPDDRPDNISMLVVTEELSRGSLGAA
GSLITRPEIMSKALLKGGTEEQKNKWLPLLASGEKFAGIMVTEPNYGSDVAGVSVTAKEVEGGFVINGVKTWCTFAGYAN
LLLILCRTEADPSLKHRGLSILLAEKPSFDGHEFSYKQEGGGSIQGKAIGTIGYRGMHSYEVSFEDYFVPKENLLGGDAG
RGKGFYFQMEGFAGGRIQTAARANGVMQAALEAALRYSQERKVFAKPIYDYTLTKFKIAKMAMIVQATRQYTNYVATLLD
DHKGQMEATLVKLYASKIAEWVTREAMQIHGGMGYAEEYPVSRYFVDARVFSIFEGAEEVMALRVVAKDLLDQALAS

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=397, Percent_Identity=32.7455919395466, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI21361497, Length=370, Percent_Identity=32.1621621621622, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI226958412, Length=395, Percent_Identity=29.620253164557, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI4557231, Length=402, Percent_Identity=29.8507462686567, Blast_Score=169, Evalue=9e-42,
Organism=Homo sapiens, GI187960098, Length=402, Percent_Identity=29.8507462686567, Blast_Score=169, Evalue=9e-42,
Organism=Homo sapiens, GI4557235, Length=372, Percent_Identity=30.9139784946237, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI76496475, Length=372, Percent_Identity=30.9139784946237, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI226958414, Length=358, Percent_Identity=30.4469273743017, Blast_Score=163, Evalue=5e-40,
Organism=Homo sapiens, GI4501859, Length=420, Percent_Identity=28.0952380952381, Blast_Score=160, Evalue=4e-39,
Organism=Homo sapiens, GI7656849, Length=408, Percent_Identity=28.921568627451, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI4501857, Length=412, Percent_Identity=26.9417475728155, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI38505218, Length=309, Percent_Identity=27.1844660194175, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI48976061, Length=293, Percent_Identity=27.9863481228669, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI211971008, Length=293, Percent_Identity=27.9863481228669, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI4503943, Length=400, Percent_Identity=24.75, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI7669494, Length=392, Percent_Identity=24.4897959183673, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI87081958, Length=364, Percent_Identity=30.7692307692308, Blast_Score=138, Evalue=9e-34,
Organism=Escherichia coli, GI1786223, Length=370, Percent_Identity=26.2162162162162, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI87082384, Length=305, Percent_Identity=26.2295081967213, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17534899, Length=403, Percent_Identity=30.5210918114144, Blast_Score=182, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17538396, Length=400, Percent_Identity=29.75, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17570075, Length=399, Percent_Identity=30.0751879699248, Blast_Score=169, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17569725, Length=400, Percent_Identity=30, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI71985184, Length=362, Percent_Identity=30.6629834254144, Blast_Score=159, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17508101, Length=402, Percent_Identity=28.6069651741293, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17506239, Length=399, Percent_Identity=26.5664160401003, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17533517, Length=406, Percent_Identity=30.5418719211823, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17505929, Length=356, Percent_Identity=28.0898876404494, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17551932, Length=350, Percent_Identity=27.4285714285714, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI71985192, Length=323, Percent_Identity=27.5541795665635, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17534353, Length=392, Percent_Identity=24.4897959183673, Blast_Score=109, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI32563615, Length=250, Percent_Identity=27.2, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71990804, Length=315, Percent_Identity=26.3492063492064, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71982178, Length=296, Percent_Identity=25, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21356377, Length=400, Percent_Identity=33, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24646207, Length=397, Percent_Identity=32.2418136020151, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24660351, Length=408, Percent_Identity=30.6372549019608, Blast_Score=176, Evalue=4e-44,
Organism=Drosophila melanogaster, GI21355753, Length=391, Percent_Identity=30.690537084399, Blast_Score=166, Evalue=6e-41,
Organism=Drosophila melanogaster, GI281363737, Length=356, Percent_Identity=30.8988764044944, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24666513, Length=395, Percent_Identity=27.5949367088608, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI19920834, Length=394, Percent_Identity=25.3807106598985, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 61604; Mature: 61473

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATAVKLEKSQAEKALNAQAALLNEVTKRLAQKNSDNGKVSVSKMDKTQHVFYQLAWMT
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHCHHHHHHHHHHHHH
AQQRVAENFIVYAWDASKGTGELEQKMALTFAAETVSNIRSELAARPAEYELTYQELFSK
HHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
LFSDEINSFVEAASKMENYEAIVDKIVDLGHFGAYGLSEDHENFRGIFKDFAENVVVPHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCH
EHVHRHDDLIPQEIINGLKDMGCFGLCIPEQFGGIQPDDRPDNISMLVVTEELSRGSLGA
HHHHHHCCCCHHHHHHHHHHCCEEEEECHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCC
AGSLITRPEIMSKALLKGGTEEQKNKWLPLLASGEKFAGIMVTEPNYGSDVAGVSVTAKE
CCCCCCCHHHHHHHHHCCCCHHHHCCCCCEEECCCCEEEEEEECCCCCCCCCCCEEEHEE
VEGGFVINGVKTWCTFAGYANLLLILCRTEADPSLKHRGLSILLAEKPSFDGHEFSYKQE
CCCCEEEECHHHHHHHHHHHHHEEEEEECCCCCCHHHCCCEEEEECCCCCCCCCCCCCCC
GGGSIQGKAIGTIGYRGMHSYEVSFEDYFVPKENLLGGDAGRGKGFYFQMEGFAGGRIQT
CCCEECCCEEEECCCCCCEEEEECHHHEECCHHHCCCCCCCCCCCEEEEECCCCCCCEEH
AARANGVMQAALEAALRYSQERKVFAKPIYDYTLTKFKIAKMAMIVQATRQYTNYVATLL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DDHKGQMEATLVKLYASKIAEWVTREAMQIHGGMGYAEEYPVSRYFVDARVFSIFEGAEE
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCHHHHHHHHHHHHHHHHHH
VMALRVVAKDLLDQALAS
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TATAVKLEKSQAEKALNAQAALLNEVTKRLAQKNSDNGKVSVSKMDKTQHVFYQLAWMT
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHCHHHHHHHHHHHHH
AQQRVAENFIVYAWDASKGTGELEQKMALTFAAETVSNIRSELAARPAEYELTYQELFSK
HHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
LFSDEINSFVEAASKMENYEAIVDKIVDLGHFGAYGLSEDHENFRGIFKDFAENVVVPHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCH
EHVHRHDDLIPQEIINGLKDMGCFGLCIPEQFGGIQPDDRPDNISMLVVTEELSRGSLGA
HHHHHHCCCCHHHHHHHHHHCCEEEEECHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCC
AGSLITRPEIMSKALLKGGTEEQKNKWLPLLASGEKFAGIMVTEPNYGSDVAGVSVTAKE
CCCCCCCHHHHHHHHHCCCCHHHHCCCCCEEECCCCEEEEEEECCCCCCCCCCCEEEHEE
VEGGFVINGVKTWCTFAGYANLLLILCRTEADPSLKHRGLSILLAEKPSFDGHEFSYKQE
CCCCEEEECHHHHHHHHHHHHHEEEEEECCCCCCHHHCCCEEEEECCCCCCCCCCCCCCC
GGGSIQGKAIGTIGYRGMHSYEVSFEDYFVPKENLLGGDAGRGKGFYFQMEGFAGGRIQT
CCCEECCCEEEECCCCCCEEEEECHHHEECCHHHCCCCCCCCCCCEEEEECCCCCCCEEH
AARANGVMQAALEAALRYSQERKVFAKPIYDYTLTKFKIAKMAMIVQATRQYTNYVATLL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DDHKGQMEATLVKLYASKIAEWVTREAMQIHGGMGYAEEYPVSRYFVDARVFSIFEGAEE
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCHHHHHHHHHHHHHHHHHH
VMALRVVAKDLLDQALAS
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]