| Definition | Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)' chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_010602 |
| Length | 3,599,677 |
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The map label for this gene is fadB3 [H]
Identifier: 183222592
GI number: 183222592
Start: 3363059
End: 3363832
Strand: Reverse
Name: fadB3 [H]
Synonym: LEPBI_I3247
Alternate gene names: 183222592
Gene position: 3363832-3363059 (Counterclockwise)
Preceding gene: 183222593
Following gene: 183222591
Centisome position: 93.45
GC content: 40.18
Gene sequence:
>774_bases ATGAACACTGTCTCACTCCAAACGATTGATTCTTATGTAGCATTCATGGAATTGAATCGACCTGAGGCAAAAAACGCGAT TTCGATTCAATTTTTGAATGAGTTACAGAACTGTATTGCAAACGTAGAATCAGGTAAATTTCGAGCCCTTGTGATCATGG GAGTCGGAGATTCCTTCTGTTCAGGTGCCGACTTAAAGGAACGAAAGACTATGTCGGAAACAGAAGTCAAAACTTTCCTT CGAAATATCAATCTATGTTTTTCCAGATTGACAAACTTACCAATCCCTACGATTGCAGCCATTAACGGCTTTGCGTTTGG AGGTGGTTTAGAATTGGCAATTTCGTGTGATATTCGTTATGCGAATAGTACAGCAATTATGGGTTTAACCGAAACAAAAC TTGGTATCATCCCTGGCGCTGGCGGAACACAAAGATTATCTCGTATTGTTGGAGAAGCAACTGCGATGGAATGGATTTTT TCTGGTAAAAAATTAACAAGTGTCGAGGCACTTGAACGGGGTTTGGTTTCGAAAGTTGTGAATCCAGAGGAACTTAAGGA TTCTTCTCTTGCCTTAGCAAGGGAGATATCAGAATCTGCACCTATCGCTGTTTCTGCTGCGAAAAAGGCAATTCGGCAAG GGTTCCAATTGCCAATGGAATCAGCATTAGTTTGGGAACAATTGTGTTATTCTGAAACGTTAACATCGAAAGATAGATTA GAAGCCTTACAAGCTTTCGCCGAAAAAAGAAAACCAATATTTAAGGGAGAATGA
Upstream 100 bases:
>100_bases AGAATCCGATTGTGTATAAAATCCTTCTCATGACTGCTTTTTCCATTATCGGATATTTTTTCCAAGATTCATTTCTATTT TTTACATTACGGGAAATTCT
Downstream 100 bases:
>100_bases ACTTTGATTTTAACTGGCAAAGAAATTTTAAAAAGACTCGGTTCCGATATCAAAATTGAACCCTATGATGAAAAACTATT AAATCCAAATTCCTATAATT
Product: 3-hydroxyacyl-CoA dehydrogenase FadB
Products: trans(or 3)-enoyl-CoA; H2O [C]
Alternate protein names: NA
Number of amino acids: Translated: 257; Mature: 257
Protein sequence:
>257_residues MNTVSLQTIDSYVAFMELNRPEAKNAISIQFLNELQNCIANVESGKFRALVIMGVGDSFCSGADLKERKTMSETEVKTFL RNINLCFSRLTNLPIPTIAAINGFAFGGGLELAISCDIRYANSTAIMGLTETKLGIIPGAGGTQRLSRIVGEATAMEWIF SGKKLTSVEALERGLVSKVVNPEELKDSSLALAREISESAPIAVSAAKKAIRQGFQLPMESALVWEQLCYSETLTSKDRL EALQAFAEKRKPIFKGE
Sequences:
>Translated_257_residues MNTVSLQTIDSYVAFMELNRPEAKNAISIQFLNELQNCIANVESGKFRALVIMGVGDSFCSGADLKERKTMSETEVKTFL RNINLCFSRLTNLPIPTIAAINGFAFGGGLELAISCDIRYANSTAIMGLTETKLGIIPGAGGTQRLSRIVGEATAMEWIF SGKKLTSVEALERGLVSKVVNPEELKDSSLALAREISESAPIAVSAAKKAIRQGFQLPMESALVWEQLCYSETLTSKDRL EALQAFAEKRKPIFKGE >Mature_257_residues MNTVSLQTIDSYVAFMELNRPEAKNAISIQFLNELQNCIANVESGKFRALVIMGVGDSFCSGADLKERKTMSETEVKTFL RNINLCFSRLTNLPIPTIAAINGFAFGGGLELAISCDIRYANSTAIMGLTETKLGIIPGAGGTQRLSRIVGEATAMEWIF SGKKLTSVEALERGLVSKVVNPEELKDSSLALAREISESAPIAVSAAKKAIRQGFQLPMESALVWEQLCYSETLTSKDRL EALQAFAEKRKPIFKGE
Specific function: Could Possibly Oxidizes Fatty Acids Using Specific Components (By Similarity). [C]
COG id: COG1024
COG function: function code I; Enoyl-CoA hydratase/carnithine racemase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]
Homologues:
Organism=Homo sapiens, GI4502327, Length=251, Percent_Identity=46.2151394422311, Blast_Score=187, Evalue=6e-48, Organism=Homo sapiens, GI194097323, Length=251, Percent_Identity=36.2549800796813, Blast_Score=167, Evalue=1e-41, Organism=Homo sapiens, GI150378541, Length=259, Percent_Identity=38.996138996139, Blast_Score=155, Evalue=3e-38, Organism=Homo sapiens, GI70995211, Length=254, Percent_Identity=30.7086614173228, Blast_Score=112, Evalue=2e-25, Organism=Homo sapiens, GI31542718, Length=247, Percent_Identity=29.5546558704453, Blast_Score=110, Evalue=1e-24, Organism=Homo sapiens, GI68989263, Length=191, Percent_Identity=34.0314136125654, Blast_Score=107, Evalue=9e-24, Organism=Homo sapiens, GI213417737, Length=230, Percent_Identity=30.4347826086957, Blast_Score=102, Evalue=4e-22, Organism=Homo sapiens, GI157694516, Length=230, Percent_Identity=30.4347826086957, Blast_Score=102, Evalue=5e-22, Organism=Homo sapiens, GI20127408, Length=178, Percent_Identity=34.8314606741573, Blast_Score=90, Evalue=2e-18, Organism=Homo sapiens, GI157694520, Length=184, Percent_Identity=31.5217391304348, Blast_Score=89, Evalue=3e-18, Organism=Homo sapiens, GI221136756, Length=220, Percent_Identity=25.4545454545455, Blast_Score=87, Evalue=1e-17, Organism=Homo sapiens, GI221136753, Length=220, Percent_Identity=25.4545454545455, Blast_Score=87, Evalue=1e-17, Organism=Homo sapiens, GI221307494, Length=220, Percent_Identity=25.4545454545455, Blast_Score=86, Evalue=2e-17, Organism=Homo sapiens, GI261878539, Length=95, Percent_Identity=43.1578947368421, Blast_Score=83, Evalue=3e-16, Organism=Homo sapiens, GI116235487, Length=233, Percent_Identity=24.8927038626609, Blast_Score=81, Evalue=1e-15, Organism=Homo sapiens, GI25453481, Length=248, Percent_Identity=22.9838709677419, Blast_Score=78, Evalue=8e-15, Organism=Homo sapiens, GI51538573, Length=248, Percent_Identity=22.9838709677419, Blast_Score=78, Evalue=8e-15, Organism=Homo sapiens, GI4757966, Length=220, Percent_Identity=24.0909090909091, Blast_Score=78, Evalue=1e-14, Organism=Homo sapiens, GI51538581, Length=220, Percent_Identity=24.0909090909091, Blast_Score=78, Evalue=1e-14, Organism=Homo sapiens, GI4757968, Length=249, Percent_Identity=23.2931726907631, Blast_Score=75, Evalue=8e-14, Organism=Homo sapiens, GI49355787, Length=249, Percent_Identity=23.2931726907631, Blast_Score=75, Evalue=8e-14, Organism=Homo sapiens, GI260274832, Length=203, Percent_Identity=28.0788177339901, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI45643119, Length=203, Percent_Identity=28.0788177339901, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI260275230, Length=203, Percent_Identity=28.0788177339901, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI62530384, Length=186, Percent_Identity=30.1075268817204, Blast_Score=70, Evalue=1e-12, Organism=Escherichia coli, GI1787659, Length=249, Percent_Identity=38.1526104417671, Blast_Score=161, Evalue=5e-41, Organism=Escherichia coli, GI221142681, Length=245, Percent_Identity=36.734693877551, Blast_Score=141, Evalue=3e-35, Organism=Escherichia coli, GI1790281, Length=198, Percent_Identity=34.3434343434343, Blast_Score=117, Evalue=7e-28, Organism=Escherichia coli, GI1788682, Length=201, Percent_Identity=35.8208955223881, Blast_Score=109, Evalue=2e-25, Organism=Escherichia coli, GI87082183, Length=263, Percent_Identity=29.6577946768061, Blast_Score=108, Evalue=4e-25, Organism=Escherichia coli, GI1787660, Length=257, Percent_Identity=32.6848249027237, Blast_Score=106, Evalue=2e-24, Organism=Escherichia coli, GI1788597, Length=249, Percent_Identity=28.9156626506024, Blast_Score=105, Evalue=2e-24, Organism=Caenorhabditis elegans, GI17540714, Length=227, Percent_Identity=45.8149779735683, Blast_Score=185, Evalue=2e-47, Organism=Caenorhabditis elegans, GI17554946, Length=246, Percent_Identity=39.8373983739837, Blast_Score=179, Evalue=2e-45, Organism=Caenorhabditis elegans, GI25145438, Length=253, Percent_Identity=38.3399209486166, Blast_Score=169, Evalue=9e-43, Organism=Caenorhabditis elegans, GI17536985, Length=261, Percent_Identity=27.2030651340996, Blast_Score=112, Evalue=2e-25, Organism=Caenorhabditis elegans, GI17534483, Length=268, Percent_Identity=26.4925373134328, Blast_Score=109, Evalue=2e-24, Organism=Caenorhabditis elegans, GI17560910, Length=244, Percent_Identity=26.2295081967213, Blast_Score=94, Evalue=5e-20, Organism=Caenorhabditis elegans, GI17558304, Length=178, Percent_Identity=32.5842696629214, Blast_Score=88, Evalue=3e-18, Organism=Caenorhabditis elegans, GI25141363, Length=230, Percent_Identity=29.1304347826087, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI25144276, Length=176, Percent_Identity=32.3863636363636, Blast_Score=85, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17508953, Length=176, Percent_Identity=32.3863636363636, Blast_Score=85, Evalue=4e-17, Organism=Caenorhabditis elegans, GI17508951, Length=176, Percent_Identity=32.3863636363636, Blast_Score=85, Evalue=4e-17, Organism=Caenorhabditis elegans, GI17540306, Length=237, Percent_Identity=29.1139240506329, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI25144157, Length=178, Percent_Identity=30.3370786516854, Blast_Score=74, Evalue=7e-14, Organism=Caenorhabditis elegans, GI25144160, Length=178, Percent_Identity=30.3370786516854, Blast_Score=74, Evalue=8e-14, Organism=Caenorhabditis elegans, GI17549921, Length=202, Percent_Identity=25.7425742574257, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI24653139, Length=254, Percent_Identity=43.3070866141732, Blast_Score=211, Evalue=4e-55, Organism=Drosophila melanogaster, GI20129971, Length=248, Percent_Identity=37.0967741935484, Blast_Score=157, Evalue=7e-39, Organism=Drosophila melanogaster, GI24653477, Length=248, Percent_Identity=37.0967741935484, Blast_Score=157, Evalue=7e-39, Organism=Drosophila melanogaster, GI24650670, Length=173, Percent_Identity=35.2601156069364, Blast_Score=105, Evalue=4e-23, Organism=Drosophila melanogaster, GI19920382, Length=270, Percent_Identity=28.1481481481481, Blast_Score=103, Evalue=9e-23, Organism=Drosophila melanogaster, GI21357171, Length=174, Percent_Identity=32.183908045977, Blast_Score=96, Evalue=2e-20, Organism=Drosophila melanogaster, GI24583165, Length=202, Percent_Identity=28.2178217821782, Blast_Score=84, Evalue=1e-16, Organism=Drosophila melanogaster, GI28571729, Length=177, Percent_Identity=28.8135593220339, Blast_Score=82, Evalue=4e-16, Organism=Drosophila melanogaster, GI28571730, Length=177, Percent_Identity=28.8135593220339, Blast_Score=82, Evalue=5e-16, Organism=Drosophila melanogaster, GI19921018, Length=173, Percent_Identity=29.4797687861272, Blast_Score=79, Evalue=2e-15, Organism=Drosophila melanogaster, GI24654903, Length=204, Percent_Identity=26.4705882352941, Blast_Score=77, Evalue=9e-15, Organism=Drosophila melanogaster, GI19922422, Length=245, Percent_Identity=24.0816326530612, Blast_Score=77, Evalue=1e-14, Organism=Drosophila melanogaster, GI19921000, Length=176, Percent_Identity=31.8181818181818, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI24583077, Length=176, Percent_Identity=31.8181818181818, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI24583079, Length=176, Percent_Identity=31.8181818181818, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI45550169, Length=217, Percent_Identity=24.8847926267281, Blast_Score=65, Evalue=5e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR014748 - InterPro: IPR001753 - InterPro: IPR018376 [H]
Pfam domain/function: PF00378 ECH [H]
EC number: 4.2.1.17 [C]
Molecular weight: Translated: 27979; Mature: 27979
Theoretical pI: Translated: 6.63; Mature: 6.63
Prosite motif: PS00166 ENOYL_COA_HYDRATASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.9 %Cys (Translated Protein) 2.7 %Met (Translated Protein) 4.7 %Cys+Met (Translated Protein) 1.9 %Cys (Mature Protein) 2.7 %Met (Mature Protein) 4.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNTVSLQTIDSYVAFMELNRPEAKNAISIQFLNELQNCIANVESGKFRALVIMGVGDSFC CCCCCHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCC SGADLKERKTMSETEVKTFLRNINLCFSRLTNLPIPTIAAINGFAFGGGLELAISCDIRY CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCEEECCCEEEEEEEEEEE ANSTAIMGLTETKLGIIPGAGGTQRLSRIVGEATAMEWIFSGKKLTSVEALERGLVSKVV CCCEEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC NPEELKDSSLALAREISESAPIAVSAAKKAIRQGFQLPMESALVWEQLCYSETLTSKDRL CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHH EALQAFAEKRKPIFKGE HHHHHHHHHCCCCCCCC >Mature Secondary Structure MNTVSLQTIDSYVAFMELNRPEAKNAISIQFLNELQNCIANVESGKFRALVIMGVGDSFC CCCCCHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCC SGADLKERKTMSETEVKTFLRNINLCFSRLTNLPIPTIAAINGFAFGGGLELAISCDIRY CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCEEECCCEEEEEEEEEEE ANSTAIMGLTETKLGIIPGAGGTQRLSRIVGEATAMEWIFSGKKLTSVEALERGLVSKVV CCCEEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC NPEELKDSSLALAREISESAPIAVSAAKKAIRQGFQLPMESALVWEQLCYSETLTSKDRL CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHH EALQAFAEKRKPIFKGE HHHHHHHHHCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): 0.05 {crotonyl-CoA}} 0.008 {2-decenoyl-CoA}} [C]
Substrates: (3S)-hydroxyacyl-CoA [C]
Specific reaction: (3S)-hydroxyacyl-CoA = trans(or 3)-enoyl-CoA + H2O [C]
General reaction: addition (of H2O to carbon carbon double bondelimination (of H2O C-O bond cleavagehydration [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9387222; 9384377 [H]