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The map label for this gene is mas [H]

Identifier: 183222532

GI number: 183222532

Start: 3297602

End: 3298621

Strand: Reverse

Name: mas [H]

Synonym: LEPBI_I3187

Alternate gene names: 183222532

Gene position: 3298621-3297602 (Counterclockwise)

Preceding gene: 183222538

Following gene: 183222527

Centisome position: 91.64

GC content: 38.53

Gene sequence:

>1020_bases
ATGCAAAGAGAAGTCTACCGCATTCACAAAACGGGATCCATCGATCATTTACAGCAAAAAAAAGAAATGTTGCGACCTCC
CGAGAACGACGAGGTCACAGTTGAGGTAAGGGCCATCGGTCTTAACTTCGCTGATGTTTTTTCTGTTTATGGTTTGTACT
CAGCAACACCGAAAGGGAGTTTCATTCCGGGATTAGAATTTTCAGGGAAAATCGTAAAAATAGGCCCAAATGTTAAGGAT
TTTGAAGTAGGAGACCAAGTTTTTGGTGTCACTCGGTTTGGTGCGTATGCAACTCATCTGAACATCTCAGAAAAAACAAT
CTTCACACTTCCAAAGGATTGGACGATGCAAGATGGTGCATCGTTTGCTGTGCAAGCACTCACTGCATACTATGCACTCA
TTCCACTTGGACAAGTGAAAGAAGGTGATCATGTATTGGTTCATAGCGCTGCAGGTGGTGTTGGAATCATGGCAGGTCAT
ATCATTCAGAAAAAAAAAGCAATCGCGATCGGACTTGTAGGTGATTCCGTTAAGTTTTCGATCTTAAAAGAGGTTGGTTA
TGATTTTTTTCTCACTCGATCACCAAATTTTAAAGAAGAGATGCATAAAATTTTGAAGGGAGCACCATTAAAAATCGTTT
TAGAATGTTTAGGTGGTCGTTATTTTCACGACAGTTATGATCTCTTAGCACCAATGGGAAGGCTTGTTACCTATGGTAGT
GCTAACTTCACACCATCACATTCATTCCGAAATTGGTTTTCGATTGTTTATTCATACCTCACAAGACCAAAAATTGATCC
GTTATCGATGATTTCAGACAATAAATCAGTATTGGGATTCAATTTAATATGGTTATGGAATGAAATTGATGAATTGAGAA
AACATTTTTCGGAATTAATGATGTTATCTTTACCAAAACAAACGATTGGACATCAATTTTCATTCGATTCAATGCATGAT
GCACTCCGTACAATGCAAAGTGGACATACGATCGGTAAGATTGTTATCAATGTTCCGTAG

Upstream 100 bases:

>100_bases
AGGGGTGTTTGTTTTAGTTCCACGGTGTTCTCTTATGTAGACTCTTCTACCATAGAAAAATGGTTTCATCGTTATGGAAT
TGAATTTTTTTTAACCCATT

Downstream 100 bases:

>100_bases
AATGAGTATTAGCCTGTTTTTTTATTTTGAATAAAAATTCATGCAAAAAATAAAATTTCTTTACATTTAAAATGATCTGA
TTTAATTATGTCGTATCAAT

Product: putative zinc-dependent dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MQREVYRIHKTGSIDHLQQKKEMLRPPENDEVTVEVRAIGLNFADVFSVYGLYSATPKGSFIPGLEFSGKIVKIGPNVKD
FEVGDQVFGVTRFGAYATHLNISEKTIFTLPKDWTMQDGASFAVQALTAYYALIPLGQVKEGDHVLVHSAAGGVGIMAGH
IIQKKKAIAIGLVGDSVKFSILKEVGYDFFLTRSPNFKEEMHKILKGAPLKIVLECLGGRYFHDSYDLLAPMGRLVTYGS
ANFTPSHSFRNWFSIVYSYLTRPKIDPLSMISDNKSVLGFNLIWLWNEIDELRKHFSELMMLSLPKQTIGHQFSFDSMHD
ALRTMQSGHTIGKIVINVP

Sequences:

>Translated_339_residues
MQREVYRIHKTGSIDHLQQKKEMLRPPENDEVTVEVRAIGLNFADVFSVYGLYSATPKGSFIPGLEFSGKIVKIGPNVKD
FEVGDQVFGVTRFGAYATHLNISEKTIFTLPKDWTMQDGASFAVQALTAYYALIPLGQVKEGDHVLVHSAAGGVGIMAGH
IIQKKKAIAIGLVGDSVKFSILKEVGYDFFLTRSPNFKEEMHKILKGAPLKIVLECLGGRYFHDSYDLLAPMGRLVTYGS
ANFTPSHSFRNWFSIVYSYLTRPKIDPLSMISDNKSVLGFNLIWLWNEIDELRKHFSELMMLSLPKQTIGHQFSFDSMHD
ALRTMQSGHTIGKIVINVP
>Mature_339_residues
MQREVYRIHKTGSIDHLQQKKEMLRPPENDEVTVEVRAIGLNFADVFSVYGLYSATPKGSFIPGLEFSGKIVKIGPNVKD
FEVGDQVFGVTRFGAYATHLNISEKTIFTLPKDWTMQDGASFAVQALTAYYALIPLGQVKEGDHVLVHSAAGGVGIMAGH
IIQKKKAIAIGLVGDSVKFSILKEVGYDFFLTRSPNFKEEMHKILKGAPLKIVLECLGGRYFHDSYDLLAPMGRLVTYGS
ANFTPSHSFRNWFSIVYSYLTRPKIDPLSMISDNKSVLGFNLIWLWNEIDELRKHFSELMMLSLPKQTIGHQFSFDSMHD
ALRTMQSGHTIGKIVINVP

Specific function: Catalyzes the elongation of N-fatty acyl-CoA with methylamalonyl-CoA (not malonyl-CoA) as the elongating agent to form mycocerosyl lipids [H]

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 acyl carrier domain [H]

Homologues:

Organism=Homo sapiens, GI18379349, Length=314, Percent_Identity=30.8917197452229, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI24308257, Length=333, Percent_Identity=26.4264264264264, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI22538446, Length=325, Percent_Identity=28.3076923076923, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI22538444, Length=325, Percent_Identity=28.3076923076923, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI194239674, Length=337, Percent_Identity=25.8160237388724, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI13236495, Length=337, Percent_Identity=25.8160237388724, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI194239676, Length=198, Percent_Identity=30.3030303030303, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI67078404, Length=224, Percent_Identity=28.125, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI28557745, Length=325, Percent_Identity=27.0769230769231, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI67078406, Length=217, Percent_Identity=28.110599078341, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI41872631, Length=320, Percent_Identity=26.25, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1790485, Length=238, Percent_Identity=31.5126050420168, Blast_Score=105, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17507255, Length=235, Percent_Identity=27.6595744680851, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI212642053, Length=317, Percent_Identity=27.1293375394322, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17536829, Length=231, Percent_Identity=30.3030303030303, Blast_Score=81, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6319520, Length=347, Percent_Identity=25.0720461095101, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI45550423, Length=234, Percent_Identity=26.4957264957265, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI19920632, Length=326, Percent_Identity=23.3128834355828, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI221330659, Length=326, Percent_Identity=23.3128834355828, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR009081
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR000794
- InterPro:   IPR011032
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016036
- InterPro:   IPR016040
- InterPro:   IPR006163
- InterPro:   IPR020842
- InterPro:   IPR020801
- InterPro:   IPR020841
- InterPro:   IPR020807
- InterPro:   IPR020843
- InterPro:   IPR013968
- InterPro:   IPR006162
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00698 Acyl_transf_1; PF08240 ADH_N; PF00107 ADH_zinc_N; PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C; PF08659 KR; PF00550 PP-binding [H]

EC number: =2.3.1.111 [H]

Molecular weight: Translated: 37963; Mature: 37963

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQREVYRIHKTGSIDHLQQKKEMLRPPENDEVTVEVRAIGLNFADVFSVYGLYSATPKGS
CCCCEEEEECCCCHHHHHHHHHHCCCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCCC
FIPGLEFSGKIVKIGPNVKDFEVGDQVFGVTRFGAYATHLNISEKTIFTLPKDWTMQDGA
CCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHCCEEEEEECCCCEEEECCCCCCCCCCH
SFAVQALTAYYALIPLGQVKEGDHVLVHSAAGGVGIMAGHIIQKKKAIAIGLVGDSVKFS
HHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCHHHH
ILKEVGYDFFLTRSPNFKEEMHKILKGAPLKIVLECLGGRYFHDSYDLLAPMGRLVTYGS
HHHHCCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHCCCEECCCHHHHHHHHHHEEECC
ANFTPSHSFRNWFSIVYSYLTRPKIDPLSMISDNKSVLGFNLIWLWNEIDELRKHFSELM
CCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEEEEEEHHHHHHHHHHHHHHH
MLSLPKQTIGHQFSFDSMHDALRTMQSGHTIGKIVINVP
HHHCCHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEECC
>Mature Secondary Structure
MQREVYRIHKTGSIDHLQQKKEMLRPPENDEVTVEVRAIGLNFADVFSVYGLYSATPKGS
CCCCEEEEECCCCHHHHHHHHHHCCCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCCC
FIPGLEFSGKIVKIGPNVKDFEVGDQVFGVTRFGAYATHLNISEKTIFTLPKDWTMQDGA
CCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHCCEEEEEECCCCEEEECCCCCCCCCCH
SFAVQALTAYYALIPLGQVKEGDHVLVHSAAGGVGIMAGHIIQKKKAIAIGLVGDSVKFS
HHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCHHHH
ILKEVGYDFFLTRSPNFKEEMHKILKGAPLKIVLECLGGRYFHDSYDLLAPMGRLVTYGS
HHHHCCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHCCCEECCCHHHHHHHHHHEEECC
ANFTPSHSFRNWFSIVYSYLTRPKIDPLSMISDNKSVLGFNLIWLWNEIDELRKHFSELM
CCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEEEEEEHHHHHHHHHHHHHHH
MLSLPKQTIGHQFSFDSMHDALRTMQSGHTIGKIVINVP
HHHCCHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1527058; 12788972 [H]