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The map label for this gene is ziaA [H]

Identifier: 183222486

GI number: 183222486

Start: 3252632

End: 3254647

Strand: Reverse

Name: ziaA [H]

Synonym: LEPBI_I3141

Alternate gene names: 183222486

Gene position: 3254647-3252632 (Counterclockwise)

Preceding gene: 183222487

Following gene: 183222485

Centisome position: 90.41

GC content: 35.47

Gene sequence:

>2016_bases
ATGAACATGATCGAACACAAACATACTTACGACAAAGACGGTAAACAAATTTGTTGCACGCAATCAGAAAAAATTTATAC
AAATGATGGTGCAGAAGATTTATTAAAAGATAAAAAAATAACTAGTGCGGTGCAAAGTCGTTTAGTCTGGATAGATAGTA
CTTTAAAACTATTTATACCTTCTTCTATTTCATTAGTTCTTTTGATCTTAGCAATTCTGTTTGATAACTATTACACGCAA
GAGTGGTTCACTGGATGGATTCGAATTATTTGGTATTCTGCTAGCTATGGACCGGTCGGCTTTCCTGTCATTAAAGAGGC
TTTTGAGAGCATTGCGAAGAAAGAGATATTTTCAGAATTTCTTTTGATGAGCATTGCAACACTAGGAGCATTTTTTATTG
GCGAGTACCCCGAAGGTGTTGCGGTAATGCTGTTTTATACTGTCGGTGAATTATTTCAAACAATGGCTGTCAAAAGAGCC
AAAGCAAACATTAAATCATTACTCGACCAAAGACCCGATGAAGTAACGATTCTACAAGACAATCGAGCAAAAACTATAAA
GGCTGAAAATGCAAGCATTGGCGATATTATCCAACTTAAGGTAGGGGAAAAATTAGGGTTAGACGGTGAACTTATATCTG
AAACAGCTTCTTTTAATACTGCAGCTCTTACGGGGGAAAGTAAACCGGATACAAAATCAAAAGGACAAACAGTTTTGGCG
GGAATGATAAATCTAAATTCCGTTTCCCTTGTAAAAGTTTCTACTCGTTATACCGACAGTAAACTATCGAAAATTTTAGA
ATTGGTACAAAATGCCACTAAACAAAAAGCCCCAACCGAGCTTTTCATTAGAAAGTTTGCAAAAATTTATACGCCTATAG
TAGTTTTTTTTGCTTTTGCAATTACTGTATTACCTTACTTTTTTGTAGATAATTATGAGTTTACAAAATGGCTTTATAGA
GCCTTGATTTTTTTGGTTATTTCTTGCCCCTGTGCCTTGGTGATTTCAATTCCATTGGGTTATTTTGGAGGGATTGGTGC
GGCTAGTAAAAATGGTATCTTATTTAAAGGTAGTAACTTCTTAGATGTCATTTCTGAAATTCAAAATGTTGTGATGGATA
AAACGGGAACAATGACTGAAGGCGTCTTTAAAGTTCAAGAAATAGAATTTAAACCAGAATTTAATAAAAAAGAAATATTA
GAAATGGTGAATGCGCTTGAAAGTCAAAGCACACACCCGGTTGCAACGGCTATACATCAATTTGCTGGAGAAATAAACCC
AAATATTAAATTAGAAAGTGTAGAGGAAATATCGGGGCACGGGTTGAAGGCAATTGTTCAGAATAAAGAACTATTAGTAG
GCAATTTTAAATTGATGGATAAATTTTCTATTACCTATGATTTAGATCCAACAAGCATTGTTTATACTTTGATAGCTATA
GCATATAATAAAAAATTTGTTGGTTACCTCACAATAGCCGATAGTATTAAGCCTGACGCAAAAGAGACTATCGACAAATT
GAAAGCATTGAAAGTAAAAATAACAATGTTAAGCGGCGACAAGCACAATGTAGTAAAATTTGTTTCAGAAAAATTAGGAA
TTACCGACGCCTTTGGAGATTTATTACCTGAAGATAAAGTAAATAAGGTAAAAGAGATCAAGGAACGAAATGAAAGCGTC
GCCTTTGTCGGTGACGGCGTAAATGACGCTCCAGTTATTGCTTTAAGTAATGTAGGTATCGCAATGGGTGGTTTAGGTAG
TGATGCCACTATTGCAACCGCTGATATTGTTATTCAGGATGATATGCCGAGTAAAATCCCGATGGCAATCAATATAGGCA
AGCAAACAAAAAAAATAGTTTGGCAGAATATAATTCTAGCATTCTCTGTGAAGGCAATTGTTTTGATTCTAGGCGCAGGC
GGATTGGCCTCGATGTGGGAAGCGGTCTTTGCGGATGTAGGTGTTGCACTACTTGCTATTGTAAATGCAGTAAGAATACA
ACGGACTAAATTTTAA

Upstream 100 bases:

>100_bases
AAAACTTTTCTTTGTAAAAAATATAGGTAGTAGATGATTAACAGATTTAATTATCAGCTCCTAAATTAAAGAGCTTCATT
GTTTTAAAAATAAATAGGAA

Downstream 100 bases:

>100_bases
TGCGAGTTTTCTGTGGTTTTTCTTAGTGTAGTGCTGCATACTTTCGTGTCTGACATTGGTTGGACACTTGAATCAATTAA
GCCGATAAATTGATTGGAAA

Product: putative zinc-exporting ATPase

Products: NA

Alternate protein names: Zn(2+)-translocating P-type ATPase [H]

Number of amino acids: Translated: 671; Mature: 671

Protein sequence:

>671_residues
MNMIEHKHTYDKDGKQICCTQSEKIYTNDGAEDLLKDKKITSAVQSRLVWIDSTLKLFIPSSISLVLLILAILFDNYYTQ
EWFTGWIRIIWYSASYGPVGFPVIKEAFESIAKKEIFSEFLLMSIATLGAFFIGEYPEGVAVMLFYTVGELFQTMAVKRA
KANIKSLLDQRPDEVTILQDNRAKTIKAENASIGDIIQLKVGEKLGLDGELISETASFNTAALTGESKPDTKSKGQTVLA
GMINLNSVSLVKVSTRYTDSKLSKILELVQNATKQKAPTELFIRKFAKIYTPIVVFFAFAITVLPYFFVDNYEFTKWLYR
ALIFLVISCPCALVISIPLGYFGGIGAASKNGILFKGSNFLDVISEIQNVVMDKTGTMTEGVFKVQEIEFKPEFNKKEIL
EMVNALESQSTHPVATAIHQFAGEINPNIKLESVEEISGHGLKAIVQNKELLVGNFKLMDKFSITYDLDPTSIVYTLIAI
AYNKKFVGYLTIADSIKPDAKETIDKLKALKVKITMLSGDKHNVVKFVSEKLGITDAFGDLLPEDKVNKVKEIKERNESV
AFVGDGVNDAPVIALSNVGIAMGGLGSDATIATADIVIQDDMPSKIPMAINIGKQTKKIVWQNIILAFSVKAIVLILGAG
GLASMWEAVFADVGVALLAIVNAVRIQRTKF

Sequences:

>Translated_671_residues
MNMIEHKHTYDKDGKQICCTQSEKIYTNDGAEDLLKDKKITSAVQSRLVWIDSTLKLFIPSSISLVLLILAILFDNYYTQ
EWFTGWIRIIWYSASYGPVGFPVIKEAFESIAKKEIFSEFLLMSIATLGAFFIGEYPEGVAVMLFYTVGELFQTMAVKRA
KANIKSLLDQRPDEVTILQDNRAKTIKAENASIGDIIQLKVGEKLGLDGELISETASFNTAALTGESKPDTKSKGQTVLA
GMINLNSVSLVKVSTRYTDSKLSKILELVQNATKQKAPTELFIRKFAKIYTPIVVFFAFAITVLPYFFVDNYEFTKWLYR
ALIFLVISCPCALVISIPLGYFGGIGAASKNGILFKGSNFLDVISEIQNVVMDKTGTMTEGVFKVQEIEFKPEFNKKEIL
EMVNALESQSTHPVATAIHQFAGEINPNIKLESVEEISGHGLKAIVQNKELLVGNFKLMDKFSITYDLDPTSIVYTLIAI
AYNKKFVGYLTIADSIKPDAKETIDKLKALKVKITMLSGDKHNVVKFVSEKLGITDAFGDLLPEDKVNKVKEIKERNESV
AFVGDGVNDAPVIALSNVGIAMGGLGSDATIATADIVIQDDMPSKIPMAINIGKQTKKIVWQNIILAFSVKAIVLILGAG
GLASMWEAVFADVGVALLAIVNAVRIQRTKF
>Mature_671_residues
MNMIEHKHTYDKDGKQICCTQSEKIYTNDGAEDLLKDKKITSAVQSRLVWIDSTLKLFIPSSISLVLLILAILFDNYYTQ
EWFTGWIRIIWYSASYGPVGFPVIKEAFESIAKKEIFSEFLLMSIATLGAFFIGEYPEGVAVMLFYTVGELFQTMAVKRA
KANIKSLLDQRPDEVTILQDNRAKTIKAENASIGDIIQLKVGEKLGLDGELISETASFNTAALTGESKPDTKSKGQTVLA
GMINLNSVSLVKVSTRYTDSKLSKILELVQNATKQKAPTELFIRKFAKIYTPIVVFFAFAITVLPYFFVDNYEFTKWLYR
ALIFLVISCPCALVISIPLGYFGGIGAASKNGILFKGSNFLDVISEIQNVVMDKTGTMTEGVFKVQEIEFKPEFNKKEIL
EMVNALESQSTHPVATAIHQFAGEINPNIKLESVEEISGHGLKAIVQNKELLVGNFKLMDKFSITYDLDPTSIVYTLIAI
AYNKKFVGYLTIADSIKPDAKETIDKLKALKVKITMLSGDKHNVVKFVSEKLGITDAFGDLLPEDKVNKVKEIKERNESV
AFVGDGVNDAPVIALSNVGIAMGGLGSDATIATADIVIQDDMPSKIPMAINIGKQTKKIVWQNIILAFSVKAIVLILGAG
GLASMWEAVFADVGVALLAIVNAVRIQRTKF

Specific function: Involved In Export Of Lead, Cadmium, Zinc And Mercury. [C]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=590, Percent_Identity=26.4406779661017, Blast_Score=219, Evalue=6e-57,
Organism=Homo sapiens, GI55743073, Length=550, Percent_Identity=27.0909090909091, Blast_Score=207, Evalue=3e-53,
Organism=Homo sapiens, GI115529486, Length=310, Percent_Identity=30, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI237681111, Length=282, Percent_Identity=22.6950354609929, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI21361181, Length=282, Percent_Identity=22.6950354609929, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI237681109, Length=282, Percent_Identity=22.6950354609929, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1789879, Length=575, Percent_Identity=33.0434782608696, Blast_Score=301, Evalue=9e-83,
Organism=Escherichia coli, GI1786691, Length=549, Percent_Identity=28.5974499089253, Blast_Score=219, Evalue=6e-58,
Organism=Escherichia coli, GI1786914, Length=466, Percent_Identity=22.7467811158798, Blast_Score=108, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17556548, Length=587, Percent_Identity=27.0868824531516, Blast_Score=173, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI193203354, Length=205, Percent_Identity=28.780487804878, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI193203356, Length=205, Percent_Identity=28.780487804878, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71997262, Length=184, Percent_Identity=28.2608695652174, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71997275, Length=184, Percent_Identity=28.2608695652174, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71997269, Length=166, Percent_Identity=27.710843373494, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320475, Length=539, Percent_Identity=28.5714285714286, Blast_Score=190, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6319772, Length=561, Percent_Identity=24.4206773618538, Blast_Score=141, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6321271, Length=193, Percent_Identity=29.0155440414508, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320244, Length=195, Percent_Identity=27.6923076923077, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320243, Length=195, Percent_Identity=27.6923076923077, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6325221, Length=160, Percent_Identity=27.5, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI221329854, Length=350, Percent_Identity=25.7142857142857, Blast_Score=115, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.5 [H]

Molecular weight: Translated: 73977; Mature: 73977

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00154 ATPASE_E1_E2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMIEHKHTYDKDGKQICCTQSEKIYTNDGAEDLLKDKKITSAVQSRLVWIDSTLKLFIP
CCCCCCCCCCCCCCCEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHEEEEECCEEEECC
SSISLVLLILAILFDNYYTQEWFTGWIRIIWYSASYGPVGFPVIKEAFESIAKKEIFSEF
CHHHHHHHHHHHHHCCHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
LLMSIATLGAFFIGEYPEGVAVMLFYTVGELFQTMAVKRAKANIKSLLDQRPDEVTILQD
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
NRAKTIKAENASIGDIIQLKVGEKLGLDGELISETASFNTAALTGESKPDTKSKGQTVLA
CCCCEEEECCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCEEECCCCCCCCCCCCCEEEE
GMINLNSVSLVKVSTRYTDSKLSKILELVQNATKQKAPTELFIRKFAKIYTPIVVFFAFA
EEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
ITVLPYFFVDNYEFTKWLYRALIFLVISCPCALVISIPLGYFGGIGAASKNGILFKGSNF
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCH
LDVISEIQNVVMDKTGTMTEGVFKVQEIEFKPEFNKKEILEMVNALESQSTHPVATAIHQ
HHHHHHHHHHHHCCCCCCHHHHEEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
FAGEINPNIKLESVEEISGHGLKAIVQNKELLVGNFKLMDKFSITYDLDPTSIVYTLIAI
HHHCCCCCEEEECHHHHCCCCCEEHHCCCEEEEECEEEEEEEEEEEECCHHHHHHHHHHH
AYNKKFVGYLTIADSIKPDAKETIDKLKALKVKITMLSGDKHNVVKFVSEKLGITDAFGD
HHCCCEEEEEEEECCCCCCHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHHCCCCHHHHH
LLPEDKVNKVKEIKERNESVAFVGDGVNDAPVIALSNVGIAMGGLGSDATIATADIVIQD
CCCCHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEECCCEEECCCCCCCEEEEEEEEEEC
DMPSKIPMAINIGKQTKKIVWQNIILAFSVKAIVLILGAGGLASMWEAVFADVGVALLAI
CCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHH
VNAVRIQRTKF
HHHHHHHHCCC
>Mature Secondary Structure
MNMIEHKHTYDKDGKQICCTQSEKIYTNDGAEDLLKDKKITSAVQSRLVWIDSTLKLFIP
CCCCCCCCCCCCCCCEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHEEEEECCEEEECC
SSISLVLLILAILFDNYYTQEWFTGWIRIIWYSASYGPVGFPVIKEAFESIAKKEIFSEF
CHHHHHHHHHHHHHCCHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
LLMSIATLGAFFIGEYPEGVAVMLFYTVGELFQTMAVKRAKANIKSLLDQRPDEVTILQD
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
NRAKTIKAENASIGDIIQLKVGEKLGLDGELISETASFNTAALTGESKPDTKSKGQTVLA
CCCCEEEECCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCEEECCCCCCCCCCCCCEEEE
GMINLNSVSLVKVSTRYTDSKLSKILELVQNATKQKAPTELFIRKFAKIYTPIVVFFAFA
EEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
ITVLPYFFVDNYEFTKWLYRALIFLVISCPCALVISIPLGYFGGIGAASKNGILFKGSNF
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCH
LDVISEIQNVVMDKTGTMTEGVFKVQEIEFKPEFNKKEILEMVNALESQSTHPVATAIHQ
HHHHHHHHHHHHCCCCCCHHHHEEEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHH
FAGEINPNIKLESVEEISGHGLKAIVQNKELLVGNFKLMDKFSITYDLDPTSIVYTLIAI
HHHCCCCCEEEECHHHHCCCCCEEHHCCCEEEEECEEEEEEEEEEEECCHHHHHHHHHHH
AYNKKFVGYLTIADSIKPDAKETIDKLKALKVKITMLSGDKHNVVKFVSEKLGITDAFGD
HHCCCEEEEEEEECCCCCCHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHHCCCCHHHHH
LLPEDKVNKVKEIKERNESVAFVGDGVNDAPVIALSNVGIAMGGLGSDATIATADIVIQD
CCCCHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEECCCEEECCCCCCCEEEEEEEEEEC
DMPSKIPMAINIGKQTKKIVWQNIILAFSVKAIVLILGAGGLASMWEAVFADVGVALLAI
CCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHH
VNAVRIQRTKF
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231; 9724772 [H]