Definition Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)' chromosome chromosome I, complete sequence.
Accession NC_010602
Length 3,599,677

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The map label for this gene is cyaB [H]

Identifier: 183222392

GI number: 183222392

Start: 3159542

End: 3160477

Strand: Direct

Name: cyaB [H]

Synonym: LEPBI_I3046

Alternate gene names: 183222392

Gene position: 3159542-3160477 (Clockwise)

Preceding gene: 183222391

Following gene: 183222393

Centisome position: 87.77

GC content: 40.6

Gene sequence:

>936_bases
ATGGACATCAATAAGGTTTTGGAAGAGGAAAAAGCCAAGTATGAAGAATTGGAAGTCCTTTACCAAAACATCATTGACCA
CTCTACCGAAATCGAAAACGAACTTCTAGAAAATAATAAAAAGATCCAAATGTACTTGGATCGAATGCGCCGGTATCTCT
CTCCCCAATTGTATGAAATGATTACTGGCGCTGAAGTGGAAACATCCATCTCTCACCAAAGGCGAAAACTCACCATTTTT
TTCTCTGACATTGTTGGCTTTACTACCATTACAGATTCTATCGAACCAGAAATTCTCTCCGATTGTTTGAATAAATATTT
GGACGTAATGTCAAGCATTGCCATCAAATACGGTGGGACCATCGACAAATTCATAGGTGATGCCATTATGATTTTTTTTG
GCGCTCCCAGTTTTGAAAACGACAAGGCCCATGCGTTAAACTGTGTGAAGATGGCCATTGAAATGAGAGACAGTTTGCCT
GCGTTAGACGAATATTGGCGAAAATCAGGGATCAATCACAACCTAACATGCCGTATAGGAATCAATACAGGTTACGTGAC
AGTGGGAAATTTCGGAACCAACGAAAGGATGGATTATACCATCATCGGTGGGCCTGTGAATGTTGCTTCCCGTTTAGAAA
ATGCATCGAATGCTGGAGAGATCTTAATTTCCAACGCAACCAAATCCCTGATAGACGAATTCATAGAAACTATCCCAAAA
GGTGAGGTCCTTGTGAAAGGTGTACACACCCCAATTGAAACCTTTCAAGTGATTGGACTAAAGAATGACCAAGAGAAAAA
GGAGAATCCTTTTGTGAAATTTGATGGAGAAGGATTCCTTTTAAAACCACTCCACTTCGACAAACTCAGCACAAACCCCG
AAGAACGCCGATTAATGCAAAATGCATTAGAAAAAGCGCTTGCGGCTTTGAAGTAG

Upstream 100 bases:

>100_bases
TTGGCAGCCATATTCCAAGACATCTATGTTTTTATCGATGGGATGGATGTGTATGATGACATTACCATTATGATCATGAG
GAAACGAGGTTAAGGGTTTT

Downstream 100 bases:

>100_bases
TTTCGCTACATTCTTTAGTTGAACTACGAATATGCGAAAATATGGAAATCTAACCCACACATCGTATTCTGATAAAAAGC
CAGAATCCATCATCGAAATC

Product: putative adenylate/guanylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 2; Adenylyl cyclase 2; AC2 [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MDINKVLEEEKAKYEELEVLYQNIIDHSTEIENELLENNKKIQMYLDRMRRYLSPQLYEMITGAEVETSISHQRRKLTIF
FSDIVGFTTITDSIEPEILSDCLNKYLDVMSSIAIKYGGTIDKFIGDAIMIFFGAPSFENDKAHALNCVKMAIEMRDSLP
ALDEYWRKSGINHNLTCRIGINTGYVTVGNFGTNERMDYTIIGGPVNVASRLENASNAGEILISNATKSLIDEFIETIPK
GEVLVKGVHTPIETFQVIGLKNDQEKKENPFVKFDGEGFLLKPLHFDKLSTNPEERRLMQNALEKALAALK

Sequences:

>Translated_311_residues
MDINKVLEEEKAKYEELEVLYQNIIDHSTEIENELLENNKKIQMYLDRMRRYLSPQLYEMITGAEVETSISHQRRKLTIF
FSDIVGFTTITDSIEPEILSDCLNKYLDVMSSIAIKYGGTIDKFIGDAIMIFFGAPSFENDKAHALNCVKMAIEMRDSLP
ALDEYWRKSGINHNLTCRIGINTGYVTVGNFGTNERMDYTIIGGPVNVASRLENASNAGEILISNATKSLIDEFIETIPK
GEVLVKGVHTPIETFQVIGLKNDQEKKENPFVKFDGEGFLLKPLHFDKLSTNPEERRLMQNALEKALAALK
>Mature_311_residues
MDINKVLEEEKAKYEELEVLYQNIIDHSTEIENELLENNKKIQMYLDRMRRYLSPQLYEMITGAEVETSISHQRRKLTIF
FSDIVGFTTITDSIEPEILSDCLNKYLDVMSSIAIKYGGTIDKFIGDAIMIFFGAPSFENDKAHALNCVKMAIEMRDSLP
ALDEYWRKSGINHNLTCRIGINTGYVTVGNFGTNERMDYTIIGGPVNVASRLENASNAGEILISNATKSLIDEFIETIPK
GEVLVKGVHTPIETFQVIGLKNDQEKKENPFVKFDGEGFLLKPLHFDKLSTNPEERRLMQNALEKALAALK

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Homo sapiens, GI167830411, Length=249, Percent_Identity=28.5140562248996, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4580422, Length=239, Percent_Identity=28.8702928870293, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI134152694, Length=231, Percent_Identity=31.6017316017316, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4557257, Length=199, Percent_Identity=25.6281407035176, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI10947061, Length=196, Percent_Identity=29.0816326530612, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI10181096, Length=196, Percent_Identity=29.0816326530612, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI222080083, Length=231, Percent_Identity=27.7056277056277, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI148536830, Length=163, Percent_Identity=27.6073619631902, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI34486092, Length=239, Percent_Identity=26.3598326359833, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI4557255, Length=164, Percent_Identity=29.2682926829268, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI4504217, Length=219, Percent_Identity=30.1369863013699, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17534659, Length=253, Percent_Identity=31.2252964426877, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI193207841, Length=247, Percent_Identity=31.1740890688259, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI193206632, Length=202, Percent_Identity=33.1683168316832, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI212659371, Length=207, Percent_Identity=32.3671497584541, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI212645052, Length=267, Percent_Identity=28.8389513108614, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI193206054, Length=209, Percent_Identity=29.6650717703349, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17534657, Length=246, Percent_Identity=29.6747967479675, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17561804, Length=236, Percent_Identity=30.5084745762712, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17561800, Length=251, Percent_Identity=27.4900398406374, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17534649, Length=244, Percent_Identity=30.327868852459, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17561802, Length=251, Percent_Identity=27.8884462151394, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71995305, Length=251, Percent_Identity=29.0836653386454, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32563954, Length=198, Percent_Identity=27.7777777777778, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17534651, Length=239, Percent_Identity=30.9623430962343, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17534653, Length=245, Percent_Identity=30.6122448979592, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17568383, Length=181, Percent_Identity=30.939226519337, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17534655, Length=276, Percent_Identity=27.536231884058, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71989805, Length=209, Percent_Identity=26.3157894736842, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71989822, Length=209, Percent_Identity=26.3157894736842, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI62484298, Length=247, Percent_Identity=31.1740890688259, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI62484477, Length=247, Percent_Identity=31.1740890688259, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI116008008, Length=247, Percent_Identity=31.1740890688259, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221330470, Length=218, Percent_Identity=29.3577981651376, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281366459, Length=221, Percent_Identity=33.4841628959276, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281366457, Length=221, Percent_Identity=33.4841628959276, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281366455, Length=221, Percent_Identity=33.4841628959276, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI56292422, Length=221, Percent_Identity=33.4841628959276, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI56292424, Length=221, Percent_Identity=33.4841628959276, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24666940, Length=221, Percent_Identity=33.4841628959276, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221330468, Length=218, Percent_Identity=29.3577981651376, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24663843, Length=203, Percent_Identity=31.0344827586207, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24663839, Length=203, Percent_Identity=31.0344827586207, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI161078020, Length=292, Percent_Identity=28.4246575342466, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI161076872, Length=227, Percent_Identity=31.2775330396476, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24647268, Length=191, Percent_Identity=31.9371727748691, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574512, Length=227, Percent_Identity=31.2775330396476, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24585694, Length=156, Percent_Identity=28.2051282051282, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI62473752, Length=162, Percent_Identity=27.7777777777778, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17137448, Length=162, Percent_Identity=27.7777777777778, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI161084260, Length=200, Percent_Identity=26.5, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI281366320, Length=200, Percent_Identity=26.5, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24667100, Length=223, Percent_Identity=26.9058295964126, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00211 Guanylate_cyc; PF00072 Response_reg [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 35256; Mature: 35256

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MDINKVLEEEKAKYEELEVLYQNIIDHSTEIENELLENNKKIQMYLDRMRRYLSPQLYEM
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHH
ITGAEVETSISHQRRKLTIFFSDIVGFTTITDSIEPEILSDCLNKYLDVMSSIAIKYGGT
HCCCCHHHHHHHHHEEEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
IDKFIGDAIMIFFGAPSFENDKAHALNCVKMAIEMRDSLPALDEYWRKSGINHNLTCRIG
HHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEE
INTGYVTVGNFGTNERMDYTIIGGPVNVASRLENASNAGEILISNATKSLIDEFIETIPK
CCCCEEEECCCCCCCCEEEEEECCCHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHCCC
GEVLVKGVHTPIETFQVIGLKNDQEKKENPFVKFDGEGFLLKPLHFDKLSTNPEERRLMQ
CCEEEEECCCHHHHHEEECCCCCCHHHCCCCEEECCCCEEECCEECCCCCCCHHHHHHHH
NALEKALAALK
HHHHHHHHHCC
>Mature Secondary Structure
MDINKVLEEEKAKYEELEVLYQNIIDHSTEIENELLENNKKIQMYLDRMRRYLSPQLYEM
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHH
ITGAEVETSISHQRRKLTIFFSDIVGFTTITDSIEPEILSDCLNKYLDVMSSIAIKYGGT
HCCCCHHHHHHHHHEEEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
IDKFIGDAIMIFFGAPSFENDKAHALNCVKMAIEMRDSLPALDEYWRKSGINHNLTCRIG
HHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEE
INTGYVTVGNFGTNERMDYTIIGGPVNVASRLENASNAGEILISNATKSLIDEFIETIPK
CCCCEEEECCCCCCCCEEEEEECCCHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHCCC
GEVLVKGVHTPIETFQVIGLKNDQEKKENPFVKFDGEGFLLKPLHFDKLSTNPEERRLMQ
CCEEEEECCCHHHHHEEECCCCCCHHHCCCCEEECCCCEEECCEECCCCCCCHHHHHHHH
NALEKALAALK
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]