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The map label for this gene is moaE [H]

Identifier: 183222133

GI number: 183222133

Start: 2875798

End: 2876223

Strand: Direct

Name: moaE [H]

Synonym: LEPBI_I2776

Alternate gene names: 183222133

Gene position: 2875798-2876223 (Clockwise)

Preceding gene: 183222132

Following gene: 183222134

Centisome position: 79.89

GC content: 40.38

Gene sequence:

>426_bases
ATGGACCACATCACAGAAAACAAAATCGAAATTACAGATATTATTCCTTCACTACCGAGTATGGGAGGATATGTGCTCTT
CGCAGGTATCGTGAGGAATCTCAATGAAGGAAAGATGGTGACCCATTTGGAGTATGAAGCATATTCAGAAATGGCAAATC
AAATGATACACTCTATCATTATGGATTCGAAAAACAAATGGGAACTACAATATGCAAATTGTATTCACCGCTTAGGGTCA
CTGGATGTCGGAGAAATCGCTGTCATCGTATCCACTGGCTCTGTCCACCGAGAGGAAGCTTATTTGGCAAATCGTTACAT
CATCGATAGAGTGAAACACGAAGTGCCCATTTGGAAAAAAGAATATTTTACTGATGGTAGTTCGGAATGGTCCAAGGGTT
GTGTTCATGACACAAATCACGAATGA

Upstream 100 bases:

>100_bases
GTTTCTATCAATCAAAGAATTGTCAAAGAAGCAGAAATCATTCCAGAAAATGCAATCATTGCAATTTTACCTCCCTCAAG
TGGAGGATAAAGAATCAAAA

Downstream 100 bases:

>100_bases
TCTGATATTTCTCTTACTTGTTGGAGGGAAAAGCATTCGAATGGGGGAAGATAAAGCTTTTTTATCATTTGGAAAAAAAT
CAAATTTCGTAAATGTCCTC

Product: molybdopterin-converting factor subunit 2

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 141; Mature: 141

Protein sequence:

>141_residues
MDHITENKIEITDIIPSLPSMGGYVLFAGIVRNLNEGKMVTHLEYEAYSEMANQMIHSIIMDSKNKWELQYANCIHRLGS
LDVGEIAVIVSTGSVHREEAYLANRYIIDRVKHEVPIWKKEYFTDGSSEWSKGCVHDTNHE

Sequences:

>Translated_141_residues
MDHITENKIEITDIIPSLPSMGGYVLFAGIVRNLNEGKMVTHLEYEAYSEMANQMIHSIIMDSKNKWELQYANCIHRLGS
LDVGEIAVIVSTGSVHREEAYLANRYIIDRVKHEVPIWKKEYFTDGSSEWSKGCVHDTNHE
>Mature_141_residues
MDHITENKIEITDIIPSLPSMGGYVLFAGIVRNLNEGKMVTHLEYEAYSEMANQMIHSIIMDSKNKWELQYANCIHRLGS
LDVGEIAVIVSTGSVHREEAYLANRYIIDRVKHEVPIWKKEYFTDGSSEWSKGCVHDTNHE

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=132, Percent_Identity=40.1515151515151, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1787003, Length=105, Percent_Identity=37.1428571428571, Blast_Score=79, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17509279, Length=119, Percent_Identity=32.7731092436975, Blast_Score=75, Evalue=8e-15,
Organism=Drosophila melanogaster, GI21356259, Length=111, Percent_Identity=41.4414414414414, Blast_Score=87, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 16154; Mature: 16154

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHITENKIEITDIIPSLPSMGGYVLFAGIVRNLNEGKMVTHLEYEAYSEMANQMIHSII
CCCCCCCCEEHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHH
MDSKNKWELQYANCIHRLGSLDVGEIAVIVSTGSVHREEAYLANRYIIDRVKHEVPIWKK
HCCCCCEEEHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHH
EYFTDGSSEWSKGCVHDTNHE
HHCCCCCCCHHCCCCCCCCCC
>Mature Secondary Structure
MDHITENKIEITDIIPSLPSMGGYVLFAGIVRNLNEGKMVTHLEYEAYSEMANQMIHSII
CCCCCCCCEEHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHH
MDSKNKWELQYANCIHRLGSLDVGEIAVIVSTGSVHREEAYLANRYIIDRVKHEVPIWKK
HCCCCCEEEHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHH
EYFTDGSSEWSKGCVHDTNHE
HHCCCCCCCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]