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The map label for this gene is cueR [H]

Identifier: 183222099

GI number: 183222099

Start: 2832590

End: 2832982

Strand: Direct

Name: cueR [H]

Synonym: LEPBI_I2741

Alternate gene names: 183222099

Gene position: 2832590-2832982 (Clockwise)

Preceding gene: 183222090

Following gene: 183222101

Centisome position: 78.69

GC content: 37.66

Gene sequence:

>393_bases
ATGAATATCGGTGAACTTTCCAAGTCCTCAGGCGTTACGACAAAACTCATCCGCCATTACGAGAGCATTGGCCTCATCCC
AAAGACGCGAAGGACAGACAACGGGTATAGGCTTTATTCTGAAGACGACGTACACTATGTACGTTTCATCAAACGATCCA
GAGAACTTGGATTTTCATTAGAAGACATTAAAAGTTTGATCGGACTTTGGAAAAACAAATCCAGAAGTAGCAAACAAGTC
AAACAACTAGCTGAAAAACATTTGGAGGAATTAAATTTAAAATTAAAACAAATCAAAGACATGACAGATACTCTCAAACA
TTTAGTAAACCATTGTCATGGAGACCATAGGCCAGACTGCCCTATCTTAAAAAAATTAGAAACAGAAGCTTAA

Upstream 100 bases:

>100_bases
ACTCCAGTGTAAACCTTCCCACCGTTGGAAGGTCAATAGGCGATTTAAAATTTTTTCCCTTTTTTTTACTTTTTTTTGAT
CCCAATTTTGGAGTAAAATG

Downstream 100 bases:

>100_bases
AATTCAATTCAAAACATATCTTTGATTCGGTCTGCCATCAATCGATTGGCTTTTTCATTGAAGTGAATGTCTTCTCTTTG
TAAGAGTTGTTTTTGGTTTC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 130; Mature: 130

Protein sequence:

>130_residues
MNIGELSKSSGVTTKLIRHYESIGLIPKTRRTDNGYRLYSEDDVHYVRFIKRSRELGFSLEDIKSLIGLWKNKSRSSKQV
KQLAEKHLEELNLKLKQIKDMTDTLKHLVNHCHGDHRPDCPILKKLETEA

Sequences:

>Translated_130_residues
MNIGELSKSSGVTTKLIRHYESIGLIPKTRRTDNGYRLYSEDDVHYVRFIKRSRELGFSLEDIKSLIGLWKNKSRSSKQV
KQLAEKHLEELNLKLKQIKDMTDTLKHLVNHCHGDHRPDCPILKKLETEA
>Mature_130_residues
MNIGELSKSSGVTTKLIRHYESIGLIPKTRRTDNGYRLYSEDDVHYVRFIKRSRELGFSLEDIKSLIGLWKNKSRSSKQV
KQLAEKHLEELNLKLKQIKDMTDTLKHLVNHCHGDHRPDCPILKKLETEA

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=126, Percent_Identity=34.9206349206349, Blast_Score=99, Evalue=1e-22,
Organism=Escherichia coli, GI1789687, Length=131, Percent_Identity=33.587786259542, Blast_Score=84, Evalue=4e-18,
Organism=Escherichia coli, GI1790498, Length=123, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15140; Mature: 15140

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIGELSKSSGVTTKLIRHYESIGLIPKTRRTDNGYRLYSEDDVHYVRFIKRSRELGFSL
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHCCCCH
EDIKSLIGLWKNKSRSSKQVKQLAEKHLEELNLKLKQIKDMTDTLKHLVNHCHGDHRPDC
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PILKKLETEA
HHHHHHCCCC
>Mature Secondary Structure
MNIGELSKSSGVTTKLIRHYESIGLIPKTRRTDNGYRLYSEDDVHYVRFIKRSRELGFSL
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHCCCCH
EDIKSLIGLWKNKSRSSKQVKQLAEKHLEELNLKLKQIKDMTDTLKHLVNHCHGDHRPDC
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PILKKLETEA
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]