Click here to switch to the map view.

The map label for this gene is mapB [C]

Identifier: 183222069

GI number: 183222069

Start: 2808152

End: 2808907

Strand: Direct

Name: mapB [C]

Synonym: LEPBI_I2711

Alternate gene names: 183222069

Gene position: 2808152-2808907 (Clockwise)

Preceding gene: 183222068

Following gene: 183222070

Centisome position: 78.01

GC content: 45.37

Gene sequence:

>756_bases
GTGATCTATATCAAAAACAAATCAGAAATTGAAAAGATGAGAAAGGCGGGCAAATTTGCCGCCGAACTCCTCGTTTATCT
GGAACCCTTTGTGAAATCTGGTGTTTCCACTTTGGAACTGAACGACATTGCAGAGGCCTATACCAAAAAAAACGGCCACC
GCTCAGCCCCACTCGGTTACAAAGGATTCCCAAAATCCATTTGCACCTCCATCAACCAAGTGGTCTGCCATGGAATCCCG
AAAAAAGAAGACGTGCTGGCAGATGGTGACATCGTCAATTTAGATGTCTCTCCCATTGTAGATGGTTACATTGGAGATAC
GTCCAAAACCTTCATCGTCGGTGGAAAAACCACTCCCGAAGCAGAAAAACTCGTCTTTGACACCGAAAAAGCCATGTGGA
TTGGGATTGAACAAATCAAACCGGGCAACCGCATCGATGATATCGGTAACGCCATTGATGATTTCCTAACCCCACTTGGG
TATGGGATCGTCCGAGACCTAATGGGCCACGGCGTGGGTCGAAATTTCCATGAAGAACCACAAGTCCCCCATTTTCGTTC
GCCACGGAAATTAGCCAAAATCGAACCAGGAATGATCTTTACCGTGGAACCAATGGTCAATTTGGGTACTTGGGAAGTCA
ATTTTGATCGTTCCGATAAATGGACGGTCCGCACCAAAGATGGAAAATTATCGGCTCAATTCGAACACACCATCCTTGTC
ACAGACAAAGGGTATGAAATTCTAACAAAAGTTTGA

Upstream 100 bases:

>100_bases
CGACGGTATCAACGAAGAAATTTACCGTTTGATCGACAAAGCTCTCGAAAGAACTTCTGCCAACAAAAGAACAACGGTTC
GGTCGACTGATTTCTAATCC

Downstream 100 bases:

>100_bases
AGAAAAGGTTCTTGCCTTCGCAAAGTATCTATCGTCTAATTTGAAAAGAGGTTATCACATGAAGATTACTGTTACTCTAC
TCAGCGTATTATTGTTCACA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MIYIKNKSEIEKMRKAGKFAAELLVYLEPFVKSGVSTLELNDIAEAYTKKNGHRSAPLGYKGFPKSICTSINQVVCHGIP
KKEDVLADGDIVNLDVSPIVDGYIGDTSKTFIVGGKTTPEAEKLVFDTEKAMWIGIEQIKPGNRIDDIGNAIDDFLTPLG
YGIVRDLMGHGVGRNFHEEPQVPHFRSPRKLAKIEPGMIFTVEPMVNLGTWEVNFDRSDKWTVRTKDGKLSAQFEHTILV
TDKGYEILTKV

Sequences:

>Translated_251_residues
MIYIKNKSEIEKMRKAGKFAAELLVYLEPFVKSGVSTLELNDIAEAYTKKNGHRSAPLGYKGFPKSICTSINQVVCHGIP
KKEDVLADGDIVNLDVSPIVDGYIGDTSKTFIVGGKTTPEAEKLVFDTEKAMWIGIEQIKPGNRIDDIGNAIDDFLTPLG
YGIVRDLMGHGVGRNFHEEPQVPHFRSPRKLAKIEPGMIFTVEPMVNLGTWEVNFDRSDKWTVRTKDGKLSAQFEHTILV
TDKGYEILTKV
>Mature_251_residues
MIYIKNKSEIEKMRKAGKFAAELLVYLEPFVKSGVSTLELNDIAEAYTKKNGHRSAPLGYKGFPKSICTSINQVVCHGIP
KKEDVLADGDIVNLDVSPIVDGYIGDTSKTFIVGGKTTPEAEKLVFDTEKAMWIGIEQIKPGNRIDDIGNAIDDFLTPLG
YGIVRDLMGHGVGRNFHEEPQVPHFRSPRKLAKIEPGMIFTVEPMVNLGTWEVNFDRSDKWTVRTKDGKLSAQFEHTILV
TDKGYEILTKV

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=249, Percent_Identity=40.5622489959839, Blast_Score=192, Evalue=2e-49,
Organism=Homo sapiens, GI40385867, Length=250, Percent_Identity=37.6, Blast_Score=170, Evalue=1e-42,
Organism=Escherichia coli, GI1786364, Length=249, Percent_Identity=53.4136546184739, Blast_Score=258, Evalue=2e-70,
Organism=Escherichia coli, GI1788728, Length=250, Percent_Identity=26.8, Blast_Score=93, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71996291, Length=250, Percent_Identity=39.6, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6323273, Length=248, Percent_Identity=44.3548387096774, Blast_Score=214, Evalue=1e-56,
Organism=Drosophila melanogaster, GI21355531, Length=254, Percent_Identity=40.9448818897638, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24583427, Length=247, Percent_Identity=39.6761133603239, Blast_Score=177, Evalue=8e-45,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27970; Mature: 27970

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYIKNKSEIEKMRKAGKFAAELLVYLEPFVKSGVSTLELNDIAEAYTKKNGHRSAPLGY
CEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCCCCCCC
KGFPKSICTSINQVVCHGIPKKEDVLADGDIVNLDVSPIVDGYIGDTSKTFIVGGKTTPE
CCCCHHHHHHHHHHHHCCCCCCCCEECCCCEEEEEHHHHCCCCCCCCCCEEEECCCCCCC
AEKLVFDTEKAMWIGIEQIKPGNRIDDIGNAIDDFLTPLGYGIVRDLMGHGVGRNFHEEP
HHHEEEECCCEEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
QVPHFRSPRKLAKIEPGMIFTVEPMVNLGTWEVNFDRSDKWTVRTKDGKLSAQFEHTILV
CCCCCCCCCHHHHCCCCEEEEECCCCCCCEEEEECCCCCCEEEEECCCCEEEEEEEEEEE
TDKGYEILTKV
ECCCCEEEECC
>Mature Secondary Structure
MIYIKNKSEIEKMRKAGKFAAELLVYLEPFVKSGVSTLELNDIAEAYTKKNGHRSAPLGY
CEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCCCCCCC
KGFPKSICTSINQVVCHGIPKKEDVLADGDIVNLDVSPIVDGYIGDTSKTFIVGGKTTPE
CCCCHHHHHHHHHHHHCCCCCCCCEECCCCEEEEEHHHHCCCCCCCCCCEEEECCCCCCC
AEKLVFDTEKAMWIGIEQIKPGNRIDDIGNAIDDFLTPLGYGIVRDLMGHGVGRNFHEEP
HHHEEEECCCEEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
QVPHFRSPRKLAKIEPGMIFTVEPMVNLGTWEVNFDRSDKWTVRTKDGKLSAQFEHTILV
CCCCCCCCCHHHHCCCCEEEEECCCCCCCEEEEECCCCCCEEEEECCCCEEEEEEEEEEE
TDKGYEILTKV
ECCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]