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The map label for this gene is nadR [H]

Identifier: 183222060

GI number: 183222060

Start: 2799101

End: 2800144

Strand: Direct

Name: nadR [H]

Synonym: LEPBI_I2702

Alternate gene names: 183222060

Gene position: 2799101-2800144 (Clockwise)

Preceding gene: 183222059

Following gene: 183222064

Centisome position: 77.76

GC content: 39.56

Gene sequence:

>1044_bases
ATGATCCATGGTCTCATCCTTGGAAAATTTTATCCACCACACAAAGGCCACCTCCATTTGATAAAGGAAGCCAAAAAAAA
ATGCGATGTATTAACAGTCCTTATGTGTTCATTAGAAAAGGAACTCATTCCAGGTAATCTTCGTTATGAATGGATGTTGG
AACTTCTACCAAATCCAAATATAGAAATCGTTTGGGTCAAAGATGAAAATCCGCAATACCCAGAAGAACATCCAAATTTT
TGGCAAATTTGGAAACAAACGATCAATTCCCATACCAATCAACAAATTGATATTGTATTCACTTCAGAACTCTATGGCGA
CCAATTAGCATCTGTTCTCGGGTGTCAACACATCCCCATTGACATTGATCGAAAAGTAGTCCCGATCTCTGGCACACAAA
TCAGAGAAAAACCCATTCAATTCTTTGAATGGATCCCAGAACCAATCCGACCCTATTTTGTAAAAAGGATTGTTCTCACA
GGAAGTGAGTCTGTTGGCAAAACCACACTGGCCAAAAAACTCGCAGATCATTTTCAAACCAATTGGATTCCAGAATATGC
GAGAGACTATTTAGAAAAAAAGTCAACACCAATGGCTGAATCCGATTTTTTACCAATCGCGAAAGGACACCTACTTTCCG
AAGTGGAGGCCGCCAAATCTTCTCATGGAATTTTATTTTTAGACACAGACCTACTCACTACCAAGGTGTACTTAGAACGG
TATTATCAAAGAGAAATCCCATGGCTCACCGAACGGGCGCTTGGTTTACAATATGATACTTCTTTATTTTTAGACATCGA
CATCCCTTGGGAAAAGGACAAATTACGAGACTTAGGTGAGGAACGTGAGGGAATGAAAACTCGATTTTTAGAAGCGATGG
AAGAAGCAAAAAGAGATTTTTTTTGGGTCAAAGGTAATTTTATGGAAAGAGAGAGACTGGCAATCGACTATGTGAATCAA
ATCAAAGAGGGGCCCATGAACCCTGTGGCATTTACGAAAGAGCAGACTCTTTTACGTACGATTGGATCAGATCCGATGGC
ATAA

Upstream 100 bases:

>100_bases
TTTTTGGACCTAGATCCCAAGTAAAGCTGTCTAACAACTTCCCGTTAGATGGCAAAAAAAAAATCGCGTTTATCAATTCC
TATCGAAATGAGGAAACGAT

Downstream 100 bases:

>100_bases
TTTCGCCAGTGATGAGTTGTTTCATTTCATACAAAGTGGTCCCCTTCGAACCATTATCGATATTTTTCGGACCAAAATGG
CGTTTGATATGTTCACCGAT

Product: NadR family transcriptional regulator

Products: NA

Alternate protein names: Transcriptional regulator NadR; Nicotinamide mononucleotide adenylyltransferase; NMN adenylyltransferase; NMN-AT; NMNAT; Nicotinamide ribonucleotide adenylyltransferase; Nicotinamide-nucleotide adenylyltransferase; Ribosylnicotinamide kinase; RNK; Nicotinamide riboside kinase; NRK; NmR-K [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MIHGLILGKFYPPHKGHLHLIKEAKKKCDVLTVLMCSLEKELIPGNLRYEWMLELLPNPNIEIVWVKDENPQYPEEHPNF
WQIWKQTINSHTNQQIDIVFTSELYGDQLASVLGCQHIPIDIDRKVVPISGTQIREKPIQFFEWIPEPIRPYFVKRIVLT
GSESVGKTTLAKKLADHFQTNWIPEYARDYLEKKSTPMAESDFLPIAKGHLLSEVEAAKSSHGILFLDTDLLTTKVYLER
YYQREIPWLTERALGLQYDTSLFLDIDIPWEKDKLRDLGEEREGMKTRFLEAMEEAKRDFFWVKGNFMERERLAIDYVNQ
IKEGPMNPVAFTKEQTLLRTIGSDPMA

Sequences:

>Translated_347_residues
MIHGLILGKFYPPHKGHLHLIKEAKKKCDVLTVLMCSLEKELIPGNLRYEWMLELLPNPNIEIVWVKDENPQYPEEHPNF
WQIWKQTINSHTNQQIDIVFTSELYGDQLASVLGCQHIPIDIDRKVVPISGTQIREKPIQFFEWIPEPIRPYFVKRIVLT
GSESVGKTTLAKKLADHFQTNWIPEYARDYLEKKSTPMAESDFLPIAKGHLLSEVEAAKSSHGILFLDTDLLTTKVYLER
YYQREIPWLTERALGLQYDTSLFLDIDIPWEKDKLRDLGEEREGMKTRFLEAMEEAKRDFFWVKGNFMERERLAIDYVNQ
IKEGPMNPVAFTKEQTLLRTIGSDPMA
>Mature_347_residues
MIHGLILGKFYPPHKGHLHLIKEAKKKCDVLTVLMCSLEKELIPGNLRYEWMLELLPNPNIEIVWVKDENPQYPEEHPNF
WQIWKQTINSHTNQQIDIVFTSELYGDQLASVLGCQHIPIDIDRKVVPISGTQIREKPIQFFEWIPEPIRPYFVKRIVLT
GSESVGKTTLAKKLADHFQTNWIPEYARDYLEKKSTPMAESDFLPIAKGHLLSEVEAAKSSHGILFLDTDLLTTKVYLER
YYQREIPWLTERALGLQYDTSLFLDIDIPWEKDKLRDLGEEREGMKTRFLEAMEEAKRDFFWVKGNFMERERLAIDYVNQ
IKEGPMNPVAFTKEQTLLRTIGSDPMA

Specific function: This enzyme has three activities:DNA binding, nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The DNA-binding domain binds to the nadB operator sequence in an NAD- and ATP-dependent manner. As NAD levels increase

COG id: COG1056

COG function: function code H; Nicotinamide mononucleotide adenylyltransferase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein. Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH cro/C1-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082440, Length=326, Percent_Identity=31.9018404907975, Blast_Score=164, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016429
- InterPro:   IPR004821
- InterPro:   IPR001387
- InterPro:   IPR010982
- InterPro:   IPR006417
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01381 HTH_3 [H]

EC number: =2.7.7.1; =2.7.1.22 [H]

Molecular weight: Translated: 40545; Mature: 40545

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHGLILGKFYPPHKGHLHLIKEAKKKCDVLTVLMCSLEKELIPGNLRYEWMLELLPNPN
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCC
IEIVWVKDENPQYPEEHPNFWQIWKQTINSHTNQQIDIVFTSELYGDQLASVLGCQHIPI
EEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHCCCCCCC
DIDRKVVPISGTQIREKPIQFFEWIPEPIRPYFVKRIVLTGSESVGKTTLAKKLADHFQT
CCCCEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHC
NWIPEYARDYLEKKSTPMAESDFLPIAKGHLLSEVEAAKSSHGILFLDTDLLTTKVYLER
CCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHH
YYQREIPWLTERALGLQYDTSLFLDIDIPWEKDKLRDLGEEREGMKTRFLEAMEEAKRDF
HHHHCCCHHHHHHCCCEECCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCE
FWVKGNFMERERLAIDYVNQIKEGPMNPVAFTKEQTLLRTIGSDPMA
EEEECCCCCHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIHGLILGKFYPPHKGHLHLIKEAKKKCDVLTVLMCSLEKELIPGNLRYEWMLELLPNPN
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCC
IEIVWVKDENPQYPEEHPNFWQIWKQTINSHTNQQIDIVFTSELYGDQLASVLGCQHIPI
EEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHCCCCCCC
DIDRKVVPISGTQIREKPIQFFEWIPEPIRPYFVKRIVLTGSESVGKTTLAKKLADHFQT
CCCCEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHC
NWIPEYARDYLEKKSTPMAESDFLPIAKGHLLSEVEAAKSSHGILFLDTDLLTTKVYLER
CCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHH
YYQREIPWLTERALGLQYDTSLFLDIDIPWEKDKLRDLGEEREGMKTRFLEAMEEAKRDF
HHHHCCCHHHHHHCCCEECCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCE
FWVKGNFMERERLAIDYVNQIKEGPMNPVAFTKEQTLLRTIGSDPMA
EEEECCCCCHHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 1327967 [H]