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The map label for this gene is acpS

Identifier: 183222004

GI number: 183222004

Start: 2737362

End: 2737745

Strand: Reverse

Name: acpS

Synonym: LEPBI_I2645

Alternate gene names: 183222004

Gene position: 2737745-2737362 (Counterclockwise)

Preceding gene: 183222005

Following gene: 183222003

Centisome position: 76.06

GC content: 46.09

Gene sequence:

>384_bases
ATGTTATCAGTCGGGAACGACATTGTCGAAAACGAACGAATTCGAGAATTATTACAAAAACACGGTGATCGGTTTTTGAA
ACGGGTTTTTACCGATGACGAAGTTGAATACTGCCACAAACACAAGGACCCTGTGCCTTTTTTGGCAGGCCGGTTTGCTT
GTAAAGAGGCCGTCATCAAAGCCCTCAATCTAGAGCCAGGCCAGGTTGCGGATATGCGTGAGATTGAACTCGCAGGCACC
AATTTTGGGAAAAAAACGCTAGTCATCCATGGGAAAACTGAGAAGTTTTTCCGTGAGAAAGGATTTACGGGAAGTTCAGT
GTCGATTAGCCACGCCGACCACTATTCCACCGCCGTTGTCGTATTCTTTAAGGAGCCCAAATGA

Upstream 100 bases:

>100_bases
TTGATTATTCCGAGCGGGTGAAACTTAGGCGGCCATACCACAAAGAAAACAATCGATTATTTGCTCGACTCACAGCACTT
CGGCGTAATTCAATCTAGAT

Downstream 100 bases:

>100_bases
TCGTAAGTGATAAAATGAAGTCAGTGATTGTCCATTACAACCAAGGACTAACATTGTACAAATCTCGAAAATTTGCTGAA
GCAAAAGAAGAATTCAAAAA

Product: holo-[acyl-carrier-protein] synthase

Products: NA

Alternate protein names: Holo-ACP synthase; 4'-phosphopantetheinyl transferase AcpS

Number of amino acids: Translated: 127; Mature: 127

Protein sequence:

>127_residues
MLSVGNDIVENERIRELLQKHGDRFLKRVFTDDEVEYCHKHKDPVPFLAGRFACKEAVIKALNLEPGQVADMREIELAGT
NFGKKTLVIHGKTEKFFREKGFTGSSVSISHADHYSTAVVVFFKEPK

Sequences:

>Translated_127_residues
MLSVGNDIVENERIRELLQKHGDRFLKRVFTDDEVEYCHKHKDPVPFLAGRFACKEAVIKALNLEPGQVADMREIELAGT
NFGKKTLVIHGKTEKFFREKGFTGSSVSISHADHYSTAVVVFFKEPK
>Mature_127_residues
MLSVGNDIVENERIRELLQKHGDRFLKRVFTDDEVEYCHKHKDPVPFLAGRFACKEAVIKALNLEPGQVADMREIELAGT
NFGKKTLVIHGKTEKFFREKGFTGSSVSISHADHYSTAVVVFFKEPK

Specific function: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein

COG id: COG0736

COG function: function code I; Phosphopantetheinyl transferase (holo-ACP synthase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the P-Pant transferase superfamily. AcpS family

Homologues:

Organism=Escherichia coli, GI1788916, Length=122, Percent_Identity=33.6065573770492, Blast_Score=74, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6325025, Length=103, Percent_Identity=36.8932038834951, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACPS_LEPBA (B0SE17)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001963626.1
- ProteinModelPortal:   B0SE17
- SMR:   B0SE17
- GeneID:   6389238
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_2564
- HOGENOM:   HBG734479
- OMA:   DYAIAFI
- ProtClustDB:   CLSK574788
- BioCyc:   LBIF355278:LBF_2564-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00101
- InterPro:   IPR008278
- InterPro:   IPR002582
- InterPro:   IPR004568
- ProDom:   PD004282
- TIGRFAMs:   TIGR00516
- TIGRFAMs:   TIGR00556

Pfam domain/function: PF01648 ACPS; SSF56214 4-PPT_transf

EC number: =2.7.8.7

Molecular weight: Translated: 14422; Mature: 14422

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSVGNDIVENERIRELLQKHGDRFLKRVFTDDEVEYCHKHKDPVPFLAGRFACKEAVIK
CCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHH
ALNLEPGQVADMREIELAGTNFGKKTLVIHGKTEKFFREKGFTGSSVSISHADHYSTAVV
HHCCCCCCCCCCCEEEECCCCCCCEEEEEECCHHHHHHHCCCCCCCEEECCCCCCCEEEE
VFFKEPK
EEEECCC
>Mature Secondary Structure
MLSVGNDIVENERIRELLQKHGDRFLKRVFTDDEVEYCHKHKDPVPFLAGRFACKEAVIK
CCCCCCHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHH
ALNLEPGQVADMREIELAGTNFGKKTLVIHGKTEKFFREKGFTGSSVSISHADHYSTAVV
HHCCCCCCCCCCCEEEECCCCCCCEEEEEECCHHHHHHHCCCCCCCEEECCCCCCCEEEE
VFFKEPK
EEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA