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The map label for this gene is crp [C]

Identifier: 183221884

GI number: 183221884

Start: 2604043

End: 2605197

Strand: Direct

Name: crp [C]

Synonym: LEPBI_I2520

Alternate gene names: 183221884

Gene position: 2604043-2605197 (Clockwise)

Preceding gene: 183221882

Following gene: 183221885

Centisome position: 72.34

GC content: 43.55

Gene sequence:

>1155_bases
ATGGGGAATTTATCGCCGAACAACCGTTATCATGCAATTATGTTCTCTAAGCCAACATCCCTAGCGATTAAAGAAATCAT
CACAGGAACTGATTTATTCCTGAACCTCTCACCTGAAACAAAAGAACACCTAGCAAAGTCGTTCGTTAAAGTCAAAGTTC
CCAAGAACAAGGTTGTGATCAAACAAGGAGAACACGGGGATGCACTCTATCTTGTGGCAACCGGAAGTTTTAGCGTTTAT
GTAACAACAGACGGAAAAAAAGAGAAAGTGGGTGAAATCAAACCTGGCAGTTGTTTTGGCGAAGGTGCTCTTGTGACAGA
CGAACCAAGGAACGCCACTGTGATCTCAGAGCAGATAGGAACCGTCTACAGAATTGGTCGTGAAGAATTCAAAAAAGCCT
TCAAAGATCGTTCGGAAGAACTAAAGGCTTTCGTTAAACTGATCAGTCGTAGGTCACGTGCTTTGCATCGTAGTGTGTTT
CGTCCTGAACCGAGGCGTATCAAAGAACTCATTTCGACAGTTTCCCTTTTTAGTGGCGTGGGTGCAAAACTCATCTCTGA
GCTTGAACCTCAAATGGAATGGATCTTTTTACCTGGTGGAGAAACTCTCATGCGCCAAGGCGACAAAGCCGACGGAATGT
ATGTTGTCGTCAATGGTAGTCTTGTGTATGAAGTGAGAAATCTTGAGAACACCATTGTCTCTACTGGTTCTTTTTCCAAA
GGTGATATCATTGGTGAAATCGCCCTTCTCACTGGGGAACCGCGGACCGCCACAGTTGTTGCAACACTCTCCTGTGAGAT
AGTGAAAATCAGCACAGCTGCATTTGAAGCCGTTTTCTCCAAACATCCACCCAGCATGTATGCGATTACCAAACTGATCG
CAGAACGATTCTCAAACGATCGGATGGGCAAACGAATGCCCAAACAAGCAAGGAGTATCATTACACTCTTCCCTTTACAG
AAAGATCTTTCTGCTCGTAATTTTGCTCAAAACCTTTCACAAGCTTTAAAAAAATTTGGACGCACCGCAATCATCGAAAG
TCGCGATTTTAAAAAACGCCTTGGCAATCGAGAATATGCCGTTTCAGACTTACTCGAATCACTGTATCAAATGCAGGATT
CCCATGAATTCCTAATCCTTTGCCCTGACTTTTAG

Upstream 100 bases:

>100_bases
TACATTTTTCCAATTTTTTAAAAAAAAATAGATTCGCCATGAAACTACCCAGTCTCGCATGATCCTCATTGGATTCCGTT
GATTCATTTCTCAATTTAAC

Downstream 100 bases:

>100_bases
GACAAACTTTGGACAGAAACAATTCTACACCATACCAATCGCATTTTGTTGTTAAGTGAGGCGCATAGAACTGGTGGACT
TACCGCAGAAGAAATCCGTT

Product: putative cAMP-dependent protein kinase

Products: NA

Alternate protein names: Cyclic AMP Receptor Protein; Patatin; Sodium/Hydrogen Exchanger Family Protein; Esterase; Transcription Regulator Crp Family; Alpha-Beta Hydrolase Family Esterase; CAMP-Dependent Protein Kinase

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MGNLSPNNRYHAIMFSKPTSLAIKEIITGTDLFLNLSPETKEHLAKSFVKVKVPKNKVVIKQGEHGDALYLVATGSFSVY
VTTDGKKEKVGEIKPGSCFGEGALVTDEPRNATVISEQIGTVYRIGREEFKKAFKDRSEELKAFVKLISRRSRALHRSVF
RPEPRRIKELISTVSLFSGVGAKLISELEPQMEWIFLPGGETLMRQGDKADGMYVVVNGSLVYEVRNLENTIVSTGSFSK
GDIIGEIALLTGEPRTATVVATLSCEIVKISTAAFEAVFSKHPPSMYAITKLIAERFSNDRMGKRMPKQARSIITLFPLQ
KDLSARNFAQNLSQALKKFGRTAIIESRDFKKRLGNREYAVSDLLESLYQMQDSHEFLILCPDF

Sequences:

>Translated_384_residues
MGNLSPNNRYHAIMFSKPTSLAIKEIITGTDLFLNLSPETKEHLAKSFVKVKVPKNKVVIKQGEHGDALYLVATGSFSVY
VTTDGKKEKVGEIKPGSCFGEGALVTDEPRNATVISEQIGTVYRIGREEFKKAFKDRSEELKAFVKLISRRSRALHRSVF
RPEPRRIKELISTVSLFSGVGAKLISELEPQMEWIFLPGGETLMRQGDKADGMYVVVNGSLVYEVRNLENTIVSTGSFSK
GDIIGEIALLTGEPRTATVVATLSCEIVKISTAAFEAVFSKHPPSMYAITKLIAERFSNDRMGKRMPKQARSIITLFPLQ
KDLSARNFAQNLSQALKKFGRTAIIESRDFKKRLGNREYAVSDLLESLYQMQDSHEFLILCPDF
>Mature_383_residues
GNLSPNNRYHAIMFSKPTSLAIKEIITGTDLFLNLSPETKEHLAKSFVKVKVPKNKVVIKQGEHGDALYLVATGSFSVYV
TTDGKKEKVGEIKPGSCFGEGALVTDEPRNATVISEQIGTVYRIGREEFKKAFKDRSEELKAFVKLISRRSRALHRSVFR
PEPRRIKELISTVSLFSGVGAKLISELEPQMEWIFLPGGETLMRQGDKADGMYVVVNGSLVYEVRNLENTIVSTGSFSKG
DIIGEIALLTGEPRTATVVATLSCEIVKISTAAFEAVFSKHPPSMYAITKLIAERFSNDRMGKRMPKQARSIITLFPLQK
DLSARNFAQNLSQALKKFGRTAIIESRDFKKRLGNREYAVSDLLESLYQMQDSHEFLILCPDF

Specific function: This Protein Complexes With Cyclic AMP And Binds To Specific DNA Sites Near The Promoter To Regulate The Transcription Of Several Catabolite-Sensitive Operons. The Protein Induces A Severe Bend In The DNA. Acts As A Negative Regulator Of Its Own Synthesi

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI148727290, Length=377, Percent_Identity=23.0769230769231, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI148727335, Length=377, Percent_Identity=23.0769230769231, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI47132585, Length=280, Percent_Identity=26.7857142857143, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI4758958, Length=281, Percent_Identity=25.9786476868327, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI260656041, Length=348, Percent_Identity=21.264367816092, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI116256487, Length=348, Percent_Identity=21.264367816092, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI260656043, Length=347, Percent_Identity=21.3256484149856, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI258613977, Length=262, Percent_Identity=28.2442748091603, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI258613975, Length=262, Percent_Identity=28.2442748091603, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI258613973, Length=262, Percent_Identity=28.2442748091603, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI258613971, Length=262, Percent_Identity=28.2442748091603, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI258613969, Length=262, Percent_Identity=28.2442748091603, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI38257139, Length=262, Percent_Identity=28.2442748091603, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI260656037, Length=348, Percent_Identity=21.264367816092, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI47132583, Length=262, Percent_Identity=27.8625954198473, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI47132581, Length=262, Percent_Identity=27.8625954198473, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4506063, Length=262, Percent_Identity=27.8625954198473, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI260656039, Length=337, Percent_Identity=21.3649851632047, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI1789756, Length=120, Percent_Identity=28.3333333333333, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115534999, Length=249, Percent_Identity=26.5060240963855, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI133901990, Length=249, Percent_Identity=26.5060240963855, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71994934, Length=249, Percent_Identity=26.5060240963855, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17539608, Length=255, Percent_Identity=23.921568627451, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17539610, Length=255, Percent_Identity=23.921568627451, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI25145047, Length=255, Percent_Identity=23.921568627451, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71989393, Length=255, Percent_Identity=23.921568627451, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6322156, Length=245, Percent_Identity=27.7551020408163, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323581, Length=243, Percent_Identity=26.7489711934156, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI161076490, Length=248, Percent_Identity=27.0161290322581, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28573932, Length=231, Percent_Identity=27.2727272727273, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28573930, Length=231, Percent_Identity=27.2727272727273, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17647815, Length=231, Percent_Identity=27.2727272727273, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI161076492, Length=231, Percent_Identity=27.2727272727273, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI62472300, Length=259, Percent_Identity=27.4131274131274, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI62472310, Length=259, Percent_Identity=27.4131274131274, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI28574654, Length=259, Percent_Identity=27.4131274131274, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI28574656, Length=259, Percent_Identity=27.4131274131274, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI62472279, Length=259, Percent_Identity=27.4131274131274, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI62472291, Length=259, Percent_Identity=27.4131274131274, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24667745, Length=259, Percent_Identity=27.4131274131274, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI221513359, Length=259, Percent_Identity=27.4131274131274, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI62472332, Length=259, Percent_Identity=27.4131274131274, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI62472322, Length=259, Percent_Identity=27.4131274131274, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI28574658, Length=259, Percent_Identity=27.4131274131274, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI281376913, Length=363, Percent_Identity=22.8650137741047, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28571388, Length=363, Percent_Identity=22.8650137741047, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 42852; Mature: 42721

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS00888 CNMP_BINDING_1 ; PS00889 CNMP_BINDING_2 ; PS50042 CNMP_BINDING_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNLSPNNRYHAIMFSKPTSLAIKEIITGTDLFLNLSPETKEHLAKSFVKVKVPKNKVVI
CCCCCCCCCEEEEEEECCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHEEEECCCCEEEE
KQGEHGDALYLVATGSFSVYVTTDGKKEKVGEIKPGSCFGEGALVTDEPRNATVISEQIG
EECCCCCEEEEEEECCEEEEEEECCCHHHCCCCCCCCCCCCCCEEECCCCCCEEEHHHHH
TVYRIGREEFKKAFKDRSEELKAFVKLISRRSRALHRSVFRPEPRRIKELISTVSLFSGV
HHHHHCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
GAKLISELEPQMEWIFLPGGETLMRQGDKADGMYVVVNGSLVYEVRNLENTIVSTGSFSK
HHHHHHHCCCCEEEEEECCCHHHHHCCCCCCCEEEEECCEEEEEEECCCHHEEECCCCCC
GDIIGEIALLTGEPRTATVVATLSCEIVKISTAAFEAVFSKHPPSMYAITKLIAERFSND
CCEEEEEEEEECCCCCEEEEEEEEEEEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
RMGKRMPKQARSIITLFPLQKDLSARNFAQNLSQALKKFGRTAIIESRDFKKRLGNREYA
CHHHCCCHHHHCEEEEECCHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHCCCCHH
VSDLLESLYQMQDSHEFLILCPDF
HHHHHHHHHHHCCCCCEEEECCCC
>Mature Secondary Structure 
GNLSPNNRYHAIMFSKPTSLAIKEIITGTDLFLNLSPETKEHLAKSFVKVKVPKNKVVI
CCCCCCCCEEEEEEECCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHEEEECCCCEEEE
KQGEHGDALYLVATGSFSVYVTTDGKKEKVGEIKPGSCFGEGALVTDEPRNATVISEQIG
EECCCCCEEEEEEECCEEEEEEECCCHHHCCCCCCCCCCCCCCEEECCCCCCEEEHHHHH
TVYRIGREEFKKAFKDRSEELKAFVKLISRRSRALHRSVFRPEPRRIKELISTVSLFSGV
HHHHHCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
GAKLISELEPQMEWIFLPGGETLMRQGDKADGMYVVVNGSLVYEVRNLENTIVSTGSFSK
HHHHHHHCCCCEEEEEECCCHHHHHCCCCCCCEEEEECCEEEEEEECCCHHEEECCCCCC
GDIIGEIALLTGEPRTATVVATLSCEIVKISTAAFEAVFSKHPPSMYAITKLIAERFSND
CCEEEEEEEEECCCCCEEEEEEEEEEEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
RMGKRMPKQARSIITLFPLQKDLSARNFAQNLSQALKKFGRTAIIESRDFKKRLGNREYA
CHHHCCCHHHHCEEEEECCHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHCCCCHH
VSDLLESLYQMQDSHEFLILCPDF
HHHHHHHHHHHCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA