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The map label for this gene is cyaA [H]

Identifier: 183221873

GI number: 183221873

Start: 2591656

End: 2592846

Strand: Direct

Name: cyaA [H]

Synonym: LEPBI_I2508

Alternate gene names: 183221873

Gene position: 2591656-2592846 (Clockwise)

Preceding gene: 183221868

Following gene: 183221875

Centisome position: 72.0

GC content: 34.84

Gene sequence:

>1191_bases
ATGAAAAATGAAAAAACTGTAGCGCTTGTCCGATTTGCATTATTTTCAATTACCTCCATAATGGATTTTGTATCGTATCT
TGGATGGATCAGTTATACAATTGTCACACCAAGTTTGATCACAGTTGGACTTGATTTGACGTTTCTCGTTTTTGCCAGTA
TCGTATTAATTTTTGTAAATTTTTTACCTTATAAACCATATTTAAAATTTTTCACAATTGCATTCGATTATTTCATCATA
GGGCTTATGATGTTTTTAGATCCAACGATCATCAAAGCAAATGGTCTGATTTACTTTATCGCAATGACAAGCGCCATTTT
TATTTTCCAACTCAATTTATTAAGGCATTCTAAAACGGGAACCATATACGGCGCAATCCTAGCTTTTATATATTTTATGG
TAGTTTCAGTTGGTTTAGGTGATGGATATCCCTTTGATTTGATTCCCATGATTTTTGGTTTGGGAATGTTGTTAGCCATT
GGTTATGTGACTACCGTATCGAATATTGAAATGGTAAAAGAAGCCAATACAAAACAAATGATGGAAAGATTCCTTCCTTC
ACAGTTAGTAGGTGAGTTCTATAAAAACAAAGTACAACTAGAACCTGGAGGCGAAAACAAAGAAGTCACTATTCTTTTTT
CAGATATCCGTGCATTTACAAAATTTTCAGAACAAAGGTCAGCTGAAGAAGTTGTTACATTTTTAAATGACTATTTGTCT
CGCATGACTGATGTGATCTTCAAATTCAACGGTACGATAGATAAATTTATCGGTGATGCGATCATGACTATATTTGGTGC
TCCATTCAAAAGAGATGACGATGCTCTCCGCGCCGTTAAAACTGCAGTTGCCATGATGCGTGAAATAGAATCGTTAAATC
AGAAACAAAAATGTCCTGAAGACAAAATACATGTAGGAATCGGAATCCATACAGGAGAAGCAATTGTTGGCAATATTGGA
TCGGAACGAAGGTTGGATTATACTGTCATTGGTGACAATGTAAACTTAGCCTCAAGGATCGAAGGGTTAACAAAACATTA
TAATTGCCCAATCTTAATTTCTGAAGTGACTTACAAACAAGTAGTCGGCAAATATTCAACCGAAGATGGTTTTGAAATCA
GAGAAATTGACCAAGTCATTGTCAAAGGAAAATCGAAACCAATCACAGTGTGTGAAGTAGTTTGTTTGTGA

Upstream 100 bases:

>100_bases
CCAATTCAAGGGGTCTGGGTCTGTTAACGGGAAAAATCCTAATTTTTTGGTTAAATAAATGAAACATTCGTTAGTTGATG
AAATCCTAATCGCAAGGGAG

Downstream 100 bases:

>100_bases
ATTAGTTATCCATATTCACTCAATTACAAACAAATTTCCAAGAAGTATTAATAGTTTTTTTTAAATTTTTTAAAAAGATA
TCCTATTAACACAGCTGGAA

Product: putative adenylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; AC 1 [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MKNEKTVALVRFALFSITSIMDFVSYLGWISYTIVTPSLITVGLDLTFLVFASIVLIFVNFLPYKPYLKFFTIAFDYFII
GLMMFLDPTIIKANGLIYFIAMTSAIFIFQLNLLRHSKTGTIYGAILAFIYFMVVSVGLGDGYPFDLIPMIFGLGMLLAI
GYVTTVSNIEMVKEANTKQMMERFLPSQLVGEFYKNKVQLEPGGENKEVTILFSDIRAFTKFSEQRSAEEVVTFLNDYLS
RMTDVIFKFNGTIDKFIGDAIMTIFGAPFKRDDDALRAVKTAVAMMREIESLNQKQKCPEDKIHVGIGIHTGEAIVGNIG
SERRLDYTVIGDNVNLASRIEGLTKHYNCPILISEVTYKQVVGKYSTEDGFEIREIDQVIVKGKSKPITVCEVVCL

Sequences:

>Translated_396_residues
MKNEKTVALVRFALFSITSIMDFVSYLGWISYTIVTPSLITVGLDLTFLVFASIVLIFVNFLPYKPYLKFFTIAFDYFII
GLMMFLDPTIIKANGLIYFIAMTSAIFIFQLNLLRHSKTGTIYGAILAFIYFMVVSVGLGDGYPFDLIPMIFGLGMLLAI
GYVTTVSNIEMVKEANTKQMMERFLPSQLVGEFYKNKVQLEPGGENKEVTILFSDIRAFTKFSEQRSAEEVVTFLNDYLS
RMTDVIFKFNGTIDKFIGDAIMTIFGAPFKRDDDALRAVKTAVAMMREIESLNQKQKCPEDKIHVGIGIHTGEAIVGNIG
SERRLDYTVIGDNVNLASRIEGLTKHYNCPILISEVTYKQVVGKYSTEDGFEIREIDQVIVKGKSKPITVCEVVCL
>Mature_396_residues
MKNEKTVALVRFALFSITSIMDFVSYLGWISYTIVTPSLITVGLDLTFLVFASIVLIFVNFLPYKPYLKFFTIAFDYFII
GLMMFLDPTIIKANGLIYFIAMTSAIFIFQLNLLRHSKTGTIYGAILAFIYFMVVSVGLGDGYPFDLIPMIFGLGMLLAI
GYVTTVSNIEMVKEANTKQMMERFLPSQLVGEFYKNKVQLEPGGENKEVTILFSDIRAFTKFSEQRSAEEVVTFLNDYLS
RMTDVIFKFNGTIDKFIGDAIMTIFGAPFKRDDDALRAVKTAVAMMREIESLNQKQKCPEDKIHVGIGIHTGEAIVGNIG
SERRLDYTVIGDNVNLASRIEGLTKHYNCPILISEVTYKQVVGKYSTEDGFEIREIDQVIVKGKSKPITVCEVVCL

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain [H]

Homologues:

Organism=Homo sapiens, GI50959205, Length=180, Percent_Identity=32.2222222222222, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI148536830, Length=268, Percent_Identity=25.7462686567164, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI167830411, Length=233, Percent_Identity=30.4721030042918, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4557255, Length=227, Percent_Identity=28.1938325991189, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI4557257, Length=166, Percent_Identity=28.9156626506024, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4580422, Length=188, Percent_Identity=30.3191489361702, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4504215, Length=228, Percent_Identity=31.5789473684211, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI134152694, Length=215, Percent_Identity=28.8372093023256, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71989822, Length=183, Percent_Identity=32.2404371584699, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71989805, Length=184, Percent_Identity=33.1521739130435, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17508769, Length=150, Percent_Identity=35.3333333333333, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17551720, Length=210, Percent_Identity=29.5238095238095, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17561804, Length=231, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17534657, Length=210, Percent_Identity=32.3809523809524, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17534655, Length=208, Percent_Identity=30.2884615384615, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71982300, Length=237, Percent_Identity=28.2700421940928, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17561802, Length=252, Percent_Identity=28.1746031746032, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17561800, Length=252, Percent_Identity=28.1746031746032, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17534659, Length=226, Percent_Identity=29.646017699115, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI212645052, Length=261, Percent_Identity=27.9693486590038, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI193207841, Length=223, Percent_Identity=29.1479820627803, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71994363, Length=221, Percent_Identity=27.6018099547511, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17534649, Length=207, Percent_Identity=28.9855072463768, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17534665, Length=186, Percent_Identity=29.0322580645161, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI193206632, Length=224, Percent_Identity=29.4642857142857, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17534653, Length=234, Percent_Identity=28.6324786324786, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17568383, Length=145, Percent_Identity=33.1034482758621, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193210669, Length=216, Percent_Identity=28.7037037037037, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17534651, Length=207, Percent_Identity=28.0193236714976, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI212645647, Length=192, Percent_Identity=28.125, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI193205840, Length=221, Percent_Identity=26.6968325791855, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI221330468, Length=214, Percent_Identity=31.3084112149533, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI221330470, Length=214, Percent_Identity=31.3084112149533, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24585694, Length=173, Percent_Identity=31.7919075144509, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI161078020, Length=213, Percent_Identity=30.9859154929577, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI28574512, Length=208, Percent_Identity=30.7692307692308, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI161076872, Length=208, Percent_Identity=30.7692307692308, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI62473752, Length=183, Percent_Identity=27.3224043715847, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI17137448, Length=183, Percent_Identity=27.3224043715847, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24647268, Length=186, Percent_Identity=31.7204301075269, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24651577, Length=233, Percent_Identity=27.4678111587983, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24663839, Length=205, Percent_Identity=28.780487804878, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24642014, Length=190, Percent_Identity=27.3684210526316, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281366320, Length=187, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI62484477, Length=209, Percent_Identity=29.6650717703349, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI62484298, Length=209, Percent_Identity=29.6650717703349, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI116008008, Length=209, Percent_Identity=29.6650717703349, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24663843, Length=206, Percent_Identity=29.126213592233, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI161084260, Length=187, Percent_Identity=29.4117647058824, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281366459, Length=182, Percent_Identity=31.8681318681319, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281366457, Length=182, Percent_Identity=31.8681318681319, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281366455, Length=182, Percent_Identity=31.8681318681319, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI56292422, Length=182, Percent_Identity=31.8681318681319, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI56292424, Length=182, Percent_Identity=31.8681318681319, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24666940, Length=182, Percent_Identity=31.8681318681319, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054 [H]

Pfam domain/function: PF00211 Guanylate_cyc [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 44558; Mature: 44558

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNEKTVALVRFALFSITSIMDFVSYLGWISYTIVTPSLITVGLDLTFLVFASIVLIFVN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLPYKPYLKFFTIAFDYFIIGLMMFLDPTIIKANGLIYFIAMTSAIFIFQLNLLRHSKTG
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCEEEEHHHHHHHHHHHHHHHHCCCCC
TIYGAILAFIYFMVVSVGLGDGYPFDLIPMIFGLGMLLAIGYVTTVSNIEMVKEANTKQM
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
MERFLPSQLVGEFYKNKVQLEPGGENKEVTILFSDIRAFTKFSEQRSAEEVVTFLNDYLS
HHHHCHHHHHHHHHHCEEEECCCCCCCEEEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHH
RMTDVIFKFNGTIDKFIGDAIMTIFGAPFKRDDDALRAVKTAVAMMREIESLNQKQKCPE
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DKIHVGIGIHTGEAIVGNIGSERRLDYTVIGDNVNLASRIEGLTKHYNCPILISEVTYKQ
CCEEEEEEEECCCHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEHHHHHHH
VVGKYSTEDGFEIREIDQVIVKGKSKPITVCEVVCL
HHCCCCCCCCCHHHHHHHHHHCCCCCCEEHHEEEEC
>Mature Secondary Structure
MKNEKTVALVRFALFSITSIMDFVSYLGWISYTIVTPSLITVGLDLTFLVFASIVLIFVN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLPYKPYLKFFTIAFDYFIIGLMMFLDPTIIKANGLIYFIAMTSAIFIFQLNLLRHSKTG
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCEEEEHHHHHHHHHHHHHHHHCCCCC
TIYGAILAFIYFMVVSVGLGDGYPFDLIPMIFGLGMLLAIGYVTTVSNIEMVKEANTKQM
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
MERFLPSQLVGEFYKNKVQLEPGGENKEVTILFSDIRAFTKFSEQRSAEEVVTFLNDYLS
HHHHCHHHHHHHHHHCEEEECCCCCCCEEEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHH
RMTDVIFKFNGTIDKFIGDAIMTIFGAPFKRDDDALRAVKTAVAMMREIESLNQKQKCPE
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DKIHVGIGIHTGEAIVGNIGSERRLDYTVIGDNVNLASRIEGLTKHYNCPILISEVTYKQ
CCEEEEEEEECCCHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEHHHHHHH
VVGKYSTEDGFEIREIDQVIVKGKSKPITVCEVVCL
HHCCCCCCCCCHHHHHHHHHHCCCCCCEEHHEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]