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The map label for this gene is mmgC [H]

Identifier: 183221677

GI number: 183221677

Start: 2370332

End: 2371462

Strand: Direct

Name: mmgC [H]

Synonym: LEPBI_I2302

Alternate gene names: 183221677

Gene position: 2370332-2371462 (Clockwise)

Preceding gene: 183221676

Following gene: 183221681

Centisome position: 65.85

GC content: 45.18

Gene sequence:

>1131_bases
ATGGAGCGTATCCTCCCCTTTACTGAAGAACACCAACAATTCCGCGAGATGGCTCGGAAATTTTTTGAAACAGAAGTCAA
ACCACACCACGAGGAATGGGAAAAAAACCACATAGTCCCAAAGGAAGTCTGGAGGAAGGCAGGCGACAACGGACTGCTTT
GTCCCGATGTACCGGCGGAATACGGTGGCTCTGGGGCTGACTTTCTTTACAACATCATCATCATCGAAGAATCCTCACGG
GTTGGAAATAGCGGCTTTTTTATCTCCCTCCACAATGACGTGATTGCACCGTACATTTCGACCTATGCAAACGACGAACA
AAAGAAACGTTGGTTGCCAAAATGTGCTTCAGGCGAATCCATACTCGCGGTTGCCATGACTGAACCAGGAGCTGGCTCCG
ATTTAAAATCCCTTCGAACCAGTGCCGTCGATAAGGGAGATCATTTTGTGGTGAACGGACAAAAGACGTTCATTTCGAAC
GGACAATTGGCTGATCTCATCATCACAGCCGTGAAACATGATAACGGAACCATCTCACTTCTGATGATCGAAGAAGGGAT
GAAGGGATTTGAAAGAGGTCGTAACCTCGATAAAATCGGACTCAAAGCCCAAGATACTTCTGAATTGTATTTCAATGATG
TGATTGTTCCCAAAACCAACCTCATTGGTAAACAAGGACAAGGGTTTCGTTACCTGATGCAAAAACTAGCACAGGAACGT
TTGGTGCTCGCGGTAGCAGCCGTGGAAGCAACAAGGCTTGTACAAACCATCACCCTCCAGTACATCAAAGAAAGAAAAGC
ATTCGGCCAAAAGATTGGATCTTTCCAAAACACAAAGTTCAAAATGGCAGAGATGGCAACTGAACTTGAAATGGCACAAG
TTTTTTGTGACAAAGTGGTCATGGAACACATGAAAGGTGAGAACACAACTGCCGAAGCTTCCATGTGCAAATGGTATGCG
ACTGAGATGCAAAAACGCCATACCGATGAGTGCCTACAATTCTTTGGTGGCTATGGTTATATGATGGAGTATCCAATTGC
AAGAGCTTATCTCGATGCAAGGATCCAAACCATCTATGCGGGAACCACTGAGATCATGAAAGAAATCATTGGTAGAAGCT
TAGGCCTCTAA

Upstream 100 bases:

>100_bases
CAAGAAAAATCCTGGTGTCTATATGAAGCTGAACACTGTTTATAATTGACCTCATTTCGCCATTTCTGTAACATTTCCAT
ATCAAGGAGTCACAAATTTT

Downstream 100 bases:

>100_bases
GGATCTAATTGATTTAAGTCTATCCCTTTCTGTATTCTTTGGCATATGGAAAGTTCTGAAAAACTTTTCTTTTGGTTCTA
ATGAAGCGAAAACCAGGCAA

Product: acyl coenzyme A dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MERILPFTEEHQQFREMARKFFETEVKPHHEEWEKNHIVPKEVWRKAGDNGLLCPDVPAEYGGSGADFLYNIIIIEESSR
VGNSGFFISLHNDVIAPYISTYANDEQKKRWLPKCASGESILAVAMTEPGAGSDLKSLRTSAVDKGDHFVVNGQKTFISN
GQLADLIITAVKHDNGTISLLMIEEGMKGFERGRNLDKIGLKAQDTSELYFNDVIVPKTNLIGKQGQGFRYLMQKLAQER
LVLAVAAVEATRLVQTITLQYIKERKAFGQKIGSFQNTKFKMAEMATELEMAQVFCDKVVMEHMKGENTTAEASMCKWYA
TEMQKRHTDECLQFFGGYGYMMEYPIARAYLDARIQTIYAGTTEIMKEIIGRSLGL

Sequences:

>Translated_376_residues
MERILPFTEEHQQFREMARKFFETEVKPHHEEWEKNHIVPKEVWRKAGDNGLLCPDVPAEYGGSGADFLYNIIIIEESSR
VGNSGFFISLHNDVIAPYISTYANDEQKKRWLPKCASGESILAVAMTEPGAGSDLKSLRTSAVDKGDHFVVNGQKTFISN
GQLADLIITAVKHDNGTISLLMIEEGMKGFERGRNLDKIGLKAQDTSELYFNDVIVPKTNLIGKQGQGFRYLMQKLAQER
LVLAVAAVEATRLVQTITLQYIKERKAFGQKIGSFQNTKFKMAEMATELEMAQVFCDKVVMEHMKGENTTAEASMCKWYA
TEMQKRHTDECLQFFGGYGYMMEYPIARAYLDARIQTIYAGTTEIMKEIIGRSLGL
>Mature_376_residues
MERILPFTEEHQQFREMARKFFETEVKPHHEEWEKNHIVPKEVWRKAGDNGLLCPDVPAEYGGSGADFLYNIIIIEESSR
VGNSGFFISLHNDVIAPYISTYANDEQKKRWLPKCASGESILAVAMTEPGAGSDLKSLRTSAVDKGDHFVVNGQKTFISN
GQLADLIITAVKHDNGTISLLMIEEGMKGFERGRNLDKIGLKAQDTSELYFNDVIVPKTNLIGKQGQGFRYLMQKLAQER
LVLAVAAVEATRLVQTITLQYIKERKAFGQKIGSFQNTKFKMAEMATELEMAQVFCDKVVMEHMKGENTTAEASMCKWYA
TEMQKRHTDECLQFFGGYGYMMEYPIARAYLDARIQTIYAGTTEIMKEIIGRSLGL

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501857, Length=374, Percent_Identity=44.1176470588235, Blast_Score=343, Evalue=1e-94,
Organism=Homo sapiens, GI226958412, Length=377, Percent_Identity=35.0132625994695, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI226958414, Length=341, Percent_Identity=36.3636363636364, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI4557233, Length=373, Percent_Identity=33.7801608579088, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=31.6353887399464, Blast_Score=212, Evalue=4e-55,
Organism=Homo sapiens, GI7656849, Length=373, Percent_Identity=31.9034852546917, Blast_Score=208, Evalue=8e-54,
Organism=Homo sapiens, GI187960098, Length=374, Percent_Identity=31.283422459893, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI4557231, Length=374, Percent_Identity=31.283422459893, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI21361497, Length=388, Percent_Identity=30.9278350515464, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI76496475, Length=393, Percent_Identity=30.7888040712468, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI4557235, Length=393, Percent_Identity=30.7888040712468, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI4503943, Length=375, Percent_Identity=25.6, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI7669494, Length=295, Percent_Identity=26.7796610169492, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI38505218, Length=407, Percent_Identity=25.5528255528256, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI48976061, Length=283, Percent_Identity=24.7349823321555, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI211971008, Length=283, Percent_Identity=24.7349823321555, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI87081958, Length=375, Percent_Identity=28, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1786223, Length=373, Percent_Identity=23.3243967828418, Blast_Score=129, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17538396, Length=380, Percent_Identity=33.9473684210526, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17533517, Length=367, Percent_Identity=34.6049046321526, Blast_Score=214, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17570075, Length=376, Percent_Identity=33.5106382978723, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17551932, Length=375, Percent_Identity=31.4666666666667, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17508101, Length=371, Percent_Identity=28.5714285714286, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17506239, Length=371, Percent_Identity=30.188679245283, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17569725, Length=378, Percent_Identity=30.6878306878307, Blast_Score=190, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI17505929, Length=375, Percent_Identity=29.6, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17534899, Length=376, Percent_Identity=30.0531914893617, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71990804, Length=278, Percent_Identity=32.3741007194245, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71985184, Length=347, Percent_Identity=30.2593659942363, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71982178, Length=281, Percent_Identity=29.1814946619217, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI32563615, Length=225, Percent_Identity=31.1111111111111, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17534353, Length=380, Percent_Identity=27.1052631578947, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71985192, Length=265, Percent_Identity=32.0754716981132, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=26.3598326359833, Blast_Score=104, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17562446, Length=287, Percent_Identity=27.5261324041812, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17531913, Length=176, Percent_Identity=26.7045454545455, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21356377, Length=375, Percent_Identity=32.8, Blast_Score=228, Evalue=5e-60,
Organism=Drosophila melanogaster, GI21355753, Length=375, Percent_Identity=34.4, Blast_Score=221, Evalue=7e-58,
Organism=Drosophila melanogaster, GI24666513, Length=373, Percent_Identity=31.9034852546917, Blast_Score=214, Evalue=9e-56,
Organism=Drosophila melanogaster, GI24660351, Length=377, Percent_Identity=31.8302387267904, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24646207, Length=378, Percent_Identity=29.6296296296296, Blast_Score=188, Evalue=6e-48,
Organism=Drosophila melanogaster, GI281363737, Length=333, Percent_Identity=31.5315315315315, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI19920834, Length=374, Percent_Identity=25.9358288770053, Blast_Score=118, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42488; Mature: 42488

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERILPFTEEHQQFREMARKFFETEVKPHHEEWEKNHIVPKEVWRKAGDNGLLCPDVPAE
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHCCCCCCCCCCCCHH
YGGSGADFLYNIIIIEESSRVGNSGFFISLHNDVIAPYISTYANDEQKKRWLPKCASGES
HCCCCCCEEEEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHCCCCCCCCC
ILAVAMTEPGAGSDLKSLRTSAVDKGDHFVVNGQKTFISNGQLADLIITAVKHDNGTISL
EEEEEEECCCCCCHHHHHHHHHCCCCCEEEECCCEEEECCCCHHHHHHEEEECCCCCEEE
LMIEEGMKGFERGRNLDKIGLKAQDTSELYFNDVIVPKTNLIGKQGQGFRYLMQKLAQER
EEEHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCEECCCCCCCCCCCCCHHHHHHHHHHHH
LVLAVAAVEATRLVQTITLQYIKERKAFGQKIGSFQNTKFKMAEMATELEMAQVFCDKVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
MEHMKGENTTAEASMCKWYATEMQKRHTDECLQFFGGYGYMMEYPIARAYLDARIQTIYA
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
GTTEIMKEIIGRSLGL
CHHHHHHHHHHHHCCC
>Mature Secondary Structure
MERILPFTEEHQQFREMARKFFETEVKPHHEEWEKNHIVPKEVWRKAGDNGLLCPDVPAE
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHCCCCCCCCCCCCHH
YGGSGADFLYNIIIIEESSRVGNSGFFISLHNDVIAPYISTYANDEQKKRWLPKCASGES
HCCCCCCEEEEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHCCCCCCCCC
ILAVAMTEPGAGSDLKSLRTSAVDKGDHFVVNGQKTFISNGQLADLIITAVKHDNGTISL
EEEEEEECCCCCCHHHHHHHHHCCCCCEEEECCCEEEECCCCHHHHHHEEEECCCCCEEE
LMIEEGMKGFERGRNLDKIGLKAQDTSELYFNDVIVPKTNLIGKQGQGFRYLMQKLAQER
EEEHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCEECCCCCCCCCCCCCHHHHHHHHHHHH
LVLAVAAVEATRLVQTITLQYIKERKAFGQKIGSFQNTKFKMAEMATELEMAQVFCDKVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
MEHMKGENTTAEASMCKWYATEMQKRHTDECLQFFGGYGYMMEYPIARAYLDARIQTIYA
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
GTTEIMKEIIGRSLGL
CHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]