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The map label for this gene is trxA2 [H]

Identifier: 183221675

GI number: 183221675

Start: 2367797

End: 2368108

Strand: Direct

Name: trxA2 [H]

Synonym: LEPBI_I2300

Alternate gene names: 183221675

Gene position: 2367797-2368108 (Clockwise)

Preceding gene: 183221674

Following gene: 183221676

Centisome position: 65.78

GC content: 39.42

Gene sequence:

>312_bases
ATGGCACTTACAGAAATCAATGACGCCAATTTCAAAGCAGAAACTGCAAATGGCGTGGTTTTAGTAGATTGTTGGGCAGA
ATGGTGTGGACCTTGTAGAATGGTAGCCCCTGTTCTTGACGAACTTTCGCAAGAAATGGCGGATATCAAAATTACAAAAC
TAAACGTTGATTTCAACCAGAAGACAGCGCAGGAGCTCGGTATCCAATCCATCCCTACCCTTCTTCTCTATAAAGATGGA
GTTTTAGTTGATAAAGCAATTGGTGCTTTACCAAAACCGCAAATTAAAAAATTTATAGAAAATCACAAGTAG

Upstream 100 bases:

>100_bases
CGAGAAAAAGAAAAAAAAGAAACAATAATCGACGTTTTTCCCTAGAATCCCCAGTCTAGTTTATAGAAAGGTTATACGTT
TCAAAAGGAGATTTCGAAAT

Downstream 100 bases:

>100_bases
GAAATAAATTATCCCCTAATGGTCAGTTCCGAACCGAATGGTTTTACAGCGCTCCCTAGAGGGGGATATTTAGTCGATAC
TTCAGAAGGGTACATCCAGT

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 103; Mature: 102

Protein sequence:

>103_residues
MALTEINDANFKAETANGVVLVDCWAEWCGPCRMVAPVLDELSQEMADIKITKLNVDFNQKTAQELGIQSIPTLLLYKDG
VLVDKAIGALPKPQIKKFIENHK

Sequences:

>Translated_103_residues
MALTEINDANFKAETANGVVLVDCWAEWCGPCRMVAPVLDELSQEMADIKITKLNVDFNQKTAQELGIQSIPTLLLYKDG
VLVDKAIGALPKPQIKKFIENHK
>Mature_102_residues
ALTEINDANFKAETANGVVLVDCWAEWCGPCRMVAPVLDELSQEMADIKITKLNVDFNQKTAQELGIQSIPTLLLYKDGV
LVDKAIGALPKPQIKKFIENHK

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI87082331, Length=101, Percent_Identity=45.5445544554455, Blast_Score=100, Evalue=2e-23,
Organism=Escherichia coli, GI1788936, Length=74, Percent_Identity=40.5405405405405, Blast_Score=76, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17510299, Length=85, Percent_Identity=37.6470588235294, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17507705, Length=88, Percent_Identity=32.9545454545455, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=83, Percent_Identity=36.144578313253, Blast_Score=66, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=92, Percent_Identity=36.9565217391304, Blast_Score=74, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323072, Length=73, Percent_Identity=42.4657534246575, Blast_Score=70, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6319925, Length=75, Percent_Identity=41.3333333333333, Blast_Score=69, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24639826, Length=85, Percent_Identity=36.4705882352941, Blast_Score=69, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24658597, Length=93, Percent_Identity=34.4086021505376, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17648013, Length=80, Percent_Identity=40, Blast_Score=65, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24583090, Length=80, Percent_Identity=40, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11412; Mature: 11281

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALTEINDANFKAETANGVVLVDCWAEWCGPCRMVAPVLDELSQEMADIKITKLNVDFNQ
CCCCCCCCCCCEEECCCCEEEEEEHHHHCCCHHHHHHHHHHHHHHHHCEEEEEEECCCCH
KTAQELGIQSIPTLLLYKDGVLVDKAIGALPKPQIKKFIENHK
HHHHHCCHHCCCCEEEECCCEEEHHHHCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
ALTEINDANFKAETANGVVLVDCWAEWCGPCRMVAPVLDELSQEMADIKITKLNVDFNQ
CCCCCCCCCCEEECCCCEEEEEEHHHHCCCHHHHHHHHHHHHHHHHCEEEEEEECCCCH
KTAQELGIQSIPTLLLYKDGVLVDKAIGALPKPQIKKFIENHK
HHHHHCCHHCCCCEEEECCCEEEHHHHCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2559145; 8969504; 9384377; 8755892 [H]