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The map label for this gene is 183221409

Identifier: 183221409

GI number: 183221409

Start: 2109117

End: 2110163

Strand: Reverse

Name: 183221409

Synonym: LEPBI_I2027

Alternate gene names: NA

Gene position: 2110163-2109117 (Counterclockwise)

Preceding gene: 183221410

Following gene: 183221408

Centisome position: 58.62

GC content: 39.06

Gene sequence:

>1047_bases
ATGAATACAATTACAATTAATCAACGAAAAATTGGGAAAGAATTTCCTCCTTATATCATCGCTGAGCTTTCGGCTAATCA
TAATGGTAAGATTGAACGTGCATTGGAAACTATTAAATTCGCCAAAGAATCTGGTGCAGATGCAATCAAAATTCAAACAT
ATACTGCTGATACAATGACAATTGATTGTGATAAAGAAGACTTCCAGATTCACGGTGGTCTTTGGGATGGATATAAACTA
TACGATCTATATAAATGGGCAGAAACTCCTTTTGAATGGCATAAAGAGATTTTTGATTATGCAAAAAAAATTGGAATCAC
AATATTTTCTACTCCGTTTGATGAGACAGCTGTTGACCTCCTCGAAGATTTGAATGCCCCCGCTTATAAAGTTGCTTCTT
TTGAAGCAACTGATTTGCCTCTGATTCGTTATATAGCATCTACAAAAAAGCCTATGATCATGTCGACTGGAATGGCCAAT
TATCAAGAGATACTAGAGATGGTGGACGCAGCAAGGAGTGGAGGGTGTAAGGATTTGATTTTGCTACATTGTATCAGCAG
TTATCCTGCTCCGATAGATCAATCAAATTTGCTAACGATCCCTGATATGCGAGAGAAATTTGGGGTTCAAATTGGCCTTT
CTGATCATACCCTAACAAATACGGCTTCCATTACGTCAGTTGCTTTAGGTGCGACTGTTATCGAAAAACACTTCATTATC
GATCGATCTGAGAAGGGGCCGGACTCTGAATTTTCTATCACCCCTGAAGAACTATATGCCCTATGCCGCGAAACAAAGGA
CGCATGGCTTGCGTTAGGTGTAGCAGGTTATGATCGAAAACCTGCAGAAGAAGCAAATTTAGTATTTAGAAGATCCCTAT
ATTTTATCAAAGATTTGAAAGCCGGGGATACGGTTAAAAAGGGAGATATTCGTCGAATACGTCCAGGATATGGCTTGGCT
CCGAAGTATGCAGAAGAATTGATTGGCAAAAAACTGAAACACGATGTTACCGTTGGAACCGCCGTAAAATGGGAGTTATT
GGATTAA

Upstream 100 bases:

>100_bases
CGCATATTAATTTTGGAAAGTACCAACTGAAATTTAACCAAGCAAAATACTTTGATGGAAAACTATCAGCTAACGTAGAT
TTTATTTTGAAAGAAGAATT

Downstream 100 bases:

>100_bases
TTTATGGAAAAGGCTAAAACTAAAATAGTTGCTACGATCGAAGCAAGGATGACTTCCTCTCGATTACCAGGGAAAGTATT
AAAGGAAGTATTCAATAAGC

Product: N-acetylneuraminic acid synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MNTITINQRKIGKEFPPYIIAELSANHNGKIERALETIKFAKESGADAIKIQTYTADTMTIDCDKEDFQIHGGLWDGYKL
YDLYKWAETPFEWHKEIFDYAKKIGITIFSTPFDETAVDLLEDLNAPAYKVASFEATDLPLIRYIASTKKPMIMSTGMAN
YQEILEMVDAARSGGCKDLILLHCISSYPAPIDQSNLLTIPDMREKFGVQIGLSDHTLTNTASITSVALGATVIEKHFII
DRSEKGPDSEFSITPEELYALCRETKDAWLALGVAGYDRKPAEEANLVFRRSLYFIKDLKAGDTVKKGDIRRIRPGYGLA
PKYAEELIGKKLKHDVTVGTAVKWELLD

Sequences:

>Translated_348_residues
MNTITINQRKIGKEFPPYIIAELSANHNGKIERALETIKFAKESGADAIKIQTYTADTMTIDCDKEDFQIHGGLWDGYKL
YDLYKWAETPFEWHKEIFDYAKKIGITIFSTPFDETAVDLLEDLNAPAYKVASFEATDLPLIRYIASTKKPMIMSTGMAN
YQEILEMVDAARSGGCKDLILLHCISSYPAPIDQSNLLTIPDMREKFGVQIGLSDHTLTNTASITSVALGATVIEKHFII
DRSEKGPDSEFSITPEELYALCRETKDAWLALGVAGYDRKPAEEANLVFRRSLYFIKDLKAGDTVKKGDIRRIRPGYGLA
PKYAEELIGKKLKHDVTVGTAVKWELLD
>Mature_348_residues
MNTITINQRKIGKEFPPYIIAELSANHNGKIERALETIKFAKESGADAIKIQTYTADTMTIDCDKEDFQIHGGLWDGYKL
YDLYKWAETPFEWHKEIFDYAKKIGITIFSTPFDETAVDLLEDLNAPAYKVASFEATDLPLIRYIASTKKPMIMSTGMAN
YQEILEMVDAARSGGCKDLILLHCISSYPAPIDQSNLLTIPDMREKFGVQIGLSDHTLTNTASITSVALGATVIEKHFII
DRSEKGPDSEFSITPEELYALCRETKDAWLALGVAGYDRKPAEEANLVFRRSLYFIKDLKAGDTVKKGDIRRIRPGYGLA
PKYAEELIGKKLKHDVTVGTAVKWELLD

Specific function: Unknown

COG id: COG2089

COG function: function code M; Sialic acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis spsE [H]

Homologues:

Organism=Homo sapiens, GI12056473, Length=348, Percent_Identity=30.1724137931034, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI21357081, Length=248, Percent_Identity=33.8709677419355, Blast_Score=139, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006190
- InterPro:   IPR013785
- InterPro:   IPR013132
- InterPro:   IPR013974 [H]

Pfam domain/function: PF03102 NeuB; PF08666 SAF [H]

EC number: NA

Molecular weight: Translated: 39048; Mature: 39048

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS50844 AFP_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTITINQRKIGKEFPPYIIAELSANHNGKIERALETIKFAKESGADAIKIQTYTADTMT
CCEEECCHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCEEE
IDCDKEDFQIHGGLWDGYKLYDLYKWAETPFEWHKEIFDYAKKIGITIFSTPFDETAVDL
EECCCCCEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEEECCCCHHHHHH
LEDLNAPAYKVASFEATDLPLIRYIASTKKPMIMSTGMANYQEILEMVDAARSGGCKDLI
HHHCCCCCEEEEECCCCCCHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCCHHHH
LLHCISSYPAPIDQSNLLTIPDMREKFGVQIGLSDHTLTNTASITSVALGATVIEKHFII
HHHHHHHCCCCCCCCCEEECCCHHHHCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHEE
DRSEKGPDSEFSITPEELYALCRETKDAWLALGVAGYDRKPAEEANLVFRRSLYFIKDLK
ECCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCC
AGDTVKKGDIRRIRPGYGLAPKYAEELIGKKLKHDVTVGTAVKWELLD
CCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCEECCEEEEEECC
>Mature Secondary Structure
MNTITINQRKIGKEFPPYIIAELSANHNGKIERALETIKFAKESGADAIKIQTYTADTMT
CCEEECCHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCEEE
IDCDKEDFQIHGGLWDGYKLYDLYKWAETPFEWHKEIFDYAKKIGITIFSTPFDETAVDL
EECCCCCEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEEECCCCHHHHHH
LEDLNAPAYKVASFEATDLPLIRYIASTKKPMIMSTGMANYQEILEMVDAARSGGCKDLI
HHHCCCCCEEEEECCCCCCHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCCHHHH
LLHCISSYPAPIDQSNLLTIPDMREKFGVQIGLSDHTLTNTASITSVALGATVIEKHFII
HHHHHHHCCCCCCCCCEEECCCHHHHCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHEE
DRSEKGPDSEFSITPEELYALCRETKDAWLALGVAGYDRKPAEEANLVFRRSLYFIKDLK
ECCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCC
AGDTVKKGDIRRIRPGYGLAPKYAEELIGKKLKHDVTVGTAVKWELLD
CCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCEECCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]