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The map label for this gene is hldD [H]

Identifier: 183221364

GI number: 183221364

Start: 2059721

End: 2060692

Strand: Reverse

Name: hldD [H]

Synonym: LEPBI_I1982

Alternate gene names: 183221364

Gene position: 2060692-2059721 (Counterclockwise)

Preceding gene: 183221365

Following gene: 183221360

Centisome position: 57.25

GC content: 39.4

Gene sequence:

>972_bases
ATGGCAAAAAAACTCACATTAGTTACAGGCGGCGCGGGTCTTATTGGTTCGCAGATCATAGAAGACCTAAATCACAATGG
GAAGACCGATATTTTGGTTGTGGATCATTTGGGAACCACTGAAAAATGGAAGAACCTCCAGCGTAATTTTTTTTTGGACT
ATTATGAAAAAGACCAGTTTGAGTCATTTTTAGATTCGGGCCATTCCATCCTCTCAGACATTTCTGAAATTTACCATCTT
GGTGCTTGTTCTGCCACCACAGAAAAAGATGCAACTTACCTAATCCAGAATAACTTCCGTTATACGAAAAAGCTCGCGGA
ATTTGCTGTAGGAAAAAACATTCCCTTTTTATATGCTTCGAGTGCTGCCACTTATGGTGAAGGGGAATTTGGTTATGATG
ACAAAGCTCCCATTGAAAACCTAAAACCTTTGAATATGTATGGATACTCGAAACATCTTTTTGATCTGTATGCCAAACAA
ACAAAAATTGCCGACAAACTCATCGGCCTAAAGTATTTCAATGTGTTTGGTTATGGAGAAGCGCATAAAGGTGACATGCG
CAGTTTAGTTCTCAAAGGGTATGAACAAATCCGAGACACAGGCAAACTCAAACTGTTTAAGTCTTATAAACCCGAATACA
AAGATGGAGAACAAAAACGTGATTTTCTTTATGTCAAGGATGCCAGTAAGATCAGTATCTATTTACTGAGTGAACGAAAA
TTCGGATTGTACAATGTGGGACGTGGTATGGCGGAAACTTGGAATGATTTAGCTTCCGCACTCTTTAAAGCCATGAACAC
ACAAGTAAACATTGAATATGTAGAAATGCCCGAATCACTCAAAGGCAAATACCAATACTATACCTGCGCGGATATGGAAA
AGTTAGCAGGAGTTGGCTATCCCTTTGGTTTTACCAACCTCCAGGATTCCATTCAAGAATATGTCCACCTCTTAGAACAA
GAGGCGAAATGA

Upstream 100 bases:

>100_bases
TGGATTGATACCTTATAAGTTGGGAATTGGATTTCTTTTCCTAATTCCCAAAGAAAAGTTGATAGATGGATTCTCTTAGG
AAAAAAGAATCATCAGAGAG

Downstream 100 bases:

>100_bases
CGCTTACTTTTTGTACACTTTCACAATGGTTTGGATGAGATCTTTGAACTTCGCGTCTTTCAAACGATAAAAGACTTGGT
TCGAAGATTTTCTTGATTCT

Product: ADP-L-glycero-D-manno-heptose-6-epimerase

Products: NA

Alternate protein names: ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MAKKLTLVTGGAGLIGSQIIEDLNHNGKTDILVVDHLGTTEKWKNLQRNFFLDYYEKDQFESFLDSGHSILSDISEIYHL
GACSATTEKDATYLIQNNFRYTKKLAEFAVGKNIPFLYASSAATYGEGEFGYDDKAPIENLKPLNMYGYSKHLFDLYAKQ
TKIADKLIGLKYFNVFGYGEAHKGDMRSLVLKGYEQIRDTGKLKLFKSYKPEYKDGEQKRDFLYVKDASKISIYLLSERK
FGLYNVGRGMAETWNDLASALFKAMNTQVNIEYVEMPESLKGKYQYYTCADMEKLAGVGYPFGFTNLQDSIQEYVHLLEQ
EAK

Sequences:

>Translated_323_residues
MAKKLTLVTGGAGLIGSQIIEDLNHNGKTDILVVDHLGTTEKWKNLQRNFFLDYYEKDQFESFLDSGHSILSDISEIYHL
GACSATTEKDATYLIQNNFRYTKKLAEFAVGKNIPFLYASSAATYGEGEFGYDDKAPIENLKPLNMYGYSKHLFDLYAKQ
TKIADKLIGLKYFNVFGYGEAHKGDMRSLVLKGYEQIRDTGKLKLFKSYKPEYKDGEQKRDFLYVKDASKISIYLLSERK
FGLYNVGRGMAETWNDLASALFKAMNTQVNIEYVEMPESLKGKYQYYTCADMEKLAGVGYPFGFTNLQDSIQEYVHLLEQ
EAK
>Mature_322_residues
AKKLTLVTGGAGLIGSQIIEDLNHNGKTDILVVDHLGTTEKWKNLQRNFFLDYYEKDQFESFLDSGHSILSDISEIYHLG
ACSATTEKDATYLIQNNFRYTKKLAEFAVGKNIPFLYASSAATYGEGEFGYDDKAPIENLKPLNMYGYSKHLFDLYAKQT
KIADKLIGLKYFNVFGYGEAHKGDMRSLVLKGYEQIRDTGKLKLFKSYKPEYKDGEQKRDFLYVKDASKISIYLLSERKF
GLYNVGRGMAETWNDLASALFKAMNTQVNIEYVEMPESLKGKYQYYTCADMEKLAGVGYPFGFTNLQDSIQEYVHLLEQE
AK

Specific function: Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. HldD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790049, Length=320, Percent_Identity=39.6875, Blast_Score=223, Evalue=2e-59,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR011912
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.20 [H]

Molecular weight: Translated: 36846; Mature: 36715

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKLTLVTGGAGLIGSQIIEDLNHNGKTDILVVDHLGTTEKWKNLQRNFFLDYYEKDQF
CCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
ESFLDSGHSILSDISEIYHLGACSATTEKDATYLIQNNFRYTKKLAEFAVGKNIPFLYAS
HHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEC
SAATYGEGEFGYDDKAPIENLKPLNMYGYSKHLFDLYAKQTKIADKLIGLKYFNVFGYGE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCC
AHKGDMRSLVLKGYEQIRDTGKLKLFKSYKPEYKDGEQKRDFLYVKDASKISIYLLSERK
CCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEEEECCCEEEEEEEECCC
FGLYNVGRGMAETWNDLASALFKAMNTQVNIEYVEMPESLKGKYQYYTCADMEKLAGVGY
CCHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHCCCEEEEEECCHHHHHCCCC
PFGFTNLQDSIQEYVHLLEQEAK
CCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKKLTLVTGGAGLIGSQIIEDLNHNGKTDILVVDHLGTTEKWKNLQRNFFLDYYEKDQF
CCEEEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
ESFLDSGHSILSDISEIYHLGACSATTEKDATYLIQNNFRYTKKLAEFAVGKNIPFLYAS
HHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEC
SAATYGEGEFGYDDKAPIENLKPLNMYGYSKHLFDLYAKQTKIADKLIGLKYFNVFGYGE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCC
AHKGDMRSLVLKGYEQIRDTGKLKLFKSYKPEYKDGEQKRDFLYVKDASKISIYLLSERK
CCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEEEECCCEEEEEEEECCC
FGLYNVGRGMAETWNDLASALFKAMNTQVNIEYVEMPESLKGKYQYYTCADMEKLAGVGY
CCHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHCCCEEEEEECCHHHHHCCCC
PFGFTNLQDSIQEYVHLLEQEAK
CCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA