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The map label for this gene is clpP1 [H]

Identifier: 183221092

GI number: 183221092

Start: 1779414

End: 1780022

Strand: Direct

Name: clpP1 [H]

Synonym: LEPBI_I1706

Alternate gene names: 183221092

Gene position: 1779414-1780022 (Clockwise)

Preceding gene: 183221091

Following gene: 183221093

Centisome position: 49.43

GC content: 40.89

Gene sequence:

>609_bases
ATGCCAGAAGAAGAAACACCAGAAAAAGAAATCACCGAAACCATCCAAGATCTCATTAGCGATAAAAACATGGGAAAGAA
GTTCCTGGAAAAACGGAAAATCTTTCTCTGGGGTCCTGTCACTGACGAATCCTCTAAAGAACTCACTGCCAAATTGATGT
ATTTGGAAATGGTGGATCCTGGGAAACCAATTACTTTTTATATCAATAGTCCCGGTGGTGTTGTCACCTCAGGTCTTGTT
GTTTATGACACAATGCAAATGATTTCCTCTCCCGTTCATACAGTTTGTATGGGAATGGCAGCTTCTATGGGATCCATTTT
ACTCATTGGTGGAAAAAAAGGAAATCGTTACATTTGGCCAAATGGTCGAGTGATGATCCACCAACCATCCATTGGTGGGC
AAATCCAAGCACCAGCAACGGATTTACTCATCCATGCACAGGACATTGTCAAAACAAAAGAAAAACTCAATCAAATGTTA
GCTGACGCTTGTGGAAAATCCTACGAACAATTGGTGGAAGACACTGATCGCGATTATTATATGGATGCAGAACAAGCACT
TGCTTATGGCATCGTAGATAAGATCGTAAACACAATTGACGTCGTCTAA

Upstream 100 bases:

>100_bases
CGATTCTTTTATATTTCTTTTAGTGTTTTCCTGATTCTAGGTGTGTACTACAAGCTGAAACGCTTGCCTCATACGTCTAA
CCAGAAAAGACTGAACTAAT

Downstream 100 bases:

>100_bases
CAAAGATTTTAAACCAAGAAGATTTTTAGAAGGTCGACACCTTCAAACTGTCTACAACGTACTCTTTCCTCCAGACAACG
CTTTGGAGGATGAGTATTAT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 2 [H]

Number of amino acids: Translated: 202; Mature: 201

Protein sequence:

>202_residues
MPEEETPEKEITETIQDLISDKNMGKKFLEKRKIFLWGPVTDESSKELTAKLMYLEMVDPGKPITFYINSPGGVVTSGLV
VYDTMQMISSPVHTVCMGMAASMGSILLIGGKKGNRYIWPNGRVMIHQPSIGGQIQAPATDLLIHAQDIVKTKEKLNQML
ADACGKSYEQLVEDTDRDYYMDAEQALAYGIVDKIVNTIDVV

Sequences:

>Translated_202_residues
MPEEETPEKEITETIQDLISDKNMGKKFLEKRKIFLWGPVTDESSKELTAKLMYLEMVDPGKPITFYINSPGGVVTSGLV
VYDTMQMISSPVHTVCMGMAASMGSILLIGGKKGNRYIWPNGRVMIHQPSIGGQIQAPATDLLIHAQDIVKTKEKLNQML
ADACGKSYEQLVEDTDRDYYMDAEQALAYGIVDKIVNTIDVV
>Mature_201_residues
PEEETPEKEITETIQDLISDKNMGKKFLEKRKIFLWGPVTDESSKELTAKLMYLEMVDPGKPITFYINSPGGVVTSGLVV
YDTMQMISSPVHTVCMGMAASMGSILLIGGKKGNRYIWPNGRVMIHQPSIGGQIQAPATDLLIHAQDIVKTKEKLNQMLA
DACGKSYEQLVEDTDRDYYMDAEQALAYGIVDKIVNTIDVV

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=170, Percent_Identity=44.1176470588235, Blast_Score=149, Evalue=2e-36,
Organism=Escherichia coli, GI1786641, Length=170, Percent_Identity=49.4117647058824, Blast_Score=177, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17538017, Length=170, Percent_Identity=45.2941176470588, Blast_Score=160, Evalue=5e-40,
Organism=Drosophila melanogaster, GI20129427, Length=170, Percent_Identity=46.4705882352941, Blast_Score=166, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22421; Mature: 22290

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEEETPEKEITETIQDLISDKNMGKKFLEKRKIFLWGPVTDESSKELTAKLMYLEMVDP
CCCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCEEEECCCCCCCHHHHHHHHHEEEEECC
GKPITFYINSPGGVVTSGLVVYDTMQMISSPVHTVCMGMAASMGSILLIGGKKGNRYIWP
CCCEEEEEECCCCHHHCCHHHHHHHHHHHCHHHHHHHHHHHCCCCEEEEECCCCCEEECC
NGRVMIHQPSIGGQIQAPATDLLIHAQDIVKTKEKLNQMLADACGKSYEQLVEDTDRDYY
CCEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCEE
MDAEQALAYGIVDKIVNTIDVV
ECHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PEEETPEKEITETIQDLISDKNMGKKFLEKRKIFLWGPVTDESSKELTAKLMYLEMVDP
CCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCEEEECCCCCCCHHHHHHHHHEEEEECC
GKPITFYINSPGGVVTSGLVVYDTMQMISSPVHTVCMGMAASMGSILLIGGKKGNRYIWP
CCCEEEEEECCCCHHHCCHHHHHHHHHHHCHHHHHHHHHHHCCCCEEEEECCCCCEEECC
NGRVMIHQPSIGGQIQAPATDLLIHAQDIVKTKEKLNQMLADACGKSYEQLVEDTDRDYY
CCEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCEE
MDAEQALAYGIVDKIVNTIDVV
ECHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA