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The map label for this gene is 183220768

Identifier: 183220768

GI number: 183220768

Start: 1436065

End: 1437846

Strand: Reverse

Name: 183220768

Synonym: LEPBI_I1379

Alternate gene names: NA

Gene position: 1437846-1436065 (Counterclockwise)

Preceding gene: 183220769

Following gene: 183220764

Centisome position: 39.94

GC content: 39.84

Gene sequence:

>1782_bases
TTGGATTATATTACTTCTATATTGTCCAAAGAACGGGAAGAGGAACGAAATCTATTTTTAGAAAAAGAATCGGAAACCCA
ATCCATCAAATCCGCTGAACTTGTAGACCTTCGATTCGTGGTGGGAAATACTTGGAGAGCCGAATTTGTAGCAAATGTTT
CCCTCAAATCCAAACGTTGGTTAAAAAAAGGAGTACCAGTCCTTTTACAAAACCAAAACGAATCCATTTATGGAAACATA
TTCCAATGGAATGAACCAAAACTTGTGATCCAAGTGCGCGGAGATTATGAATGGGACGCGGAAACATACTCTATCTCCAA
ATGGTTCCCCGAATCCACTTATGATTTGTACAATGAAATCATCGGAAAAGTAAGAGCTGAAAAAGAAACTGATTCCTACA
AAAAACTAAAATGGGCCCTCGGTTATGGACTGGGTGATAAACCCTCCCCTCCCAAAAAAACGATGGAACTCACCGCTTTG
GAACGGATTTTTTCCATTTCCGATTTTGGAATGGTCTTTGGACCACCAGGAACCGGAAAAACCACCTTACTCATGCAAGC
TGTTTCACAGATCACACAACAAAAGGAATCAGTGCTTACACTTTGTCCCACAAACTTTGCTTGCGATTACATTGTAGAGC
TTGCGATCCAAAAGGGAATTCGTGTGATCCGATTGGGTAACTCCACAAAAATCAAAGAAGAAGTATTACCTTATCACCTA
GACCACCTCATCCAAACCCATCCCGATCAAAAACAAATCCAAAATTGGCAAACCGAATTGAAAGTGATCCAAAAAAAAAT
CAATTCCTGGAAACGCAATTTTGGCAAGGAAGAACGAGAAGAACGTAACAATCTGCGAAAAGAAGCAAAGTTTCTAGTCC
ATACCATACGCGAACAAGAATCCACAATCAGAACCAAACTCTTAGACACAAGTGAACTAATTGTTTCTACGTTTGCAGGT
TTTGGTAATGAATTTAAAAAAGGTAGGAAATTTGATTATACATTCGTAGATGAAGCCACACAAAGTGTAGACCCTGGCTG
TTATATGGCAATGTTTTCAGGGAAAAAAACTTTCTTTTTTGGAGATCCCAAACAACTCGGAGTGAACTATTCCCATCCAG
ACCACAAAACTGTTGCTAGTTTTTTGGAAAAAGTGATCGATTTGGATTCGGGGGAACGAACCATCTTTTTAGAAAAACAA
TTCCGCATGAAACCCGAGATCCTCGGTTTTCCCAATCTGACCTATTACGAAAACAAAGTATTCACTCATCCCAATCTCAC
ATTTTTAACTTCTCCCCCGTTTTCTGAAATCTTCGGATCCGATACCCCAATCTTATGGGTTGATACAGCGGGCAGTGATA
CTTCCGAAGAAACAGAAGGTGAAGAGATGAGTTTTTTCAATGAAACAGAAATTGGTCTCATTGAAACTTTTTTTGAAAGA
GGGTTACCAAAAGAAACAACAGCTGTAGTATCACCTTACAGAGGGCAGGTGGACAAATTAAACCTAAGAGCAGATGGGCG
TTGGATTGGTCAAACCATTGATTCCTTCCAAGGCCGGGAATCTGAAATTGTGATCTTAAGTTTGGTCCGATCAAATCCTG
ATGGAGAAATTGGTTTTTTAATGAATCCCAAACGTTTGAATGTGGCCCTCACCCGTGCCAAGTCCCACCTCATATTGATC
GGAGACTCATCTACCTTGTGTCGTCATAAAGAGTTCCAGGATTTGTACAATTACATCGAATCCAATGGAGAAATTCGTTC
CATTTATGAATTTCTAGACTGA

Upstream 100 bases:

>100_bases
TCGATTTTGCACCACTCCTCAGGAATGGATTTTTTACTACCTTGGAGAACATCGAATGGGAAGAACCATAAAACAAACGT
TTGGTTCATTAGAAGAAGAA

Downstream 100 bases:

>100_bases
AAGAAGATTTTCGGTTTTAAATTGTAACTTCCAAGTTCAGTTTACAATTTATAAAACAACCCACTTTGGTTCATCCAGTG
TGTACAGAAGTTTAAACGCA

Product: putative helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 593; Mature: 593

Protein sequence:

>593_residues
MDYITSILSKEREEERNLFLEKESETQSIKSAELVDLRFVVGNTWRAEFVANVSLKSKRWLKKGVPVLLQNQNESIYGNI
FQWNEPKLVIQVRGDYEWDAETYSISKWFPESTYDLYNEIIGKVRAEKETDSYKKLKWALGYGLGDKPSPPKKTMELTAL
ERIFSISDFGMVFGPPGTGKTTLLMQAVSQITQQKESVLTLCPTNFACDYIVELAIQKGIRVIRLGNSTKIKEEVLPYHL
DHLIQTHPDQKQIQNWQTELKVIQKKINSWKRNFGKEEREERNNLRKEAKFLVHTIREQESTIRTKLLDTSELIVSTFAG
FGNEFKKGRKFDYTFVDEATQSVDPGCYMAMFSGKKTFFFGDPKQLGVNYSHPDHKTVASFLEKVIDLDSGERTIFLEKQ
FRMKPEILGFPNLTYYENKVFTHPNLTFLTSPPFSEIFGSDTPILWVDTAGSDTSEETEGEEMSFFNETEIGLIETFFER
GLPKETTAVVSPYRGQVDKLNLRADGRWIGQTIDSFQGRESEIVILSLVRSNPDGEIGFLMNPKRLNVALTRAKSHLILI
GDSSTLCRHKEFQDLYNYIESNGEIRSIYEFLD

Sequences:

>Translated_593_residues
MDYITSILSKEREEERNLFLEKESETQSIKSAELVDLRFVVGNTWRAEFVANVSLKSKRWLKKGVPVLLQNQNESIYGNI
FQWNEPKLVIQVRGDYEWDAETYSISKWFPESTYDLYNEIIGKVRAEKETDSYKKLKWALGYGLGDKPSPPKKTMELTAL
ERIFSISDFGMVFGPPGTGKTTLLMQAVSQITQQKESVLTLCPTNFACDYIVELAIQKGIRVIRLGNSTKIKEEVLPYHL
DHLIQTHPDQKQIQNWQTELKVIQKKINSWKRNFGKEEREERNNLRKEAKFLVHTIREQESTIRTKLLDTSELIVSTFAG
FGNEFKKGRKFDYTFVDEATQSVDPGCYMAMFSGKKTFFFGDPKQLGVNYSHPDHKTVASFLEKVIDLDSGERTIFLEKQ
FRMKPEILGFPNLTYYENKVFTHPNLTFLTSPPFSEIFGSDTPILWVDTAGSDTSEETEGEEMSFFNETEIGLIETFFER
GLPKETTAVVSPYRGQVDKLNLRADGRWIGQTIDSFQGRESEIVILSLVRSNPDGEIGFLMNPKRLNVALTRAKSHLILI
GDSSTLCRHKEFQDLYNYIESNGEIRSIYEFLD
>Mature_593_residues
MDYITSILSKEREEERNLFLEKESETQSIKSAELVDLRFVVGNTWRAEFVANVSLKSKRWLKKGVPVLLQNQNESIYGNI
FQWNEPKLVIQVRGDYEWDAETYSISKWFPESTYDLYNEIIGKVRAEKETDSYKKLKWALGYGLGDKPSPPKKTMELTAL
ERIFSISDFGMVFGPPGTGKTTLLMQAVSQITQQKESVLTLCPTNFACDYIVELAIQKGIRVIRLGNSTKIKEEVLPYHL
DHLIQTHPDQKQIQNWQTELKVIQKKINSWKRNFGKEEREERNNLRKEAKFLVHTIREQESTIRTKLLDTSELIVSTFAG
FGNEFKKGRKFDYTFVDEATQSVDPGCYMAMFSGKKTFFFGDPKQLGVNYSHPDHKTVASFLEKVIDLDSGERTIFLEKQ
FRMKPEILGFPNLTYYENKVFTHPNLTFLTSPPFSEIFGSDTPILWVDTAGSDTSEETEGEEMSFFNETEIGLIETFFER
GLPKETTAVVSPYRGQVDKLNLRADGRWIGQTIDSFQGRESEIVILSLVRSNPDGEIGFLMNPKRLNVALTRAKSHLILI
GDSSTLCRHKEFQDLYNYIESNGEIRSIYEFLD

Specific function: Unknown

COG id: COG1112

COG function: function code L; Superfamily I DNA and RNA helicases and helicase subunits

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA2/NAM7 helicase family [H]

Homologues:

Organism=Homo sapiens, GI119392094, Length=453, Percent_Identity=31.7880794701987, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI18375673, Length=443, Percent_Identity=28.4424379232506, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI122937299, Length=452, Percent_Identity=24.1150442477876, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI194272168, Length=471, Percent_Identity=24.8407643312102, Blast_Score=117, Evalue=4e-26,
Organism=Homo sapiens, GI14211540, Length=471, Percent_Identity=24.8407643312102, Blast_Score=117, Evalue=4e-26,
Organism=Homo sapiens, GI113722133, Length=511, Percent_Identity=25.6360078277886, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI254826809, Length=427, Percent_Identity=25.2927400468384, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI14251207, Length=316, Percent_Identity=28.1645569620253, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI255759910, Length=301, Percent_Identity=28.9036544850498, Blast_Score=90, Evalue=8e-18,
Organism=Homo sapiens, GI255759908, Length=301, Percent_Identity=27.906976744186, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI156105695, Length=487, Percent_Identity=23.2032854209446, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI156105693, Length=487, Percent_Identity=23.2032854209446, Blast_Score=73, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17510163, Length=493, Percent_Identity=26.5720081135903, Blast_Score=144, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71981659, Length=452, Percent_Identity=26.3274336283186, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17533987, Length=438, Percent_Identity=25.7990867579909, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17533985, Length=438, Percent_Identity=25.7990867579909, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322835, Length=503, Percent_Identity=28.2306163021869, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6323726, Length=440, Percent_Identity=27.7272727272727, Blast_Score=148, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6323462, Length=557, Percent_Identity=23.8779174147217, Blast_Score=126, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6321958, Length=462, Percent_Identity=24.6753246753247, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321024, Length=483, Percent_Identity=25.4658385093168, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI18859757, Length=446, Percent_Identity=30.4932735426009, Blast_Score=156, Evalue=4e-38,
Organism=Drosophila melanogaster, GI281363531, Length=469, Percent_Identity=26.226012793177, Blast_Score=116, Evalue=6e-26,
Organism=Drosophila melanogaster, GI281363529, Length=469, Percent_Identity=26.226012793177, Blast_Score=116, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24660647, Length=445, Percent_Identity=24.7191011235955, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI221330969, Length=447, Percent_Identity=24.6085011185682, Blast_Score=100, Evalue=5e-21,
Organism=Drosophila melanogaster, GI45550425, Length=441, Percent_Identity=24.4897959183673, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR004483 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 68290; Mature: 68290

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00093 N4_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYITSILSKEREEERNLFLEKESETQSIKSAELVDLRFVVGNTWRAEFVANVSLKSKRW
CHHHHHHHHHHHHHHHCEEEECCCHHHHHCCCCEEEEEEEECCCEEEHEEEECCHHHHHH
LKKGVPVLLQNQNESIYGNIFQWNEPKLVIQVRGDYEWDAETYSISKWFPESTYDLYNEI
HHCCCCEEEECCCCCEEECEEEECCCEEEEEECCCCCCCCCEEEEHHCCCCHHHHHHHHH
IGKVRAEKETDSYKKLKWALGYGLGDKPSPPKKTMELTALERIFSISDFGMVFGPPGTGK
HHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCH
TTLLMQAVSQITQQKESVLTLCPTNFACDYIVELAIQKGIRVIRLGNSTKIKEEVLPYHL
HHHHHHHHHHHHHHHHCEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHH
DHLIQTHPDQKQIQNWQTELKVIQKKINSWKRNFGKEEREERNNLRKEAKFLVHTIREQE
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
STIRTKLLDTSELIVSTFAGFGNEFKKGRKFDYTFVDEATQSVDPGCYMAMFSGKKTFFF
HHHHHHHCCHHHHHHHHHHHCCHHHHCCCCCCEEEHHHHHHCCCCCEEEEEECCCEEEEE
GDPKQLGVNYSHPDHKTVASFLEKVIDLDSGERTIFLEKQFRMKPEILGFPNLTYYENKV
CCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEHHHCCCCCCCCCCCCEEECCEE
FTHPNLTFLTSPPFSEIFGSDTPILWVDTAGSDTSEETEGEEMSFFNETEIGLIETFFER
EECCCEEEEECCCHHHHCCCCCCEEEEECCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHC
GLPKETTAVVSPYRGQVDKLNLRADGRWIGQTIDSFQGRESEIVILSLVRSNPDGEIGFL
CCCCCHHHHCCCCCCCCEEEEEEECCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEEE
MNPKRLNVALTRAKSHLILIGDSSTLCRHKEFQDLYNYIESNGEIRSIYEFLD
ECCCCEEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
>Mature Secondary Structure
MDYITSILSKEREEERNLFLEKESETQSIKSAELVDLRFVVGNTWRAEFVANVSLKSKRW
CHHHHHHHHHHHHHHHCEEEECCCHHHHHCCCCEEEEEEEECCCEEEHEEEECCHHHHHH
LKKGVPVLLQNQNESIYGNIFQWNEPKLVIQVRGDYEWDAETYSISKWFPESTYDLYNEI
HHCCCCEEEECCCCCEEECEEEECCCEEEEEECCCCCCCCCEEEEHHCCCCHHHHHHHHH
IGKVRAEKETDSYKKLKWALGYGLGDKPSPPKKTMELTALERIFSISDFGMVFGPPGTGK
HHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCH
TTLLMQAVSQITQQKESVLTLCPTNFACDYIVELAIQKGIRVIRLGNSTKIKEEVLPYHL
HHHHHHHHHHHHHHHHCEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHH
DHLIQTHPDQKQIQNWQTELKVIQKKINSWKRNFGKEEREERNNLRKEAKFLVHTIREQE
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
STIRTKLLDTSELIVSTFAGFGNEFKKGRKFDYTFVDEATQSVDPGCYMAMFSGKKTFFF
HHHHHHHCCHHHHHHHHHHHCCHHHHCCCCCCEEEHHHHHHCCCCCEEEEEECCCEEEEE
GDPKQLGVNYSHPDHKTVASFLEKVIDLDSGERTIFLEKQFRMKPEILGFPNLTYYENKV
CCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEHHHCCCCCCCCCCCCEEECCEE
FTHPNLTFLTSPPFSEIFGSDTPILWVDTAGSDTSEETEGEEMSFFNETEIGLIETFFER
EECCCEEEEECCCHHHHCCCCCCEEEEECCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHC
GLPKETTAVVSPYRGQVDKLNLRADGRWIGQTIDSFQGRESEIVILSLVRSNPDGEIGFL
CCCCCHHHHCCCCCCCCEEEEEEECCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEEE
MNPKRLNVALTRAKSHLILIGDSSTLCRHKEFQDLYNYIESNGEIRSIYEFLD
ECCCCEEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]