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The map label for this gene is erg3 [H]

Identifier: 183220753

GI number: 183220753

Start: 1420472

End: 1421683

Strand: Reverse

Name: erg3 [H]

Synonym: LEPBI_I1363

Alternate gene names: 183220753

Gene position: 1421683-1420472 (Counterclockwise)

Preceding gene: 183220764

Following gene: 183220750

Centisome position: 39.49

GC content: 41.25

Gene sequence:

>1212_bases
ATGAATAGCGATGCCTTTATGGAATACGCCTTTATCGTCATGGTCGCACTGATCGGTATTGAAATTTTTGTTTCTTATAT
GAAGGGCAAACAATTTTACCGTTTGAATGTTCTCATAGCTGATGTTAGCACAGGTGTCATCTTTGCACTTGTGGGAGTGG
TCATCTTACTTGGTGCCCTTTATGTTTATGATATCGTCGAAAAGAATTACTCTTTGTCTGCACTTGGTTATCATTTTTTC
CCTCTGATAAGTCCCTTCCAATTTTCACCTAGTTTTGTTGTGAATTGGCAGGCCCTTGGTGCTTGGACTTTCTCTGTGGT
ATTTGCTGATTTTATCTACTACTGGTTTCACAGGCATTGCCATGAAATCAATTTGTTTTGGGCAACCCATGTCACCCACC
ATTCCACTCAAGAAATGAACCTATCGGTGGCGTTTCGTGGGAACGGCTTACAAAGGATTTTTGAATATACGTACTTCCTT
GCGATGGCACTCCTTGGAATCCCATGGGCGATGTTTTTATTGAGCCACCGGATCTTAAAAGTATACCAATTTGTGGTCCA
CACCCGTTTCATTGGCAAACTTGGATTTTTGGAAGAATTTATGGTGACTCCTTCTAACCATAGAGTCCACCACGGAACCC
AAAGGAAGTATCTCGATCGTAACCACGGTGGGATCTTTATCATTTGGGACCGTTTGTTTGGATCCTTTGAGTGGGAAACA
GATGAACCAATCTATGGTTTGACAAAACCAGTGAACTCATTTAATCCCATCACAGTCAACTTACACGTGTTTAAGGATAT
GTTCTTTCAAATCTTCAAATGTAAGTCGATGGGAGATATTTTCAAAACTATTTTTGGACCTCCCGGTTGGAAACCAACCT
ACTTACAAACGCCTGAGGATGCCTTCAAAGAACCAGCTTACACGGAAAAGTATGATCCAAAACCTCCTATGGGTGTGATG
GTCTATGTGGCACTGCAAGCGGCTGTCCTTATGGCAGTGGGACTTGTGATTTGGAAAGTTGCCAAAATCAATTTAGAACA
AGATATGACAAGCCTTGGGATCTTATCCTTAGTGATCATTTTTAGTTTGTTTTCCATTGATCGAACAATGGAAATGAAAC
GTTGGTCACGCCGGACAGAAGTGGTGCGGAATATGCTCTTTATAGTTGCTTTTGTTCTGGCACTTGTTTATTCCAATATC
CCCCAATATTGA

Upstream 100 bases:

>100_bases
CATAGAAACGTCACAATCTATGTAGTTTATTGGAAAGAAATGGACATTGACTTAGTGGACGTGATTCAAAAGCCTAGTCT
CTAGTGAGGAAAATACACGC

Downstream 100 bases:

>100_bases
AATTTTTGCCATCCCACTCATTGGCCTTTCGTTTGTATCCTTAGTTTGGATCATCCTCAAACGAAAAACTTTTTTTGATT
TGAGTAATATTTCTAATACT

Product: putative sterol desaturase-related protein

Products: NA

Alternate protein names: Sterol-C5-desaturase [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MNSDAFMEYAFIVMVALIGIEIFVSYMKGKQFYRLNVLIADVSTGVIFALVGVVILLGALYVYDIVEKNYSLSALGYHFF
PLISPFQFSPSFVVNWQALGAWTFSVVFADFIYYWFHRHCHEINLFWATHVTHHSTQEMNLSVAFRGNGLQRIFEYTYFL
AMALLGIPWAMFLLSHRILKVYQFVVHTRFIGKLGFLEEFMVTPSNHRVHHGTQRKYLDRNHGGIFIIWDRLFGSFEWET
DEPIYGLTKPVNSFNPITVNLHVFKDMFFQIFKCKSMGDIFKTIFGPPGWKPTYLQTPEDAFKEPAYTEKYDPKPPMGVM
VYVALQAAVLMAVGLVIWKVAKINLEQDMTSLGILSLVIIFSLFSIDRTMEMKRWSRRTEVVRNMLFIVAFVLALVYSNI
PQY

Sequences:

>Translated_403_residues
MNSDAFMEYAFIVMVALIGIEIFVSYMKGKQFYRLNVLIADVSTGVIFALVGVVILLGALYVYDIVEKNYSLSALGYHFF
PLISPFQFSPSFVVNWQALGAWTFSVVFADFIYYWFHRHCHEINLFWATHVTHHSTQEMNLSVAFRGNGLQRIFEYTYFL
AMALLGIPWAMFLLSHRILKVYQFVVHTRFIGKLGFLEEFMVTPSNHRVHHGTQRKYLDRNHGGIFIIWDRLFGSFEWET
DEPIYGLTKPVNSFNPITVNLHVFKDMFFQIFKCKSMGDIFKTIFGPPGWKPTYLQTPEDAFKEPAYTEKYDPKPPMGVM
VYVALQAAVLMAVGLVIWKVAKINLEQDMTSLGILSLVIIFSLFSIDRTMEMKRWSRRTEVVRNMLFIVAFVLALVYSNI
PQY
>Mature_403_residues
MNSDAFMEYAFIVMVALIGIEIFVSYMKGKQFYRLNVLIADVSTGVIFALVGVVILLGALYVYDIVEKNYSLSALGYHFF
PLISPFQFSPSFVVNWQALGAWTFSVVFADFIYYWFHRHCHEINLFWATHVTHHSTQEMNLSVAFRGNGLQRIFEYTYFL
AMALLGIPWAMFLLSHRILKVYQFVVHTRFIGKLGFLEEFMVTPSNHRVHHGTQRKYLDRNHGGIFIIWDRLFGSFEWET
DEPIYGLTKPVNSFNPITVNLHVFKDMFFQIFKCKSMGDIFKTIFGPPGWKPTYLQTPEDAFKEPAYTEKYDPKPPMGVM
VYVALQAAVLMAVGLVIWKVAKINLEQDMTSLGILSLVIIFSLFSIDRTMEMKRWSRRTEVVRNMLFIVAFVLALVYSNI
PQY

Specific function: Unknown

COG id: COG3000

COG function: function code I; Sterol desaturase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sterol desaturase family [H]

Homologues:

Organism=Homo sapiens, GI51972212, Length=402, Percent_Identity=30.5970149253731, Blast_Score=184, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI25144659, Length=392, Percent_Identity=29.0816326530612, Blast_Score=151, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006694 [H]

Pfam domain/function: PF04116 FA_hydroxylase [H]

EC number: NA

Molecular weight: Translated: 46765; Mature: 46765

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSDAFMEYAFIVMVALIGIEIFVSYMKGKQFYRLNVLIADVSTGVIFALVGVVILLGAL
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEHHHHHHHHHHHHHHHHHHH
YVYDIVEKNYSLSALGYHFFPLISPFQFSPSFVVNWQALGAWTFSVVFADFIYYWFHRHC
HHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
HEINLFWATHVTHHSTQEMNLSVAFRGNGLQRIFEYTYFLAMALLGIPWAMFLLSHRILK
HHEEEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VYQFVVHTRFIGKLGFLEEFMVTPSNHRVHHGTQRKYLDRNHGGIFIIWDRLFGSFEWET
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCEEEEHHHHHCCCCCCC
DEPIYGLTKPVNSFNPITVNLHVFKDMFFQIFKCKSMGDIFKTIFGPPGWKPTYLQTPED
CCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
AFKEPAYTEKYDPKPPMGVMVYVALQAAVLMAVGLVIWKVAKINLEQDMTSLGILSLVII
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
FSLFSIDRTMEMKRWSRRTEVVRNMLFIVAFVLALVYSNIPQY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNSDAFMEYAFIVMVALIGIEIFVSYMKGKQFYRLNVLIADVSTGVIFALVGVVILLGAL
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEHHHHHHHHHHHHHHHHHHH
YVYDIVEKNYSLSALGYHFFPLISPFQFSPSFVVNWQALGAWTFSVVFADFIYYWFHRHC
HHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
HEINLFWATHVTHHSTQEMNLSVAFRGNGLQRIFEYTYFLAMALLGIPWAMFLLSHRILK
HHEEEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VYQFVVHTRFIGKLGFLEEFMVTPSNHRVHHGTQRKYLDRNHGGIFIIWDRLFGSFEWET
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCEEEEHHHHHCCCCCCC
DEPIYGLTKPVNSFNPITVNLHVFKDMFFQIFKCKSMGDIFKTIFGPPGWKPTYLQTPED
CCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
AFKEPAYTEKYDPKPPMGVMVYVALQAAVLMAVGLVIWKVAKINLEQDMTSLGILSLVII
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
FSLFSIDRTMEMKRWSRRTEVVRNMLFIVAFVLALVYSNIPQY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]