Click here to switch to the map view.

The map label for this gene is hemC [H]

Identifier: 183220566

GI number: 183220566

Start: 1218853

End: 1220388

Strand: Reverse

Name: hemC [H]

Synonym: LEPBI_I1170

Alternate gene names: 183220566

Gene position: 1220388-1218853 (Counterclockwise)

Preceding gene: 183220567

Following gene: 183220565

Centisome position: 33.9

GC content: 37.5

Gene sequence:

>1536_bases
TTGTCTGAAACAATCAAAATAGGAGGTAGGTCCTCCCTACTCTCTCGCATACAAATCCACACTGTTACGAATGCCCTCAA
AGAAAAAAACAAAGATCTAAACTTCGAAACGATTTTCAGAGAATCAAGTGGTGATAAAGACCTAACCACCCCACTTTGGC
AATTTGGTGGACAAGGGATCTTTACCAAAGATTTACAAGAAGATTTACTAAACCACAAAGTTGATATCGTGATCCATTCC
TATAAAGATATGGATTTAAAAGAAAGGAAAGAAACAACACTGATCCCTGTTTTACCAAGGGAAGATGTTCGAGATGTTTT
ACTCTTTAAAAAAAACAAATGGATCAATTTACCAAATGAAATTACCATTTTAACTTCTTCACCTAGAAGAGAATACCACA
TCAAAGAATTTTTAAGGAATTACTTTCCTACACCCATCAATAATTTTGAAATCAAAATCGAATCCGTTCGGGGAAACATA
CAAACAAGATTACGTAAATATTTGGATCACGAATCAGGTGGAATTTTAGTCGCAAAAGCTGCCTTAGATCGAATCCTAAA
CTTCCAAGACCCCGACCAACTTTTACCAGAACTGAAAGAAATACAACAACTCATTAAGGATACCATGAATGTATCGCTTT
TTATGGTATTACCTTCATCAATCTTCCCAAGTGCTCCCGCACAAGGTGCGTTATGTGCTGAAATCAGAAAAGAAGACAAA
CATCTCGAAACCTTATTGTCAAAGATTTCAGATTCTGAAACCAATCTGACTACAAATGAAGAAAGAGAAATCCTCTCTCG
ATATGGTGGTGGTTGCCATCAAAAAATTGGAGTCACTGTTTTACATAGAGAGTATGGTAAGGTATGCTTCATACGTGGAA
TCACTGAAGATGGTCAAATTTTGCAAACCAAAGAACTTTCAGAAAGCCCAAATTATTCTTTCTCCAGAGATGAAGTATGG
CCACCTAACGCAAAAATGGCGGCAAGACAAAGGGAAAGATTAACTTATAGCATTCCCAAAGATGTGGATGTTTTTGTTTC
TCGTGGGTATGCCTTTCCTTTGGATTTATCAGTCAATCCAAGTAATCAAATCCTTTGGTCAGCAGGGTTATCTACATGGA
AAGATTTAGCATTACGTGGTTTTTGGGTGAATGGAACCTGTGATGGTCTTGGAGAGAGTGAACCACCAGAAATCGATACC
ATATTAGGTAGAAAAACAAAATTTGTCAAACTCAGCCATATGGATTCGGACAAACACTCCAGTATTTATCCCGTGATTCC
TACGTATTTTGTTTCTGCACCCGAAATTCCAATCCCATTTGATACTTCTAAAATCAAAGCCGCTTACTGGCGTAGTGGAT
CTGAATTTGACATTGTCACCAAAAGATACCCGGAACTTTTGAATGTCATACATTTTGTTGGACCTGGATCAACGTTTCGA
AAAATCAAACACGCACTAGGTGAAAATGGTTCCAAAAACAAAGTATTTGTTTCCCTGTCATTTGATTCTTGGGTGGAGAG
GTACATCAAACCATGA

Upstream 100 bases:

>100_bases
ATCCAAAATGTAAAAATGGACTTACAATATTTTCTCACGGAACTGACTCGGGAACGGGAGGAAGAACAATTACATATCAT
GAATGGATGGGAAGATTTAC

Downstream 100 bases:

>100_bases
AAAAACAAACACTTCGATTACGTTCCCACAAGTCACTCCGTCATCTGAGCGAATCAGGTTCCTTAAATGTGAACAAAATG
ATCCAACCTTTATTCCTTGT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MSETIKIGGRSSLLSRIQIHTVTNALKEKNKDLNFETIFRESSGDKDLTTPLWQFGGQGIFTKDLQEDLLNHKVDIVIHS
YKDMDLKERKETTLIPVLPREDVRDVLLFKKNKWINLPNEITILTSSPRREYHIKEFLRNYFPTPINNFEIKIESVRGNI
QTRLRKYLDHESGGILVAKAALDRILNFQDPDQLLPELKEIQQLIKDTMNVSLFMVLPSSIFPSAPAQGALCAEIRKEDK
HLETLLSKISDSETNLTTNEEREILSRYGGGCHQKIGVTVLHREYGKVCFIRGITEDGQILQTKELSESPNYSFSRDEVW
PPNAKMAARQRERLTYSIPKDVDVFVSRGYAFPLDLSVNPSNQILWSAGLSTWKDLALRGFWVNGTCDGLGESEPPEIDT
ILGRKTKFVKLSHMDSDKHSSIYPVIPTYFVSAPEIPIPFDTSKIKAAYWRSGSEFDIVTKRYPELLNVIHFVGPGSTFR
KIKHALGENGSKNKVFVSLSFDSWVERYIKP

Sequences:

>Translated_511_residues
MSETIKIGGRSSLLSRIQIHTVTNALKEKNKDLNFETIFRESSGDKDLTTPLWQFGGQGIFTKDLQEDLLNHKVDIVIHS
YKDMDLKERKETTLIPVLPREDVRDVLLFKKNKWINLPNEITILTSSPRREYHIKEFLRNYFPTPINNFEIKIESVRGNI
QTRLRKYLDHESGGILVAKAALDRILNFQDPDQLLPELKEIQQLIKDTMNVSLFMVLPSSIFPSAPAQGALCAEIRKEDK
HLETLLSKISDSETNLTTNEEREILSRYGGGCHQKIGVTVLHREYGKVCFIRGITEDGQILQTKELSESPNYSFSRDEVW
PPNAKMAARQRERLTYSIPKDVDVFVSRGYAFPLDLSVNPSNQILWSAGLSTWKDLALRGFWVNGTCDGLGESEPPEIDT
ILGRKTKFVKLSHMDSDKHSSIYPVIPTYFVSAPEIPIPFDTSKIKAAYWRSGSEFDIVTKRYPELLNVIHFVGPGSTFR
KIKHALGENGSKNKVFVSLSFDSWVERYIKP
>Mature_510_residues
SETIKIGGRSSLLSRIQIHTVTNALKEKNKDLNFETIFRESSGDKDLTTPLWQFGGQGIFTKDLQEDLLNHKVDIVIHSY
KDMDLKERKETTLIPVLPREDVRDVLLFKKNKWINLPNEITILTSSPRREYHIKEFLRNYFPTPINNFEIKIESVRGNIQ
TRLRKYLDHESGGILVAKAALDRILNFQDPDQLLPELKEIQQLIKDTMNVSLFMVLPSSIFPSAPAQGALCAEIRKEDKH
LETLLSKISDSETNLTTNEEREILSRYGGGCHQKIGVTVLHREYGKVCFIRGITEDGQILQTKELSESPNYSFSRDEVWP
PNAKMAARQRERLTYSIPKDVDVFVSRGYAFPLDLSVNPSNQILWSAGLSTWKDLALRGFWVNGTCDGLGESEPPEIDTI
LGRKTKFVKLSHMDSDKHSSIYPVIPTYFVSAPEIPIPFDTSKIKAAYWRSGSEFDIVTKRYPELLNVIHFVGPGSTFRK
IKHALGENGSKNKVFVSLSFDSWVERYIKP

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=283, Percent_Identity=32.5088339222615, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI20149500, Length=282, Percent_Identity=32.6241134751773, Blast_Score=108, Evalue=1e-23,
Organism=Escherichia coli, GI48994974, Length=278, Percent_Identity=29.4964028776978, Blast_Score=112, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6319996, Length=313, Percent_Identity=33.2268370607029, Blast_Score=110, Evalue=6e-25,
Organism=Drosophila melanogaster, GI20130425, Length=282, Percent_Identity=30.4964539007092, Blast_Score=106, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 58333; Mature: 58202

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETIKIGGRSSLLSRIQIHTVTNALKEKNKDLNFETIFRESSGDKDLTTPLWQFGGQGI
CCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEECCCCCCCCCCHHHHHCCCCC
FTKDLQEDLLNHKVDIVIHSYKDMDLKERKETTLIPVLPREDVRDVLLFKKNKWINLPNE
CHHHHHHHHHCCEEEEEEECCCCCCHHHCCCCCEEECCCCHHHHHHHHEECCCCCCCCCE
ITILTSSPRREYHIKEFLRNYFPTPINNFEIKIESVRGNIQTRLRKYLDHESGGILVAKA
EEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCEEEEHH
ALDRILNFQDPDQLLPELKEIQQLIKDTMNVSLFMVLPSSIFPSAPAQGALCAEIRKEDK
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEEECHHHCCCCCCCCHHHHHHHHHHH
HLETLLSKISDSETNLTTNEEREILSRYGGGCHQKIGVTVLHREYGKVCFIRGITEDGQI
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCHHHCEEEEECCCCCEEEEEECCCCCCE
LQTKELSESPNYSFSRDEVWPPNAKMAARQRERLTYSIPKDVDVFVSRGYAFPLDLSVNP
EEHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEECCCCHHHHHCCCEEEEEEEEECC
SNQILWSAGLSTWKDLALRGFWVNGTCDGLGESEPPEIDTILGRKTKFVKLSHMDSDKHS
CCCEEECCCCHHHHHHHHEEEEECCCCCCCCCCCCCCHHHHHCCCEEEEEEECCCCCCCC
SIYPVIPTYFVSAPEIPIPFDTSKIKAAYWRSGSEFDIVTKRYPELLNVIHFVGPGSTFR
CCCCCHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHCCCCHHHH
KIKHALGENGSKNKVFVSLSFDSWVERYIKP
HHHHHHCCCCCCCEEEEEEEHHHHHHHHCCC
>Mature Secondary Structure 
SETIKIGGRSSLLSRIQIHTVTNALKEKNKDLNFETIFRESSGDKDLTTPLWQFGGQGI
CCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEECCCCCCCCCCHHHHHCCCCC
FTKDLQEDLLNHKVDIVIHSYKDMDLKERKETTLIPVLPREDVRDVLLFKKNKWINLPNE
CHHHHHHHHHCCEEEEEEECCCCCCHHHCCCCCEEECCCCHHHHHHHHEECCCCCCCCCE
ITILTSSPRREYHIKEFLRNYFPTPINNFEIKIESVRGNIQTRLRKYLDHESGGILVAKA
EEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCEEEEHH
ALDRILNFQDPDQLLPELKEIQQLIKDTMNVSLFMVLPSSIFPSAPAQGALCAEIRKEDK
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEEECHHHCCCCCCCCHHHHHHHHHHH
HLETLLSKISDSETNLTTNEEREILSRYGGGCHQKIGVTVLHREYGKVCFIRGITEDGQI
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCHHHCEEEEECCCCCEEEEEECCCCCCE
LQTKELSESPNYSFSRDEVWPPNAKMAARQRERLTYSIPKDVDVFVSRGYAFPLDLSVNP
EEHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEECCCCHHHHHCCCEEEEEEEEECC
SNQILWSAGLSTWKDLALRGFWVNGTCDGLGESEPPEIDTILGRKTKFVKLSHMDSDKHS
CCCEEECCCCHHHHHHHHEEEEECCCCCCCCCCCCCCHHHHHCCCEEEEEEECCCCCCCC
SIYPVIPTYFVSAPEIPIPFDTSKIKAAYWRSGSEFDIVTKRYPELLNVIHFVGPGSTFR
CCCCCHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHCCCCHHHH
KIKHALGENGSKNKVFVSLSFDSWVERYIKP
HHHHHHCCCCCCCEEEEEEEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA