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The map label for this gene is gltA [H]

Identifier: 183220446

GI number: 183220446

Start: 1084118

End: 1085407

Strand: Reverse

Name: gltA [H]

Synonym: LEPBI_I1043

Alternate gene names: 183220446

Gene position: 1085407-1084118 (Counterclockwise)

Preceding gene: 183220447

Following gene: 183220445

Centisome position: 30.15

GC content: 40.39

Gene sequence:

>1290_bases
ATGTCCGAAAAGGCAATTCTGAAAGTGGATGGAAAAGAGTACGAACTTCCGATCGTTGCGGGAAGTGAAGACGAAAAGGC
AATTGATATTACAAAACTCCGCCAATTGTCCGGTTATGTTACGATTGATTCTGGTTATTTAAATACAGGTGCCTGCACAA
GTGAAATCACCTTTCTCGATGGTGAAAAAGGAATCCTCAGATATCGTGGAATCCCAATCGAAGATTTAGCAGCAAAGTCA
ACCTTCACAGAAGTTGCTTATTTACTCATCTACGGAAAACTTCCAAACGATGCACAGCTCAAAGAGTGGAATAGTTCGAT
CACAAAACACACCATGATCCATGAAGACCTCAAACGTCTGTTCAATGGATTCCCAAAAGATGGACACCCTATGGCAATCA
TGTCATGTATGATGGGATGTTTGTCTACATACTACCAAGATAGTTATGATCCAATGAATGAGGAACATAGAGAAATTTCC
ATCATTCGACTCCTTGCAAAATTTCCTACAATTGCGGCCTATGCGTATAAAAAATCAATTGGACAACCTATCATCCATCC
TTTGAACGAGTTAGACTATGCATCTAACTTTCTCAATATGATGTTTGCTGTTCCTGCAGAAGACTACCATATTGATCCGG
AAATTGTTTCAGCACTTAATTTACTCCTCATCTTACATGCAGACCACGAACAAAACTGTTCTACATCAACTGTTCGTTTG
GTGGGATCTTCTCTTGCCAATTTATATGGTGCGATTTCTGCAGGGATCCTTGCGCTTTGGGGGCCACGCCATGGTGGAGC
CAACCAAGAAGTTTTGGAAATGTTGGAAGGCATTAAAAAAAGTGGACTATCTGTTAAAAAGATCGTCGAACAAGCAAAAG
ACAAAAACTCAAGTTTCCGATTGAATGGATTTGGACACCGTGTTTACAAAAACTTTGACCCACGTGCCAAAATCATCAAA
GTAGCTTGTGACAAGGTATTAAACAAACTCGGAATCAAAGACCCACTTCTTGACATTGCAAAAGAATTGGAAGAAGCGGC
ACTCAATGACCCTTACTTTGTGGAAAGAAAACTCTATCCAAACGTAGACTTTTACTCAGGTATCATCTACCGAGCACTAG
GAATCCCAACCAATATGTTCACTGTGATGTTTGCGATGGGAAGACTACCAGGATGGATTGCACAATGGAAAGAAATGATT
GAAGACCCGAACTTAAAAATTGGTCGTCCACGACAAATTTACACCGGTCCAAAAGAAATTTCTTACGAAACGGCAAAAAA
ACAGGCCTAA

Upstream 100 bases:

>100_bases
ACGATATCATGAAAAAATACCATAAGTTGTAAAAAATGGCTTTTCCCCTCCCTTTCCCCTGTCTATTCTTTGAAATAGAC
AGAGATATACAGGAGAAGAT

Downstream 100 bases:

>100_bases
GTCAATACGACACAGGACAAGGGAATCTCCCTTGTCCCTTCCCAACACTTGAAACCGATTTTATCCAAATTCACTCTCCT
CTTCACACTCTACAGTCTTT

Product: citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MSEKAILKVDGKEYELPIVAGSEDEKAIDITKLRQLSGYVTIDSGYLNTGACTSEITFLDGEKGILRYRGIPIEDLAAKS
TFTEVAYLLIYGKLPNDAQLKEWNSSITKHTMIHEDLKRLFNGFPKDGHPMAIMSCMMGCLSTYYQDSYDPMNEEHREIS
IIRLLAKFPTIAAYAYKKSIGQPIIHPLNELDYASNFLNMMFAVPAEDYHIDPEIVSALNLLLILHADHEQNCSTSTVRL
VGSSLANLYGAISAGILALWGPRHGGANQEVLEMLEGIKKSGLSVKKIVEQAKDKNSSFRLNGFGHRVYKNFDPRAKIIK
VACDKVLNKLGIKDPLLDIAKELEEAALNDPYFVERKLYPNVDFYSGIIYRALGIPTNMFTVMFAMGRLPGWIAQWKEMI
EDPNLKIGRPRQIYTGPKEISYETAKKQA

Sequences:

>Translated_429_residues
MSEKAILKVDGKEYELPIVAGSEDEKAIDITKLRQLSGYVTIDSGYLNTGACTSEITFLDGEKGILRYRGIPIEDLAAKS
TFTEVAYLLIYGKLPNDAQLKEWNSSITKHTMIHEDLKRLFNGFPKDGHPMAIMSCMMGCLSTYYQDSYDPMNEEHREIS
IIRLLAKFPTIAAYAYKKSIGQPIIHPLNELDYASNFLNMMFAVPAEDYHIDPEIVSALNLLLILHADHEQNCSTSTVRL
VGSSLANLYGAISAGILALWGPRHGGANQEVLEMLEGIKKSGLSVKKIVEQAKDKNSSFRLNGFGHRVYKNFDPRAKIIK
VACDKVLNKLGIKDPLLDIAKELEEAALNDPYFVERKLYPNVDFYSGIIYRALGIPTNMFTVMFAMGRLPGWIAQWKEMI
EDPNLKIGRPRQIYTGPKEISYETAKKQA
>Mature_428_residues
SEKAILKVDGKEYELPIVAGSEDEKAIDITKLRQLSGYVTIDSGYLNTGACTSEITFLDGEKGILRYRGIPIEDLAAKST
FTEVAYLLIYGKLPNDAQLKEWNSSITKHTMIHEDLKRLFNGFPKDGHPMAIMSCMMGCLSTYYQDSYDPMNEEHREISI
IRLLAKFPTIAAYAYKKSIGQPIIHPLNELDYASNFLNMMFAVPAEDYHIDPEIVSALNLLLILHADHEQNCSTSTVRLV
GSSLANLYGAISAGILALWGPRHGGANQEVLEMLEGIKKSGLSVKKIVEQAKDKNSSFRLNGFGHRVYKNFDPRAKIIKV
ACDKVLNKLGIKDPLLDIAKELEEAALNDPYFVERKLYPNVDFYSGIIYRALGIPTNMFTVMFAMGRLPGWIAQWKEMIE
DPNLKIGRPRQIYTGPKEISYETAKKQA

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=423, Percent_Identity=27.4231678486998, Blast_Score=120, Evalue=4e-27,
Organism=Escherichia coli, GI1786939, Length=426, Percent_Identity=53.5211267605634, Blast_Score=476, Evalue=1e-135,
Organism=Escherichia coli, GI1786527, Length=374, Percent_Identity=31.5508021390374, Blast_Score=162, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17555174, Length=390, Percent_Identity=29.2307692307692, Blast_Score=115, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6319850, Length=392, Percent_Identity=29.0816326530612, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6324328, Length=406, Percent_Identity=27.5862068965517, Blast_Score=116, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6325257, Length=403, Percent_Identity=26.0545905707196, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24640126, Length=413, Percent_Identity=27.8450363196126, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24640124, Length=413, Percent_Identity=27.8450363196126, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI21356863, Length=442, Percent_Identity=27.3755656108597, Blast_Score=112, Evalue=5e-25,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 48143; Mature: 48012

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKAILKVDGKEYELPIVAGSEDEKAIDITKLRQLSGYVTIDSGYLNTGACTSEITFLD
CCCCCEEEECCCEEEEEEEECCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEC
GEKGILRYRGIPIEDLAAKSTFTEVAYLLIYGKLPNDAQLKEWNSSITKHTMIHEDLKRL
CCCCEEEECCCCHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FNGFPKDGHPMAIMSCMMGCLSTYYQDSYDPMNEEHREISIIRLLAKFPTIAAYAYKKSI
HCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHC
GQPIIHPLNELDYASNFLNMMFAVPAEDYHIDPEIVSALNLLLILHADHEQNCSTSTVRL
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEEECCCCCCCCHHHHHH
VGSSLANLYGAISAGILALWGPRHGGANQEVLEMLEGIKKSGLSVKKIVEQAKDKNSSFR
HHHHHHHHHHHHHHCHHEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEE
LNGFGHRVYKNFDPRAKIIKVACDKVLNKLGIKDPLLDIAKELEEAALNDPYFVERKLYP
ECCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEECCC
NVDFYSGIIYRALGIPTNMFTVMFAMGRLPGWIAQWKEMIEDPNLKIGRPRQIYTGPKEI
CCCHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHC
SYETAKKQA
CHHHHHCCC
>Mature Secondary Structure 
SEKAILKVDGKEYELPIVAGSEDEKAIDITKLRQLSGYVTIDSGYLNTGACTSEITFLD
CCCCEEEECCCEEEEEEEECCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEC
GEKGILRYRGIPIEDLAAKSTFTEVAYLLIYGKLPNDAQLKEWNSSITKHTMIHEDLKRL
CCCCEEEECCCCHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FNGFPKDGHPMAIMSCMMGCLSTYYQDSYDPMNEEHREISIIRLLAKFPTIAAYAYKKSI
HCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHC
GQPIIHPLNELDYASNFLNMMFAVPAEDYHIDPEIVSALNLLLILHADHEQNCSTSTVRL
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEEECCCCCCCCHHHHHH
VGSSLANLYGAISAGILALWGPRHGGANQEVLEMLEGIKKSGLSVKKIVEQAKDKNSSFR
HHHHHHHHHHHHHHCHHEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEE
LNGFGHRVYKNFDPRAKIIKVACDKVLNKLGIKDPLLDIAKELEEAALNDPYFVERKLYP
ECCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEECCC
NVDFYSGIIYRALGIPTNMFTVMFAMGRLPGWIAQWKEMIEDPNLKIGRPRQIYTGPKEI
CCCHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHC
SYETAKKQA
CHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]