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The map label for this gene is gpo [H]

Identifier: 183220048

GI number: 183220048

Start: 640416

End: 640889

Strand: Direct

Name: gpo [H]

Synonym: LEPBI_I0635

Alternate gene names: 183220048

Gene position: 640416-640889 (Clockwise)

Preceding gene: 183220043

Following gene: 183220049

Centisome position: 17.79

GC content: 37.76

Gene sequence:

>474_bases
ATGACTTTCCATGATTTAAAAACCATCACCATCCAAGGAAAAGAAATTTCGCTCGGAGAATACAAAGGCCACCCAGTGCT
TGTGGTCAATGTTGCATCTAAATGTGGTTATACGCCACAATATGAAGGATTGGAAAAACTCCACTTAGCATACAAAGACA
AAGGTTTGAAAGTCGTTGGTTTTCCATCCAATGATTTCGGTGGCCAAGAGCCAGGAACGGAAGCCCAAATTGCAGAATTT
TGTAAGCTCAATTTTGGTGTTAGTTTTGATCTAATGAAAAAAACCAAAGTGCTTGGAAATGACAAGGATCCAGTTTACCA
ATTTCTTACAGAGAACGCAAAAGAAAAAGGGGATGTAAAATGGAACTTTGAAAAGTTTCTCATCGATAAAAATGGAAATA
TAGTGAACCGATTCCCTTCTTCTACCAAACCAGAAAGTGTCGAACTCAAACAAGCCATTGAAAGCATCTTATAA

Upstream 100 bases:

>100_bases
GCATAGTCTAAGGTTGGAGCAGGGGGTTCTTGTGCAAAGAAAAGTTTTGTTTGCTATTTTTCTATTTGTCAGTTTTAGTC
TGATTGCTGGAGGAAAAAAA

Downstream 100 bases:

>100_bases
GAGAATTCTTTTCTTTTTAGTTGTAACATTTTCTGTTTACGGATTGTTTGGACAAGAAAGTCCAAACAATGTGCAAATTG
TACGGACAAAAACTCCTGAG

Product: putative glutathione peroxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 157; Mature: 156

Protein sequence:

>157_residues
MTFHDLKTITIQGKEISLGEYKGHPVLVVNVASKCGYTPQYEGLEKLHLAYKDKGLKVVGFPSNDFGGQEPGTEAQIAEF
CKLNFGVSFDLMKKTKVLGNDKDPVYQFLTENAKEKGDVKWNFEKFLIDKNGNIVNRFPSSTKPESVELKQAIESIL

Sequences:

>Translated_157_residues
MTFHDLKTITIQGKEISLGEYKGHPVLVVNVASKCGYTPQYEGLEKLHLAYKDKGLKVVGFPSNDFGGQEPGTEAQIAEF
CKLNFGVSFDLMKKTKVLGNDKDPVYQFLTENAKEKGDVKWNFEKFLIDKNGNIVNRFPSSTKPESVELKQAIESIL
>Mature_156_residues
TFHDLKTITIQGKEISLGEYKGHPVLVVNVASKCGYTPQYEGLEKLHLAYKDKGLKVVGFPSNDFGGQEPGTEAQIAEFC
KLNFGVSFDLMKKTKVLGNDKDPVYQFLTENAKEKGDVKWNFEKFLIDKNGNIVNRFPSSTKPESVELKQAIESIL

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI75709200, Length=152, Percent_Identity=38.8157894736842, Blast_Score=110, Evalue=4e-25,
Organism=Homo sapiens, GI90903240, Length=152, Percent_Identity=38.8157894736842, Blast_Score=110, Evalue=7e-25,
Organism=Homo sapiens, GI15618997, Length=147, Percent_Identity=35.3741496598639, Blast_Score=104, Evalue=3e-23,
Organism=Homo sapiens, GI192455698, Length=135, Percent_Identity=36.2962962962963, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI90903238, Length=130, Percent_Identity=37.6923076923077, Blast_Score=91, Evalue=4e-19,
Organism=Homo sapiens, GI4557629, Length=170, Percent_Identity=34.1176470588235, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI6006001, Length=171, Percent_Identity=32.7485380116959, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI33186887, Length=154, Percent_Identity=33.1168831168831, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI32967607, Length=183, Percent_Identity=28.9617486338798, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI41406084, Length=172, Percent_Identity=30.2325581395349, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1788003, Length=169, Percent_Identity=37.2781065088757, Blast_Score=121, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71993584, Length=162, Percent_Identity=38.2716049382716, Blast_Score=117, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17535473, Length=162, Percent_Identity=38.2716049382716, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17506887, Length=160, Percent_Identity=38.125, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI193210707, Length=157, Percent_Identity=40.1273885350318, Blast_Score=102, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17550320, Length=177, Percent_Identity=30.5084745762712, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI193209493, Length=180, Percent_Identity=28.8888888888889, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71993573, Length=96, Percent_Identity=37.5, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6319721, Length=159, Percent_Identity=51.5723270440252, Blast_Score=162, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6322228, Length=160, Percent_Identity=48.75, Blast_Score=157, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6322826, Length=158, Percent_Identity=40.5063291139241, Blast_Score=126, Evalue=2e-30,
Organism=Drosophila melanogaster, GI85726443, Length=159, Percent_Identity=38.3647798742138, Blast_Score=109, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24656772, Length=153, Percent_Identity=38.562091503268, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24656767, Length=153, Percent_Identity=38.562091503268, Blast_Score=96, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24656777, Length=153, Percent_Identity=38.562091503268, Blast_Score=96, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 17576; Mature: 17445

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFHDLKTITIQGKEISLGEYKGHPVLVVNVASKCGYTPQYEGLEKLHLAYKDKGLKVVG
CCCCCEEEEEEECCEEECCCCCCCCEEEEEEHHHCCCCCCCCCHHHHHHHCCCCCCEEEE
FPSNDFGGQEPGTEAQIAEFCKLNFGVSFDLMKKTKVLGNDKDPVYQFLTENAKEKGDVK
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEE
WNFEKFLIDKNGNIVNRFPSSTKPESVELKQAIESIL
ECCEEEEEECCCCEEECCCCCCCCCCCHHHHHHHHHC
>Mature Secondary Structure 
TFHDLKTITIQGKEISLGEYKGHPVLVVNVASKCGYTPQYEGLEKLHLAYKDKGLKVVG
CCCCEEEEEEECCEEECCCCCCCCEEEEEEHHHCCCCCCCCCHHHHHHHCCCCCCEEEE
FPSNDFGGQEPGTEAQIAEFCKLNFGVSFDLMKKTKVLGNDKDPVYQFLTENAKEKGDVK
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEE
WNFEKFLIDKNGNIVNRFPSSTKPESVELKQAIESIL
ECCEEEEEECCCCEEECCCCCCCCCCCHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]