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The map label for this gene is fabG [C]

Identifier: 183220037

GI number: 183220037

Start: 626405

End: 627112

Strand: Direct

Name: fabG [C]

Synonym: LEPBI_I0623

Alternate gene names: 183220037

Gene position: 626405-627112 (Clockwise)

Preceding gene: 183220036

Following gene: 183220043

Centisome position: 17.4

GC content: 35.88

Gene sequence:

>708_bases
ATGACCCAAGTAGCCGTTGTGACTGGTGCTTCTCGTGGAATTGGCCTCTCAATATCCAAGGTATTACTCGAGTTAGGTTA
TACAGTTTATGGAATCTGTAGAAACCCAGAAACATGTAATTTTTACGAAGAAAATTTCCATTTGATCAAAGGTGACTTAA
AAGATCCTAAAACGATTCCCATATTTTTGGAACAAATTCCCAATAGAGACAAAATTCGTATCCTTGTGAATAATGCAGGA
CTCTCGTACTTCGCACCCATTGAGGAATTATCATCGGATAAAATTTCAGAAATGACTCAGGTTCTTTTGAATGCACCCAT
GATACTTTCAAGTTCACTGACAAGGATTTTGAAACAAAACGAAGGAAGAATCTTCTTTATTGGTTCTGTATCTGGATTTC
AAATTTCTCCTTGGGGGAATGTGTATGGCTCACTGAAAGCAGGATTACACCAATTTGCTAGATTATTGTATGATGAACTT
CGTAAATATTCAGTGAAGGTTCATTTGGTGATTCCAGATATTACCAAAACTGATTTTTATCATGATTTGAACATTGAGCC
AGACTCAGATCCAAGATCATATTTAATACCAGATCAGATTGCTAATGTAGTGAAGCAGATACTATTGGATCAGAGTGGAT
TGGTTGTACCGGAAATTGTAGTGAGACCTGAAGTTTTTAAACTGAAACGTAAGAAGTTTCAAAAATAA

Upstream 100 bases:

>100_bases
GGCCTGGAGAAACACCAATGATTCCTTTTATCAATCAAGGAAAAACTACGAAAGTAATTGATGGGTCAATGTTGGTTTGG
GAATTTATGGAAAGTATAAA

Downstream 100 bases:

>100_bases
ATCATTCCCCAATTGATTGGGCATCGTCAGTGAAAGTGTTTAATGGCACTTGTCCTAAACTCTCTTCATTCGAAGCTGAT
GCACCATCATTTGATAAAGA

Product: SDR family dehydrogenase

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MTQVAVVTGASRGIGLSISKVLLELGYTVYGICRNPETCNFYEENFHLIKGDLKDPKTIPIFLEQIPNRDKIRILVNNAG
LSYFAPIEELSSDKISEMTQVLLNAPMILSSSLTRILKQNEGRIFFIGSVSGFQISPWGNVYGSLKAGLHQFARLLYDEL
RKYSVKVHLVIPDITKTDFYHDLNIEPDSDPRSYLIPDQIANVVKQILLDQSGLVVPEIVVRPEVFKLKRKKFQK

Sequences:

>Translated_235_residues
MTQVAVVTGASRGIGLSISKVLLELGYTVYGICRNPETCNFYEENFHLIKGDLKDPKTIPIFLEQIPNRDKIRILVNNAG
LSYFAPIEELSSDKISEMTQVLLNAPMILSSSLTRILKQNEGRIFFIGSVSGFQISPWGNVYGSLKAGLHQFARLLYDEL
RKYSVKVHLVIPDITKTDFYHDLNIEPDSDPRSYLIPDQIANVVKQILLDQSGLVVPEIVVRPEVFKLKRKKFQK
>Mature_234_residues
TQVAVVTGASRGIGLSISKVLLELGYTVYGICRNPETCNFYEENFHLIKGDLKDPKTIPIFLEQIPNRDKIRILVNNAGL
SYFAPIEELSSDKISEMTQVLLNAPMILSSSLTRILKQNEGRIFFIGSVSGFQISPWGNVYGSLKAGLHQFARLLYDELR
KYSVKVHLVIPDITKTDFYHDLNIEPDSDPRSYLIPDQIANVVKQILLDQSGLVVPEIVVRPEVFKLKRKKFQK

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=192, Percent_Identity=26.5625, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1787335, Length=232, Percent_Identity=27.5862068965517, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1786701, Length=243, Percent_Identity=24.6913580246914, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1787820, Length=192, Percent_Identity=26.5625, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=202, Percent_Identity=28.7128712871287, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322067, Length=185, Percent_Identity=31.3513513513514, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6322226, Length=205, Percent_Identity=31.7073170731707, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24644339, Length=201, Percent_Identity=27.8606965174129, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI116007234, Length=246, Percent_Identity=27.6422764227642, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 26582; Mature: 26451

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQVAVVTGASRGIGLSISKVLLELGYTVYGICRNPETCNFYEENFHLIKGDLKDPKTIP
CCEEEEEECCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCEECCCEEEEECCCCCCCEEE
IFLEQIPNRDKIRILVNNAGLSYFAPIEELSSDKISEMTQVLLNAPMILSSSLTRILKQN
HHHHHCCCCCEEEEEEECCCCCEECCHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHCC
EGRIFFIGSVSGFQISPWGNVYGSLKAGLHQFARLLYDELRKYSVKVHLVIPDITKTDFY
CCCEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCE
HDLNIEPDSDPRSYLIPDQIANVVKQILLDQSGLVVPEIVVRPEVFKLKRKKFQK
EECCCCCCCCCCCEECHHHHHHHHHHHHHCCCCCCCCHHEECCHHHHHHHHHCCC
>Mature Secondary Structure 
TQVAVVTGASRGIGLSISKVLLELGYTVYGICRNPETCNFYEENFHLIKGDLKDPKTIP
CEEEEEECCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCEECCCEEEEECCCCCCCEEE
IFLEQIPNRDKIRILVNNAGLSYFAPIEELSSDKISEMTQVLLNAPMILSSSLTRILKQN
HHHHHCCCCCEEEEEEECCCCCEECCHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHCC
EGRIFFIGSVSGFQISPWGNVYGSLKAGLHQFARLLYDELRKYSVKVHLVIPDITKTDFY
CCCEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCE
HDLNIEPDSDPRSYLIPDQIANVVKQILLDQSGLVVPEIVVRPEVFKLKRKKFQK
EECCCCCCCCCCCEECHHHHHHHHHHHHHCCCCCCCCHHEECCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12950922 [H]