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The map label for this gene is glmS [H]

Identifier: 183219935

GI number: 183219935

Start: 515326

End: 517161

Strand: Direct

Name: glmS [H]

Synonym: LEPBI_I0517

Alternate gene names: 183219935

Gene position: 515326-517161 (Clockwise)

Preceding gene: 183219934

Following gene: 183219936

Centisome position: 14.32

GC content: 40.58

Gene sequence:

>1836_bases
ATGTGTGGAATCGTAGGTTATTTAGGTAAAAGACAGGCACTCCCTGTTATCATTAAAGGTTTAAAAAGATTAGAATACCG
AGGGTATGACAGTGCCGGTGTGGCTCTGTTAAACGGTGGTTTGGAGATTGTCAAAAAAAAAGGGAAGGTCGCTGATTTAG
AATCTGAAATTGGAAACCGGAAATTGGAAGCAAGTCTCGGAATTGGTCACACACGTTGGGCCACACACGGTGAACCTAAT
GATCGTAATGCGCACCCTCACACAAGTTCGGATGGAAAACTTGCCATCATCCATAACGGTATCATTGAAAACTATAGTTC
TATCAAAAAGGAACTTGAGAGTAATGGACATGTATTCAAATCTGATACAGATTCTGAAGTACTCATCCATCTGATCGAAG
AGATCAAAAAACAAAATAATTGTACGATCGAAGAAGCTGTTCGTCTTGCATTGAATGAAGTGGTAGGAGCTTACGCCATC
GTTGTACTTTCGAAAGACAATGAACGCAGTATGATTGCCGCAAGGAAAGGTTCTCCACTCGTGATTGGAATTGGTGAGGA
TGAATACTTTGTGGCATCAGATGCAACTCCGATCATCGAATATACAAATAATGTAACCTATCTCAATGACCAAGAAATGG
CGATCATCAAAGACGGAAGCCTCGTTGTCAAAAATTTAGAGAACGTAACCAAAACTCCATTCATTCAAAAATTAGAATTG
GATTTGGAAGACATAGAGAAAGGTGGATACCCACACTTTATGTTGAAGGAAATTTTTGAACAGCCAAAGTCCATTCGGGA
TGCGATGCGTGGTCGTTTGGTTTCGCGCGAACACCATTTGTTCTTAAGTGGGATAGACCAATATTTAAATCGATTTTTAA
ATGCTGATCGACTGATATTGGTTGGGTGCGGAACCTCTTGGCATGCAGGGCTCATTGGTGAATATTTATTTGAAGATATT
GCTCGTATCCCAACAGAAGTTGAATATGCATCCGAATTTCGTTATCGTAATCCGATTGTTACGGAAAGAGATGTGGTGAT
CGCCGTTTCGCAGTCAGGTGAAACAGCTGATACGCTGGCTGCCATCGAACTTGCGAAGTCTAAAGGTGCTTTGATTTTTG
GTGTATGTAATGTCGTGGGTTCATCAATTGCGCGTGCCTCTCACGCAGGTGCTTATTTGCATGCTGGTCCTGAGATTGGT
GTGGCTTCCACAAAAGCGTTTACATCACAAGTCACCATCTTAACCATGATGGCTCTTTATTTAGGATTAAAAAAAGGAAC
GATCTCGTTATCGGATTACCAAACTTTACTCTTAGAGCTTGACTCCATTCCTGATAAAGTCGCAAAAATTTTAACCAAAG
ACGAAGAGATTCGAAATATATCTGAAAATTTTTATAGAGCATCTAACTTCCTTTATTTGGGACGAGGTTTTAATTTCCCT
GTTGCATTGGAAGGAGCCTTAAAGTTAAAGGAAATCTCTTATATCCATGCGGAAGGATACCCTGCTGCTGAAATGAAACA
TGGACCAATTGCTCTCATTGATGAAGATATGCCGGTTGTTTTCATTGCGACTAAAGATAGCTCGTATGAAAAGGTGATTT
CAAATATCCAAGAAGTGAAAGCAAGAAAAGGTAAGGTAATTGCCATTGTGACGGACGGAGATACTGAAATCCAAAGTATG
GCAGATTTTACATTCCAGATTCCAAAAACTGCGGACGCCCTCGTTCCTTTACTTGCAGTCATTCCTTTACAGTTGTTATC
GTATCACATAGCAATCCTTAGAGGGTGCAATGTGGACCAACCTAGGAACTTAGCAAAATCTGTTACAGTGGAGTGA

Upstream 100 bases:

>100_bases
GGATCCACATCAGACCTTCCAATACGGAACCTATATTTCGTGTCATTACAGAAACAAAATCCCAATCGGATTTGGAATCT
ACCTTAAAGAGAGTAAAACA

Downstream 100 bases:

>100_bases
TTTGTGAATCTCTTATTCGACGATTCTAAACGTAATCCCTCTCTTGAACCACTTTCGAGGTTCCATTCATTTTTTGAATG
GAACTTAGGAGGAATGAATC

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 611; Mature: 611

Protein sequence:

>611_residues
MCGIVGYLGKRQALPVIIKGLKRLEYRGYDSAGVALLNGGLEIVKKKGKVADLESEIGNRKLEASLGIGHTRWATHGEPN
DRNAHPHTSSDGKLAIIHNGIIENYSSIKKELESNGHVFKSDTDSEVLIHLIEEIKKQNNCTIEEAVRLALNEVVGAYAI
VVLSKDNERSMIAARKGSPLVIGIGEDEYFVASDATPIIEYTNNVTYLNDQEMAIIKDGSLVVKNLENVTKTPFIQKLEL
DLEDIEKGGYPHFMLKEIFEQPKSIRDAMRGRLVSREHHLFLSGIDQYLNRFLNADRLILVGCGTSWHAGLIGEYLFEDI
ARIPTEVEYASEFRYRNPIVTERDVVIAVSQSGETADTLAAIELAKSKGALIFGVCNVVGSSIARASHAGAYLHAGPEIG
VASTKAFTSQVTILTMMALYLGLKKGTISLSDYQTLLLELDSIPDKVAKILTKDEEIRNISENFYRASNFLYLGRGFNFP
VALEGALKLKEISYIHAEGYPAAEMKHGPIALIDEDMPVVFIATKDSSYEKVISNIQEVKARKGKVIAIVTDGDTEIQSM
ADFTFQIPKTADALVPLLAVIPLQLLSYHIAILRGCNVDQPRNLAKSVTVE

Sequences:

>Translated_611_residues
MCGIVGYLGKRQALPVIIKGLKRLEYRGYDSAGVALLNGGLEIVKKKGKVADLESEIGNRKLEASLGIGHTRWATHGEPN
DRNAHPHTSSDGKLAIIHNGIIENYSSIKKELESNGHVFKSDTDSEVLIHLIEEIKKQNNCTIEEAVRLALNEVVGAYAI
VVLSKDNERSMIAARKGSPLVIGIGEDEYFVASDATPIIEYTNNVTYLNDQEMAIIKDGSLVVKNLENVTKTPFIQKLEL
DLEDIEKGGYPHFMLKEIFEQPKSIRDAMRGRLVSREHHLFLSGIDQYLNRFLNADRLILVGCGTSWHAGLIGEYLFEDI
ARIPTEVEYASEFRYRNPIVTERDVVIAVSQSGETADTLAAIELAKSKGALIFGVCNVVGSSIARASHAGAYLHAGPEIG
VASTKAFTSQVTILTMMALYLGLKKGTISLSDYQTLLLELDSIPDKVAKILTKDEEIRNISENFYRASNFLYLGRGFNFP
VALEGALKLKEISYIHAEGYPAAEMKHGPIALIDEDMPVVFIATKDSSYEKVISNIQEVKARKGKVIAIVTDGDTEIQSM
ADFTFQIPKTADALVPLLAVIPLQLLSYHIAILRGCNVDQPRNLAKSVTVE
>Mature_611_residues
MCGIVGYLGKRQALPVIIKGLKRLEYRGYDSAGVALLNGGLEIVKKKGKVADLESEIGNRKLEASLGIGHTRWATHGEPN
DRNAHPHTSSDGKLAIIHNGIIENYSSIKKELESNGHVFKSDTDSEVLIHLIEEIKKQNNCTIEEAVRLALNEVVGAYAI
VVLSKDNERSMIAARKGSPLVIGIGEDEYFVASDATPIIEYTNNVTYLNDQEMAIIKDGSLVVKNLENVTKTPFIQKLEL
DLEDIEKGGYPHFMLKEIFEQPKSIRDAMRGRLVSREHHLFLSGIDQYLNRFLNADRLILVGCGTSWHAGLIGEYLFEDI
ARIPTEVEYASEFRYRNPIVTERDVVIAVSQSGETADTLAAIELAKSKGALIFGVCNVVGSSIARASHAGAYLHAGPEIG
VASTKAFTSQVTILTMMALYLGLKKGTISLSDYQTLLLELDSIPDKVAKILTKDEEIRNISENFYRASNFLYLGRGFNFP
VALEGALKLKEISYIHAEGYPAAEMKHGPIALIDEDMPVVFIATKDSSYEKVISNIQEVKARKGKVIAIVTDGDTEIQSM
ADFTFQIPKTADALVPLLAVIPLQLLSYHIAILRGCNVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=684, Percent_Identity=40.3508771929825, Blast_Score=506, Evalue=1e-143,
Organism=Homo sapiens, GI205277386, Length=683, Percent_Identity=39.8243045387994, Blast_Score=503, Evalue=1e-142,
Organism=Homo sapiens, GI29570798, Length=198, Percent_Identity=29.7979797979798, Blast_Score=71, Evalue=4e-12,
Organism=Escherichia coli, GI1790167, Length=618, Percent_Identity=43.042071197411, Blast_Score=499, Evalue=1e-142,
Organism=Escherichia coli, GI1788651, Length=217, Percent_Identity=30.8755760368664, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17532899, Length=433, Percent_Identity=44.5727482678984, Blast_Score=369, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17532897, Length=433, Percent_Identity=44.5727482678984, Blast_Score=369, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17539970, Length=432, Percent_Identity=43.75, Blast_Score=364, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6322745, Length=444, Percent_Identity=43.6936936936937, Blast_Score=355, Evalue=2e-98,
Organism=Saccharomyces cerevisiae, GI6323731, Length=429, Percent_Identity=36.1305361305361, Blast_Score=278, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=37.5609756097561, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323958, Length=176, Percent_Identity=31.8181818181818, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21357745, Length=685, Percent_Identity=41.8978102189781, Blast_Score=535, Evalue=1e-152,
Organism=Drosophila melanogaster, GI28573187, Length=179, Percent_Identity=29.608938547486, Blast_Score=73, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24659598, Length=179, Percent_Identity=29.0502793296089, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24659604, Length=179, Percent_Identity=29.0502793296089, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 67227; Mature: 67227

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYLGKRQALPVIIKGLKRLEYRGYDSAGVALLNGGLEIVKKKGKVADLESEIGNR
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHCCCCCCCHHHHHCCE
KLEASLGIGHTRWATHGEPNDRNAHPHTSSDGKLAIIHNGIIENYSSIKKELESNGHVFK
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEE
SDTDSEVLIHLIEEIKKQNNCTIEEAVRLALNEVVGAYAIVVLSKDNERSMIAARKGSPL
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCEEEEEEEECCCCCCEEEECCCCCE
VIGIGEDEYFVASDATPIIEYTNNVTYLNDQEMAIIKDGSLVVKNLENVTKTPFIQKLEL
EEEECCCCEEEECCCCCEEEECCCEEEECCCCEEEEECCCHHHHHHHHHHCCCCHHHECC
DLEDIEKGGYPHFMLKEIFEQPKSIRDAMRGRLVSREHHLFLSGIDQYLNRFLNADRLIL
CHHHHHCCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCEEE
VGCGTSWHAGLIGEYLFEDIARIPTEVEYASEFRYRNPIVTERDVVIAVSQSGETADTLA
EECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHH
AIELAKSKGALIFGVCNVVGSSIARASHAGAYLHAGPEIGVASTKAFTSQVTILTMMALY
HHHHHCCCCCEEEEEHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
LGLKKGTISLSDYQTLLLELDSIPDKVAKILTKDEEIRNISENFYRASNFLYLGRGFNFP
HCCCCCEEEHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEECCCCCC
VALEGALKLKEISYIHAEGYPAAEMKHGPIALIDEDMPVVFIATKDSSYEKVISNIQEVK
EEECCCEEEEHEEEEECCCCCCCCCCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHHHH
ARKGKVIAIVTDGDTEIQSMADFTFQIPKTADALVPLLAVIPLQLLSYHIAILRGCNVDQ
HCCCCEEEEEECCCHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PRNLAKSVTVE
CHHHHHHCCCC
>Mature Secondary Structure
MCGIVGYLGKRQALPVIIKGLKRLEYRGYDSAGVALLNGGLEIVKKKGKVADLESEIGNR
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHCCCCCCCHHHHHCCE
KLEASLGIGHTRWATHGEPNDRNAHPHTSSDGKLAIIHNGIIENYSSIKKELESNGHVFK
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEE
SDTDSEVLIHLIEEIKKQNNCTIEEAVRLALNEVVGAYAIVVLSKDNERSMIAARKGSPL
CCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCEEEEEEEECCCCCCEEEECCCCCE
VIGIGEDEYFVASDATPIIEYTNNVTYLNDQEMAIIKDGSLVVKNLENVTKTPFIQKLEL
EEEECCCCEEEECCCCCEEEECCCEEEECCCCEEEEECCCHHHHHHHHHHCCCCHHHECC
DLEDIEKGGYPHFMLKEIFEQPKSIRDAMRGRLVSREHHLFLSGIDQYLNRFLNADRLIL
CHHHHHCCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCEEE
VGCGTSWHAGLIGEYLFEDIARIPTEVEYASEFRYRNPIVTERDVVIAVSQSGETADTLA
EECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHH
AIELAKSKGALIFGVCNVVGSSIARASHAGAYLHAGPEIGVASTKAFTSQVTILTMMALY
HHHHHCCCCCEEEEEHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
LGLKKGTISLSDYQTLLLELDSIPDKVAKILTKDEEIRNISENFYRASNFLYLGRGFNFP
HCCCCCEEEHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEECCCCCC
VALEGALKLKEISYIHAEGYPAAEMKHGPIALIDEDMPVVFIATKDSSYEKVISNIQEVK
EEECCCEEEEHEEEEECCCCCCCCCCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHHHH
ARKGKVIAIVTDGDTEIQSMADFTFQIPKTADALVPLLAVIPLQLLSYHIAILRGCNVDQ
HCCCCEEEEEECCCHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PRNLAKSVTVE
CHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]