Click here to switch to the map view.

The map label for this gene is nhaA [H]

Identifier: 183219850

GI number: 183219850

Start: 421726

End: 423084

Strand: Direct

Name: nhaA [H]

Synonym: LEPBI_I0428

Alternate gene names: 183219850

Gene position: 421726-423084 (Clockwise)

Preceding gene: 183219849

Following gene: 183219851

Centisome position: 11.72

GC content: 36.64

Gene sequence:

>1359_bases
ATGGAAAAAATTGGAAAAATCGCTTCGATCAAAAGAGAAGCGGCTATTTACAAATTAACAAATTCCTTTCGATGGTTTTC
AGAATTTGGAGCTACCGGTGGTCTGATCCTATTTTTTATTTCGATTATAGCTTTAGTTTGGGCGAATTCTCCCTTCCAAA
ACTTTTATGAAGATTTTAAAAACATAAACCTTACATTTTCCGTTGGAAGTTTTGTAATTTCCAAAGGACTCATCCTTTGG
ATCAACGATGCTCTAATGGCAATTTTTTTCTTTGTTGTAGGTTTAGAAATCAAACGAGAATTTTTAGTTGGAGAACTTTC
AGATATTCGTAAGGCAACATTTCCGATCTTTGCGGCAATCGGAGGGATGTTAGTGCCAGCCTTGATATATTATCTTTTTA
ATCAAGAAGGAGATTTAAGAAATGGTTGGGGGATACCAATGGCAACGGATATCGCATTCGCCTTAGGTTTCCTTGCTTTA
TTAGGTTCTCGAGTACCTGTCTCCTTGAAAGTCTTTTTAACCGCACTAGCGATTGTGGATGATATCGGAGCTGTTGTTGT
GATCGGTCTCTTTTATACTGAGACAATTCATATGATTCCGATTGTATGTGCAGGATTCATATTTATTACATTGATATTTG
GGAATTCATTAGGAATCAGAACTCCCTGGTTTTATTTCATTTTTGGAATCTTTTTATGGATCGCTTTTTTAAAGTCAGGC
ATTCACGCCACTGTATCTGGAGTCCTAGCAGCATTCACGATACCATCCAAATCTCTCGTTGATGGACATCTCTTTGTAAA
AGAAGGAAAATCTTTGCTAAACGAATTTGAAAAATCAATCTCTAATGCAAATACAACAAAGAATTCGCAAATCTTACTCA
CAACAAAACAAGAGTCCGTTGTGTCCACAATGGAAACCGCATGTGAATACATCCTTCCTCCTTTGTTTCGTTTAGAACAT
TCAATTCTACCTTGGGTTACTTTTGTGATTATGCCAATCTTTGCTTTAGCAAATGCAGGGATCACCATGCAAGGTGACTT
TTTTAGTTCATTGTATCATCCTGTAACGTATGGTGTCATAGGTGGACTCTTCTTTGGAAAACCGATCGGGATTTTCATAT
TTTCCTTTTTTGCTGTAAAACTTGGCATTTCGAAATTACCAGAACATACAAGCTGGAGTCAGGTAATTGGAATCGGGTTT
TTTGCAGGGATCGGATTTACAATGTCCATATTTGTTGCAAGTTTAGCTTTCGCAAACGCTAACCATTCATTAACAAATTC
TAAAATTGGAATTTTACTCGGATCGTTCATCAGTTTGGTGGTGGGAATGGTTGTGCTCTATTTTCAAAAAAAGAAATAG

Upstream 100 bases:

>100_bases
ACACTCTTTAACTCCAGAATTCCATTTTTATGATTCAATATTTAGATAGTATCGTTTAGATAAATCTAGACATGAATCAT
CAAAGATTGAATCTTATGAA

Downstream 100 bases:

>100_bases
TGTATCGGCACACGATCAAACTTTCCGTATATGAACGATTTAGAACTGATTCGAAGATTACTTCAATTAGTTTTGCTGAA
AAATCGGATTCAAGAAAGGC

Product: sodium:proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MEKIGKIASIKREAAIYKLTNSFRWFSEFGATGGLILFFISIIALVWANSPFQNFYEDFKNINLTFSVGSFVISKGLILW
INDALMAIFFFVVGLEIKREFLVGELSDIRKATFPIFAAIGGMLVPALIYYLFNQEGDLRNGWGIPMATDIAFALGFLAL
LGSRVPVSLKVFLTALAIVDDIGAVVVIGLFYTETIHMIPIVCAGFIFITLIFGNSLGIRTPWFYFIFGIFLWIAFLKSG
IHATVSGVLAAFTIPSKSLVDGHLFVKEGKSLLNEFEKSISNANTTKNSQILLTTKQESVVSTMETACEYILPPLFRLEH
SILPWVTFVIMPIFALANAGITMQGDFFSSLYHPVTYGVIGGLFFGKPIGIFIFSFFAVKLGISKLPEHTSWSQVIGIGF
FAGIGFTMSIFVASLAFANANHSLTNSKIGILLGSFISLVVGMVVLYFQKKK

Sequences:

>Translated_452_residues
MEKIGKIASIKREAAIYKLTNSFRWFSEFGATGGLILFFISIIALVWANSPFQNFYEDFKNINLTFSVGSFVISKGLILW
INDALMAIFFFVVGLEIKREFLVGELSDIRKATFPIFAAIGGMLVPALIYYLFNQEGDLRNGWGIPMATDIAFALGFLAL
LGSRVPVSLKVFLTALAIVDDIGAVVVIGLFYTETIHMIPIVCAGFIFITLIFGNSLGIRTPWFYFIFGIFLWIAFLKSG
IHATVSGVLAAFTIPSKSLVDGHLFVKEGKSLLNEFEKSISNANTTKNSQILLTTKQESVVSTMETACEYILPPLFRLEH
SILPWVTFVIMPIFALANAGITMQGDFFSSLYHPVTYGVIGGLFFGKPIGIFIFSFFAVKLGISKLPEHTSWSQVIGIGF
FAGIGFTMSIFVASLAFANANHSLTNSKIGILLGSFISLVVGMVVLYFQKKK
>Mature_452_residues
MEKIGKIASIKREAAIYKLTNSFRWFSEFGATGGLILFFISIIALVWANSPFQNFYEDFKNINLTFSVGSFVISKGLILW
INDALMAIFFFVVGLEIKREFLVGELSDIRKATFPIFAAIGGMLVPALIYYLFNQEGDLRNGWGIPMATDIAFALGFLAL
LGSRVPVSLKVFLTALAIVDDIGAVVVIGLFYTETIHMIPIVCAGFIFITLIFGNSLGIRTPWFYFIFGIFLWIAFLKSG
IHATVSGVLAAFTIPSKSLVDGHLFVKEGKSLLNEFEKSISNANTTKNSQILLTTKQESVVSTMETACEYILPPLFRLEH
SILPWVTFVIMPIFALANAGITMQGDFFSSLYHPVTYGVIGGLFFGKPIGIFIFSFFAVKLGISKLPEHTSWSQVIGIGF
FAGIGFTMSIFVASLAFANANHSLTNSKIGILLGSFISLVVGMVVLYFQKKK

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=422, Percent_Identity=44.3127962085308, Blast_Score=318, Evalue=5e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 49771; Mature: 49771

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKIGKIASIKREAAIYKLTNSFRWFSEFGATGGLILFFISIIALVWANSPFQNFYEDFK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
NINLTFSVGSFVISKGLILWINDALMAIFFFVVGLEIKREFLVGELSDIRKATFPIFAAI
CCEEEEEHHHHHHHCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGMLVPALIYYLFNQEGDLRNGWGIPMATDIAFALGFLALLGSRVPVSLKVFLTALAIVD
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
DIGAVVVIGLFYTETIHMIPIVCAGFIFITLIFGNSLGIRTPWFYFIFGIFLWIAFLKSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHC
IHATVSGVLAAFTIPSKSLVDGHLFVKEGKSLLNEFEKSISNANTTKNSQILLTTKQESV
HHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECHHHH
VSTMETACEYILPPLFRLEHSILPWVTFVIMPIFALANAGITMQGDFFSSLYHPVTYGVI
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHH
GGLFFGKPIGIFIFSFFAVKLGISKLPEHTSWSQVIGIGFFAGIGFTMSIFVASLAFANA
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NHSLTNSKIGILLGSFISLVVGMVVLYFQKKK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEKIGKIASIKREAAIYKLTNSFRWFSEFGATGGLILFFISIIALVWANSPFQNFYEDFK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
NINLTFSVGSFVISKGLILWINDALMAIFFFVVGLEIKREFLVGELSDIRKATFPIFAAI
CCEEEEEHHHHHHHCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGMLVPALIYYLFNQEGDLRNGWGIPMATDIAFALGFLALLGSRVPVSLKVFLTALAIVD
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
DIGAVVVIGLFYTETIHMIPIVCAGFIFITLIFGNSLGIRTPWFYFIFGIFLWIAFLKSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHC
IHATVSGVLAAFTIPSKSLVDGHLFVKEGKSLLNEFEKSISNANTTKNSQILLTTKQESV
HHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECHHHH
VSTMETACEYILPPLFRLEHSILPWVTFVIMPIFALANAGITMQGDFFSSLYHPVTYGVI
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHH
GGLFFGKPIGIFIFSFFAVKLGISKLPEHTSWSQVIGIGFFAGIGFTMSIFVASLAFANA
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NHSLTNSKIGILLGSFISLVVGMVVLYFQKKK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA