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The map label for this gene is thiL1 [H]

Identifier: 183219778

GI number: 183219778

Start: 354518

End: 355699

Strand: Direct

Name: thiL1 [H]

Synonym: LEPBI_I0355

Alternate gene names: 183219778

Gene position: 354518-355699 (Clockwise)

Preceding gene: 183219776

Following gene: 183219779

Centisome position: 9.85

GC content: 44.59

Gene sequence:

>1182_bases
ATGGAACAAGTTTATATTTTGGGCGGACTGAGATCCGCATTCGGTAGTTTTGGCGGAACCCTCAAAGACATGAGTGCCGT
TGACCTTGGGGTCGAAGTTTCAAAAGCAGCACTCCAAAAAACGGGTGTTGATCCTTCCTTAATTGAAGAAAGTATTTTTG
GAAATGTTATCCCTACTGGAAAAGATGGAATCTATTTAGCACGTCATATCGGCTTAAAATCAGGTGTTCCCATCACGAGT
CCTGCATTAACACTCAACAGGCTTTGTGGTTCCGGAATGGAAGCTGTGATCCAAGCTGCCAAAAAAATCATGTTAGGTGA
AGCACACACTGTCCTTGCTGGTGGAGTCGAATCTATGAGTAACGCTCCTTATGTAGTGCGAAATGCAAGATTTGGAGTTC
GTTACGGAAATGCGGAATTTGAAGATTCACTCGCACAAGGATTAACTGACATCTATGTTGAACTTCCAATGGGAATGACG
GCTGAGAATTTATCAGACCAATACAAAATCTCGAGAGAAGAACAAGATGCGTGGGCAGCCACTTCACAAGAAAGAGCAGA
AGAGGCAACAAACAAGGGAATCTTAAAAGAAGAAATCCATCCCATCACCATTAGTGGAAAAAATCCAATTGTATTTGATA
AAGACGAATTCATCAAAGGAAAGGCGGGAGGGGCAAAACTTGCCTCACTCAAACCTGCATTCAAAAAAGATGGATCTGTT
ACTGCAGGCAATGCGTCTGGAATCAATGATGGTGCCTCTGCACTGATCGTTGCCTCTGCATCCCAAGCCAAAAAACTCGG
AAAAGAACCACTCGCCATTGTGAAATCATGGGGCCATGCAGGTTGTGATCCTGCGAAGATGGGGATTGGTCCAGCTCTTG
CGATTCCTTCTGCCTTACAAAAAGCGGGTCTAAGTTTGAAAGACATCGGTCTTGTGGAAGTGAACGAAGCGTTTGCCGCT
CAGTACTTAGCTGTGCAAAAAGAACTTGGTCTTGATCCAAAAATTACCAATGTGAATGGTGGTGCTGTTGCCATCGGACA
TCCACTCGGAGCATCGGGTAACCGTGTGACTTTGACATTGGCACTTGAGATGCAAAGACGAGGAGTGAAGTATGGTGTTG
CTTCTCTTTGTATCGGTGGAGGACAAGGGATCGCGATTGTTTTAGAAAATCCGAAAGCATAG

Upstream 100 bases:

>100_bases
TCTCGATTCATGCAGGAAGTGTACTTAAGTGGCATTCTCTTTCAAGTGAAATTTCAATTCTTAGCTGACAGGTGATGAAT
TTTGCCCATTCCTGGTTCCT

Downstream 100 bases:

>100_bases
TACAAAATGTACTTATTATTTCCGGGGCGTCACCATCTCCTCACGAGGTACCAAAAAGAGTATTTACTCCAATTGGTAGA
ACATGGACTCTCGGAAGTAT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MEQVYILGGLRSAFGSFGGTLKDMSAVDLGVEVSKAALQKTGVDPSLIEESIFGNVIPTGKDGIYLARHIGLKSGVPITS
PALTLNRLCGSGMEAVIQAAKKIMLGEAHTVLAGGVESMSNAPYVVRNARFGVRYGNAEFEDSLAQGLTDIYVELPMGMT
AENLSDQYKISREEQDAWAATSQERAEEATNKGILKEEIHPITISGKNPIVFDKDEFIKGKAGGAKLASLKPAFKKDGSV
TAGNASGINDGASALIVASASQAKKLGKEPLAIVKSWGHAGCDPAKMGIGPALAIPSALQKAGLSLKDIGLVEVNEAFAA
QYLAVQKELGLDPKITNVNGGAVAIGHPLGASGNRVTLTLALEMQRRGVKYGVASLCIGGGQGIAIVLENPKA

Sequences:

>Translated_393_residues
MEQVYILGGLRSAFGSFGGTLKDMSAVDLGVEVSKAALQKTGVDPSLIEESIFGNVIPTGKDGIYLARHIGLKSGVPITS
PALTLNRLCGSGMEAVIQAAKKIMLGEAHTVLAGGVESMSNAPYVVRNARFGVRYGNAEFEDSLAQGLTDIYVELPMGMT
AENLSDQYKISREEQDAWAATSQERAEEATNKGILKEEIHPITISGKNPIVFDKDEFIKGKAGGAKLASLKPAFKKDGSV
TAGNASGINDGASALIVASASQAKKLGKEPLAIVKSWGHAGCDPAKMGIGPALAIPSALQKAGLSLKDIGLVEVNEAFAA
QYLAVQKELGLDPKITNVNGGAVAIGHPLGASGNRVTLTLALEMQRRGVKYGVASLCIGGGQGIAIVLENPKA
>Mature_393_residues
MEQVYILGGLRSAFGSFGGTLKDMSAVDLGVEVSKAALQKTGVDPSLIEESIFGNVIPTGKDGIYLARHIGLKSGVPITS
PALTLNRLCGSGMEAVIQAAKKIMLGEAHTVLAGGVESMSNAPYVVRNARFGVRYGNAEFEDSLAQGLTDIYVELPMGMT
AENLSDQYKISREEQDAWAATSQERAEEATNKGILKEEIHPITISGKNPIVFDKDEFIKGKAGGAKLASLKPAFKKDGSV
TAGNASGINDGASALIVASASQAKKLGKEPLAIVKSWGHAGCDPAKMGIGPALAIPSALQKAGLSLKDIGLVEVNEAFAA
QYLAVQKELGLDPKITNVNGGAVAIGHPLGASGNRVTLTLALEMQRRGVKYGVASLCIGGGQGIAIVLENPKA

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=389, Percent_Identity=51.9280205655527, Blast_Score=400, Evalue=1e-112,
Organism=Homo sapiens, GI148539872, Length=393, Percent_Identity=43.2569974554707, Blast_Score=304, Evalue=9e-83,
Organism=Homo sapiens, GI4557237, Length=395, Percent_Identity=39.2405063291139, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=40.9090909090909, Blast_Score=258, Evalue=8e-69,
Organism=Homo sapiens, GI4504327, Length=428, Percent_Identity=31.5420560747664, Blast_Score=184, Evalue=9e-47,
Organism=Homo sapiens, GI194353979, Length=247, Percent_Identity=31.5789473684211, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI87082165, Length=391, Percent_Identity=45.2685421994885, Blast_Score=324, Evalue=8e-90,
Organism=Escherichia coli, GI1788554, Length=392, Percent_Identity=47.9591836734694, Blast_Score=323, Evalue=1e-89,
Organism=Escherichia coli, GI1787663, Length=400, Percent_Identity=39.75, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=42.8571428571429, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1788683, Length=425, Percent_Identity=33.8823529411765, Blast_Score=197, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI133906874, Length=388, Percent_Identity=53.8659793814433, Blast_Score=392, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17535921, Length=392, Percent_Identity=39.7959183673469, Blast_Score=263, Evalue=9e-71,
Organism=Caenorhabditis elegans, GI25147385, Length=390, Percent_Identity=36.4102564102564, Blast_Score=241, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI17551802, Length=428, Percent_Identity=32.2429906542056, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17535917, Length=388, Percent_Identity=29.8969072164948, Blast_Score=152, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6325229, Length=399, Percent_Identity=41.6040100250627, Blast_Score=262, Evalue=8e-71,
Organism=Saccharomyces cerevisiae, GI6322031, Length=398, Percent_Identity=36.9346733668342, Blast_Score=221, Evalue=2e-58,
Organism=Drosophila melanogaster, GI17648125, Length=389, Percent_Identity=49.3573264781491, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=46.0358056265985, Blast_Score=325, Evalue=3e-89,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=38.8746803069054, Blast_Score=258, Evalue=6e-69,
Organism=Drosophila melanogaster, GI17137578, Length=426, Percent_Identity=33.8028169014084, Blast_Score=191, Evalue=8e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40766; Mature: 40766

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQVYILGGLRSAFGSFGGTLKDMSAVDLGVEVSKAALQKTGVDPSLIEESIFGNVIPTG
CCEEEEECCHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCC
KDGIYLARHIGLKSGVPITSPALTLNRLCGSGMEAVIQAAKKIMLGEAHTVLAGGVESMS
CCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHEECCCHHHHC
NAPYVVRNARFGVRYGNAEFEDSLAQGLTDIYVELPMGMTAENLSDQYKISREEQDAWAA
CCCEEEECCEEEEEECCCHHHHHHHCCHHEEEEECCCCCCHHCCCCHHHCCCCHHHHHHH
TSQERAEEATNKGILKEEIHPITISGKNPIVFDKDEFIKGKAGGAKLASLKPAFKKDGSV
HHHHHHHHHHHCCCHHHCCCEEEECCCCCEEECCHHHHCCCCCCCCHHCCCHHHHCCCCE
TAGNASGINDGASALIVASASQAKKLGKEPLAIVKSWGHAGCDPAKMGIGPALAIPSALQ
ECCCCCCCCCCCCEEEEECCHHHHHCCCCHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHH
KAGLSLKDIGLVEVNEAFAAQYLAVQKELGLDPKITNVNGGAVAIGHPLGASGNRVTLTL
HCCCCCHHCCEEEECHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCCCCCCCCEEEEEE
ALEMQRRGVKYGVASLCIGGGQGIAIVLENPKA
EEEHHHCCCHHCHHHHEECCCCEEEEEEECCCC
>Mature Secondary Structure
MEQVYILGGLRSAFGSFGGTLKDMSAVDLGVEVSKAALQKTGVDPSLIEESIFGNVIPTG
CCEEEEECCHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCC
KDGIYLARHIGLKSGVPITSPALTLNRLCGSGMEAVIQAAKKIMLGEAHTVLAGGVESMS
CCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHEECCCHHHHC
NAPYVVRNARFGVRYGNAEFEDSLAQGLTDIYVELPMGMTAENLSDQYKISREEQDAWAA
CCCEEEECCEEEEEECCCHHHHHHHCCHHEEEEECCCCCCHHCCCCHHHCCCCHHHHHHH
TSQERAEEATNKGILKEEIHPITISGKNPIVFDKDEFIKGKAGGAKLASLKPAFKKDGSV
HHHHHHHHHHHCCCHHHCCCEEEECCCCCEEECCHHHHCCCCCCCCHHCCCHHHHCCCCE
TAGNASGINDGASALIVASASQAKKLGKEPLAIVKSWGHAGCDPAKMGIGPALAIPSALQ
ECCCCCCCCCCCCEEEEECCHHHHHCCCCHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHH
KAGLSLKDIGLVEVNEAFAAQYLAVQKELGLDPKITNVNGGAVAIGHPLGASGNRVTLTL
HCCCCCHHCCEEEECHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCCCCCCCCEEEEEE
ALEMQRRGVKYGVASLCIGGGQGIAIVLENPKA
EEEHHHCCCHHCHHHHEECCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA