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The map label for this gene is mapA [H]

Identifier: 183219765

GI number: 183219765

Start: 342550

End: 343305

Strand: Direct

Name: mapA [H]

Synonym: LEPBI_I0342

Alternate gene names: 183219765

Gene position: 342550-343305 (Clockwise)

Preceding gene: 183219764

Following gene: 183219766

Centisome position: 9.52

GC content: 42.2

Gene sequence:

>756_bases
ATGTCGATTCAAAATGAAAAAGACCTTCAAGGGATTTTAAAAGCAGGAAAGTTTGTCGCAAAAGTCAGAGAGTTATTAAA
ACTTTTGGCAAAACCTGGTGTGTCTACTTTGGAACTTGATTTGGCCGCCAAACATGAGTTTGAAGCCGCAGGCGCATTTT
CCGCTCCCAAATTTGATTACAAATTCCCTGGTTTCACTTGTATCAGTACCAATTTTGAAATCGCTCATGGCATTCCCAAA
AAAGAAACCATTCTAAAAGAAGGGGATTTGGTGAATGTGGATGTTTCTGCGAAACTGGACGGTTATTATGCCGACACTGG
GATTTCGTTTGTTGTGGGAAACTCCAACCAAACACTTCAAAAACTTTGTGAAACTGCCATCGAAGGCACCATGCGCGCCA
CAAAACAAGCGTTTACTGGAAATTATCTTCGACATATTGGAAAAGAAATCCATTCGGCAGCCAAAGAAAATGGATTCACT
GTGATTAAAAACTTAGCGGGCCATGGAACCGGTAAAAAACTCCATGAAGAACCGCAAGTTCTCGTTTATGAAGACAAACG
TGACCATAGGAAACTAAACCAAGGCCTAGTCCTTGCCATTGAATCTTTTATTTCCACGGGAAGCCAAACGGCATATGAGG
AAGCAGATGGATGGACACTCGTGGCAGGGAATAGACAAGGAACCCTTAGTTATGTGGCACAGTGTGAACACACAGTCATC
GTTCAAAATGGCAAACCCATCATCGCGACTTTGTAA

Upstream 100 bases:

>100_bases
CGATTTGCTTTCTTATCTAAGTCGAGAAATCGTAGTAGCAAACCATTGTTATGGATGTACGGCTGGAGCAGGGTCTAGTT
GTGGAGGGGAGATTGTATAA

Downstream 100 bases:

>100_bases
ACAGAGCTTGAAATAATCCCTTTCTTTGATTCGGATTTTGATTTTGATTCAGGTTCACATTTACATCAATTGGCCCAACT
AAGTTTTTTCAGTGTTTGGT

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP 2 [H]

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MSIQNEKDLQGILKAGKFVAKVRELLKLLAKPGVSTLELDLAAKHEFEAAGAFSAPKFDYKFPGFTCISTNFEIAHGIPK
KETILKEGDLVNVDVSAKLDGYYADTGISFVVGNSNQTLQKLCETAIEGTMRATKQAFTGNYLRHIGKEIHSAAKENGFT
VIKNLAGHGTGKKLHEEPQVLVYEDKRDHRKLNQGLVLAIESFISTGSQTAYEEADGWTLVAGNRQGTLSYVAQCEHTVI
VQNGKPIIATL

Sequences:

>Translated_251_residues
MSIQNEKDLQGILKAGKFVAKVRELLKLLAKPGVSTLELDLAAKHEFEAAGAFSAPKFDYKFPGFTCISTNFEIAHGIPK
KETILKEGDLVNVDVSAKLDGYYADTGISFVVGNSNQTLQKLCETAIEGTMRATKQAFTGNYLRHIGKEIHSAAKENGFT
VIKNLAGHGTGKKLHEEPQVLVYEDKRDHRKLNQGLVLAIESFISTGSQTAYEEADGWTLVAGNRQGTLSYVAQCEHTVI
VQNGKPIIATL
>Mature_250_residues
SIQNEKDLQGILKAGKFVAKVRELLKLLAKPGVSTLELDLAAKHEFEAAGAFSAPKFDYKFPGFTCISTNFEIAHGIPKK
ETILKEGDLVNVDVSAKLDGYYADTGISFVVGNSNQTLQKLCETAIEGTMRATKQAFTGNYLRHIGKEIHSAAKENGFTV
IKNLAGHGTGKKLHEEPQVLVYEDKRDHRKLNQGLVLAIESFISTGSQTAYEEADGWTLVAGNRQGTLSYVAQCEHTVIV
QNGKPIIATL

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=243, Percent_Identity=33.3333333333333, Blast_Score=134, Evalue=9e-32,
Organism=Homo sapiens, GI40385867, Length=241, Percent_Identity=30.7053941908714, Blast_Score=122, Evalue=2e-28,
Organism=Escherichia coli, GI1786364, Length=252, Percent_Identity=35.3174603174603, Blast_Score=159, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71996291, Length=225, Percent_Identity=33.7777777777778, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323273, Length=242, Percent_Identity=33.8842975206612, Blast_Score=129, Evalue=5e-31,
Organism=Drosophila melanogaster, GI21355531, Length=244, Percent_Identity=30.7377049180328, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24583427, Length=241, Percent_Identity=28.2157676348548, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27367; Mature: 27235

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIQNEKDLQGILKAGKFVAKVRELLKLLAKPGVSTLELDLAAKHEFEAAGAFSAPKFDY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCCCCCCCCCCCC
KFPGFTCISTNFEIAHGIPKKETILKEGDLVNVDVSAKLDGYYADTGISFVVGNSNQTLQ
CCCCEEEEECCCHHHCCCCCHHHHHCCCCEEEEEEEEEECCEEECCCEEEEECCCCHHHH
KLCETAIEGTMRATKQAFTGNYLRHIGKEIHSAAKENGFTVIKNLAGHGTGKKLHEEPQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCE
LVYEDKRDHRKLNQGLVLAIESFISTGSQTAYEEADGWTLVAGNRQGTLSYVAQCEHTVI
EEECCCHHHHHHHCCHHHHHHHHHCCCCCCHHHCCCCEEEEECCCCCHHHHHHHCCEEEE
VQNGKPIIATL
EECCCEEEEEC
>Mature Secondary Structure 
SIQNEKDLQGILKAGKFVAKVRELLKLLAKPGVSTLELDLAAKHEFEAAGAFSAPKFDY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCCCCCCCCCCCC
KFPGFTCISTNFEIAHGIPKKETILKEGDLVNVDVSAKLDGYYADTGISFVVGNSNQTLQ
CCCCEEEEECCCHHHCCCCCHHHHHCCCCEEEEEEEEEECCEEECCCEEEEECCCCHHHH
KLCETAIEGTMRATKQAFTGNYLRHIGKEIHSAAKENGFTVIKNLAGHGTGKKLHEEPQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCE
LVYEDKRDHRKLNQGLVLAIESFISTGSQTAYEEADGWTLVAGNRQGTLSYVAQCEHTVI
EEECCCHHHHHHHCCHHHHHHHHHCCCCCCHHHCCCCEEEEECCCCCHHHHHHHCCEEEE
VQNGKPIIATL
EECCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9272861; 9384377 [H]