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The map label for this gene is mutS [H]

Identifier: 183219757

GI number: 183219757

Start: 334985

End: 336526

Strand: Reverse

Name: mutS [H]

Synonym: LEPBI_I0334

Alternate gene names: 183219757

Gene position: 336526-334985 (Counterclockwise)

Preceding gene: 183219758

Following gene: 183219756

Centisome position: 9.35

GC content: 35.34

Gene sequence:

>1542_bases
TTGTATTCCTTACGAAAGGAACAACTTCAGTTTCTTAAGCAAACACTCCAATTCATTGAAGGAGAAATCTTTAGACTCAC
TGGAGATTTGAAAAAACTAAAAACAAGGGAACATTGGGAATATCCAGTTTTTGTAAGAAACCATCCACTTTCTATTGATT
TGGATCTTTGCACCAAACAAGGGTTTTTGGGGGTGTTTGATACAACTGTTACAGACAATGGATTCCAAATTTATTTGCAT
CAATTTTTGCAAGAAAAGAGTCCTTTTGGAGAATTCAAACCAAATCCAATTTCTGTAGAACAGATATTAAATCAAAGAAA
TTATCCCTTCCAACTGATGCGTAAGTTTTTGGTATTGGATGGCGAACCAAATGAAAAATTTGTTCTCCCCCAAGTCAGTC
AAAACTCTGATTTTTGGAAAAAACGAAAATGGCTCCGGTGGTTTTTTCCGATTTGGGGAATGTTTTCTCCTCTTTATATT
CTAGTTGGATTATTATTTGATCTACCTCTCATTCCCTTATTAATCCTTCTCAATGGAATTTTATTTGTGAGTTATCGCAA
AGAATCCATTTTGATATGGAAGGAAATTAAAAGTTTAAGTTTCGCATCGAATTTGTTCAAAAAAACTTTTATATTCCTTT
CGAAAGAAAGAAAAATCACCAAACAAATGCTAAAGAGGATTTCCAATTTAGGAGATTCTTCGGAATTACTCGTCTCTCCC
CTTCCCCATTTGATTTTGAATTTATTATTTTTATGGGATCTATGGAAAATCCAATCTTTACAGAAATGGAAACAAAACTT
TTTAGTCCATTGGAATGAATTACAAAACAAAATCACAACCATTGATTCTATTCTTCCTTTGATTAATTTTGGCTATTTGA
ATCCTGACGCAAACTTTGCCAAAATCTCGGACGATACAAAGTTAAACGCCGAGTCTTTGGTTCACCCACTCCTTTCCCAG
TCCCATCGAGTATTCAATCCCTTACCTGTCATGAAACCAGGAGATTTAATGATTGTCACTGGTTCGAATATGAGTGGAAA
AACAACGTATTTACGTTCGATCGCCATGTCATTGTTACTTGTTGGATCAGGTGCGCCTGTCTTGGGGAAAAATTTTGAGA
CCCCAAAATTTCAAATCCACACTTTGATACGGTCCCAAGATTCTATGGAAGATGGAGTTTCCTTTTTTTATTCCGAAGTT
AGGAGACTTTCTTCAATCATCCAAAATGCAAATGGATCCAATAAAACTCCAATTTTGTTTTTAGATGAAATCTTAAAGGG
AACCAATTCAAAAGAAAGATTCATTGCCACTCGAGAAATTTTATCTGTGTTACGCGAAAAAAACTGTATCGTCTTTTTAA
CGACTCATGATTTGAAACTGACCGAGATTCCTTGGGCAAAACGATACCACTTCACCGAACTAGAAAGAGACGGGCAAATG
GATTTTGACTACAAAATCAGAGAAGGAGTGTCTAGTTCGACAAATGCATTAAAAATCTTAAAAAAAGAAGGGATTCCGAT
TCGCAACGAAGCGGATACCTGA

Upstream 100 bases:

>100_bases
TTTTTTCTTTGCTATCGTTTATTGTTATCTTTCCAAACTTTCCTGGATCGAATATAGTCTCTCTCTATTTCTGTTACTCC
CTTTTGTATACCTTGTTCGG

Downstream 100 bases:

>100_bases
TTAAACTTTCTCAGATACTTGAGTTTCATTTTTCATGGAATGAATCCTTGACAAAGTTAAAAATTTACTTAACAGTTGTT
GAATTCTGGCTAATGCCAAC

Product: putative DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MYSLRKEQLQFLKQTLQFIEGEIFRLTGDLKKLKTREHWEYPVFVRNHPLSIDLDLCTKQGFLGVFDTTVTDNGFQIYLH
QFLQEKSPFGEFKPNPISVEQILNQRNYPFQLMRKFLVLDGEPNEKFVLPQVSQNSDFWKKRKWLRWFFPIWGMFSPLYI
LVGLLFDLPLIPLLILLNGILFVSYRKESILIWKEIKSLSFASNLFKKTFIFLSKERKITKQMLKRISNLGDSSELLVSP
LPHLILNLLFLWDLWKIQSLQKWKQNFLVHWNELQNKITTIDSILPLINFGYLNPDANFAKISDDTKLNAESLVHPLLSQ
SHRVFNPLPVMKPGDLMIVTGSNMSGKTTYLRSIAMSLLLVGSGAPVLGKNFETPKFQIHTLIRSQDSMEDGVSFFYSEV
RRLSSIIQNANGSNKTPILFLDEILKGTNSKERFIATREILSVLREKNCIVFLTTHDLKLTEIPWAKRYHFTELERDGQM
DFDYKIREGVSSSTNALKILKKEGIPIRNEADT

Sequences:

>Translated_513_residues
MYSLRKEQLQFLKQTLQFIEGEIFRLTGDLKKLKTREHWEYPVFVRNHPLSIDLDLCTKQGFLGVFDTTVTDNGFQIYLH
QFLQEKSPFGEFKPNPISVEQILNQRNYPFQLMRKFLVLDGEPNEKFVLPQVSQNSDFWKKRKWLRWFFPIWGMFSPLYI
LVGLLFDLPLIPLLILLNGILFVSYRKESILIWKEIKSLSFASNLFKKTFIFLSKERKITKQMLKRISNLGDSSELLVSP
LPHLILNLLFLWDLWKIQSLQKWKQNFLVHWNELQNKITTIDSILPLINFGYLNPDANFAKISDDTKLNAESLVHPLLSQ
SHRVFNPLPVMKPGDLMIVTGSNMSGKTTYLRSIAMSLLLVGSGAPVLGKNFETPKFQIHTLIRSQDSMEDGVSFFYSEV
RRLSSIIQNANGSNKTPILFLDEILKGTNSKERFIATREILSVLREKNCIVFLTTHDLKLTEIPWAKRYHFTELERDGQM
DFDYKIREGVSSSTNALKILKKEGIPIRNEADT
>Mature_513_residues
MYSLRKEQLQFLKQTLQFIEGEIFRLTGDLKKLKTREHWEYPVFVRNHPLSIDLDLCTKQGFLGVFDTTVTDNGFQIYLH
QFLQEKSPFGEFKPNPISVEQILNQRNYPFQLMRKFLVLDGEPNEKFVLPQVSQNSDFWKKRKWLRWFFPIWGMFSPLYI
LVGLLFDLPLIPLLILLNGILFVSYRKESILIWKEIKSLSFASNLFKKTFIFLSKERKITKQMLKRISNLGDSSELLVSP
LPHLILNLLFLWDLWKIQSLQKWKQNFLVHWNELQNKITTIDSILPLINFGYLNPDANFAKISDDTKLNAESLVHPLLSQ
SHRVFNPLPVMKPGDLMIVTGSNMSGKTTYLRSIAMSLLLVGSGAPVLGKNFETPKFQIHTLIRSQDSMEDGVSFFYSEV
RRLSSIIQNANGSNKTPILFLDEILKGTNSKERFIATREILSVLREKNCIVFLTTHDLKLTEIPWAKRYHFTELERDGQM
DFDYKIREGVSSSTNALKILKKEGIPIRNEADT

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=209, Percent_Identity=28.7081339712919, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1789089, Length=251, Percent_Identity=24.3027888446215, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17508445, Length=207, Percent_Identity=30.9178743961353, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319935, Length=282, Percent_Identity=26.241134751773, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321109, Length=200, Percent_Identity=28, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324482, Length=176, Percent_Identity=29.5454545454545, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321912, Length=267, Percent_Identity=24.7191011235955, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 59690; Mature: 59690

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSLRKEQLQFLKQTLQFIEGEIFRLTGDLKKLKTREHWEYPVFVRNHPLSIDLDLCTKQ
CCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCCEEEECCCCEEEEEHHCCC
GFLGVFDTTVTDNGFQIYLHQFLQEKSPFGEFKPNPISVEQILNQRNYPFQLMRKFLVLD
CCCEEEECEECCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHEEC
GEPNEKFVLPQVSQNSDFWKKRKWLRWFFPIWGMFSPLYILVGLLFDLPLIPLLILLNGI
CCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFVSYRKESILIWKEIKSLSFASNLFKKTFIFLSKERKITKQMLKRISNLGDSSELLVSP
HEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LPHLILNLLFLWDLWKIQSLQKWKQNFLVHWNELQNKITTIDSILPLINFGYLNPDANFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
KISDDTKLNAESLVHPLLSQSHRVFNPLPVMKPGDLMIVTGSNMSGKTTYLRSIAMSLLL
ECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
VGSGAPVLGKNFETPKFQIHTLIRSQDSMEDGVSFFYSEVRRLSSIIQNANGSNKTPILF
HCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
LDEILKGTNSKERFIATREILSVLREKNCIVFLTTHDLKLTEIPWAKRYHFTELERDGQM
HHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCEEEECCCCHHCCCHHHHCCCCCC
DFDYKIREGVSSSTNALKILKKEGIPIRNEADT
CCCHHHHCCCCCCCHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MYSLRKEQLQFLKQTLQFIEGEIFRLTGDLKKLKTREHWEYPVFVRNHPLSIDLDLCTKQ
CCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCCEEEECCCCEEEEEHHCCC
GFLGVFDTTVTDNGFQIYLHQFLQEKSPFGEFKPNPISVEQILNQRNYPFQLMRKFLVLD
CCCEEEECEECCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHEEC
GEPNEKFVLPQVSQNSDFWKKRKWLRWFFPIWGMFSPLYILVGLLFDLPLIPLLILLNGI
CCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFVSYRKESILIWKEIKSLSFASNLFKKTFIFLSKERKITKQMLKRISNLGDSSELLVSP
HEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LPHLILNLLFLWDLWKIQSLQKWKQNFLVHWNELQNKITTIDSILPLINFGYLNPDANFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
KISDDTKLNAESLVHPLLSQSHRVFNPLPVMKPGDLMIVTGSNMSGKTTYLRSIAMSLLL
ECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
VGSGAPVLGKNFETPKFQIHTLIRSQDSMEDGVSFFYSEVRRLSSIIQNANGSNKTPILF
HCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
LDEILKGTNSKERFIATREILSVLREKNCIVFLTTHDLKLTEIPWAKRYHFTELERDGQM
HHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCEEEECCCCHHCCCHHHHCCCCCC
DFDYKIREGVSSSTNALKILKKEGIPIRNEADT
CCCHHHHCCCCCCCHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA