BacMap

Definition	Clostridium perfringens str. 13, complete genome.
Accession	NC_003366
Length	3,031,430

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The map label for this gene is ppiB [H]

Identifier: 18311548

GI number: 18311548

Start: 2938609

End: 2939121

Strand: Reverse

Name: ppiB [H]

Synonym: CPE2566

Alternate gene names: 18311548

Gene position: 2939121-2938609 (Counterclockwise)

Preceding gene: 18311549

Following gene: 18311547

Centisome position: 96.95

GC content: 33.14

Gene sequence:

>513_bases
ATGAATCCAATAGTTACAATAGAAATGGCAACTGGAGAAAAAATCAAAATAGAATTATATCCAGAAATTGCTCCAAACAC
AGTTAGAAATTTCGTTAGTTTAGTTAAAAAAGGTTTTTATGATGGATTAACATTCCACAGAATTATACCAGGATTTATGA
TACAAGGAGGATGCCCAGAAGGTACAGGAATGGGTAACCCAGGATATAGAATAAAAGGTGAATTTACAAGAAACCAATTC
CCAAATAACTTAAAGCATTCAAGAGGAGTTATATCAATGGCTAGAGCTATGAATTTTGATTCAGCAGGAAGCCAATTCTT
CATAATGCACGAAAATTCACCACATTTAGATGGTCAATATGCTTCATTTGGTAAGGTTATAGAAGGTATGGACGTTGTTG
ATAAAATAGCAAATGTAAAAACTGATTACAATGATATGCCAGATGAGCCACAAGTTATGGCAAAAGTAACTGTAGAAAAT
GCAGAGGGTATAGAAGAACCAGAAATACTTTAA

Upstream 100 bases:

>100_bases
TGTTAAGAGAAATAATATATAATTTTATACAAAGAAGGATTAACATTTTAGTTTAAGTAAATAATACTAAATAGTTAAAT
TTGAAAGGAGAATTACTAAT

Downstream 100 bases:

>100_bases
TTTATGAATGTATGGGAGGAAGATTAGCATGAGTATGCTTAATAATAGCAAAGCTATTCTAACTTATGGTTTAAATGAAA
AGGAAACAAAAGACTTTCAA

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin-type

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MNPIVTIEMATGEKIKIELYPEIAPNTVRNFVSLVKKGFYDGLTFHRIIPGFMIQGGCPEGTGMGNPGYRIKGEFTRNQF
PNNLKHSRGVISMARAMNFDSAGSQFFIMHENSPHLDGQYASFGKVIEGMDVVDKIANVKTDYNDMPDEPQVMAKVTVEN
AEGIEEPEIL

Sequences:

>Translated_170_residues
MNPIVTIEMATGEKIKIELYPEIAPNTVRNFVSLVKKGFYDGLTFHRIIPGFMIQGGCPEGTGMGNPGYRIKGEFTRNQF
PNNLKHSRGVISMARAMNFDSAGSQFFIMHENSPHLDGQYASFGKVIEGMDVVDKIANVKTDYNDMPDEPQVMAKVTVEN
AEGIEEPEIL
>Mature_170_residues
MNPIVTIEMATGEKIKIELYPEIAPNTVRNFVSLVKKGFYDGLTFHRIIPGFMIQGGCPEGTGMGNPGYRIKGEFTRNQF
PNNLKHSRGVISMARAMNFDSAGSQFFIMHENSPHLDGQYASFGKVIEGMDVVDKIANVKTDYNDMPDEPQVMAKVTVEN
AEGIEEPEIL

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=147, Percent_Identity=44.2176870748299, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI19557636, Length=133, Percent_Identity=44.3609022556391, Blast_Score=107, Evalue=7e-24,
Organism=Homo sapiens, GI7706339, Length=146, Percent_Identity=41.0958904109589, Blast_Score=104, Evalue=5e-23,
Organism=Homo sapiens, GI64276486, Length=160, Percent_Identity=35.625, Blast_Score=94, Evalue=6e-20,
Organism=Homo sapiens, GI4758950, Length=153, Percent_Identity=44.4444444444444, Blast_Score=94, Evalue=7e-20,
Organism=Homo sapiens, GI5454154, Length=172, Percent_Identity=37.2093023255814, Blast_Score=90, Evalue=8e-19,
Organism=Homo sapiens, GI6631100, Length=147, Percent_Identity=40.1360544217687, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI4505991, Length=141, Percent_Identity=46.0992907801418, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI22547212, Length=146, Percent_Identity=40.4109589041096, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI7657473, Length=146, Percent_Identity=40.4109589041096, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI5031987, Length=149, Percent_Identity=42.9530201342282, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI22547215, Length=146, Percent_Identity=40.4109589041096, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI10863927, Length=148, Percent_Identity=43.2432432432432, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI310127646, Length=147, Percent_Identity=40.8163265306122, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI310114371, Length=147, Percent_Identity=40.8163265306122, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI310119221, Length=147, Percent_Identity=40.8163265306122, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI42560244, Length=155, Percent_Identity=34.8387096774194, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI4826932, Length=144, Percent_Identity=40.9722222222222, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI303305009, Length=176, Percent_Identity=36.3636363636364, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI310110104, Length=144, Percent_Identity=40.2777777777778, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI256017253, Length=130, Percent_Identity=43.0769230769231, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI221139811, Length=130, Percent_Identity=43.0769230769231, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI256017251, Length=130, Percent_Identity=43.0769230769231, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI20911035, Length=150, Percent_Identity=34.6666666666667, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI310129267, Length=144, Percent_Identity=39.5833333333333, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI310120620, Length=144, Percent_Identity=39.5833333333333, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI45439316, Length=147, Percent_Identity=39.4557823129252, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI5174637, Length=147, Percent_Identity=39.4557823129252, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI178057341, Length=141, Percent_Identity=39.7163120567376, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI150418007, Length=147, Percent_Identity=38.7755102040816, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI209417936, Length=131, Percent_Identity=41.2213740458015, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI30102944, Length=131, Percent_Identity=41.2213740458015, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI219842199, Length=131, Percent_Identity=41.2213740458015, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI169163387, Length=148, Percent_Identity=37.8378378378378, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI169164185, Length=148, Percent_Identity=37.8378378378378, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI169163623, Length=148, Percent_Identity=37.8378378378378, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI27735045, Length=163, Percent_Identity=31.2883435582822, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI310127745, Length=148, Percent_Identity=37.8378378378378, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI310119290, Length=148, Percent_Identity=37.8378378378378, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI310114540, Length=148, Percent_Identity=37.8378378378378, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1789763, Length=167, Percent_Identity=44.311377245509, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1786736, Length=169, Percent_Identity=39.0532544378698, Blast_Score=99, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17539496, Length=146, Percent_Identity=44.5205479452055, Blast_Score=112, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI71980594, Length=156, Percent_Identity=41.6666666666667, Blast_Score=107, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71980590, Length=139, Percent_Identity=43.8848920863309, Blast_Score=104, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17506311, Length=142, Percent_Identity=41.5492957746479, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17552780, Length=154, Percent_Identity=41.5584415584416, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17506307, Length=147, Percent_Identity=43.5374149659864, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17552782, Length=163, Percent_Identity=41.7177914110429, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71997782, Length=125, Percent_Identity=40.8, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17551284, Length=145, Percent_Identity=40.6896551724138, Blast_Score=86, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17551282, Length=145, Percent_Identity=40.6896551724138, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17532641, Length=155, Percent_Identity=33.5483870967742, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17532643, Length=171, Percent_Identity=37.4269005847953, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17539498, Length=155, Percent_Identity=40, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17552784, Length=162, Percent_Identity=38.2716049382716, Blast_Score=83, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17566266, Length=147, Percent_Identity=40.8163265306122, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17559074, Length=147, Percent_Identity=40.1360544217687, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17565860, Length=155, Percent_Identity=39.3548387096774, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI32563659, Length=152, Percent_Identity=36.1842105263158, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321848, Length=154, Percent_Identity=45.4545454545455, Blast_Score=100, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6320510, Length=158, Percent_Identity=42.4050632911392, Blast_Score=86, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6323562, Length=153, Percent_Identity=40.5228758169935, Blast_Score=83, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320359, Length=135, Percent_Identity=41.4814814814815, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323246, Length=144, Percent_Identity=36.1111111111111, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17986117, Length=156, Percent_Identity=46.1538461538462, Blast_Score=126, Evalue=8e-30,
Organism=Drosophila melanogaster, GI19922376, Length=136, Percent_Identity=38.9705882352941, Blast_Score=103, Evalue=4e-23,
Organism=Drosophila melanogaster, GI20130249, Length=156, Percent_Identity=42.9487179487179, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24652460, Length=133, Percent_Identity=37.593984962406, Blast_Score=90, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24664125, Length=148, Percent_Identity=41.8918918918919, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21357783, Length=148, Percent_Identity=41.8918918918919, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45549139, Length=133, Percent_Identity=43.609022556391, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21357249, Length=123, Percent_Identity=37.3983739837398, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17136360, Length=154, Percent_Identity=35.7142857142857, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI19922912, Length=147, Percent_Identity=40.8163265306122, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24586038, Length=172, Percent_Identity=33.7209302325581, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24650807, Length=155, Percent_Identity=36.1290322580645, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17647301, Length=144, Percent_Identity=38.1944444444444, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21355677, Length=177, Percent_Identity=29.9435028248588, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18889; Mature: 18889

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPIVTIEMATGEKIKIELYPEIAPNTVRNFVSLVKKGFYDGLTFHRIIPGFMIQGGCPE
CCCEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCEEEECCCCC
GTGMGNPGYRIKGEFTRNQFPNNLKHSRGVISMARAMNFDSAGSQFFIMHENSPHLDGQY
CCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCH
ASFGKVIEGMDVVDKIANVKTDYNDMPDEPQVMAKVTVENAEGIEEPEIL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MNPIVTIEMATGEKIKIELYPEIAPNTVRNFVSLVKKGFYDGLTFHRIIPGFMIQGGCPE
CCCEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCEEEECCCCC
GTGMGNPGYRIKGEFTRNQFPNNLKHSRGVISMARAMNFDSAGSQFFIMHENSPHLDGQY
CCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCH
ASFGKVIEGMDVVDKIANVKTDYNDMPDEPQVMAKVTVENAEGIEEPEIL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7934829; 8022278; 9384377; 8755892 [H]