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The map label for this gene is glmU [H]

Identifier: 18311472

GI number: 18311472

Start: 2851159

End: 2852523

Strand: Reverse

Name: glmU [H]

Synonym: CPE2490

Alternate gene names: 18311472

Gene position: 2852523-2851159 (Counterclockwise)

Preceding gene: 18311473

Following gene: 18311471

Centisome position: 94.1

GC content: 30.77

Gene sequence:

>1365_bases
ATGAATAAATGTGCTATAATATTAGCAGCAGGTCAAGGAACTAGAATAAAATCTAAGTTACCAAAAGTTCTACACAAAGC
TTGTGGAAAAGAGATGGTTAATCATGTTATCGATGCTATGAGAAATGCAGAGATAGAAGATGTTAATGTAATAATAGGAA
AAGGTGCTGAATTAGTTAAAGAAAGAACTACATCAAGAAATGTTAGTTATTCTTTACAAGCAGAACAGCTAGGAACTGGC
CATGCTGTTAAGTGTGCAAAAGACTTTTTAGAAGGAAAAACAGGAGTAGTAGCTATATTTACAGGAGATGCTCCTTTAAT
AAAGCCTGAAACTGTTAAGAATTTAGTTGATACACATATCAATGAAAAGAATTCAGCTACACTGTTAACATCAGTGATAG
AAAATCCAACTGGCTATGGAAGAATAGTTAGAAATGGTGAATCAGTTGAAAAAATTGTAGAACATAAAGATTGTAATGAA
CAAGAAATAAAAATACAAGAAGTCAATGCAGGAATGTATTGTTTTGATATAGAAAGTTTATTAACTTCTTTAGAACAACT
TTCAAATGACAATGCTCAAGGAGAATATTATTTAACAGATGTTATAGAAATATTAAAGAAAGAGAACAAGAAAGTTGGAG
CAATGATCACAGATTTTGAAGAAACTTTAGGGGTTAATTCAAGAGCTGAGCTTGCTAAAGTTGAAAGTATAATGAGAAAT
AGAATAAATAGAACTCATTTAGATAATGGAGTTACTATAATAGATCCTCTAAACACATATATAGAACCAGAAGTAGTTAT
TGGTAAGGACACTATAATCTATCCAGGTAATGTTATAGAAGGAAAAACAGTGATTGGAGAGGATTGTATTTTATATCCTA
ATTCAAGAATTAACAATAGTACAATAGGAAATGGTGTTGAAATTCAAAGTTCAGTTATTTTAGATAGTAAAATAGGTGAT
GAAACAACTGTAGGACCATTTGCTTATGTTAGACCAGAAAGTAACATTGGAGAACATGTTAGAATTGGTGATTTTGTTGA
AATTAAAAAATCAACAATTGGAAATAATACAAAGGTATCACACTTAACTTACATTGGAGACGCTGAAGTTGGAGAAAGAT
GTAACTTTGGATGCGGTACTGTTGTAGTTAACTATGATGGAAAGAAAAAACACAAAACAATCATAGGTGATGATTCATTT
ATAGGATGTAATACTAATTTAGTTTCACCTGTAGAAGTAAAAGATAATACTTATATAGCTGCAGGATCAACAATAACTAA
AGAGGTTCCAGAAGGAAGTTTAGCAATAGCAAGAGCTAAACAACAAAACATAGAGGGCTGGGTTGAAAGAAAAAAGCTTA
AATAA

Upstream 100 bases:

>100_bases
ATTGAAAATGAGAAATTTGAAGATTTCTGAAAAAAATAAGAGATTAAATTTAAATAGTATAGCTTATATAATAAAATGAG
TATCACAAAGAGGTGTTTTT

Downstream 100 bases:

>100_bases
GCATTAAATATACAAATGCCAAAGGCTAGGTTTAATTTTAAGGAGGTCTTCACTAAATGGAAAATCATTCAAAAAACATA
AAAATATTTACAGGTAATTC

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MNKCAIILAAGQGTRIKSKLPKVLHKACGKEMVNHVIDAMRNAEIEDVNVIIGKGAELVKERTTSRNVSYSLQAEQLGTG
HAVKCAKDFLEGKTGVVAIFTGDAPLIKPETVKNLVDTHINEKNSATLLTSVIENPTGYGRIVRNGESVEKIVEHKDCNE
QEIKIQEVNAGMYCFDIESLLTSLEQLSNDNAQGEYYLTDVIEILKKENKKVGAMITDFEETLGVNSRAELAKVESIMRN
RINRTHLDNGVTIIDPLNTYIEPEVVIGKDTIIYPGNVIEGKTVIGEDCILYPNSRINNSTIGNGVEIQSSVILDSKIGD
ETTVGPFAYVRPESNIGEHVRIGDFVEIKKSTIGNNTKVSHLTYIGDAEVGERCNFGCGTVVVNYDGKKKHKTIIGDDSF
IGCNTNLVSPVEVKDNTYIAAGSTITKEVPEGSLAIARAKQQNIEGWVERKKLK

Sequences:

>Translated_454_residues
MNKCAIILAAGQGTRIKSKLPKVLHKACGKEMVNHVIDAMRNAEIEDVNVIIGKGAELVKERTTSRNVSYSLQAEQLGTG
HAVKCAKDFLEGKTGVVAIFTGDAPLIKPETVKNLVDTHINEKNSATLLTSVIENPTGYGRIVRNGESVEKIVEHKDCNE
QEIKIQEVNAGMYCFDIESLLTSLEQLSNDNAQGEYYLTDVIEILKKENKKVGAMITDFEETLGVNSRAELAKVESIMRN
RINRTHLDNGVTIIDPLNTYIEPEVVIGKDTIIYPGNVIEGKTVIGEDCILYPNSRINNSTIGNGVEIQSSVILDSKIGD
ETTVGPFAYVRPESNIGEHVRIGDFVEIKKSTIGNNTKVSHLTYIGDAEVGERCNFGCGTVVVNYDGKKKHKTIIGDDSF
IGCNTNLVSPVEVKDNTYIAAGSTITKEVPEGSLAIARAKQQNIEGWVERKKLK
>Mature_454_residues
MNKCAIILAAGQGTRIKSKLPKVLHKACGKEMVNHVIDAMRNAEIEDVNVIIGKGAELVKERTTSRNVSYSLQAEQLGTG
HAVKCAKDFLEGKTGVVAIFTGDAPLIKPETVKNLVDTHINEKNSATLLTSVIENPTGYGRIVRNGESVEKIVEHKDCNE
QEIKIQEVNAGMYCFDIESLLTSLEQLSNDNAQGEYYLTDVIEILKKENKKVGAMITDFEETLGVNSRAELAKVESIMRN
RINRTHLDNGVTIIDPLNTYIEPEVVIGKDTIIYPGNVIEGKTVIGEDCILYPNSRINNSTIGNGVEIQSSVILDSKIGD
ETTVGPFAYVRPESNIGEHVRIGDFVEIKKSTIGNNTKVSHLTYIGDAEVGERCNFGCGTVVVNYDGKKKHKTIIGDDSF
IGCNTNLVSPVEVKDNTYIAAGSTITKEVPEGSLAIARAKQQNIEGWVERKKLK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=381, Percent_Identity=22.8346456692913, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1790168, Length=451, Percent_Identity=41.019955654102, Blast_Score=340, Evalue=1e-94,
Organism=Saccharomyces cerevisiae, GI6320148, Length=358, Percent_Identity=23.463687150838, Blast_Score=73, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 49676; Mature: 49676

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKCAIILAAGQGTRIKSKLPKVLHKACGKEMVNHVIDAMRNAEIEDVNVIIGKGAELVK
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHH
ERTTSRNVSYSLQAEQLGTGHAVKCAKDFLEGKTGVVAIFTGDAPLIKPETVKNLVDTHI
HHHCCCCCEEEEEHHHCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHC
NEKNSATLLTSVIENPTGYGRIVRNGESVEKIVEHKDCNEQEIKIQEVNAGMYCFDIESL
CCCCCHHHHHHHHHCCCCCCEEEECCHHHHHHHHHCCCCCHHEEEEEECCCEEEEEHHHH
LTSLEQLSNDNAQGEYYLTDVIEILKKENKKVGAMITDFEETLGVNSRAELAKVESIMRN
HHHHHHHCCCCCCCCEEHHHHHHHHHHCCCEECCEEECHHHHHCCCCHHHHHHHHHHHHH
RINRTHLDNGVTIIDPLNTYIEPEVVIGKDTIIYPGNVIEGKTVIGEDCILYPNSRINNS
CCCHHCCCCCCEEEECCCCCCCCEEEECCCEEEECCCEECCCEEECCCEEECCCCCCCCC
TIGNGVEIQSSVILDSKIGDETTVGPFAYVRPESNIGEHVRIGDFVEIKKSTIGNNTKVS
CCCCCEEEEEEEEEECCCCCCCCCCCEEEECCCCCCCCEEECCCHHEEHHHHCCCCCEEE
HLTYIGDAEVGERCNFGCGTVVVNYDGKKKHKTIIGDDSFIGCNTNLVSPVEVKDNTYIA
EEEEECCCCCCCCCCCCCCEEEEECCCCCCCCEEECCCCEEECCCCCCCCEEECCCEEEE
AGSTITKEVPEGSLAIARAKQQNIEGWVERKKLK
ECCCHHHCCCCCCEEEHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKCAIILAAGQGTRIKSKLPKVLHKACGKEMVNHVIDAMRNAEIEDVNVIIGKGAELVK
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHH
ERTTSRNVSYSLQAEQLGTGHAVKCAKDFLEGKTGVVAIFTGDAPLIKPETVKNLVDTHI
HHHCCCCCEEEEEHHHCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHC
NEKNSATLLTSVIENPTGYGRIVRNGESVEKIVEHKDCNEQEIKIQEVNAGMYCFDIESL
CCCCCHHHHHHHHHCCCCCCEEEECCHHHHHHHHHCCCCCHHEEEEEECCCEEEEEHHHH
LTSLEQLSNDNAQGEYYLTDVIEILKKENKKVGAMITDFEETLGVNSRAELAKVESIMRN
HHHHHHHCCCCCCCCEEHHHHHHHHHHCCCEECCEEECHHHHHCCCCHHHHHHHHHHHHH
RINRTHLDNGVTIIDPLNTYIEPEVVIGKDTIIYPGNVIEGKTVIGEDCILYPNSRINNS
CCCHHCCCCCCEEEECCCCCCCCEEEECCCEEEECCCEECCCEEECCCEEECCCCCCCCC
TIGNGVEIQSSVILDSKIGDETTVGPFAYVRPESNIGEHVRIGDFVEIKKSTIGNNTKVS
CCCCCEEEEEEEEEECCCCCCCCCCCEEEECCCCCCCCEEECCCHHEEHHHHCCCCCEEE
HLTYIGDAEVGERCNFGCGTVVVNYDGKKKHKTIIGDDSFIGCNTNLVSPVEVKDNTYIA
EEEEECCCCCCCCCCCCCCEEEEECCCCCCCCEEECCCCEEECCCCCCCCEEECCCEEEE
AGSTITKEVPEGSLAIARAKQQNIEGWVERKKLK
ECCCHHHCCCCCCEEEHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA