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The map label for this gene is glyS

Identifier: 18311446

GI number: 18311446

Start: 2818777

End: 2820180

Strand: Reverse

Name: glyS

Synonym: CPE2464

Alternate gene names: 18311446

Gene position: 2820180-2818777 (Counterclockwise)

Preceding gene: 18311447

Following gene: 18311445

Centisome position: 93.03

GC content: 34.33

Gene sequence:

>1404_bases
ATGGCAGTAGAAAAAACTATGGATAAAATAGTAGCCTTATGTAAAAACAGAGGATTTATATTCCCAGGTTCAGAAATATA
CGGTGGACTTGCAAACTCATGGGATTACGGTCCACTAGGAGTTGAATTCAAAAATAACGTAAAAAGAGCTTGGTGGAAAA
AGTTTGTTCAAGAGAGCAAATATAATGTTGGATTAGATTCAGCTATATTAATGAATAGAGAAGTTTGGGTTGCATCAGGT
CACGTTGGTGGATTCTCAGATCCTCTAATGGATTGTAAAGAATGTAAAGCTAGATTCAGAGCAGATAAATTAGTTGAAGA
TCATATGACTGCAAACGGAGCAGAAGTTGCTACAGCTGATGGATGGAGCAATGAAGAGTTAATGGACTACATAACTAAGA
ACAACATAGTTTGTCCTAAATGTGGAAAATTAAACTACACAGATATAAGAAAGTTCAACTTAATGTTTAAAACTTTCCAA
GGAATAACTGAAGATAGTAAAAACGAAGTATATTTAAGACCAGAAACTGCTCAAGGTATATTCGTAAACTTTAAATCAGT
ACAAAGAACTACAAGAAAGAAAGTACCATTTGGTATAGCTCAAATTGGTAAGTCTTTCAGAAACGAAATAACTCCAGGTA
ACTTCACTTTCAGAACTAGAGAGTTCGAACAAATGGAGCTTGAGTTCTTCTGTAAACCAGGAACTGATTTAGAATGGTTC
AACTTCTGGAAAGATAGTTGTTGGAACTTCCTATTAAACTTAGGAATGAAAGAAGAAAACATAAGAATGAGAGATCATGG
AGAAGAAGAATTAAGCTTCTACTCAAATGCTACTTCAGATATAGAATACTTATTCCCATTTGGATGGGGAGAACTTTGGG
GAATAGCTGATAGAACAGACTATGACTTAAATAAGCATGCTGAACACTCAGGTCAAGACATGACTTACTTAGATCCAACA
ACAAATGAAAAATATGTACCATATGTTATAGAGCCATCATTAGGAGCAGACAGGGTTGCATTAGCATTCTTAGTTGAAGC
TTATGATGAGGAAGAATTAGAAGGAGCTAATGGAAAAGTAGATGTAAGAACAGTTATGCACTTACACCCAGCTTTAGCAC
CATTTAAGGCTGCTATATTACCACTTTCTAAGAAATTATCAGAAAAAGCTGATGAAGTATATGCTGAATTAAGCAAACAC
TTCAATGTTGATTATGATGAAACAGGAAGTATCGGTAAGAGATATAGAAGACAAGATGAAATAGGAACTCCATTCTGTAT
AACAGTTGACTTCGATACTTTAGAAGATGGATGTGTAACTGTAAGAGACAGAGATAACATGGAACAACAAAGAGTTAAAA
TAGAAGATGTAAGAGCTATAATAGAAAAAAGCTTAGAATTCTAG

Upstream 100 bases:

>100_bases
ATAAAACTGTTAGAAATATTTCTCAAGGAAGTTTAAAGTTCTTTATAAAGTGAAGAATTAATATAAAATAAGTTATTTAA
TATAAATGGAGGTAATTGTA

Downstream 100 bases:

>100_bases
TTTAAAAGCAAAAATAAAAACTTATAAATATATTCCATATATATTTATAAGTTTTTTTATTTATGATTTTAAAGTACTAA
AGGACATAGTTATGAATTTT

Product: glycyl-tRNA synthetase

Products: NA

Alternate protein names: Glycine--tRNA ligase; GlyRS

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MAVEKTMDKIVALCKNRGFIFPGSEIYGGLANSWDYGPLGVEFKNNVKRAWWKKFVQESKYNVGLDSAILMNREVWVASG
HVGGFSDPLMDCKECKARFRADKLVEDHMTANGAEVATADGWSNEELMDYITKNNIVCPKCGKLNYTDIRKFNLMFKTFQ
GITEDSKNEVYLRPETAQGIFVNFKSVQRTTRKKVPFGIAQIGKSFRNEITPGNFTFRTREFEQMELEFFCKPGTDLEWF
NFWKDSCWNFLLNLGMKEENIRMRDHGEEELSFYSNATSDIEYLFPFGWGELWGIADRTDYDLNKHAEHSGQDMTYLDPT
TNEKYVPYVIEPSLGADRVALAFLVEAYDEEELEGANGKVDVRTVMHLHPALAPFKAAILPLSKKLSEKADEVYAELSKH
FNVDYDETGSIGKRYRRQDEIGTPFCITVDFDTLEDGCVTVRDRDNMEQQRVKIEDVRAIIEKSLEF

Sequences:

>Translated_467_residues
MAVEKTMDKIVALCKNRGFIFPGSEIYGGLANSWDYGPLGVEFKNNVKRAWWKKFVQESKYNVGLDSAILMNREVWVASG
HVGGFSDPLMDCKECKARFRADKLVEDHMTANGAEVATADGWSNEELMDYITKNNIVCPKCGKLNYTDIRKFNLMFKTFQ
GITEDSKNEVYLRPETAQGIFVNFKSVQRTTRKKVPFGIAQIGKSFRNEITPGNFTFRTREFEQMELEFFCKPGTDLEWF
NFWKDSCWNFLLNLGMKEENIRMRDHGEEELSFYSNATSDIEYLFPFGWGELWGIADRTDYDLNKHAEHSGQDMTYLDPT
TNEKYVPYVIEPSLGADRVALAFLVEAYDEEELEGANGKVDVRTVMHLHPALAPFKAAILPLSKKLSEKADEVYAELSKH
FNVDYDETGSIGKRYRRQDEIGTPFCITVDFDTLEDGCVTVRDRDNMEQQRVKIEDVRAIIEKSLEF
>Mature_466_residues
AVEKTMDKIVALCKNRGFIFPGSEIYGGLANSWDYGPLGVEFKNNVKRAWWKKFVQESKYNVGLDSAILMNREVWVASGH
VGGFSDPLMDCKECKARFRADKLVEDHMTANGAEVATADGWSNEELMDYITKNNIVCPKCGKLNYTDIRKFNLMFKTFQG
ITEDSKNEVYLRPETAQGIFVNFKSVQRTTRKKVPFGIAQIGKSFRNEITPGNFTFRTREFEQMELEFFCKPGTDLEWFN
FWKDSCWNFLLNLGMKEENIRMRDHGEEELSFYSNATSDIEYLFPFGWGELWGIADRTDYDLNKHAEHSGQDMTYLDPTT
NEKYVPYVIEPSLGADRVALAFLVEAYDEEELEGANGKVDVRTVMHLHPALAPFKAAILPLSKKLSEKADEVYAELSKHF
NVDYDETGSIGKRYRRQDEIGTPFCITVDFDTLEDGCVTVRDRDNMEQQRVKIEDVRAIIEKSLEF

Specific function: Catalyzes the attachment of glycine to tRNA(Gly)

COG id: COG0423

COG function: function code J; Glycyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI116805340, Length=382, Percent_Identity=32.1989528795811, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI70887790, Length=308, Percent_Identity=24.6753246753247, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32564541, Length=357, Percent_Identity=33.3333333333333, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17554996, Length=458, Percent_Identity=29.6943231441048, Blast_Score=165, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6325338, Length=366, Percent_Identity=30.0546448087432, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6319597, Length=406, Percent_Identity=29.5566502463054, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI21357965, Length=359, Percent_Identity=33.7047353760446, Blast_Score=179, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24664462, Length=359, Percent_Identity=33.7047353760446, Blast_Score=178, Evalue=7e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYG_CLOPE (Q8XHL9)

Other databases:

- EMBL:   BA000016
- RefSeq:   NP_563380.1
- ProteinModelPortal:   Q8XHL9
- SMR:   Q8XHL9
- GeneID:   990834
- GenomeReviews:   BA000016_GR
- KEGG:   cpe:CPE2464
- NMPDR:   fig|195102.1.peg.2527
- HOGENOM:   HBG319978
- OMA:   GSEWGEL
- PhylomeDB:   Q8XHL9
- ProtClustDB:   PRK04173
- BioCyc:   CPER195102:CPE2464-MONOMER
- BRENDA:   6.1.1.14
- GO:   GO:0005737
- HAMAP:   MF_00253_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR022961
- InterPro:   IPR002315
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR10745
- PRINTS:   PR01043
- TIGRFAMs:   TIGR00389

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.14

Molecular weight: Translated: 53707; Mature: 53576

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS50862 AA_TRNA_LIGASE_II; PS00109 PROTEIN_KINASE_TYR ; PS00307 LECTIN_LEGUME_BETA

Important sites: BINDING 100-100 BINDING 175-175

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVEKTMDKIVALCKNRGFIFPGSEIYGGLANSWDYGPLGVEFKNNVKRAWWKKFVQESK
CCHHHHHHHHHHHHHCCCEECCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
YNVGLDSAILMNREVWVASGHVGGFSDPLMDCKECKARFRADKLVEDHMTANGAEVATAD
CCCCCCHHEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
GWSNEELMDYITKNNIVCPKCGKLNYTDIRKFNLMFKTFQGITEDSKNEVYLRPETAQGI
CCCCHHHHHHHHHCCEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEE
FVNFKSVQRTTRKKVPFGIAQIGKSFRNEITPGNFTFRTREFEQMELEFFCKPGTDLEWF
EEEHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEECCHHHHEEEEEEECCCCCCHHH
NFWKDSCWNFLLNLGMKEENIRMRDHGEEELSFYSNATSDIEYLFPFGWGELWGIADRTD
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEEECCCHHHCCCCCCCC
YDLNKHAEHSGQDMTYLDPTTNEKYVPYVIEPSLGADRVALAFLVEAYDEEELEGANGKV
CCCCHHHHCCCCCCEEECCCCCCCCCCEEECCCCCCHHHHHHHHHHHHCHHHHCCCCCCE
DVRTVMHLHPALAPFKAAILPLSKKLSEKADEVYAELSKHFNVDYDETGSIGKRYRRQDE
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHC
IGTPFCITVDFDTLEDGCVTVRDRDNMEQQRVKIEDVRAIIEKSLEF
CCCCEEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AVEKTMDKIVALCKNRGFIFPGSEIYGGLANSWDYGPLGVEFKNNVKRAWWKKFVQESK
CHHHHHHHHHHHHHCCCEECCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
YNVGLDSAILMNREVWVASGHVGGFSDPLMDCKECKARFRADKLVEDHMTANGAEVATAD
CCCCCCHHEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
GWSNEELMDYITKNNIVCPKCGKLNYTDIRKFNLMFKTFQGITEDSKNEVYLRPETAQGI
CCCCHHHHHHHHHCCEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEE
FVNFKSVQRTTRKKVPFGIAQIGKSFRNEITPGNFTFRTREFEQMELEFFCKPGTDLEWF
EEEHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEECCHHHHEEEEEEECCCCCCHHH
NFWKDSCWNFLLNLGMKEENIRMRDHGEEELSFYSNATSDIEYLFPFGWGELWGIADRTD
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEEECCCHHHCCCCCCCC
YDLNKHAEHSGQDMTYLDPTTNEKYVPYVIEPSLGADRVALAFLVEAYDEEELEGANGKV
CCCCHHHHCCCCCCEEECCCCCCCCCCEEECCCCCCHHHHHHHHHHHHCHHHHCCCCCCE
DVRTVMHLHPALAPFKAAILPLSKKLSEKADEVYAELSKHFNVDYDETGSIGKRYRRQDE
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHC
IGTPFCITVDFDTLEDGCVTVRDRDNMEQQRVKIEDVRAIIEKSLEF
CCCCEEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11792842