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The map label for this gene is clpC [H]

Identifier: 18311423

GI number: 18311423

Start: 2788268

End: 2790712

Strand: Reverse

Name: clpC [H]

Synonym: CPE2441

Alternate gene names: 18311423

Gene position: 2790712-2788268 (Counterclockwise)

Preceding gene: 18311424

Following gene: 18311422

Centisome position: 92.06

GC content: 30.92

Gene sequence:

>2445_bases
ATGCGTCTTGATAATTTTAATGAAAATTCCAAAATAGTAATCAATAAGGGAAAAGAAAGTTCTTTAATGCTAAAACACGG
CTACATGGGAACAGAGCATTTATTAATAGGATTAATTAATGAAAATGGACAATGTTCTAAAATTTTGGAAGAAAGCAATG
TAACTGAAGAAAAGGTACTTAGTTTTATTAAGCTATATGTTGGAATTGGAGAGGTAAATTATAGTTTAGATGAGGTGCCT
TTTACGCCTAGATGCAAAAAGATTTTAGATAGAAGTGTTGAAATTGCTAAGGAATATGGTCATAGTATTTCAAGACCAGA
GCACATATTATTAGCCTTAATAAAAGAAAGAGAAGGTGTAGCTAATTTAATTCTAACTAAAATAGTAAAAAATGATATAA
AAAATATAAGTGATAAGTTAAATAACATACTAGGTAGAATTCCAAGTAAGGAAAGTAAAAGCCTTAAGGAAAAGGAAAAA
CCAAAAAGAAAAGATACTCCTACATTAAATCTTTATGGTATAAATTTAATAGAAAGGGCAGATAAAAATAAGCTTGATCC
TGTAATAGGGAGAAAGGATGAAACTCAAAGACTTTTAGAAATACTTTGTAGAAGAATGAAAAATAATCCTTGTTTAATAG
GAGAACCTGGAGTAGGAAAAACTGCCGTTGTTGAAGGCTTAGCTCAGAGGATTTTATTAGGTGAAGTACCGGATATTATT
AAGGATAAAAGAATATTTACCTTAGATGTGACTTCTATGTTAGCTGGGGCAAAATATAGAGGAGAATTTGAGGAAAGACT
TAAAAAGGTTTTAAACGAAGTAAAAGATTCAGATGATATAATACTCTTTATAGATGAAATGCATAATATTGTTGGGGCTG
GTGGAGCAGAAGGTGCTATAGATGCATCAAATATATTAAAACCAGCTTTAGCAAGAGGTGAAATACAATGTATAGGTGCG
ACAACAACTGATGAATATAGAAAAAATATAGAAAAGGATTCTGCTTTAGAGAGAAGATTCCAACCAGTAGTTGTAAAAGA
GCCTAGTAAAGAAGATTCCGTATTAATATTAAAGGGATTAAGAGAAAAGTATGAAGTACATCACAATGTAAAATTAACAG
ATGAAGCCATAGAGGCAGCTGTTAATTTATCAAGTAGATATATAACAGATAGATTTCTACCAGATAAGGCCATAGATCTA
ATAGATGAGGCTGCGGCAAAGGTAAGAATAGAAAGTATGATTGTTCCTCCTAGACTTTTTAAGCAGGAAGAATTAATAGC
TAACTTAAAAGTTGAAAAAGAAGAAGCTATAAAATTACAGGACTTTGAATTAGCTGCAAAGTTAAGAGATGAAGAATTAA
TGTTACAGGAAGAACTAGAGCGAGATAAAGAACTTTGGAGAGAAGAAAATTATAATAAAATCTACGAAGTTAATAAAGAA
CATATTGCAAAGGTTGTTTCAAAGTGGACTCAGATACCAGTAGAAAGGCTTACAGAGAAAGAATCTAGTAGACTTCTTAA
GCTAGAAGAAAAGCTTAGTAAAAGAGTTATAGGACAATTAGAAGCAATAAGAACCATATCAAAGGCTGTAAGAAGATCAA
GGGTAGGTCTTAAAGATCCTAAAAGGCCTATTGGATCCTTTGCCTTTTTAGGACCTACTGGAGTAGGGAAAACAGAGCTT
TGTAAGGCTTTAGCAGAGGCTATGTTTGGTGATGAGAATAAATTTATTAGACTTGATATGTCTGAATATATGGAAAAGCA
TGGTGTATCTAGACTTATTGGAGCTCCTCCAGGATATGTAGGATATGAAGAGGGTGGTCAGCTTACAGAAAAGGTAAGAA
GAAATCCTTACTCAGTAATACTTTTTGATGAAATAGAGAAAGCACATCCAGATATATTTAATGTTCTTCTTCAAATATTA
GAAGATGGTGTTCTTACAGATGGAAAAGGTAAAACAGTAGATTTTAAGAATACAATAATCATAATGACTTCAAATATTGG
AGCAGATAAATTAGATAAGAAAAATGCAGTTGGATTTAGTGCTAAAGAGGATAAGGAACGAGATTATGATAAAATGAAAG
GAATTATGTTAGAAGAGCTAAAACAAAACTTCAAACCGGAATTTGTAAATAGATTAGATGACATAGTTGTATTCCATAGT
TTAGAAAAGGATCATCTTTTAAAAATTGTTGATCTTATGATATGTTCTCTAAAAGAGAGGTTAAATGATTTACAACTTTC
TTTGAATTTTTCTCAAGAGTGTAAAGAATTTTTAGTTAAAAAGGGCACTGAATTAAAATATGGAGCACGTCCATTAAGAA
GAGTTATAACTAAATATATTGAAGATAGATTAAGTGAAGAACTTTTAAGTGGAAATATATTAAGAGGATCTAAGGTTGAT
GTTTTCTTAGAAGACGACGTTGTAAAATTTAAAAAAACTGTTTGA

Upstream 100 bases:

>100_bases
ATCAATTAAAAGGAGAGATATACAAAGTTTAAAAATAGAAAGAGCCAAAATTATTAGAAATGCTTTAAACACATAATTAT
AGGGTATTGGGAGGTAAAAG

Downstream 100 bases:

>100_bases
TTTTAAGAATAAATAAGGTTATATATGATAAAACATATATGACCTTATTTTTTTATTATTTATCTATATATTGTATTTTA
AATTTCGGAATATAATAGAG

Product: negative regulator of genetic competence MecB/ClpC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 814; Mature: 814

Protein sequence:

>814_residues
MRLDNFNENSKIVINKGKESSLMLKHGYMGTEHLLIGLINENGQCSKILEESNVTEEKVLSFIKLYVGIGEVNYSLDEVP
FTPRCKKILDRSVEIAKEYGHSISRPEHILLALIKEREGVANLILTKIVKNDIKNISDKLNNILGRIPSKESKSLKEKEK
PKRKDTPTLNLYGINLIERADKNKLDPVIGRKDETQRLLEILCRRMKNNPCLIGEPGVGKTAVVEGLAQRILLGEVPDII
KDKRIFTLDVTSMLAGAKYRGEFEERLKKVLNEVKDSDDIILFIDEMHNIVGAGGAEGAIDASNILKPALARGEIQCIGA
TTTDEYRKNIEKDSALERRFQPVVVKEPSKEDSVLILKGLREKYEVHHNVKLTDEAIEAAVNLSSRYITDRFLPDKAIDL
IDEAAAKVRIESMIVPPRLFKQEELIANLKVEKEEAIKLQDFELAAKLRDEELMLQEELERDKELWREENYNKIYEVNKE
HIAKVVSKWTQIPVERLTEKESSRLLKLEEKLSKRVIGQLEAIRTISKAVRRSRVGLKDPKRPIGSFAFLGPTGVGKTEL
CKALAEAMFGDENKFIRLDMSEYMEKHGVSRLIGAPPGYVGYEEGGQLTEKVRRNPYSVILFDEIEKAHPDIFNVLLQIL
EDGVLTDGKGKTVDFKNTIIIMTSNIGADKLDKKNAVGFSAKEDKERDYDKMKGIMLEELKQNFKPEFVNRLDDIVVFHS
LEKDHLLKIVDLMICSLKERLNDLQLSLNFSQECKEFLVKKGTELKYGARPLRRVITKYIEDRLSEELLSGNILRGSKVD
VFLEDDVVKFKKTV

Sequences:

>Translated_814_residues
MRLDNFNENSKIVINKGKESSLMLKHGYMGTEHLLIGLINENGQCSKILEESNVTEEKVLSFIKLYVGIGEVNYSLDEVP
FTPRCKKILDRSVEIAKEYGHSISRPEHILLALIKEREGVANLILTKIVKNDIKNISDKLNNILGRIPSKESKSLKEKEK
PKRKDTPTLNLYGINLIERADKNKLDPVIGRKDETQRLLEILCRRMKNNPCLIGEPGVGKTAVVEGLAQRILLGEVPDII
KDKRIFTLDVTSMLAGAKYRGEFEERLKKVLNEVKDSDDIILFIDEMHNIVGAGGAEGAIDASNILKPALARGEIQCIGA
TTTDEYRKNIEKDSALERRFQPVVVKEPSKEDSVLILKGLREKYEVHHNVKLTDEAIEAAVNLSSRYITDRFLPDKAIDL
IDEAAAKVRIESMIVPPRLFKQEELIANLKVEKEEAIKLQDFELAAKLRDEELMLQEELERDKELWREENYNKIYEVNKE
HIAKVVSKWTQIPVERLTEKESSRLLKLEEKLSKRVIGQLEAIRTISKAVRRSRVGLKDPKRPIGSFAFLGPTGVGKTEL
CKALAEAMFGDENKFIRLDMSEYMEKHGVSRLIGAPPGYVGYEEGGQLTEKVRRNPYSVILFDEIEKAHPDIFNVLLQIL
EDGVLTDGKGKTVDFKNTIIIMTSNIGADKLDKKNAVGFSAKEDKERDYDKMKGIMLEELKQNFKPEFVNRLDDIVVFHS
LEKDHLLKIVDLMICSLKERLNDLQLSLNFSQECKEFLVKKGTELKYGARPLRRVITKYIEDRLSEELLSGNILRGSKVD
VFLEDDVVKFKKTV
>Mature_814_residues
MRLDNFNENSKIVINKGKESSLMLKHGYMGTEHLLIGLINENGQCSKILEESNVTEEKVLSFIKLYVGIGEVNYSLDEVP
FTPRCKKILDRSVEIAKEYGHSISRPEHILLALIKEREGVANLILTKIVKNDIKNISDKLNNILGRIPSKESKSLKEKEK
PKRKDTPTLNLYGINLIERADKNKLDPVIGRKDETQRLLEILCRRMKNNPCLIGEPGVGKTAVVEGLAQRILLGEVPDII
KDKRIFTLDVTSMLAGAKYRGEFEERLKKVLNEVKDSDDIILFIDEMHNIVGAGGAEGAIDASNILKPALARGEIQCIGA
TTTDEYRKNIEKDSALERRFQPVVVKEPSKEDSVLILKGLREKYEVHHNVKLTDEAIEAAVNLSSRYITDRFLPDKAIDL
IDEAAAKVRIESMIVPPRLFKQEELIANLKVEKEEAIKLQDFELAAKLRDEELMLQEELERDKELWREENYNKIYEVNKE
HIAKVVSKWTQIPVERLTEKESSRLLKLEEKLSKRVIGQLEAIRTISKAVRRSRVGLKDPKRPIGSFAFLGPTGVGKTEL
CKALAEAMFGDENKFIRLDMSEYMEKHGVSRLIGAPPGYVGYEEGGQLTEKVRRNPYSVILFDEIEKAHPDIFNVLLQIL
EDGVLTDGKGKTVDFKNTIIIMTSNIGADKLDKKNAVGFSAKEDKERDYDKMKGIMLEELKQNFKPEFVNRLDDIVVFHS
LEKDHLLKIVDLMICSLKERLNDLQLSLNFSQECKEFLVKKGTELKYGARPLRRVITKYIEDRLSEELLSGNILRGSKVD
VFLEDDVVKFKKTV

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=329, Percent_Identity=36.4741641337386, Blast_Score=203, Evalue=6e-52,
Organism=Escherichia coli, GI1788943, Length=874, Percent_Identity=44.1647597254005, Blast_Score=707, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=397, Percent_Identity=40.0503778337531, Blast_Score=284, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6320464, Length=756, Percent_Identity=46.4285714285714, Blast_Score=620, Evalue=1e-178,
Organism=Saccharomyces cerevisiae, GI6323002, Length=796, Percent_Identity=38.4422110552764, Blast_Score=508, Evalue=1e-144,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR001943 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 92647; Mature: 92647

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS50151 UVR ; PS00870 CLPAB_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLDNFNENSKIVINKGKESSLMLKHGYMGTEHLLIGLINENGQCSKILEESNVTEEKVL
CCCCCCCCCCEEEEECCCCCCEEEECCCCCCCEEEEEEECCCCHHHHHHHHCCCCHHHHH
SFIKLYVGIGEVNYSLDEVPFTPRCKKILDRSVEIAKEYGHSISRPEHILLALIKEREGV
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHH
ANLILTKIVKNDIKNISDKLNNILGRIPSKESKSLKEKEKPKRKDTPTLNLYGINLIERA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCEEEEECCHHHHHC
DKNKLDPVIGRKDETQRLLEILCRRMKNNPCLIGEPGVGKTAVVEGLAQRILLGEVPDII
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHCCCHHHH
KDKRIFTLDVTSMLAGAKYRGEFEERLKKVLNEVKDSDDIILFIDEMHNIVGAGGAEGAI
CCCEEEEEEHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCCCC
DASNILKPALARGEIQCIGATTTDEYRKNIEKDSALERRFQPVVVKEPSKEDSVLILKGL
CHHHHHHHHHCCCCEEEEECCCHHHHHHCCCHHHHHHHHCCCEEEECCCCCCCEEHHHHH
REKYEVHHNVKLTDEAIEAAVNLSSRYITDRFLPDKAIDLIDEAAAKVRIESMIVPPRLF
HHHHHHHCCCEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHH
KQEELIANLKVEKEEAIKLQDFELAAKLRDEELMLQEELERDKELWREENYNKIYEVNKE
HHHHHHHHCCCCHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHH
HIAKVVSKWTQIPVERLTEKESSRLLKLEEKLSKRVIGQLEAIRTISKAVRRSRVGLKDP
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
KRPIGSFAFLGPTGVGKTELCKALAEAMFGDENKFIRLDMSEYMEKHGVSRLIGAPPGYV
CCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHCCCHHHHCCCCCCC
GYEEGGQLTEKVRRNPYSVILFDEIEKAHPDIFNVLLQILEDGVLTDGKGKTVDFKNTII
CCCCCCHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCEECCCCCEEEECCEEE
IMTSNIGADKLDKKNAVGFSAKEDKERDYDKMKGIMLEELKQNFKPEFVNRLDDIVVFHS
EEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
LEKDHLLKIVDLMICSLKERLNDLQLSLNFSQECKEFLVKKGTELKYGARPLRRVITKYI
CCHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
EDRLSEELLSGNILRGSKVDVFLEDDVVKFKKTV
HHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHCC
>Mature Secondary Structure
MRLDNFNENSKIVINKGKESSLMLKHGYMGTEHLLIGLINENGQCSKILEESNVTEEKVL
CCCCCCCCCCEEEEECCCCCCEEEECCCCCCCEEEEEEECCCCHHHHHHHHCCCCHHHHH
SFIKLYVGIGEVNYSLDEVPFTPRCKKILDRSVEIAKEYGHSISRPEHILLALIKEREGV
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHH
ANLILTKIVKNDIKNISDKLNNILGRIPSKESKSLKEKEKPKRKDTPTLNLYGINLIERA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCEEEEECCHHHHHC
DKNKLDPVIGRKDETQRLLEILCRRMKNNPCLIGEPGVGKTAVVEGLAQRILLGEVPDII
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHCCCHHHH
KDKRIFTLDVTSMLAGAKYRGEFEERLKKVLNEVKDSDDIILFIDEMHNIVGAGGAEGAI
CCCEEEEEEHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCCCC
DASNILKPALARGEIQCIGATTTDEYRKNIEKDSALERRFQPVVVKEPSKEDSVLILKGL
CHHHHHHHHHCCCCEEEEECCCHHHHHHCCCHHHHHHHHCCCEEEECCCCCCCEEHHHHH
REKYEVHHNVKLTDEAIEAAVNLSSRYITDRFLPDKAIDLIDEAAAKVRIESMIVPPRLF
HHHHHHHCCCEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHH
KQEELIANLKVEKEEAIKLQDFELAAKLRDEELMLQEELERDKELWREENYNKIYEVNKE
HHHHHHHHCCCCHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHH
HIAKVVSKWTQIPVERLTEKESSRLLKLEEKLSKRVIGQLEAIRTISKAVRRSRVGLKDP
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
KRPIGSFAFLGPTGVGKTELCKALAEAMFGDENKFIRLDMSEYMEKHGVSRLIGAPPGYV
CCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHCCCHHHHCCCCCCC
GYEEGGQLTEKVRRNPYSVILFDEIEKAHPDIFNVLLQILEDGVLTDGKGKTVDFKNTII
CCCCCCHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCEECCCCCEEEECCEEE
IMTSNIGADKLDKKNAVGFSAKEDKERDYDKMKGIMLEELKQNFKPEFVNRLDDIVVFHS
EEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
LEKDHLLKIVDLMICSLKERLNDLQLSLNFSQECKEFLVKKGTELKYGARPLRRVITKYI
CCHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
EDRLSEELLSGNILRGSKVDVFLEDDVVKFKKTV
HHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]