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The map label for this gene is disA

Identifier: 18311414

GI number: 18311414

Start: 2780401

End: 2781465

Strand: Reverse

Name: disA

Synonym: CPE2432

Alternate gene names: 18311414

Gene position: 2781465-2780401 (Counterclockwise)

Preceding gene: 18311415

Following gene: 18311412

Centisome position: 91.75

GC content: 30.23

Gene sequence:

>1065_bases
ATGAGAACTGTACATGATGATGAGTTAAAAAAAATATTAAAAATAATGAGTCCAGGTACTTCTTTAAGGGAAGGATTAGA
TAATATACTTAGAGCCAAAACAGGAGGACTTATAGTATTAGGGGATAATGAAGAAATATTAGATTTAGTAGATGGTGGAT
TTAATATAAATTCTGAATATAGTCCAGCATATATATATGAGCTTGCTAAGATGGATGGAGCATTAGTACTTACTTCAGAT
AGAAAAAGAATACTCTACGCAAATGCTCAGCTTATGCCAAATCAATCTATAAGTACTTTTGAAACAGGAACAAGACATAG
AACTGCTCAAAGGGTTGCAAAGCAAACAAATAAAATAGCAATAGCTATATCACAAAGAAGAAATATAATTACTGTTTATA
AAGGTGACATAAAATATGTTTTAAGGGATAGTGCAGTTATATTAAGTAAAGCAAATCAGGCTATACAAACATTAGAGAAG
TATGTAGCTGTACTTGAAAGAGTAACAAATAATCTTAACATACTTGAGTTTCAAGACCTAGCAACTCTTTTTGATGTAAC
TACAGCTATACAGAGAACTGAAATGGTAATGAGGATAGTTGAAGAGATAGAGGGCTACATTATTGAGCTAGGAAATGAGG
GAAGACTTATTTCTATGCAATTAAATGAATTAGTAAGAAGTATAGAACAAGATGGAGTCCTTTTAATAAGAGATTATTGC
TATGACAAGATGGAATATAATGATGTCTACAAAGAAATTCAAGAGTTATCGGCTGAAGATTTATTAGATTTAGATATAAT
AGCAAAAGAATTAGGATATGTAGGAAAATCTTTAATTGACACATTAGTGTCACCAAGAGGGTATAGAATATCAAATAAGG
TACCAAGAATACCTTCAAATGTAATAGAAAATTTAGTAGGACATTTTGGAAAGCTTAAATATATTCTTGAAGCTGGAAAT
GAAGAATTAGATCAAGTAGAGGGAATTGGAGAAGCTAGAGCTAGAGCGATAAAAAATGGATTAAGAAGAATAAGAGAACA
AGTTGCTTTAAATAAAAATTTATAA

Upstream 100 bases:

>100_bases
AGTTTAGAAAAATTAAAGGGAAGTAAATTAAACCTTATAGGAGTAAAAACTGTAAGGGAAGCAATAGGAAAGATATTTTA
AGATGGATAGGTGTGAGTAA

Downstream 100 bases:

>100_bases
AAAGAAGTGCCATATAAATATGGCACTTAATATTTATCTAAAAGTAAACTTACCTAAAGTATCCATTTTGTTATATTCTT
TTAATAAGATATCAAATAGG

Product: DNA integrity scanning protein DisA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MRTVHDDELKKILKIMSPGTSLREGLDNILRAKTGGLIVLGDNEEILDLVDGGFNINSEYSPAYIYELAKMDGALVLTSD
RKRILYANAQLMPNQSISTFETGTRHRTAQRVAKQTNKIAIAISQRRNIITVYKGDIKYVLRDSAVILSKANQAIQTLEK
YVAVLERVTNNLNILEFQDLATLFDVTTAIQRTEMVMRIVEEIEGYIIELGNEGRLISMQLNELVRSIEQDGVLLIRDYC
YDKMEYNDVYKEIQELSAEDLLDLDIIAKELGYVGKSLIDTLVSPRGYRISNKVPRIPSNVIENLVGHFGKLKYILEAGN
EELDQVEGIGEARARAIKNGLRRIREQVALNKNL

Sequences:

>Translated_354_residues
MRTVHDDELKKILKIMSPGTSLREGLDNILRAKTGGLIVLGDNEEILDLVDGGFNINSEYSPAYIYELAKMDGALVLTSD
RKRILYANAQLMPNQSISTFETGTRHRTAQRVAKQTNKIAIAISQRRNIITVYKGDIKYVLRDSAVILSKANQAIQTLEK
YVAVLERVTNNLNILEFQDLATLFDVTTAIQRTEMVMRIVEEIEGYIIELGNEGRLISMQLNELVRSIEQDGVLLIRDYC
YDKMEYNDVYKEIQELSAEDLLDLDIIAKELGYVGKSLIDTLVSPRGYRISNKVPRIPSNVIENLVGHFGKLKYILEAGN
EELDQVEGIGEARARAIKNGLRRIREQVALNKNL
>Mature_354_residues
MRTVHDDELKKILKIMSPGTSLREGLDNILRAKTGGLIVLGDNEEILDLVDGGFNINSEYSPAYIYELAKMDGALVLTSD
RKRILYANAQLMPNQSISTFETGTRHRTAQRVAKQTNKIAIAISQRRNIITVYKGDIKYVLRDSAVILSKANQAIQTLEK
YVAVLERVTNNLNILEFQDLATLFDVTTAIQRTEMVMRIVEEIEGYIIELGNEGRLISMQLNELVRSIEQDGVLLIRDYC
YDKMEYNDVYKEIQELSAEDLLDLDIIAKELGYVGKSLIDTLVSPRGYRISNKVPRIPSNVIENLVGHFGKLKYILEAGN
EELDQVEGIGEARARAIKNGLRRIREQVALNKNL

Specific function: Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, disA pauses at

COG id: COG1623

COG function: function code R; Predicted nucleic-acid-binding protein (contains the HHH domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the disA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DISA_CLOPE (Q8XHQ0)

Other databases:

- EMBL:   BA000016
- RefSeq:   NP_563348.1
- ProteinModelPortal:   Q8XHQ0
- SMR:   Q8XHQ0
- GeneID:   990794
- GenomeReviews:   BA000016_GR
- KEGG:   cpe:CPE2432
- NMPDR:   fig|195102.1.peg.2495
- HOGENOM:   HBG292471
- OMA:   ISVSQSM
- ProtClustDB:   PRK13482
- BioCyc:   CPER195102:CPE2432-MONOMER
- HAMAP:   MF_01438
- InterPro:   IPR018906
- InterPro:   IPR003390
- InterPro:   IPR003583
- InterPro:   IPR010994
- SMART:   SM00278

Pfam domain/function: PF10635 DisA-linker; PF02457 DisA_N; SSF47781 RuvA_2_like

EC number: NA

Molecular weight: Translated: 40005; Mature: 40005

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTVHDDELKKILKIMSPGTSLREGLDNILRAKTGGLIVLGDNEEILDLVDGGFNINSEY
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCCCCCCC
SPAYIYELAKMDGALVLTSDRKRILYANAQLMPNQSISTFETGTRHRTAQRVAKQTNKIA
CHHHHHHHHHCCCEEEEECCCCEEEEECCEECCCCCCCHHHCCHHHHHHHHHHHHCCCEE
IAISQRRNIITVYKGDIKYVLRDSAVILSKANQAIQTLEKYVAVLERVTNNLNILEFQDL
EEEECCCCEEEEEECCEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHH
ATLFDVTTAIQRTEMVMRIVEEIEGYIIELGNEGRLISMQLNELVRSIEQDGVLLIRDYC
HHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEHHHHHHHHHHHHCCEEEEHHHH
YDKMEYNDVYKEIQELSAEDLLDLDIIAKELGYVGKSLIDTLVSPRGYRISNKVPRIPSN
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
VIENLVGHFGKLKYILEAGNEELDQVEGIGEARARAIKNGLRRIREQVALNKNL
HHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRTVHDDELKKILKIMSPGTSLREGLDNILRAKTGGLIVLGDNEEILDLVDGGFNINSEY
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCCCCCCC
SPAYIYELAKMDGALVLTSDRKRILYANAQLMPNQSISTFETGTRHRTAQRVAKQTNKIA
CHHHHHHHHHCCCEEEEECCCCEEEEECCEECCCCCCCHHHCCHHHHHHHHHHHHCCCEE
IAISQRRNIITVYKGDIKYVLRDSAVILSKANQAIQTLEKYVAVLERVTNNLNILEFQDL
EEEECCCCEEEEEECCEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHH
ATLFDVTTAIQRTEMVMRIVEEIEGYIIELGNEGRLISMQLNELVRSIEQDGVLLIRDYC
HHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEHHHHHHHHHHHHCCEEEEHHHH
YDKMEYNDVYKEIQELSAEDLLDLDIIAKELGYVGKSLIDTLVSPRGYRISNKVPRIPSN
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
VIENLVGHFGKLKYILEAGNEELDQVEGIGEARARAIKNGLRRIREQVALNKNL
HHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11792842