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The map label for this gene is pepD [H]

Identifier: 18311130

GI number: 18311130

Start: 2459328

End: 2460779

Strand: Reverse

Name: pepD [H]

Synonym: CPE2148

Alternate gene names: 18311130

Gene position: 2460779-2459328 (Counterclockwise)

Preceding gene: 18311132

Following gene: 18311129

Centisome position: 81.18

GC content: 29.89

Gene sequence:

>1452_bases
ATGAATGTATTAAAAGGTTTAGAACCACAAAGTGTTTTAAAATATTTTGAAGAAATATCACAAATTCCAAGAGGATCAGG
TAATGAAAAGGGAATAAGTGATTTCCTAGTTAACTTTGGAAAAAGTTTAGGACTTGAAACAATACAAGATGAATCATTAA
ATGTAATAATAAGAAAACCTGCAACTCCAGGATATGAAAATGCACCAGGAGTAATAATACAAGGTCATATGGATATGGTA
TGTGAAAAAAATAAAGATACTATACATGATTTTGAAAAAGATCCTATTGAACTTAGAGTAGATGGAGATTATATATATGC
TACAGGAACTACATTAGGAGCAGATAATGGTATAGCAGTAGCTTATGGAATGGCTGTTTTAGCTTCAAATGATATAGCAC
ACCCTGCTATAGAGCTTTTAGTTACAACTGATGAAGAAGTTGGAATGGGTGGAGCTATTGCTTTAGATGGAACTTTATTA
AAAGGTAAATATCTTTTAAACATAGATTCAGAGGAAGAAGGAAAACTTTTAGTAAGCTGTGCAGGTGGAGCTAGAAGTGA
AGTTACTTTACCAATAAACTTTGAAGAAATGGAAAAAGATTTTGAAGTTTATGAAATCATGCTAAGAGGACTAAAAGGTG
GTCACTCTGGAATGGAAATAGATAAACAAAGAGGAAACTCTAATAAGTTAATGGGAAGAGTATTAAATGATATTAATGCT
AACTGTGATATTAGATTAATATCAATTAATGGTGGATCTAAGGTAAATGCTATTCCAAGAGAATGTGACACTTTACTAGC
TGTTAAAAAAGAAGATGTTAAAAAATTAGAAGAATTAATTCAAAAATGGGATTCAATATTAAAGGATGAATACCATGCTA
ATGATAGTGGAGTTAATGTAACTTTAGTTAAAAAAGAAGAAAATCATAAAGTATTTTCTAAAGACACTACATTTAAGGCA
ATAAAAATAATGAACTTAATTCCTGATGGAGTTGATACTTATAGTATAGAAATGAAAGGATTAGTTCAAAGTTCAACAAA
CCTAGGTGTTGTTACTACAGAAGGGGATAAAATTGTTTTTGCTAGTTCAACAAGAAGTTCAGTTGAAACTTTAAAAACTA
AACTTTTAGATGAAATAGCTGACGTTGCAGAAGTATTAGGTGGAGAATTTGAAATACAAGCACCATACCCAGCTTGGCAA
TATAATCCTGATTCAAAAATAAGAGAACTTTGCAGCAATGTATATAAAAATATGACAGGAAAAGATCCTGAAATAATAGC
TATACATGCTGGATTAGAATGTGGATTATTAGGAGAAAAAATAGAAGGATTAGATATGATTTCATTTGGTCCTAATATGT
ATGATGTTCATACTCCAAATGAACATGTTAGCATATCTTCAGTAAAAAATGTTTGGGATTTCTTAGTTGAAATATTAAAA
GCTATAAAATAA

Upstream 100 bases:

>100_bases
GTTTAGTGATTGCTTTAAAAGTTTGATATATTTGATATAATAGAATAAATTATTAAATTAATTATATTTTACCACAATAA
TAGGAAGGGATGGGTAAAAA

Downstream 100 bases:

>100_bases
TTAAGAATTAATTTAAGGTTGTATCTAAATTACCTAAAAAACTTATAAATATATTTTAGAATTATTGGATTTTTATAAGG
GTTTATTACAGTTACTAATA

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MNVLKGLEPQSVLKYFEEISQIPRGSGNEKGISDFLVNFGKSLGLETIQDESLNVIIRKPATPGYENAPGVIIQGHMDMV
CEKNKDTIHDFEKDPIELRVDGDYIYATGTTLGADNGIAVAYGMAVLASNDIAHPAIELLVTTDEEVGMGGAIALDGTLL
KGKYLLNIDSEEEGKLLVSCAGGARSEVTLPINFEEMEKDFEVYEIMLRGLKGGHSGMEIDKQRGNSNKLMGRVLNDINA
NCDIRLISINGGSKVNAIPRECDTLLAVKKEDVKKLEELIQKWDSILKDEYHANDSGVNVTLVKKEENHKVFSKDTTFKA
IKIMNLIPDGVDTYSIEMKGLVQSSTNLGVVTTEGDKIVFASSTRSSVETLKTKLLDEIADVAEVLGGEFEIQAPYPAWQ
YNPDSKIRELCSNVYKNMTGKDPEIIAIHAGLECGLLGEKIEGLDMISFGPNMYDVHTPNEHVSISSVKNVWDFLVEILK
AIK

Sequences:

>Translated_483_residues
MNVLKGLEPQSVLKYFEEISQIPRGSGNEKGISDFLVNFGKSLGLETIQDESLNVIIRKPATPGYENAPGVIIQGHMDMV
CEKNKDTIHDFEKDPIELRVDGDYIYATGTTLGADNGIAVAYGMAVLASNDIAHPAIELLVTTDEEVGMGGAIALDGTLL
KGKYLLNIDSEEEGKLLVSCAGGARSEVTLPINFEEMEKDFEVYEIMLRGLKGGHSGMEIDKQRGNSNKLMGRVLNDINA
NCDIRLISINGGSKVNAIPRECDTLLAVKKEDVKKLEELIQKWDSILKDEYHANDSGVNVTLVKKEENHKVFSKDTTFKA
IKIMNLIPDGVDTYSIEMKGLVQSSTNLGVVTTEGDKIVFASSTRSSVETLKTKLLDEIADVAEVLGGEFEIQAPYPAWQ
YNPDSKIRELCSNVYKNMTGKDPEIIAIHAGLECGLLGEKIEGLDMISFGPNMYDVHTPNEHVSISSVKNVWDFLVEILK
AIK
>Mature_483_residues
MNVLKGLEPQSVLKYFEEISQIPRGSGNEKGISDFLVNFGKSLGLETIQDESLNVIIRKPATPGYENAPGVIIQGHMDMV
CEKNKDTIHDFEKDPIELRVDGDYIYATGTTLGADNGIAVAYGMAVLASNDIAHPAIELLVTTDEEVGMGGAIALDGTLL
KGKYLLNIDSEEEGKLLVSCAGGARSEVTLPINFEEMEKDFEVYEIMLRGLKGGHSGMEIDKQRGNSNKLMGRVLNDINA
NCDIRLISINGGSKVNAIPRECDTLLAVKKEDVKKLEELIQKWDSILKDEYHANDSGVNVTLVKKEENHKVFSKDTTFKA
IKIMNLIPDGVDTYSIEMKGLVQSSTNLGVVTTEGDKIVFASSTRSSVETLKTKLLDEIADVAEVLGGEFEIQAPYPAWQ
YNPDSKIRELCSNVYKNMTGKDPEIIAIHAGLECGLLGEKIEGLDMISFGPNMYDVHTPNEHVSISSVKNVWDFLVEILK
AIK

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=484, Percent_Identity=39.2561983471074, Blast_Score=357, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 52976; Mature: 52976

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVLKGLEPQSVLKYFEEISQIPRGSGNEKGISDFLVNFGKSLGLETIQDESLNVIIRKP
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEECCCCCEEEEECC
ATPGYENAPGVIIQGHMDMVCEKNKDTIHDFEKDPIELRVDGDYIYATGTTLGADNGIAV
CCCCCCCCCCEEEECCCCEEECCCCCHHHHCCCCCEEEEECCCEEEEECCEECCCCCEEH
AYGMAVLASNDIAHPAIELLVTTDEEVGMGGAIALDGTLLKGKYLLNIDSEEEGKLLVSC
HHHHHHEECCCCCCCEEEEEEECCCCCCCCCEEEECCEEEECEEEEECCCCCCCCEEEEE
AGGARSEVTLPINFEEMEKDFEVYEIMLRGLKGGHSGMEIDKQRGNSNKLMGRVLNDINA
CCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHCCCCHHHHHHHHHHCCC
NCDIRLISINGGSKVNAIPRECDTLLAVKKEDVKKLEELIQKWDSILKDEYHANDSGVNV
CCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
TLVKKEENHKVFSKDTTFKAIKIMNLIPDGVDTYSIEMKGLVQSSTNLGVVTTEGDKIVF
EEEEECCCCEEECCCCCCHHEEEEHHCCCCCCEEEEEEEEEEECCCCCEEEEECCCEEEE
ASSTRSSVETLKTKLLDEIADVAEVLGGEFEIQAPYPAWQYNPDSKIRELCSNVYKNMTG
ECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCC
KDPEIIAIHAGLECGLLGEKIEGLDMISFGPNMYDVHTPNEHVSISSVKNVWDFLVEILK
CCCCEEEEECCCEECCCCCCCCCCEEEECCCCEEEECCCCCCEEHHHHHHHHHHHHHHHH
AIK
HCC
>Mature Secondary Structure
MNVLKGLEPQSVLKYFEEISQIPRGSGNEKGISDFLVNFGKSLGLETIQDESLNVIIRKP
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEECCCCCEEEEECC
ATPGYENAPGVIIQGHMDMVCEKNKDTIHDFEKDPIELRVDGDYIYATGTTLGADNGIAV
CCCCCCCCCCEEEECCCCEEECCCCCHHHHCCCCCEEEEECCCEEEEECCEECCCCCEEH
AYGMAVLASNDIAHPAIELLVTTDEEVGMGGAIALDGTLLKGKYLLNIDSEEEGKLLVSC
HHHHHHEECCCCCCCEEEEEEECCCCCCCCCEEEECCEEEECEEEEECCCCCCCCEEEEE
AGGARSEVTLPINFEEMEKDFEVYEIMLRGLKGGHSGMEIDKQRGNSNKLMGRVLNDINA
CCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHCCCCHHHHHHHHHHCCC
NCDIRLISINGGSKVNAIPRECDTLLAVKKEDVKKLEELIQKWDSILKDEYHANDSGVNV
CCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
TLVKKEENHKVFSKDTTFKAIKIMNLIPDGVDTYSIEMKGLVQSSTNLGVVTTEGDKIVF
EEEEECCCCEEECCCCCCHHEEEEHHCCCCCCEEEEEEEEEEECCCCCEEEEECCCEEEE
ASSTRSSVETLKTKLLDEIADVAEVLGGEFEIQAPYPAWQYNPDSKIRELCSNVYKNMTG
ECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCC
KDPEIIAIHAGLECGLLGEKIEGLDMISFGPNMYDVHTPNEHVSISSVKNVWDFLVEILK
CCCCEEEEECCCEECCCCCCCCCCEEEECCCCEEEECCCCCCEEHHHHHHHHHHHHHHHH
AIK
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]