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The map label for this gene is comEA [H]

Identifier: 18311102

GI number: 18311102

Start: 2432199

End: 2432981

Strand: Reverse

Name: comEA [H]

Synonym: CPE2120

Alternate gene names: 18311102

Gene position: 2432981-2432199 (Counterclockwise)

Preceding gene: 18311104

Following gene: 18311100

Centisome position: 80.26

GC content: 26.95

Gene sequence:

>783_bases
ATGAAGAGAAAAGAAAAAATTATAGGTAGTTTAATAATTGCTGTAATAGCTATTTTATTTTTATTTATTGGTTACTCAAA
GACAAATGATAAAAAAATAAGTGATAGTGATATGGAAAAACTATTTTTAGATAGAGAGGAATCAGAAGAGAATAATGAAT
TGGAAGAGAATAATGAATTAGAAAAGTTTAATGAAAAAGAATCAAGTTCAAAGAAAGAAGAGAGTAATAATATTAAAGAA
GAAAAAGATAGTGATATAGAAAGTGAAAAAGAAGAAAAAGAAACTAGCTTAGGTGAAGAAAAAATAGTTGTAGAGATTAA
GGGCGAGGTAAAAAAGCCTAATGTCTATGAATTAAAAAATGGAAGTAGAATTTATGAACTTATAGAGGAAGCTGGGGGAC
CGACTAATGAAGCGGATTTAAGTAATATAAATAGAGCTTTATATTTAAGTGATGGGCAATGTATAGTAATTAAAAATATA
AATGATGTTGAAAGTGAAGAGGTAAATTTAAATGAAAGTTTAAATGCTGAAGTTACTAATAGTATTCCTACTAATTCATC
AGGTGACAAAGGTGAGAAAAATGAAAGTTCAGTTATAAATATAAATACTGCCTCTAAAGAAACACTTATGACCTTAAATG
GAATAGGAGAAAGTAAGGCACAGGCCATAATAGATTATAGAGATGAAATTGGCGGATTTAAAAGTGTTGATGATATTACA
AATGTAAGTGGTATAGGAGAAAAAACATTAGAGAAGATAAAAGATAAAATTTCTATAAAGTAA

Upstream 100 bases:

>100_bases
TGGAGAAATTGTCAATAATGTTAAAGAAATATGAGAATTTATTGATTTGAAACTTTATTTTTTAATAAATTTCTAAGAAT
TTATATAATATGGAGGGTTC

Downstream 100 bases:

>100_bases
TATGATATAATGAATATTATTATTTAGAAAAGAGGTGGAGTTTTATGATAGAAAAAAGACTAACAGAGCTATCAAAGACT
TCTGGCTGAGCAGCCAAAAT

Product: ComE operon protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MKRKEKIIGSLIIAVIAILFLFIGYSKTNDKKISDSDMEKLFLDREESEENNELEENNELEKFNEKESSSKKEESNNIKE
EKDSDIESEKEEKETSLGEEKIVVEIKGEVKKPNVYELKNGSRIYELIEEAGGPTNEADLSNINRALYLSDGQCIVIKNI
NDVESEEVNLNESLNAEVTNSIPTNSSGDKGEKNESSVININTASKETLMTLNGIGESKAQAIIDYRDEIGGFKSVDDIT
NVSGIGEKTLEKIKDKISIK

Sequences:

>Translated_260_residues
MKRKEKIIGSLIIAVIAILFLFIGYSKTNDKKISDSDMEKLFLDREESEENNELEENNELEKFNEKESSSKKEESNNIKE
EKDSDIESEKEEKETSLGEEKIVVEIKGEVKKPNVYELKNGSRIYELIEEAGGPTNEADLSNINRALYLSDGQCIVIKNI
NDVESEEVNLNESLNAEVTNSIPTNSSGDKGEKNESSVININTASKETLMTLNGIGESKAQAIIDYRDEIGGFKSVDDIT
NVSGIGEKTLEKIKDKISIK
>Mature_260_residues
MKRKEKIIGSLIIAVIAILFLFIGYSKTNDKKISDSDMEKLFLDREESEENNELEENNELEKFNEKESSSKKEESNNIKE
EKDSDIESEKEEKETSLGEEKIVVEIKGEVKKPNVYELKNGSRIYELIEEAGGPTNEADLSNINRALYLSDGQCIVIKNI
NDVESEEVNLNESLNAEVTNSIPTNSSGDKGEKNESSVININTASKETLMTLNGIGESKAQAIIDYRDEIGGFKSVDDIT
NVSGIGEKTLEKIKDKISIK

Specific function: Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect [H]

COG id: COG1555

COG function: function code L; DNA uptake protein and related DNA-binding proteins

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HhH domains [H]

Homologues:

Organism=Homo sapiens, GI71043966, Length=61, Percent_Identity=49.1803278688525, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004787
- InterPro:   IPR004509
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR019554 [H]

Pfam domain/function: PF00633 HHH; PF10531 SLBB [H]

EC number: NA

Molecular weight: Translated: 29036; Mature: 29036

Theoretical pI: Translated: 4.27; Mature: 4.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRKEKIIGSLIIAVIAILFLFIGYSKTNDKKISDSDMEKLFLDREESEENNELEENNEL
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHCCHH
EKFNEKESSSKKEESNNIKEEKDSDIESEKEEKETSLGEEKIVVEIKGEVKKPNVYELKN
HHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEECC
GSRIYELIEEAGGPTNEADLSNINRALYLSDGQCIVIKNINDVESEEVNLNESLNAEVTN
CHHHHHHHHHCCCCCCCHHHHHCCEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCEECC
SIPTNSSGDKGEKNESSVININTASKETLMTLNGIGESKAQAIIDYRDEIGGFKSVDDIT
CCCCCCCCCCCCCCCCCEEEEECCCCHHEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHH
NVSGIGEKTLEKIKDKISIK
CCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKRKEKIIGSLIIAVIAILFLFIGYSKTNDKKISDSDMEKLFLDREESEENNELEENNEL
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHCCHH
EKFNEKESSSKKEESNNIKEEKDSDIESEKEEKETSLGEEKIVVEIKGEVKKPNVYELKN
HHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEECC
GSRIYELIEEAGGPTNEADLSNINRALYLSDGQCIVIKNINDVESEEVNLNESLNAEVTN
CHHHHHHHHHCCCCCCCHHHHHCCEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCEECC
SIPTNSSGDKGEKNESSVININTASKETLMTLNGIGESKAQAIIDYRDEIGGFKSVDDIT
CCCCCCCCCCCCCCCCCEEEEECCCCHHEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHH
NVSGIGEKTLEKIKDKISIK
CCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377; 7768800 [H]