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The map label for this gene is clcA [H]

Identifier: 18310899

GI number: 18310899

Start: 2195318

End: 2196877

Strand: Reverse

Name: clcA [H]

Synonym: CPE1917

Alternate gene names: 18310899

Gene position: 2196877-2195318 (Counterclockwise)

Preceding gene: 18310900

Following gene: 18310897

Centisome position: 72.47

GC content: 29.74

Gene sequence:

>1560_bases
ATGGATAAGGATAAAGAGATAAGTGGATTAAATAATTTAGAGTTTAAAATAATAGTACAAGGAATATTAGTAGGCATAAT
TGTTGGAATTGTAATAATGATTTATAAGACCATAATAGGATTTGGAATGGAAGGCTTTAATAAGGTATATTCATATACAA
GAGAAAATCCAAAGCTTATAATTCCTTTATTTTTAGTTCTTATATTTTTAGGGTTTATAGTTGGCCTTATAGTTAAAAAG
AATCCTATGATAGGTGGAAGTGGTATTCCACAGGTAGAAGGGGAGTTAAGTGGAAAAATAAGCGTAAACTGGCTAAGAGT
ATTTAGAGATAAGTTTATTGGCGGAATAATATGTATGGCATCTGGTCTTTCATTAGGTAAAGAGGGGCCCTCAGTTCAAA
TTGGAGCTTCAATAGGAGAAGGCTTTGCTAAAATATTTAAAAGAAGTGACTTTGAAAAGAGATTGTTAATAACAGGGGGA
GCAAGTTCAGGTCTTGCTGTAATATTTAATGCCCCTTTATCAGGAGCTATATTTGCTCTTGAAGAAGTACATAGAAGTTT
TTCTCTGCCAGTTATGTTGGCTGCACTTTCAGCTTCTCTTACAGGAGTTTTTGTGGATAATCTTATTTTAGGAAATGATT
TTTGCATAAAAATACCACCTACAAATTCATTGCCAATACAATATTATTGGACATTATTAATATTAGGAGCCATATTAGGA
GTAACAGGATGGGTTTTTAATAAAGGCCTTTTAAAAACACAGGATTTTTATGTGAAGACTTTAAAAAAAATTCCTATTCA
ATTTAAAACAATAATACCTTTTGTTATGGTTGGAATTTTGGCATTAACAATTCCAGAAGCAATTGATGGAGGAGACTCTT
TAATTGAAAGTGTAATAGGAAATAATATTGCAATAAAACTTTTAATAGTAATTTTAGTAATAAAATTTATATTTACATTC
TTTAGTTATTCATCAGGAGTGCCAGGAGGAATATTCTTTCCTTTATTAGCTATAGGTGCTTTAGTAGGAGCAATATTTGG
ATTACTTTTAAATAAATATTTAGGAATAAGTGATTCCTTAATAGTCAACTTTATAGTGCTAGCTATGGCAGCACAATTTG
CATCAATAGTTAAGGCTCCTATTACTGGATTAATGCTTATAACTGAGATGACAGGAACTTTTAAACACTTATTACCAGTG
GCTATAACAGTTACTGTGGCATATTTAGTTTCTGATATGCTTAATAATAAGCCTATTTATGAAAGTTTATTAGAGAAATT
ATTAGAAAGAATGAATATTAAGTTTAATACTGGTGTAAAGAAAAAAGAAATTTTTGATTTTGAAGTAAAGATTGGTTCTG
AATTAGATGGAAAACTTATAAAAGATGTGAAATGGCCTGAGGGTAGTTTAATAATAACTATTTTTAGAGGAGCAGAGGAA
ATTATACCAAATGGAGAGGTTAAAATTCAGTCTGGGGATGTGTTAGAAGTAATATTTAGCAAAGAAAAACAAGCGCAGTA
CTATGATGAAATATCAAAAAAAATATATTGTGAAATTTAA

Upstream 100 bases:

>100_bases
ATAAATTGTATTTAACTGGATAAATGAGAAAATTAAAATTTGAACTATTGTTAACAAAAGGTATATAATTTATTCATAAA
ATATTATGGATGTGATTAAT

Downstream 100 bases:

>100_bases
TTAATAAAAACATATTAAATTAAAAGCTAATAAAAAAACTTACAAATAATTCTTAAAGAAATAGGGTAACTCTTTAAGTA
AATTTGTAAGTTTTTTATTT

Product: hypothetical protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MDKDKEISGLNNLEFKIIVQGILVGIIVGIVIMIYKTIIGFGMEGFNKVYSYTRENPKLIIPLFLVLIFLGFIVGLIVKK
NPMIGGSGIPQVEGELSGKISVNWLRVFRDKFIGGIICMASGLSLGKEGPSVQIGASIGEGFAKIFKRSDFEKRLLITGG
ASSGLAVIFNAPLSGAIFALEEVHRSFSLPVMLAALSASLTGVFVDNLILGNDFCIKIPPTNSLPIQYYWTLLILGAILG
VTGWVFNKGLLKTQDFYVKTLKKIPIQFKTIIPFVMVGILALTIPEAIDGGDSLIESVIGNNIAIKLLIVILVIKFIFTF
FSYSSGVPGGIFFPLLAIGALVGAIFGLLLNKYLGISDSLIVNFIVLAMAAQFASIVKAPITGLMLITEMTGTFKHLLPV
AITVTVAYLVSDMLNNKPIYESLLEKLLERMNIKFNTGVKKKEIFDFEVKIGSELDGKLIKDVKWPEGSLIITIFRGAEE
IIPNGEVKIQSGDVLEVIFSKEKQAQYYDEISKKIYCEI

Sequences:

>Translated_519_residues
MDKDKEISGLNNLEFKIIVQGILVGIIVGIVIMIYKTIIGFGMEGFNKVYSYTRENPKLIIPLFLVLIFLGFIVGLIVKK
NPMIGGSGIPQVEGELSGKISVNWLRVFRDKFIGGIICMASGLSLGKEGPSVQIGASIGEGFAKIFKRSDFEKRLLITGG
ASSGLAVIFNAPLSGAIFALEEVHRSFSLPVMLAALSASLTGVFVDNLILGNDFCIKIPPTNSLPIQYYWTLLILGAILG
VTGWVFNKGLLKTQDFYVKTLKKIPIQFKTIIPFVMVGILALTIPEAIDGGDSLIESVIGNNIAIKLLIVILVIKFIFTF
FSYSSGVPGGIFFPLLAIGALVGAIFGLLLNKYLGISDSLIVNFIVLAMAAQFASIVKAPITGLMLITEMTGTFKHLLPV
AITVTVAYLVSDMLNNKPIYESLLEKLLERMNIKFNTGVKKKEIFDFEVKIGSELDGKLIKDVKWPEGSLIITIFRGAEE
IIPNGEVKIQSGDVLEVIFSKEKQAQYYDEISKKIYCEI
>Mature_519_residues
MDKDKEISGLNNLEFKIIVQGILVGIIVGIVIMIYKTIIGFGMEGFNKVYSYTRENPKLIIPLFLVLIFLGFIVGLIVKK
NPMIGGSGIPQVEGELSGKISVNWLRVFRDKFIGGIICMASGLSLGKEGPSVQIGASIGEGFAKIFKRSDFEKRLLITGG
ASSGLAVIFNAPLSGAIFALEEVHRSFSLPVMLAALSASLTGVFVDNLILGNDFCIKIPPTNSLPIQYYWTLLILGAILG
VTGWVFNKGLLKTQDFYVKTLKKIPIQFKTIIPFVMVGILALTIPEAIDGGDSLIESVIGNNIAIKLLIVILVIKFIFTF
FSYSSGVPGGIFFPLLAIGALVGAIFGLLLNKYLGISDSLIVNFIVLAMAAQFASIVKAPITGLMLITEMTGTFKHLLPV
AITVTVAYLVSDMLNNKPIYESLLEKLLERMNIKFNTGVKKKEIFDFEVKIGSELDGKLIKDVKWPEGSLIITIFRGAEE
IIPNGEVKIQSGDVLEVIFSKEKQAQYYDEISKKIYCEI

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Homo sapiens, GI55770838, Length=430, Percent_Identity=25.3488372093023, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI55770840, Length=430, Percent_Identity=25.5813953488372, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI153252026, Length=424, Percent_Identity=22.4056603773585, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI4557473, Length=425, Percent_Identity=23.7647058823529, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI189217923, Length=425, Percent_Identity=23.7647058823529, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI189217921, Length=425, Percent_Identity=23.7647058823529, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI1786350, Length=437, Percent_Identity=31.8077803203661, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI87081943, Length=312, Percent_Identity=25.3205128205128, Blast_Score=76, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17532615, Length=391, Percent_Identity=26.5984654731458, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71985148, Length=441, Percent_Identity=24.0362811791383, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71985141, Length=439, Percent_Identity=24.373576309795, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17559050, Length=408, Percent_Identity=24.5098039215686, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322500, Length=393, Percent_Identity=24.4274809160305, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24665008, Length=416, Percent_Identity=25.4807692307692, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI45551566, Length=402, Percent_Identity=26.1194029850746, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI19922112, Length=463, Percent_Identity=23.9740820734341, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 56685; Mature: 56685

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKDKEISGLNNLEFKIIVQGILVGIIVGIVIMIYKTIIGFGMEGFNKVYSYTRENPKLI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEE
IPLFLVLIFLGFIVGLIVKKNPMIGGSGIPQVEGELSGKISVNWLRVFRDKFIGGIICMA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
SGLSLGKEGPSVQIGASIGEGFAKIFKRSDFEKRLLITGGASSGLAVIFNAPLSGAIFAL
CCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEECCCCHHHHHH
EEVHRSFSLPVMLAALSASLTGVFVDNLILGNDFCIKIPPTNSLPIQYYWTLLILGAILG
HHHHHHCCHHHHHHHHHHHHHHHHHHHEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHH
VTGWVFNKGLLKTQDFYVKTLKKIPIQFKTIIPFVMVGILALTIPEAIDGGDSLIESVIG
HHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHC
NNIAIKLLIVILVIKFIFTFFSYSSGVPGGIFFPLLAIGALVGAIFGLLLNKYLGISDSL
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IVNFIVLAMAAQFASIVKAPITGLMLITEMTGTFKHLLPVAITVTVAYLVSDMLNNKPIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
ESLLEKLLERMNIKFNTGVKKKEIFDFEVKIGSELDGKLIKDVKWPEGSLIITIFRGAEE
HHHHHHHHHHCCCEECCCCCHHHEEEEEEEECCCCCCHHHHCCCCCCCCEEEEEECCHHH
IIPNGEVKIQSGDVLEVIFSKEKQAQYYDEISKKIYCEI
HCCCCCEEEECCCEEEEHHCCHHHHHHHHHHHHHEECCC
>Mature Secondary Structure
MDKDKEISGLNNLEFKIIVQGILVGIIVGIVIMIYKTIIGFGMEGFNKVYSYTRENPKLI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEE
IPLFLVLIFLGFIVGLIVKKNPMIGGSGIPQVEGELSGKISVNWLRVFRDKFIGGIICMA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
SGLSLGKEGPSVQIGASIGEGFAKIFKRSDFEKRLLITGGASSGLAVIFNAPLSGAIFAL
CCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEECCCCHHHHHH
EEVHRSFSLPVMLAALSASLTGVFVDNLILGNDFCIKIPPTNSLPIQYYWTLLILGAILG
HHHHHHCCHHHHHHHHHHHHHHHHHHHEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHH
VTGWVFNKGLLKTQDFYVKTLKKIPIQFKTIIPFVMVGILALTIPEAIDGGDSLIESVIG
HHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHC
NNIAIKLLIVILVIKFIFTFFSYSSGVPGGIFFPLLAIGALVGAIFGLLLNKYLGISDSL
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IVNFIVLAMAAQFASIVKAPITGLMLITEMTGTFKHLLPVAITVTVAYLVSDMLNNKPIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
ESLLEKLLERMNIKFNTGVKKKEIFDFEVKIGSELDGKLIKDVKWPEGSLIITIFRGAEE
HHHHHHHHHHCCCEECCCCCHHHEEEEEEEECCCCCCHHHHCCCCCCCCEEEEEECCHHH
IIPNGEVKIQSGDVLEVIFSKEKQAQYYDEISKKIYCEI
HCCCCCEEEECCCEEEEHHCCHHHHHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA