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The map label for this gene is dapA [H]

Identifier: 18310887

GI number: 18310887

Start: 2184296

End: 2185171

Strand: Direct

Name: dapA [H]

Synonym: CPE1905

Alternate gene names: 18310887

Gene position: 2184296-2185171 (Clockwise)

Preceding gene: 18310886

Following gene: 18310888

Centisome position: 72.05

GC content: 28.88

Gene sequence:

>876_bases
ATGTTTAAAGGGTCTTGTGTAGCTTTAATAACACCATTTACTGAAGATGGCGTTAATTATGAAGAGCTAAGAAAATTATT
AGAATGGCATATTAAAAATCATACTGACGCTATTTTAGTTTGTGGAACTACAGGAGAAGGTTCTACTATGACTTTAGAAG
AAAAGAAAGAAGTTATAAAATTCTCTGTGGAAGTTGTAAATAAAAGAGTTCCTGTAATAGCTGGAACTGGAACAAATAAT
ACTAAGGCTTCAATAGAATTAAGTAAATATGCTGAAGAAGTTGGCGCTGATATGGTATTAATAATAACTCCATATTATAA
TAAAACTTCTCAAAAAGGATTATATGCTCATTTTAGTGCTATAAATGATGCAATAAATATTCCTATTATGCTTTATAATG
TTCCATCAAGAACTGGAATGAATATAACTCCATTAATGCTTGATAAACTTGCAGATTTAAATAATGTAGTTGCTATAAAA
GAAGCTAGCGGAGATCTTTCACAAGTAGCTAAAATGGCTGAATTATGTGGTGATAGAATTGCTATCTATTCAGGTAATGA
TGATCAAATAGTTCCAATTTTATCTTTAGGCGGAGCTGGTGTTGTTTCAGTTTTAGCAAATATTCTTCCTGAAGAAACTC
ACAATATATGTGAAAAATATTTCTTAGGAGAAGTTATTGAATCACGTAACCTTCAACTTAAATATCTTTCATTAGCAAAT
TCTTTATTTATAGAAACAAATCCAATCCCAGTTAAAACAGCTATGAATTTAATGAATTTTAACTGTGGACCATTAAGATT
ACCATTATGCGAAATGGAAGATTCTAATTTAATAATATTAGAAGAAAACTTAAAAGCTAATGGTTTAATAAAATAA

Upstream 100 bases:

>100_bases
TGTGGCTGATAATATAAGAAAAGGGGCAGCTCTTAATGCAATTCAAATTGCTGAAATACTTATAAACGAAAAATAATTTA
TTTTTTTGGAGGTAATACGT

Downstream 100 bases:

>100_bases
TCTATTATATAATAAGCATAATCGCCTTTAGGTGGTTATGCTTATTTAAAACTAATATCGGAGGTACCAATTATGGTTAA
AGTTATATTAAATGGTTGTT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MFKGSCVALITPFTEDGVNYEELRKLLEWHIKNHTDAILVCGTTGEGSTMTLEEKKEVIKFSVEVVNKRVPVIAGTGTNN
TKASIELSKYAEEVGADMVLIITPYYNKTSQKGLYAHFSAINDAINIPIMLYNVPSRTGMNITPLMLDKLADLNNVVAIK
EASGDLSQVAKMAELCGDRIAIYSGNDDQIVPILSLGGAGVVSVLANILPEETHNICEKYFLGEVIESRNLQLKYLSLAN
SLFIETNPIPVKTAMNLMNFNCGPLRLPLCEMEDSNLIILEENLKANGLIK

Sequences:

>Translated_291_residues
MFKGSCVALITPFTEDGVNYEELRKLLEWHIKNHTDAILVCGTTGEGSTMTLEEKKEVIKFSVEVVNKRVPVIAGTGTNN
TKASIELSKYAEEVGADMVLIITPYYNKTSQKGLYAHFSAINDAINIPIMLYNVPSRTGMNITPLMLDKLADLNNVVAIK
EASGDLSQVAKMAELCGDRIAIYSGNDDQIVPILSLGGAGVVSVLANILPEETHNICEKYFLGEVIESRNLQLKYLSLAN
SLFIETNPIPVKTAMNLMNFNCGPLRLPLCEMEDSNLIILEENLKANGLIK
>Mature_291_residues
MFKGSCVALITPFTEDGVNYEELRKLLEWHIKNHTDAILVCGTTGEGSTMTLEEKKEVIKFSVEVVNKRVPVIAGTGTNN
TKASIELSKYAEEVGADMVLIITPYYNKTSQKGLYAHFSAINDAINIPIMLYNVPSRTGMNITPLMLDKLADLNNVVAIK
EASGDLSQVAKMAELCGDRIAIYSGNDDQIVPILSLGGAGVVSVLANILPEETHNICEKYFLGEVIESRNLQLKYLSLAN
SLFIETNPIPVKTAMNLMNFNCGPLRLPLCEMEDSNLIILEENLKANGLIK

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=291, Percent_Identity=26.1168384879725, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI13540533, Length=283, Percent_Identity=27.208480565371, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1788823, Length=292, Percent_Identity=39.7260273972603, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI1786463, Length=251, Percent_Identity=31.0756972111554, Blast_Score=147, Evalue=7e-37,
Organism=Escherichia coli, GI87082415, Length=250, Percent_Identity=28.8, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1789620, Length=280, Percent_Identity=27.8571428571429, Blast_Score=112, Evalue=3e-26,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31912; Mature: 31912

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKGSCVALITPFTEDGVNYEELRKLLEWHIKNHTDAILVCGTTGEGSTMTLEEKKEVIK
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEHHHHHHHHH
FSVEVVNKRVPVIAGTGTNNTKASIELSKYAEEVGADMVLIITPYYNKTSQKGLYAHFSA
HHHHHHCCCCCEEEECCCCCCEEEEEHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEHHH
INDAINIPIMLYNVPSRTGMNITPLMLDKLADLNNVVAIKEASGDLSQVAKMAELCGDRI
HCCCCCCCEEEEECCCCCCCEEHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCEE
AIYSGNDDQIVPILSLGGAGVVSVLANILPEETHNICEKYFLGEVIESRNLQLKYLSLAN
EEEECCCCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECC
SLFIETNPIPVKTAMNLMNFNCGPLRLPLCEMEDSNLIILEENLKANGLIK
EEEEECCCCCHHHHHHHHCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCC
>Mature Secondary Structure
MFKGSCVALITPFTEDGVNYEELRKLLEWHIKNHTDAILVCGTTGEGSTMTLEEKKEVIK
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEHHHHHHHHH
FSVEVVNKRVPVIAGTGTNNTKASIELSKYAEEVGADMVLIITPYYNKTSQKGLYAHFSA
HHHHHHCCCCCEEEECCCCCCEEEEEHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEHHH
INDAINIPIMLYNVPSRTGMNITPLMLDKLADLNNVVAIKEASGDLSQVAKMAELCGDRI
HCCCCCCCEEEEECCCCCCCEEHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCEE
AIYSGNDDQIVPILSLGGAGVVSVLANILPEETHNICEKYFLGEVIESRNLQLKYLSLAN
EEEECCCCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECC
SLFIETNPIPVKTAMNLMNFNCGPLRLPLCEMEDSNLIILEENLKANGLIK
EEEEECCCCCHHHHHHHHCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA