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The map label for this gene is moeA [H]

Identifier: 18310775

GI number: 18310775

Start: 2071842

End: 2073062

Strand: Reverse

Name: moeA [H]

Synonym: CPE1793

Alternate gene names: 18310775

Gene position: 2073062-2071842 (Counterclockwise)

Preceding gene: 18310776

Following gene: 18310774

Centisome position: 68.39

GC content: 30.22

Gene sequence:

>1221_bases
TTGAAAAAATTTATAGCTTTAGAAGAAGCTCTTGAAATATTAAATAAGAACACTAAGGCTTTAAAAAGTGAGGTTGTTAG
CATAAAGGATTCTTTAAAGAGAGTTTTGTATGGTGATGTTAAATCTAAGATTAATAATCCTCCCTTTAATAAGTCAGTTT
TTGATGGATATGCTTTTAAATCAGAAGATTCTAAGGGAACTTCAAAAGAAAATCCTATAGAGCTTAAAATAGTAGATGAG
ATATTTGCAGGGATGTGGCCAGAAATAGAAATAAAACATGGAGAGGCTATTAGAATTATGACTGGGGCTCCAATCCCTAT
GGGAGCTGATTGCGTACTTAAGCAAGAAGAAACAGAAAGACATGGAGATTTGGTTAAAATATTTAAGGAAATGAAATCTT
ATGAGAATATATCTTTTATGGGAGAGGATATAAAGATTGGAGAAACTTTAATTAAAAAAGGTAAAAGACTTGATTATGCT
GATTTAGGTATAATGGCTAGCTCTGGTATAAGTGAGGTACTTGTTTATAAAAAGCCAAGAGTTTCAATAATTAGCACAGG
TGATGAGGTATGTGATATAAATTCCACCTTAAAACCAGGAAAAATATATGACAGTAATTTATATAGTTTAAGTGCAAGAA
TTGAAGAGCTAGGATACAATGTTTTGTCTATGGAACATGTAGGAGACAATATCTTAAAAATAGGAGAAGCCATAGAAAAA
GCCTTTGAAAAATCAGATATAGTATTTACTACAGGAGGAGCTTCTGTAGGAGAAAAGGATCTTATGCAAAAGGTTTCTGA
AAGTATAGGCTTTGAAAAGTTATTTTGGAAAATAAAAATTAAACCTGGCTCTGCAGTTGTATGTAGCAAAAAGGAAGAAA
AAATATTAATAAGCCTTTCTGGAAATCCTAATGCTGCCTTAACTACATTTGAATTATTAGGAAAGCCTGTACTTAAAAAA
TTAGAGGGAGAGGAAGAAAATATAAATATTAAAAGAGAAAAGGGAGTCTTAATGGATTCTTTTAATAAAAAAAGCCCTCA
AAGAAGATTTTTAAGAGGGAATGTTATATATGATGAAAAGGGAACAAAGGTTTATATAACTCAAATTAAAAGTGGAAATG
GTATATTAAGTTCTCTTCTAAATGCCAATTGCTTAATAGAAATTGAAAAAGGAAATGAAGGCTTAAATAGAGGAGAGGTA
GTAAACATAATAAAATTATAA

Upstream 100 bases:

>100_bases
AATATTAAGGTCTAAAAGGACTATTTAATTTAATGCTTATTATTCTTGTTGGTATAACAAAAATAATAAGCATTTTATTT
TATAAAGGGATGGTGATATT

Downstream 100 bases:

>100_bases
ATAAATAATTAGCTTAAAAATAAGTTTATAGGAGGTGTATTAAGGTGATAAAAAAGAGTGCTGCTATTTTAGCAGGAGGG
AAAAGTAGTAGAATGAATTA

Product: molybdenum cofactor biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MKKFIALEEALEILNKNTKALKSEVVSIKDSLKRVLYGDVKSKINNPPFNKSVFDGYAFKSEDSKGTSKENPIELKIVDE
IFAGMWPEIEIKHGEAIRIMTGAPIPMGADCVLKQEETERHGDLVKIFKEMKSYENISFMGEDIKIGETLIKKGKRLDYA
DLGIMASSGISEVLVYKKPRVSIISTGDEVCDINSTLKPGKIYDSNLYSLSARIEELGYNVLSMEHVGDNILKIGEAIEK
AFEKSDIVFTTGGASVGEKDLMQKVSESIGFEKLFWKIKIKPGSAVVCSKKEEKILISLSGNPNAALTTFELLGKPVLKK
LEGEEENINIKREKGVLMDSFNKKSPQRRFLRGNVIYDEKGTKVYITQIKSGNGILSSLLNANCLIEIEKGNEGLNRGEV
VNIIKL

Sequences:

>Translated_406_residues
MKKFIALEEALEILNKNTKALKSEVVSIKDSLKRVLYGDVKSKINNPPFNKSVFDGYAFKSEDSKGTSKENPIELKIVDE
IFAGMWPEIEIKHGEAIRIMTGAPIPMGADCVLKQEETERHGDLVKIFKEMKSYENISFMGEDIKIGETLIKKGKRLDYA
DLGIMASSGISEVLVYKKPRVSIISTGDEVCDINSTLKPGKIYDSNLYSLSARIEELGYNVLSMEHVGDNILKIGEAIEK
AFEKSDIVFTTGGASVGEKDLMQKVSESIGFEKLFWKIKIKPGSAVVCSKKEEKILISLSGNPNAALTTFELLGKPVLKK
LEGEEENINIKREKGVLMDSFNKKSPQRRFLRGNVIYDEKGTKVYITQIKSGNGILSSLLNANCLIEIEKGNEGLNRGEV
VNIIKL
>Mature_406_residues
MKKFIALEEALEILNKNTKALKSEVVSIKDSLKRVLYGDVKSKINNPPFNKSVFDGYAFKSEDSKGTSKENPIELKIVDE
IFAGMWPEIEIKHGEAIRIMTGAPIPMGADCVLKQEETERHGDLVKIFKEMKSYENISFMGEDIKIGETLIKKGKRLDYA
DLGIMASSGISEVLVYKKPRVSIISTGDEVCDINSTLKPGKIYDSNLYSLSARIEELGYNVLSMEHVGDNILKIGEAIEK
AFEKSDIVFTTGGASVGEKDLMQKVSESIGFEKLFWKIKIKPGSAVVCSKKEEKILISLSGNPNAALTTFELLGKPVLKK
LEGEEENINIKREKGVLMDSFNKKSPQRRFLRGNVIYDEKGTKVYITQIKSGNGILSSLLNANCLIEIEKGNEGLNRGEV
VNIIKL

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=422, Percent_Identity=31.7535545023697, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI66932975, Length=422, Percent_Identity=31.7535545023697, Blast_Score=198, Evalue=6e-51,
Organism=Escherichia coli, GI1787049, Length=389, Percent_Identity=35.4755784061697, Blast_Score=214, Evalue=9e-57,
Organism=Caenorhabditis elegans, GI25147659, Length=334, Percent_Identity=31.1377245508982, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17562606, Length=410, Percent_Identity=26.3414634146341, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17136978, Length=367, Percent_Identity=29.9727520435967, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24638841, Length=367, Percent_Identity=29.9727520435967, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 45096; Mature: 45096

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFIALEEALEILNKNTKALKSEVVSIKDSLKRVLYGDVKSKINNPPFNKSVFDGYAFK
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCEEEC
SEDSKGTSKENPIELKIVDEIFAGMWPEIEIKHGEAIRIMTGAPIPMGADCVLKQEETER
CCCCCCCCCCCCEEEEEHHHHHCCCCCCEEEECCCEEEEEECCCCCCCCCEEEECHHHHH
HGDLVKIFKEMKSYENISFMGEDIKIGETLIKKGKRLDYADLGIMASSGISEVLVYKKPR
CCHHHHHHHHHHHCCCCEECCCCCCHHHHHHHCCCCCCHHHHCEEECCCCCEEEEECCCC
VSIISTGDEVCDINSTLKPGKIYDSNLYSLSARIEELGYNVLSMEHVGDNILKIGEAIEK
EEEEECCCCEEECCCCCCCCCEECCCHHHHHHHHHHHCCCEEEHHHHCHHHHHHHHHHHH
AFEKSDIVFTTGGASVGEKDLMQKVSESIGFEKLFWKIKIKPGSAVVCSKKEEKILISLS
HHCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEEEECCCCEEEECCCCCEEEEEEC
GNPNAALTTFELLGKPVLKKLEGEEENINIKREKGVLMDSFNKKSPQRRFLRGNVIYDEK
CCCCCHHHHHHHHCHHHHHHHCCCCCCCCEEHHCCCCHHCCCCCCCHHHHHCCCEEEECC
GTKVYITQIKSGNGILSSLLNANCLIEIEKGNEGLNRGEVVNIIKL
CCEEEEEEEECCCHHHHHHCCCEEEEEEECCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MKKFIALEEALEILNKNTKALKSEVVSIKDSLKRVLYGDVKSKINNPPFNKSVFDGYAFK
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCEEEC
SEDSKGTSKENPIELKIVDEIFAGMWPEIEIKHGEAIRIMTGAPIPMGADCVLKQEETER
CCCCCCCCCCCCEEEEEHHHHHCCCCCCEEEECCCEEEEEECCCCCCCCCEEEECHHHHH
HGDLVKIFKEMKSYENISFMGEDIKIGETLIKKGKRLDYADLGIMASSGISEVLVYKKPR
CCHHHHHHHHHHHCCCCEECCCCCCHHHHHHHCCCCCCHHHHCEEECCCCCEEEEECCCC
VSIISTGDEVCDINSTLKPGKIYDSNLYSLSARIEELGYNVLSMEHVGDNILKIGEAIEK
EEEEECCCCEEECCCCCCCCCEECCCHHHHHHHHHHHCCCEEEHHHHCHHHHHHHHHHHH
AFEKSDIVFTTGGASVGEKDLMQKVSESIGFEKLFWKIKIKPGSAVVCSKKEEKILISLS
HHCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEEEECCCCEEEECCCCCEEEEEEC
GNPNAALTTFELLGKPVLKKLEGEEENINIKREKGVLMDSFNKKSPQRRFLRGNVIYDEK
CCCCCHHHHHHHHCHHHHHHHCCCCCCCCEEHHCCCCHHCCCCCCCHHHHHCCCEEEECC
GTKVYITQIKSGNGILSSLLNANCLIEIEKGNEGLNRGEVVNIIKL
CCEEEEEEEECCCHHHHHHCCCEEEEEEECCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA