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The map label for this gene is coaBC [H]

Identifier: 18310728

GI number: 18310728

Start: 2023888

End: 2025075

Strand: Reverse

Name: coaBC [H]

Synonym: CPE1746

Alternate gene names: 18310728

Gene position: 2025075-2023888 (Counterclockwise)

Preceding gene: 18310729

Following gene: 18310727

Centisome position: 66.8

GC content: 32.74

Gene sequence:

>1188_bases
ATGAAAGATAAGAAATGTGTTGTTGTAGGAGTAAGTGGAGGAGTAGCTGTTTATAAAGCCTTAGACGTTATAAGCAGACT
AAGAAAAAAAGATGTAGAAGTACATGTAATAATGACTAAATCCGCTACTGAGTTTGTAACACCATTATCTTTTCAATCAT
TAAGCCAAAACATGGTTATAACAGATATGTTTGCTGAACCAAAGGCTTGGGAAATACAGCATATATCACTAGCAAAGAAA
GCAGATTTAATGCTTATTGTACCAGCTACAGCAAACATTATAGGAAAGGTTGCAAATGGCATAGCTGACGATATGTTATC
AACAACTATAATGGCAACAAAGGCGCCAGTTGTTTTTTGCCCTGCAATGAATACAAACATGTATGAAAATCCTATAGTTC
AAAGGAACATAAGTCTTCTAAAGGAGCTTGGTTATGAATTTATAGAGCCAGCTAGTGGAAGATTAGCATGTGGTGATGAG
GGGAAAGGTAAACTTCAAGATACCGAAATTATTGCAGAAGAAACATTGAGAAGGTTACATTCTACTAAGGATTTACTTGG
TAAGAAGGTTGTTGTTACTGCAGGACCTACTATAGTGCCAATAGATCCAGTAAGAATTTTAACAAATAGATCTTCAGGTA
AAATGGGATACTCAATAGCAGAGGAAGCGAGAGATAGGGGAGCAGAAGTTGTTCTTATATCAGGACCTACTTCTTTAAGA
AAACCTAATGGAATTAAAGTTATTGATATAAAGACAAATGAAGATATGTTTAATGCTATAAAAAATGAATTTAAAGATGC
TGATATAGTTATTAAGTCAGCAGCTGTGGCTGATTATAAAGCTAAAAATTATAGCAATGAAAAGATTAAAAAAACAGGTG
ATGATTTAAATTTAATTTTTGAGAGAGATAGAGATATTCTAAAAACTCTTGGAGATATGAAAGAAAATCAAATTCTAGTA
GGCTTTGCAGCAGAAAGTAGCAACTTAAAAGAAAACGCTAAAGGTAAACTGGATAGGAAAAATCTAGATTATATTGTTGC
AAATGACATAAGTAAGTCAGAAACAGGTTTTGCAAGTGATGAAAATAAAGTTACTATAATAAGCAAATCTGGTGAAGAGG
TATCTTTAGAAAAGATGTCTAAAAGAGAAGTTGCAAAGAATATATTTGACATTATAAAAGGGCGCTAA

Upstream 100 bases:

>100_bases
CTTTTGTTGATGTTGAGTCAAATAAGCCATTAACAATAGCTATAAATGAAATAGATGAAGGATTTGTAAATTACAAAGAC
ACTGAGGAGAAATAAGAGCT

Downstream 100 bases:

>100_bases
TTGCGCCTTTTTATTCTATATGAACAAGGGTGATTATTTTGGAGAAATTTGCTGAAGTAATTGTAAATAGTGAAGCTGTT
ACAATTGATAAGCCTTTTAC

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MKDKKCVVVGVSGGVAVYKALDVISRLRKKDVEVHVIMTKSATEFVTPLSFQSLSQNMVITDMFAEPKAWEIQHISLAKK
ADLMLIVPATANIIGKVANGIADDMLSTTIMATKAPVVFCPAMNTNMYENPIVQRNISLLKELGYEFIEPASGRLACGDE
GKGKLQDTEIIAEETLRRLHSTKDLLGKKVVVTAGPTIVPIDPVRILTNRSSGKMGYSIAEEARDRGAEVVLISGPTSLR
KPNGIKVIDIKTNEDMFNAIKNEFKDADIVIKSAAVADYKAKNYSNEKIKKTGDDLNLIFERDRDILKTLGDMKENQILV
GFAAESSNLKENAKGKLDRKNLDYIVANDISKSETGFASDENKVTIISKSGEEVSLEKMSKREVAKNIFDIIKGR

Sequences:

>Translated_395_residues
MKDKKCVVVGVSGGVAVYKALDVISRLRKKDVEVHVIMTKSATEFVTPLSFQSLSQNMVITDMFAEPKAWEIQHISLAKK
ADLMLIVPATANIIGKVANGIADDMLSTTIMATKAPVVFCPAMNTNMYENPIVQRNISLLKELGYEFIEPASGRLACGDE
GKGKLQDTEIIAEETLRRLHSTKDLLGKKVVVTAGPTIVPIDPVRILTNRSSGKMGYSIAEEARDRGAEVVLISGPTSLR
KPNGIKVIDIKTNEDMFNAIKNEFKDADIVIKSAAVADYKAKNYSNEKIKKTGDDLNLIFERDRDILKTLGDMKENQILV
GFAAESSNLKENAKGKLDRKNLDYIVANDISKSETGFASDENKVTIISKSGEEVSLEKMSKREVAKNIFDIIKGR
>Mature_395_residues
MKDKKCVVVGVSGGVAVYKALDVISRLRKKDVEVHVIMTKSATEFVTPLSFQSLSQNMVITDMFAEPKAWEIQHISLAKK
ADLMLIVPATANIIGKVANGIADDMLSTTIMATKAPVVFCPAMNTNMYENPIVQRNISLLKELGYEFIEPASGRLACGDE
GKGKLQDTEIIAEETLRRLHSTKDLLGKKVVVTAGPTIVPIDPVRILTNRSSGKMGYSIAEEARDRGAEVVLISGPTSLR
KPNGIKVIDIKTNEDMFNAIKNEFKDADIVIKSAAVADYKAKNYSNEKIKKTGDDLNLIFERDRDILKTLGDMKENQILV
GFAAESSNLKENAKGKLDRKNLDYIVANDISKSETGFASDENKVTIISKSGEEVSLEKMSKREVAKNIFDIIKGR

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=185, Percent_Identity=36.7567567567568, Blast_Score=117, Evalue=3e-26,
Organism=Escherichia coli, GI87082301, Length=375, Percent_Identity=42.1333333333333, Blast_Score=281, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI17560194, Length=167, Percent_Identity=33.5329341317365, Blast_Score=92, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6322762, Length=203, Percent_Identity=31.0344827586207, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24657262, Length=194, Percent_Identity=31.4432989690722, Blast_Score=99, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43400; Mature: 43400

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDKKCVVVGVSGGVAVYKALDVISRLRKKDVEVHVIMTKSATEFVTPLSFQSLSQNMVI
CCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHCCCCHHHHCCCEEE
TDMFAEPKAWEIQHISLAKKADLMLIVPATANIIGKVANGIADDMLSTTIMATKAPVVFC
EEECCCCCCCEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHEECCCEEEE
PAMNTNMYENPIVQRNISLLKELGYEFIEPASGRLACGDEGKGKLQDTEIIAEETLRRLH
ECCCCCCCCCCHHHHHHHHHHHCCHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHH
STKDLLGKKVVVTAGPTIVPIDPVRILTNRSSGKMGYSIAEEARDRGAEVVLISGPTSLR
HHHHHHCCEEEEEECCEEEECCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCCC
KPNGIKVIDIKTNEDMFNAIKNEFKDADIVIKSAAVADYKAKNYSNEKIKKTGDDLNLIF
CCCCEEEEEEECCHHHHHHHHHHCCCCCEEEEEHHHHHHHHCCCCCCHHHHCCCCEEEEE
ERDRDILKTLGDMKENQILVGFAAESSNLKENAKGKLDRKNLDYIVANDISKSETGFASD
CCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCC
ENKVTIISKSGEEVSLEKMSKREVAKNIFDIIKGR
CCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKDKKCVVVGVSGGVAVYKALDVISRLRKKDVEVHVIMTKSATEFVTPLSFQSLSQNMVI
CCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHCCCCHHHHCCCEEE
TDMFAEPKAWEIQHISLAKKADLMLIVPATANIIGKVANGIADDMLSTTIMATKAPVVFC
EEECCCCCCCEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHEECCCEEEE
PAMNTNMYENPIVQRNISLLKELGYEFIEPASGRLACGDEGKGKLQDTEIIAEETLRRLH
ECCCCCCCCCCHHHHHHHHHHHCCHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHH
STKDLLGKKVVVTAGPTIVPIDPVRILTNRSSGKMGYSIAEEARDRGAEVVLISGPTSLR
HHHHHHCCEEEEEECCEEEECCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCCC
KPNGIKVIDIKTNEDMFNAIKNEFKDADIVIKSAAVADYKAKNYSNEKIKKTGDDLNLIF
CCCCEEEEEEECCHHHHHHHHHHCCCCCEEEEEHHHHHHHHCCCCCCHHHHCCCCEEEEE
ERDRDILKTLGDMKENQILVGFAAESSNLKENAKGKLDRKNLDYIVANDISKSETGFASD
CCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCC
ENKVTIISKSGEEVSLEKMSKREVAKNIFDIIKGR
CCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]