Click here to switch to the map view.

The map label for this gene is thiN [H]

Identifier: 18310717

GI number: 18310717

Start: 2011946

End: 2012575

Strand: Reverse

Name: thiN [H]

Synonym: CPE1735

Alternate gene names: 18310717

Gene position: 2012575-2011946 (Counterclockwise)

Preceding gene: 18310718

Following gene: 18310715

Centisome position: 66.39

GC content: 28.1

Gene sequence:

>630_bases
ATGAAAGTTCTTATAATAGCTGGGGGAGAAAAGCCTAGTAGTGAGTTATTAAAAAGTGAAATTAAAGAGTGTGACTTATT
AATAGCTGCTGATAGGGGAGCTGAAGCCTATTTAGAAAATGGATTTACTCCAGATTATGCCCTAGGAGACTTTGATTCTA
TAGGAGAAGAATATAAGGATATATTAGATAAAATAAAAGTAGAAAAATTTAATCCTGAGAAGGATAATACTGATACAGAG
ATTGCTTTTTTTAAAGCAGTTGAATTAGGAGCTACAGAAATTGTCTTCTTAGGGGTTACAGGAACAAGATTAGATCATGT
TATGGCTAATTTAGGACTTTTAAGAGAAGCTTTAGAGAGAGGTATTGAGGCATATATTATTGATAATAATAATAAAATTT
ACCTAAAGAATAAAGAGACAACTCTAAAAAAAGAATTTGGTGATTATATATCATTTCAAGCTTTTGGTTCTCCAGTAAAT
AATTTTTCTATAAAAGGTTCTAAATATGAACTTTATAATCATAAACTTTTAATAGGAGATTCATTATGTGTGTCTAATGA
GTTTAATGATGAATATATTGATATATCTTTTGAAAAAGGTGAAGTTTTAGTTATATATTCAAGAGATTAA

Upstream 100 bases:

>100_bases
ATAGTAGAAGCTGGAGCTAATGTTTTAGTTGCTGGATCAGCTGTATTTAAAGAAGATAAAATAGAAGAAAACATTAAAGC
TTTAAGAGAGGCACTATAAA

Downstream 100 bases:

>100_bases
ACACAATTTGAGTTTCTTCTGCATAAAATAAAATAAGAAATAATTTTAAAGGTAGGAGAGAGTTTATGAGAATAATGACT
ATTAAATTACCAAAGTTCTT

Product: thiamine pyrophosphokinase

Products: NA

Alternate protein names: TPK; Thiamine diphosphokinase [H]

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MKVLIIAGGEKPSSELLKSEIKECDLLIAADRGAEAYLENGFTPDYALGDFDSIGEEYKDILDKIKVEKFNPEKDNTDTE
IAFFKAVELGATEIVFLGVTGTRLDHVMANLGLLREALERGIEAYIIDNNNKIYLKNKETTLKKEFGDYISFQAFGSPVN
NFSIKGSKYELYNHKLLIGDSLCVSNEFNDEYIDISFEKGEVLVIYSRD

Sequences:

>Translated_209_residues
MKVLIIAGGEKPSSELLKSEIKECDLLIAADRGAEAYLENGFTPDYALGDFDSIGEEYKDILDKIKVEKFNPEKDNTDTE
IAFFKAVELGATEIVFLGVTGTRLDHVMANLGLLREALERGIEAYIIDNNNKIYLKNKETTLKKEFGDYISFQAFGSPVN
NFSIKGSKYELYNHKLLIGDSLCVSNEFNDEYIDISFEKGEVLVIYSRD
>Mature_209_residues
MKVLIIAGGEKPSSELLKSEIKECDLLIAADRGAEAYLENGFTPDYALGDFDSIGEEYKDILDKIKVEKFNPEKDNTDTE
IAFFKAVELGATEIVFLGVTGTRLDHVMANLGLLREALERGIEAYIIDNNNKIYLKNKETTLKKEFGDYISFQAFGSPVN
NFSIKGSKYELYNHKLLIGDSLCVSNEFNDEYIDISFEKGEVLVIYSRD

Specific function: Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate [H]

COG id: COG1564

COG function: function code H; Thiamine pyrophosphokinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine pyrophosphokinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006282
- InterPro:   IPR007373
- InterPro:   IPR007371 [H]

Pfam domain/function: PF04263 TPK_catalytic [H]

EC number: =2.7.6.2 [H]

Molecular weight: Translated: 23508; Mature: 23508

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLIIAGGEKPSSELLKSEIKECDLLIAADRGAEAYLENGFTPDYALGDFDSIGEEYKD
CEEEEEECCCCCHHHHHHHHHHHCEEEEEECCCCHHHHHCCCCCCCCCCCHHHHHHHHHH
ILDKIKVEKFNPEKDNTDTEIAFFKAVELGATEIVFLGVTGTRLDHVMANLGLLREALER
HHHHHCCCCCCCCCCCCCCEEEEEEEEECCCEEEEEEECCCHHHHHHHHHHHHHHHHHHC
GIEAYIIDNNNKIYLKNKETTLKKEFGDYISFQAFGSPVNNFSIKGSKYELYNHKLLIGD
CCEEEEEECCCEEEEECCCHHHHHHHCCCEEEEECCCCCCCEEECCCEEEEECCEEEEEC
SLCVSNEFNDEYIDISFEKGEVLVIYSRD
CEEECCCCCCCEEEEEECCCCEEEEEECC
>Mature Secondary Structure
MKVLIIAGGEKPSSELLKSEIKECDLLIAADRGAEAYLENGFTPDYALGDFDSIGEEYKD
CEEEEEECCCCCHHHHHHHHHHHCEEEEEECCCCHHHHHCCCCCCCCCCCHHHHHHHHHH
ILDKIKVEKFNPEKDNTDTEIAFFKAVELGATEIVFLGVTGTRLDHVMANLGLLREALER
HHHHHCCCCCCCCCCCCCCEEEEEEEEECCCEEEEEEECCCHHHHHHHHHHHHHHHHHHC
GIEAYIIDNNNKIYLKNKETTLKKEFGDYISFQAFGSPVNNFSIKGSKYELYNHKLLIGD
CCEEEEEECCCEEEEECCCHHHHHHHCCCEEEEECCCCCCCEEECCCEEEEECCEEEEEC
SLCVSNEFNDEYIDISFEKGEVLVIYSRD
CEEECCCCCCCEEEEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]