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The map label for this gene is rnc

Identifier: 18310700

GI number: 18310700

Start: 1997415

End: 1998128

Strand: Reverse

Name: rnc

Synonym: CPE1718

Alternate gene names: 18310700

Gene position: 1998128-1997415 (Counterclockwise)

Preceding gene: 18310701

Following gene: 18310699

Centisome position: 65.91

GC content: 27.45

Gene sequence:

>714_bases
GTGAAAGATATAAATTTAATAGAAGTTGAAAAACTTATAGGAATTGAGTTTGAAAACAAAGGAGTGCTTATAACAGCATT
AACGCATAGTTCATATGCAAATCAATTTAAAGATGTAAAATATAATGAAAGATTAGAATTTTTAGGAGATTCAGTTTTAC
AGCTTTGTGTTACAAAATATTTATTTAATAATTACAAAGATAAATCTGAAGGTGAATTAACAAAAATAAGAGCTTTAGTA
GTTTGTGAAAATTCTTTACATAAAGTTTCAAAAAATCTATCACTTGGTAAGTATATAAGAATGAGTAAAGGTGAGGAGCT
AACTGGAGGAAGAGAAAGAACTTCAATACAAGCTGATGCATTAGAAGCAGTAATTGCTGCAGTTTATTTAGATAAAGGAA
TTGAAGTTGCAAATGACTTTATTTTAAGAAACTTCAAAGATGTTATAGATAAGGCTATAAATGAAGAAATAATATTAGAC
TTTAAAACTAGATTACAAGAAGTTCTTCAAAAAAATGGGGAAGTTAATATTGTTTATAATTTAGTTAAGCATGAAGGACC
ACCTCACAGAAGAAAATTCTTTACAGACCTTTTAATTAATAATGAGATTATGGGTCAAGGTGTTGGATTTAGTAAAAAAG
AATCAGAACAAAATGCAGCTAAAGCAGCACTACAAAGGTTAGGTGAAATTAAATGGGAAAAAGACACTATATAA

Upstream 100 bases:

>100_bases
AATAAAGTCCCGCAATAAGCGGGATTTTTAATTTAAGTTTATTCTTGAAGTTGTTTCACAAACAACTTGAAGAATAAACC
TTAAGGAGATGAATTTTAAG

Downstream 100 bases:

>100_bases
TCCCAATTTTTGTTCCTCATGAAGGATGTCCACATGATTGCGTGTTTTGTAATCAAGGGAAAATAACTGGAGAAAATAAA
GAGATTATATTAGGGCCAAA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MKDINLIEVEKLIGIEFENKGVLITALTHSSYANQFKDVKYNERLEFLGDSVLQLCVTKYLFNNYKDKSEGELTKIRALV
VCENSLHKVSKNLSLGKYIRMSKGEELTGGRERTSIQADALEAVIAAVYLDKGIEVANDFILRNFKDVIDKAINEEIILD
FKTRLQEVLQKNGEVNIVYNLVKHEGPPHRRKFFTDLLINNEIMGQGVGFSKKESEQNAAKAALQRLGEIKWEKDTI

Sequences:

>Translated_237_residues
MKDINLIEVEKLIGIEFENKGVLITALTHSSYANQFKDVKYNERLEFLGDSVLQLCVTKYLFNNYKDKSEGELTKIRALV
VCENSLHKVSKNLSLGKYIRMSKGEELTGGRERTSIQADALEAVIAAVYLDKGIEVANDFILRNFKDVIDKAINEEIILD
FKTRLQEVLQKNGEVNIVYNLVKHEGPPHRRKFFTDLLINNEIMGQGVGFSKKESEQNAAKAALQRLGEIKWEKDTI
>Mature_237_residues
MKDINLIEVEKLIGIEFENKGVLITALTHSSYANQFKDVKYNERLEFLGDSVLQLCVTKYLFNNYKDKSEGELTKIRALV
VCENSLHKVSKNLSLGKYIRMSKGEELTGGRERTSIQADALEAVIAAVYLDKGIEVANDFILRNFKDVIDKAINEEIILD
FKTRLQEVLQKNGEVNIVYNLVKHEGPPHRRKFFTDLLINNEIMGQGVGFSKKESEQNAAKAALQRLGEIKWEKDTI

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030236, Length=256, Percent_Identity=31.25, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI155030234, Length=256, Percent_Identity=31.25, Blast_Score=105, Evalue=4e-23,
Organism=Escherichia coli, GI1788920, Length=232, Percent_Identity=33.6206896551724, Blast_Score=113, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17506883, Length=234, Percent_Identity=27.7777777777778, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI193202651, Length=234, Percent_Identity=27.7777777777778, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17137682, Length=226, Percent_Identity=29.646017699115, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_CLOPE (Q8XJN8)

Other databases:

- EMBL:   BA000016
- RefSeq:   NP_562634.1
- ProteinModelPortal:   Q8XJN8
- SMR:   Q8XJN8
- GeneID:   990028
- GenomeReviews:   BA000016_GR
- KEGG:   cpe:CPE1718
- NMPDR:   fig|195102.1.peg.1781
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- PhylomeDB:   Q8XJN8
- ProtClustDB:   PRK00102
- BioCyc:   CPER195102:CPE1718-MONOMER
- BRENDA:   3.1.26.3
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 26981; Mature: 26981

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDINLIEVEKLIGIEFENKGVLITALTHSSYANQFKDVKYNERLEFLGDSVLQLCVTKY
CCCCCHHHHHHHHCEEECCCCEEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LFNNYKDKSEGELTKIRALVVCENSLHKVSKNLSLGKYIRMSKGEELTGGRERTSIQADA
HHHCCCCCCCCHHHHHHHHEEECHHHHHHHHCCCHHHHHCCCCCCCCCCCCHHHHHHHHH
LEAVIAAVYLDKGIEVANDFILRNFKDVIDKAINEEIILDFKTRLQEVLQKNGEVNIVYN
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEE
LVKHEGPPHRRKFFTDLLINNEIMGQGVGFSKKESEQNAAKAALQRLGEIKWEKDTI
EECCCCCCHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKDINLIEVEKLIGIEFENKGVLITALTHSSYANQFKDVKYNERLEFLGDSVLQLCVTKY
CCCCCHHHHHHHHCEEECCCCEEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LFNNYKDKSEGELTKIRALVVCENSLHKVSKNLSLGKYIRMSKGEELTGGRERTSIQADA
HHHCCCCCCCCHHHHHHHHEEECHHHHHHHHCCCHHHHHCCCCCCCCCCCCHHHHHHHHH
LEAVIAAVYLDKGIEVANDFILRNFKDVIDKAINEEIILDFKTRLQEVLQKNGEVNIVYN
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEE
LVKHEGPPHRRKFFTDLLINNEIMGQGVGFSKKESEQNAAKAALQRLGEIKWEKDTI
EECCCCCCHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792842