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The map label for this gene is ffh [H]

Identifier: 18310695

GI number: 18310695

Start: 1989788

End: 1991146

Strand: Reverse

Name: ffh [H]

Synonym: CPE1713

Alternate gene names: 18310695

Gene position: 1991146-1989788 (Counterclockwise)

Preceding gene: 18310696

Following gene: 18310694

Centisome position: 65.68

GC content: 32.52

Gene sequence:

>1359_bases
ATGGCTTTTGATGGATTAGCGTCTAAATTACAAGACACGCTTAAAAAATTAAAGGGTAAAGGTAAGCTAACAGAAAAAGA
TATAAAAGAAGCCATGAGAGAAGTAAAGCTTGCGCTTTTAGAGGCAGATGTTAACTTCAAGGTGGTAAAAAAGTTTATAT
CAAATGTTAAAGATAAATGTGTTGGTGAGGAAGTATTAAATAGTTTAACTCCAGGTCAACAGGTTATTAAAATAGTTAAT
GACGAATTAACAACTCTTATGGGAGAGACTGAGAGTAAATTAAAATACTCAGACAATGGACCAACAGTGTTCATGTTAGT
AGGTCTTCAAGGTGCAGGTAAAACAACTATGGCTGGAAAACTTGCATTGCACTTAAGAAAGAAAAACAAAAAGCCATTAC
TTGTGGCTTGTGATATATATAGACCTGCAGCTATAAAGCAATTACAGGTTGTAGGAAAACAAATAGATATACCAGTATTC
TCAATGGGAGATAAGGTTAAGGCTGTAGATATTGCCAAAGCTGCAATAGAGCATGCAAAAGACAATGGAAATAACGTTGT
TATAATAGATACCGCTGGTAGACTTCATATAGATGAAGATTTAATGCAAGAGTTAAAAGATGTTAAAGAAGTTTCAAATC
CTAGTGAAATATTATTAGTAGTTGATGCTATGACAGGTCAAGATGCTGTTAATGTAGCTGAGACATTTAATAACTCATTA
GATCTTTCGGGAATAATATTAACAAAGTTAGATGGTGATACAAGAGGTGGTGCTGCTCTTTCAATAAGAGACATTACTGG
TAAACCAATTAAATTTGTTGGTGTTGGTGAAAAGATGAGTGATATTGAAGTATTCCATCCAGATAGAATGGCTTCAAGAA
TATTAGGAATGGGAGATGTCCTTTCTTTAATAGAAAAAGCTCAGCAAGCTATTGACCAAGATGAAGCAAGTAAGTTAAGT
GAAAAAATGTTAAATCAAGAATTTAACTTTGATGACTACTTATCAGCTATGGATCAAATGAAAAAGCTTGGACCTATAAA
TAAATTGATAGAGATGATTCCAGGTGTTAACACAAAGGAACTTGAAGGCATTGATTTTTCTCAAGGAGAAAAACAAATGG
CTACAGTTAAAGCTATCATACAATCAATGACAGCTAAAGAAAGAAAACAACCTTCTTTAGTAATAGGAAATGGTTCAAGA
AAGAGAAGAATAGCTAAAGGTTCTGGTACAACAGTACAAGAAGTAAATAAAGTCTTAAAAGGCTATGAAATGATGAAAAA
GCAAATGAAGCAAATGAAATCATTCCAAAAAAATGCTAGTAAAAAGGGATTTTTAAGTAAACTTCCTTTTATGAAATAA

Upstream 100 bases:

>100_bases
TTATGGCAGAATTAAATAAGAACTCTAATTTAGATGAAAATATAAAAAAATATATAGATGAGAAATTAGAGGAAATTATA
AACGCTTAGGAGGGTTAAGC

Downstream 100 bases:

>100_bases
ATTGAACACACTTTTGAAGGAGGTGAAAATGTAATGGCAGTTAAAATAAGATTAAGAAGAATGGGTGCTCACAAAGCTCC
TTTCTACAGAGTAGTTGTTG

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MAFDGLASKLQDTLKKLKGKGKLTEKDIKEAMREVKLALLEADVNFKVVKKFISNVKDKCVGEEVLNSLTPGQQVIKIVN
DELTTLMGETESKLKYSDNGPTVFMLVGLQGAGKTTMAGKLALHLRKKNKKPLLVACDIYRPAAIKQLQVVGKQIDIPVF
SMGDKVKAVDIAKAAIEHAKDNGNNVVIIDTAGRLHIDEDLMQELKDVKEVSNPSEILLVVDAMTGQDAVNVAETFNNSL
DLSGIILTKLDGDTRGGAALSIRDITGKPIKFVGVGEKMSDIEVFHPDRMASRILGMGDVLSLIEKAQQAIDQDEASKLS
EKMLNQEFNFDDYLSAMDQMKKLGPINKLIEMIPGVNTKELEGIDFSQGEKQMATVKAIIQSMTAKERKQPSLVIGNGSR
KRRIAKGSGTTVQEVNKVLKGYEMMKKQMKQMKSFQKNASKKGFLSKLPFMK

Sequences:

>Translated_452_residues
MAFDGLASKLQDTLKKLKGKGKLTEKDIKEAMREVKLALLEADVNFKVVKKFISNVKDKCVGEEVLNSLTPGQQVIKIVN
DELTTLMGETESKLKYSDNGPTVFMLVGLQGAGKTTMAGKLALHLRKKNKKPLLVACDIYRPAAIKQLQVVGKQIDIPVF
SMGDKVKAVDIAKAAIEHAKDNGNNVVIIDTAGRLHIDEDLMQELKDVKEVSNPSEILLVVDAMTGQDAVNVAETFNNSL
DLSGIILTKLDGDTRGGAALSIRDITGKPIKFVGVGEKMSDIEVFHPDRMASRILGMGDVLSLIEKAQQAIDQDEASKLS
EKMLNQEFNFDDYLSAMDQMKKLGPINKLIEMIPGVNTKELEGIDFSQGEKQMATVKAIIQSMTAKERKQPSLVIGNGSR
KRRIAKGSGTTVQEVNKVLKGYEMMKKQMKQMKSFQKNASKKGFLSKLPFMK
>Mature_451_residues
AFDGLASKLQDTLKKLKGKGKLTEKDIKEAMREVKLALLEADVNFKVVKKFISNVKDKCVGEEVLNSLTPGQQVIKIVND
ELTTLMGETESKLKYSDNGPTVFMLVGLQGAGKTTMAGKLALHLRKKNKKPLLVACDIYRPAAIKQLQVVGKQIDIPVFS
MGDKVKAVDIAKAAIEHAKDNGNNVVIIDTAGRLHIDEDLMQELKDVKEVSNPSEILLVVDAMTGQDAVNVAETFNNSLD
LSGIILTKLDGDTRGGAALSIRDITGKPIKFVGVGEKMSDIEVFHPDRMASRILGMGDVLSLIEKAQQAIDQDEASKLSE
KMLNQEFNFDDYLSAMDQMKKLGPINKLIEMIPGVNTKELEGIDFSQGEKQMATVKAIIQSMTAKERKQPSLVIGNGSRK
RRIAKGSGTTVQEVNKVLKGYEMMKKQMKQMKSFQKNASKKGFLSKLPFMK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=449, Percent_Identity=32.9621380846325, Blast_Score=218, Evalue=9e-57,
Organism=Homo sapiens, GI226371618, Length=387, Percent_Identity=32.5581395348837, Blast_Score=189, Evalue=6e-48,
Organism=Homo sapiens, GI23308697, Length=300, Percent_Identity=27.6666666666667, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI295424842, Length=300, Percent_Identity=27.6666666666667, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI89061728, Length=156, Percent_Identity=37.8205128205128, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1788963, Length=427, Percent_Identity=50.5854800936768, Blast_Score=416, Evalue=1e-117,
Organism=Escherichia coli, GI1789874, Length=264, Percent_Identity=34.0909090909091, Blast_Score=164, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17539958, Length=437, Percent_Identity=29.2906178489703, Blast_Score=217, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI193206261, Length=297, Percent_Identity=29.96632996633, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6325345, Length=422, Percent_Identity=32.7014218009479, Blast_Score=219, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6320498, Length=316, Percent_Identity=30.0632911392405, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI17647949, Length=441, Percent_Identity=31.5192743764172, Blast_Score=204, Evalue=9e-53,
Organism=Drosophila melanogaster, GI24641198, Length=317, Percent_Identity=27.4447949526814, Blast_Score=118, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49686; Mature: 49555

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFDGLASKLQDTLKKLKGKGKLTEKDIKEAMREVKLALLEADVNFKVVKKFISNVKDKC
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VGEEVLNSLTPGQQVIKIVNDELTTLMGETESKLKYSDNGPTVFMLVGLQGAGKTTMAGK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHCCEECCCCCEEEEEEEECCCCCCHHHHH
LALHLRKKNKKPLLVACDIYRPAAIKQLQVVGKQIDIPVFSMGDKVKAVDIAKAAIEHAK
HHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHH
DNGNNVVIIDTAGRLHIDEDLMQELKDVKEVSNPSEILLVVDAMTGQDAVNVAETFNNSL
CCCCEEEEEECCCCEEECHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHCCCC
DLSGIILTKLDGDTRGGAALSIRDITGKPIKFVGVGEKMSDIEVFHPDRMASRILGMGDV
CCCEEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCCCEEECCHHHHHHHHCHHHH
LSLIEKAQQAIDQDEASKLSEKMLNQEFNFDDYLSAMDQMKKLGPINKLIEMIPGVNTKE
HHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCC
LEGIDFSQGEKQMATVKAIIQSMTAKERKQPSLVIGNGSRKRRIAKGSGTTVQEVNKVLK
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEECCCCCCCHHHHHHHHH
GYEMMKKQMKQMKSFQKNASKKGFLSKLPFMK
HHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCC
>Mature Secondary Structure 
AFDGLASKLQDTLKKLKGKGKLTEKDIKEAMREVKLALLEADVNFKVVKKFISNVKDKC
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VGEEVLNSLTPGQQVIKIVNDELTTLMGETESKLKYSDNGPTVFMLVGLQGAGKTTMAGK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHCCEECCCCCEEEEEEEECCCCCCHHHHH
LALHLRKKNKKPLLVACDIYRPAAIKQLQVVGKQIDIPVFSMGDKVKAVDIAKAAIEHAK
HHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHH
DNGNNVVIIDTAGRLHIDEDLMQELKDVKEVSNPSEILLVVDAMTGQDAVNVAETFNNSL
CCCCEEEEEECCCCEEECHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHCCCC
DLSGIILTKLDGDTRGGAALSIRDITGKPIKFVGVGEKMSDIEVFHPDRMASRILGMGDV
CCCEEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCCCEEECCHHHHHHHHCHHHH
LSLIEKAQQAIDQDEASKLSEKMLNQEFNFDDYLSAMDQMKKLGPINKLIEMIPGVNTKE
HHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCC
LEGIDFSQGEKQMATVKAIIQSMTAKERKQPSLVIGNGSRKRRIAKGSGTTVQEVNKVLK
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEECCCCCCCHHHHHHHHH
GYEMMKKQMKQMKSFQKNASKKGFLSKLPFMK
HHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]