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The map label for this gene is dxr [H]

Identifier: 18310676

GI number: 18310676

Start: 1972918

End: 1974072

Strand: Reverse

Name: dxr [H]

Synonym: CPE1694

Alternate gene names: 18310676

Gene position: 1974072-1972918 (Counterclockwise)

Preceding gene: 18310677

Following gene: 18310675

Centisome position: 65.12

GC content: 29.18

Gene sequence:

>1155_bases
ATGAAGAGAATATCTATACTAGGGGTAACAGGTTCTATAGGAACTCAAACTTTAGATGTATTAAGATTTCATAAAGAAGA
TTTTGAATTAGTTGGTATAACAGCTAATAGAAATATAGAATTAACATTGGATATAATAAAAGAGTTTTCACCTAAATACG
TTGCAATAAATCACGAAGAATCTTATAAAAAGCTTGTAGATTTAGTAAAAAGCGAAGGATTAAAATGTGAAGTTATCTAT
GGTATGGAAGGATTAGTTAAAGTTGCTACTTTAGATGAAATTGATATAGTTGTTACTTCTGTTGTTGGTATGATTGGATT
AAAACCAACTGTAGAAGCTATAAGAAAAGGAAAAGATATCGCTTTAGCAAATAAAGAAACTTTAGTAGTAGCAGGTGAAC
TTGTTATGAGAGAAGCTAAAGAAAATGGAGTGAAAATACTTCCAGTAGACTCAGAGCATAGTGCTATATTCCAATCATTA
CAAGGAAATGCTCATAACAAAATTGATAAAATACTTTTAACTGCTTCTGGAGGACCTTTTAGAGGATTTACTATAGAAGA
TTTAAAATCAGTAACTCCAGAAAGAGCTCTTAAGCATCCAAAATGGAATATGGGTCAAAAAATATCAATAGATTCATCAA
CTCTAATGAACAAGGGATTAGAAGTTATAGAAGCTCATTGGTTATTTGATTGTTCTTATAAAGATATAGAGGTTGTAGTT
CATCCACAATCAATAATACATTCTATGGTTCAATATACTGATGGAGCAGTTATAGCTCAATTAGGTGTACCAGATATGAA
ATTACCAATTCAATATGCTTTAAATTATCCAAATAGGGAAGGAAATATTAGTGAAAAGTTAGATTTATTTAAGATTAGAG
AGTTAACTTTTGAAAAGCCAGATTTAGATACATTTAAATGCTTAAAATTAGCTTATGAAGCAGGAGAAAAGGGAAAGCTT
ATGCCAACAATCTTAAATGGTGCAAATGAAGTATGTGTTGAACTATTCCTAAATAAAAAGATAACATATCTGCAAATACC
AGAGATAATAGAAGAGTGTATGAATACTTTTGATTACAACAAAGAGGTTACTCTTGATAATGTAATAAATTTAGACAAAG
AAGTAAGACAGTATATATATGAAAAATATAACTAG

Upstream 100 bases:

>100_bases
TATTATTGTATTTAGAGATATAATGATATAAAATAATATAATAGGCTAAGTAGATAATTTTAGTCTATTATGTTTAAGGA
AGAACTTAGGAGGAAAGAAT

Downstream 100 bases:

>100_bases
GAGGGAAAAGGGTGTATATAATTTTTGCTTTATTAGCATTTAGTGCTTTAATCTTAGTTCATGAGCTTGGACATTTTATT
GTGGCTAAATTAAATGGGAT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MKRISILGVTGSIGTQTLDVLRFHKEDFELVGITANRNIELTLDIIKEFSPKYVAINHEESYKKLVDLVKSEGLKCEVIY
GMEGLVKVATLDEIDIVVTSVVGMIGLKPTVEAIRKGKDIALANKETLVVAGELVMREAKENGVKILPVDSEHSAIFQSL
QGNAHNKIDKILLTASGGPFRGFTIEDLKSVTPERALKHPKWNMGQKISIDSSTLMNKGLEVIEAHWLFDCSYKDIEVVV
HPQSIIHSMVQYTDGAVIAQLGVPDMKLPIQYALNYPNREGNISEKLDLFKIRELTFEKPDLDTFKCLKLAYEAGEKGKL
MPTILNGANEVCVELFLNKKITYLQIPEIIEECMNTFDYNKEVTLDNVINLDKEVRQYIYEKYN

Sequences:

>Translated_384_residues
MKRISILGVTGSIGTQTLDVLRFHKEDFELVGITANRNIELTLDIIKEFSPKYVAINHEESYKKLVDLVKSEGLKCEVIY
GMEGLVKVATLDEIDIVVTSVVGMIGLKPTVEAIRKGKDIALANKETLVVAGELVMREAKENGVKILPVDSEHSAIFQSL
QGNAHNKIDKILLTASGGPFRGFTIEDLKSVTPERALKHPKWNMGQKISIDSSTLMNKGLEVIEAHWLFDCSYKDIEVVV
HPQSIIHSMVQYTDGAVIAQLGVPDMKLPIQYALNYPNREGNISEKLDLFKIRELTFEKPDLDTFKCLKLAYEAGEKGKL
MPTILNGANEVCVELFLNKKITYLQIPEIIEECMNTFDYNKEVTLDNVINLDKEVRQYIYEKYN
>Mature_384_residues
MKRISILGVTGSIGTQTLDVLRFHKEDFELVGITANRNIELTLDIIKEFSPKYVAINHEESYKKLVDLVKSEGLKCEVIY
GMEGLVKVATLDEIDIVVTSVVGMIGLKPTVEAIRKGKDIALANKETLVVAGELVMREAKENGVKILPVDSEHSAIFQSL
QGNAHNKIDKILLTASGGPFRGFTIEDLKSVTPERALKHPKWNMGQKISIDSSTLMNKGLEVIEAHWLFDCSYKDIEVVV
HPQSIIHSMVQYTDGAVIAQLGVPDMKLPIQYALNYPNREGNISEKLDLFKIRELTFEKPDLDTFKCLKLAYEAGEKGKL
MPTILNGANEVCVELFLNKKITYLQIPEIIEECMNTFDYNKEVTLDNVINLDKEVRQYIYEKYN

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=387, Percent_Identity=45.4780361757106, Blast_Score=352, Evalue=2e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 43223; Mature: 43223

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRISILGVTGSIGTQTLDVLRFHKEDFELVGITANRNIELTLDIIKEFSPKYVAINHEE
CCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCEEEEHHHHHHCCCCEEEECCHH
SYKKLVDLVKSEGLKCEVIYGMEGLVKVATLDEIDIVVTSVVGMIGLKPTVEAIRKGKDI
HHHHHHHHHHCCCCEEEEEECCCCEEEEEECCHHHHHHHHHHHHHCCCHHHHHHHCCCCE
ALANKETLVVAGELVMREAKENGVKILPVDSEHSAIFQSLQGNAHNKIDKILLTASGGPF
EEECCCEEEEEHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCCCCEEEEEEEECCCCC
RGFTIEDLKSVTPERALKHPKWNMGQKISIDSSTLMNKGLEVIEAHWLFDCSYKDIEVVV
CCCCHHHHHHCCHHHHHCCCCCCCCCEEECCHHHHHHCCHHHEEEEEEEECCCCCEEEEE
HPQSIIHSMVQYTDGAVIAQLGVPDMKLPIQYALNYPNREGNISEKLDLFKIRELTFEKP
CCHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCC
DLDTFKCLKLAYEAGEKGKLMPTILNGANEVCVELFLNKKITYLQIPEIIEECMNTFDYN
CCCHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHCCCCEEEECHHHHHHHHHHHCCC
KEVTLDNVINLDKEVRQYIYEKYN
CCEEHHHHHCCCHHHHHHHHHCCC
>Mature Secondary Structure
MKRISILGVTGSIGTQTLDVLRFHKEDFELVGITANRNIELTLDIIKEFSPKYVAINHEE
CCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCEEEEHHHHHHCCCCEEEECCHH
SYKKLVDLVKSEGLKCEVIYGMEGLVKVATLDEIDIVVTSVVGMIGLKPTVEAIRKGKDI
HHHHHHHHHHCCCCEEEEEECCCCEEEEEECCHHHHHHHHHHHHHCCCHHHHHHHCCCCE
ALANKETLVVAGELVMREAKENGVKILPVDSEHSAIFQSLQGNAHNKIDKILLTASGGPF
EEECCCEEEEEHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCCCCEEEEEEEECCCCC
RGFTIEDLKSVTPERALKHPKWNMGQKISIDSSTLMNKGLEVIEAHWLFDCSYKDIEVVV
CCCCHHHHHHCCHHHHHCCCCCCCCCEEECCHHHHHHCCHHHEEEEEEEECCCCCEEEEE
HPQSIIHSMVQYTDGAVIAQLGVPDMKLPIQYALNYPNREGNISEKLDLFKIRELTFEKP
CCHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCC
DLDTFKCLKLAYEAGEKGKLMPTILNGANEVCVELFLNKKITYLQIPEIIEECMNTFDYN
CCCHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHCCCCEEEECHHHHHHHHHHHCCC
KEVTLDNVINLDKEVRQYIYEKYN
CCEEHHHHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA