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The map label for this gene is helD [H]

Identifier: 18310601

GI number: 18310601

Start: 1887300

End: 1889591

Strand: Reverse

Name: helD [H]

Synonym: CPE1619

Alternate gene names: 18310601

Gene position: 1889591-1887300 (Counterclockwise)

Preceding gene: 18310603

Following gene: 18310600

Centisome position: 62.33

GC content: 27.62

Gene sequence:

>2292_bases
ATGAGTGATAATAAGATTTTAACTTATGAGAGAGAAGTCCTTTCAGAAACTAAAAGGTGGATTGAAAGTGAAGAGGAAAG
ATTAGAAGGTGAAAAGTTAAAAGCTAATGAAAAACTAGATGCTTTAAATAAGAAATCTAAGGGAGCCTATGATCCAGAGA
TAGAAATAGTTAAGAAGTCTGTGGACTTTTTGTCAAAGGAAGAAGAAAAATTTAAAGAAGCTTATAATAAGCCATACTTT
GCAAGAATAGATTTTAGGGAGTATAGAAAAGATTTTGAAAGTTTTTATATAGGTAAATGCGGACTTGGTGATATGCTAGA
AGGAGAAGAAAAGGTAATAGATTGGAGAGCTCCACTTGCTGATCTTTATTATAGTGGTACTCAAGGAGAGGCATATTATA
AGGCACCTATTGGGGTTATTGAGGGTGAGCTTAGTTTAAAGAGAAAATTTCTTTTTGATAATGAGCATAACTTAAAGGAA
TGTTTTGATGAGGGAATTAATGAAATTATTTTAAAATCTGGTCTTAATGAAGAAGGGGATGGGTTAATAGACGAATTCCT
TAGAATAAATTTAGAAAATAGCACAGGTACTAAATTAAAAGATGTAGTAGCTACTATACAAAAAGAGCAGAATGATATAA
TAAGAGCACCTAAAAATTCACCTTTAATAATACAAGGGTCAGCAGGTTCGGGAAAAACCACTGTAGCACTTCATAGACTA
GCTTATTTATTATATAGATATAAGGAAACCATAACTGGAGAAGATATTTTAGTTGTAGCGCCAAATAAAATATTTTTAGA
TTATATTTCTGAAGTGTTGCCTAACTTAGGAGTAGATAAGGTTGAACAAAAAACTTTTGAAGAACTAGCCTTAAAAAAGT
TAGGTATGAAGGGTAAAGTTATAACTAAGGATAAAAAATTAGTAGAAATTTTAGAAAATGATTTAGAAAAAAATAAATAT
ATAATGAATGATAGTAAAATAAAAGGGTCTATATTATTTAAAGAAATGTTAGATAGATATATTCAAATTCTTGAAAGAGA
AGATAGCGATATAGATAATATAAGAATTTGTGGATATTCAGTTTTTGATTCAAAGGAGATAAAAAGATTATTCTTAAAGG
ATTTAATAAAATATCCTGTTAACAAGAGAAAGGATGAAATCAAAAACTATTTTTCTAAGAAATTAGGAGAAAAGGTAAGT
AAAGTTTTAGATAAGGTTGATTTTCAGTATGAGTATAGAATAGCTAGACTTAAAAAAAGCATGGAAGATTCTAAAGAAAG
AAGAGAAAAACTTATAGAGCTTTATGATGAGAGAGATAATCATAAAAAAGAAATAAAAAAGTCTGCTAGAAAAGAATTTA
ATGAATATTTCAATAGATGGAAGGGTATAGATACCACTAATGTTTATAAAAATTTCTTTGAAAACAAGGAAATTTTTAAT
GAAGTAACAGATGGAAAAATACCAGAGAAGTTAGCTGAATATATGAGAGAAAATTTGGCTAATAATATAGATAAAAAAAT
AATAGATTCAGATGACTTAGCAGCTATGCTTTATTTAAAATTTAGAATAGAAGGAATAGAGGAAAGCAGCTTATTAAAAC
ATATTGTCATTGATGAGGCACAGGACTATTCTATGCTACAGTTATATGTTATGTCTATGATGGCTTCAGGAAAGTCTTTA
ACAATAGTTGGAGATATTGGTCAGGGAATATATTCATTTAAAGGAATTAATGATTGGAAAGAGGCTATTAAATTGGTTTA
TGATGAAAATGCAGAGTATAAGCACTTAAGCCAAAGCTATAGAAGTACAGTAGAAATAATAAATTATGCGAATAAGGTTT
TAGTTAAACAAAATACCTATGAAGAGCCAGCAAAACCAGTTTTAAGACATGGAATGGTTCCAGAGGAAATTGAATTTAAT
AATGCAAAAGAATTTTGTGAAAGATTAGATAGAATAGTTAAAAAAGTAAAAGATGAAGGAAAAACTTCAATAGCTATAGT
TGGTAAAACCCTTGATGAATGTAAGAAGATAAGAACTTTAGTTAAGAAATATTCAAATTATGACTTTGAATTAATTAAAG
ATGATCAAAAAGAGTTTGATTTGAATTTAATAATTATACCGTCATATCTTACTAAAGGATTAGAATTTGACTGTACTATA
GTTTATAATTTAAATAAAGAAAATTATAATGATAATGAAATAGATAAGAAACTTCTTTATGTGGTTTTAACTAGAGCGTT
ACATTATGAATATATATTTTATAAAGAGGAAAAATCACCTTTAATAGGTTGA

Upstream 100 bases:

>100_bases
TTCTAGAAATTAAAATTTTTTGTTTTATAAATTATTTTTTTATTATTTATGATTTAAATGAGAAATTAAATGGGACTATT
TAGTGAGGGAGGTATTTATT

Downstream 100 bases:

>100_bases
TTTAGGAGGAGAAATAATGGAAGAAAAACAAATAATGGCTTTTAGAGATGAAGAGGGAAATAAAGTTGAATTTGAGGTTG
TTGCTAAAATATATTTAGGA

Product: ATP-dependent DNA helicase, UvrD/REP family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 763; Mature: 762

Protein sequence:

>763_residues
MSDNKILTYEREVLSETKRWIESEEERLEGEKLKANEKLDALNKKSKGAYDPEIEIVKKSVDFLSKEEEKFKEAYNKPYF
ARIDFREYRKDFESFYIGKCGLGDMLEGEEKVIDWRAPLADLYYSGTQGEAYYKAPIGVIEGELSLKRKFLFDNEHNLKE
CFDEGINEIILKSGLNEEGDGLIDEFLRINLENSTGTKLKDVVATIQKEQNDIIRAPKNSPLIIQGSAGSGKTTVALHRL
AYLLYRYKETITGEDILVVAPNKIFLDYISEVLPNLGVDKVEQKTFEELALKKLGMKGKVITKDKKLVEILENDLEKNKY
IMNDSKIKGSILFKEMLDRYIQILEREDSDIDNIRICGYSVFDSKEIKRLFLKDLIKYPVNKRKDEIKNYFSKKLGEKVS
KVLDKVDFQYEYRIARLKKSMEDSKERREKLIELYDERDNHKKEIKKSARKEFNEYFNRWKGIDTTNVYKNFFENKEIFN
EVTDGKIPEKLAEYMRENLANNIDKKIIDSDDLAAMLYLKFRIEGIEESSLLKHIVIDEAQDYSMLQLYVMSMMASGKSL
TIVGDIGQGIYSFKGINDWKEAIKLVYDENAEYKHLSQSYRSTVEIINYANKVLVKQNTYEEPAKPVLRHGMVPEEIEFN
NAKEFCERLDRIVKKVKDEGKTSIAIVGKTLDECKKIRTLVKKYSNYDFELIKDDQKEFDLNLIIIPSYLTKGLEFDCTI
VYNLNKENYNDNEIDKKLLYVVLTRALHYEYIFYKEEKSPLIG

Sequences:

>Translated_763_residues
MSDNKILTYEREVLSETKRWIESEEERLEGEKLKANEKLDALNKKSKGAYDPEIEIVKKSVDFLSKEEEKFKEAYNKPYF
ARIDFREYRKDFESFYIGKCGLGDMLEGEEKVIDWRAPLADLYYSGTQGEAYYKAPIGVIEGELSLKRKFLFDNEHNLKE
CFDEGINEIILKSGLNEEGDGLIDEFLRINLENSTGTKLKDVVATIQKEQNDIIRAPKNSPLIIQGSAGSGKTTVALHRL
AYLLYRYKETITGEDILVVAPNKIFLDYISEVLPNLGVDKVEQKTFEELALKKLGMKGKVITKDKKLVEILENDLEKNKY
IMNDSKIKGSILFKEMLDRYIQILEREDSDIDNIRICGYSVFDSKEIKRLFLKDLIKYPVNKRKDEIKNYFSKKLGEKVS
KVLDKVDFQYEYRIARLKKSMEDSKERREKLIELYDERDNHKKEIKKSARKEFNEYFNRWKGIDTTNVYKNFFENKEIFN
EVTDGKIPEKLAEYMRENLANNIDKKIIDSDDLAAMLYLKFRIEGIEESSLLKHIVIDEAQDYSMLQLYVMSMMASGKSL
TIVGDIGQGIYSFKGINDWKEAIKLVYDENAEYKHLSQSYRSTVEIINYANKVLVKQNTYEEPAKPVLRHGMVPEEIEFN
NAKEFCERLDRIVKKVKDEGKTSIAIVGKTLDECKKIRTLVKKYSNYDFELIKDDQKEFDLNLIIIPSYLTKGLEFDCTI
VYNLNKENYNDNEIDKKLLYVVLTRALHYEYIFYKEEKSPLIG
>Mature_762_residues
SDNKILTYEREVLSETKRWIESEEERLEGEKLKANEKLDALNKKSKGAYDPEIEIVKKSVDFLSKEEEKFKEAYNKPYFA
RIDFREYRKDFESFYIGKCGLGDMLEGEEKVIDWRAPLADLYYSGTQGEAYYKAPIGVIEGELSLKRKFLFDNEHNLKEC
FDEGINEIILKSGLNEEGDGLIDEFLRINLENSTGTKLKDVVATIQKEQNDIIRAPKNSPLIIQGSAGSGKTTVALHRLA
YLLYRYKETITGEDILVVAPNKIFLDYISEVLPNLGVDKVEQKTFEELALKKLGMKGKVITKDKKLVEILENDLEKNKYI
MNDSKIKGSILFKEMLDRYIQILEREDSDIDNIRICGYSVFDSKEIKRLFLKDLIKYPVNKRKDEIKNYFSKKLGEKVSK
VLDKVDFQYEYRIARLKKSMEDSKERREKLIELYDERDNHKKEIKKSARKEFNEYFNRWKGIDTTNVYKNFFENKEIFNE
VTDGKIPEKLAEYMRENLANNIDKKIIDSDDLAAMLYLKFRIEGIEESSLLKHIVIDEAQDYSMLQLYVMSMMASGKSLT
IVGDIGQGIYSFKGINDWKEAIKLVYDENAEYKHLSQSYRSTVEIINYANKVLVKQNTYEEPAKPVLRHGMVPEEIEFNN
AKEFCERLDRIVKKVKDEGKTSIAIVGKTLDECKKIRTLVKKYSNYDFELIKDDQKEFDLNLIIIPSYLTKGLEFDCTIV
YNLNKENYNDNEIDKKLLYVVLTRALHYEYIFYKEEKSPLIG

Specific function: Catalyzes the unwinding of duplex DNA in the 3' to 5' direction; this reaction is dependent on the hydrolysis of ATP [H]

COG id: COG3973

COG function: function code R; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase ATP-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 89230; Mature: 89099

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNKILTYEREVLSETKRWIESEEERLEGEKLKANEKLDALNKKSKGAYDPEIEIVKKS
CCCCCEEEHHHHHHHHHHHHHHCHHHHHCCHHHCCCHHHHHHCCCCCCCCCCHHHHHHHH
VDFLSKEEEKFKEAYNKPYFARIDFREYRKDFESFYIGKCGLGDMLEGEEKVIDWRAPLA
HHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCHH
DLYYSGTQGEAYYKAPIGVIEGELSLKRKFLFDNEHNLKECFDEGINEIILKSGLNEEGD
HHHCCCCCCCEEEECCCCEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
GLIDEFLRINLENSTGTKLKDVVATIQKEQNDIIRAPKNSPLIIQGSAGSGKTTVALHRL
HHHHHHHHEECCCCCCCHHHHHHHHHHHHCCHHEECCCCCCEEEECCCCCCCHHHHHHHH
AYLLYRYKETITGEDILVVAPNKIFLDYISEVLPNLGVDKVEQKTFEELALKKLGMKGKV
HHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCE
ITKDKKLVEILENDLEKNKYIMNDSKIKGSILFKEMLDRYIQILEREDSDIDNIRICGYS
ECCHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEE
VFDSKEIKRLFLKDLIKYPVNKRKDEIKNYFSKKLGEKVSKVLDKVDFQYEYRIARLKKS
HHCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
MEDSKERREKLIELYDERDNHKKEIKKSARKEFNEYFNRWKGIDTTNVYKNFFENKEIFN
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHH
EVTDGKIPEKLAEYMRENLANNIDKKIIDSDDLAAMLYLKFRIEGIEESSLLKHIVIDEA
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
QDYSMLQLYVMSMMASGKSLTIVGDIGQGIYSFKGINDWKEAIKLVYDENAEYKHLSQSY
CCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHH
RSTVEIINYANKVLVKQNTYEEPAKPVLRHGMVPEEIEFNNAKEFCERLDRIVKKVKDEG
HHHHHHHHHHHHHEEECCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
KTSIAIVGKTLDECKKIRTLVKKYSNYDFELIKDDQKEFDLNLIIIPSYLTKGLEFDCTI
CCEEEEECCCHHHHHHHHHHHHHHCCCCCEEECCCCHHCCEEEEEECHHHHCCCCEEEEE
VYNLNKENYNDNEIDKKLLYVVLTRALHYEYIFYKEEKSPLIG
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCC
>Mature Secondary Structure 
SDNKILTYEREVLSETKRWIESEEERLEGEKLKANEKLDALNKKSKGAYDPEIEIVKKS
CCCCEEEHHHHHHHHHHHHHHCHHHHHCCHHHCCCHHHHHHCCCCCCCCCCHHHHHHHH
VDFLSKEEEKFKEAYNKPYFARIDFREYRKDFESFYIGKCGLGDMLEGEEKVIDWRAPLA
HHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCHH
DLYYSGTQGEAYYKAPIGVIEGELSLKRKFLFDNEHNLKECFDEGINEIILKSGLNEEGD
HHHCCCCCCCEEEECCCCEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
GLIDEFLRINLENSTGTKLKDVVATIQKEQNDIIRAPKNSPLIIQGSAGSGKTTVALHRL
HHHHHHHHEECCCCCCCHHHHHHHHHHHHCCHHEECCCCCCEEEECCCCCCCHHHHHHHH
AYLLYRYKETITGEDILVVAPNKIFLDYISEVLPNLGVDKVEQKTFEELALKKLGMKGKV
HHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCE
ITKDKKLVEILENDLEKNKYIMNDSKIKGSILFKEMLDRYIQILEREDSDIDNIRICGYS
ECCHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEE
VFDSKEIKRLFLKDLIKYPVNKRKDEIKNYFSKKLGEKVSKVLDKVDFQYEYRIARLKKS
HHCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
MEDSKERREKLIELYDERDNHKKEIKKSARKEFNEYFNRWKGIDTTNVYKNFFENKEIFN
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHH
EVTDGKIPEKLAEYMRENLANNIDKKIIDSDDLAAMLYLKFRIEGIEESSLLKHIVIDEA
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
QDYSMLQLYVMSMMASGKSLTIVGDIGQGIYSFKGINDWKEAIKLVYDENAEYKHLSQSY
CCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHH
RSTVEIINYANKVLVKQNTYEEPAKPVLRHGMVPEEIEFNNAKEFCERLDRIVKKVKDEG
HHHHHHHHHHHHHEEECCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
KTSIAIVGKTLDECKKIRTLVKKYSNYDFELIKDDQKEFDLNLIIIPSYLTKGLEFDCTI
CCEEEEECCCHHHHHHHHHHHHHHCCCCCEEECCCCHHCCEEEEEECHHHHCCCCEEEEE
VYNLNKENYNDNEIDKKLLYVVLTRALHYEYIFYKEEKSPLIG
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]