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The map label for this gene is sufS [H]

Identifier: 18310451

GI number: 18310451

Start: 1725353

End: 1726639

Strand: Reverse

Name: sufS [H]

Synonym: CPE1469

Alternate gene names: 18310451

Gene position: 1726639-1725353 (Counterclockwise)

Preceding gene: 18310453

Following gene: 18310450

Centisome position: 56.96

GC content: 28.75

Gene sequence:

>1287_bases
ATGAATAATAATTTTAGAGAATTGTTTATAGGCGTTGATGAAGAAATAACTATTTATAATGGAAAAAAGATAGTACCAAT
TAATCTTGACAATGCAGCTACTACACCTGCTTTAAAGGAAGGATTAAAATGCGTTAGTGACATGTTGCATGTATATAGTT
CCATTGGAAGAGGAAAAGGATATAAAGCAAATTTTTGTAATGAATTTTATGAAAACTCAAGAAAAAAGATTTTAGAGTTT
TTTAATGTTAAGAATACAGAGGATTATACTGTAATATATGTAAAAAATGCTACTGAAGGGTTGAATCTTTTAGCACATTC
TTTAGGAAACAAAAAGGATTATATAATAAGCACTAGAATGGAACATCATGCAAATGATTTGCCTTGGAGAGAAAATAGCA
ATATTTTATATGCTGAAGTGGATGAACTAGGACTTTTAAAAAAAGAAAAGATAGAAGAATTAATTAAAAAACACAAAGGA
AAAGTAAAATACTTAACAATAACAGGTGCCTCTAATGTAACAGGATATTTAAATCCAATAAATGAAATAGCAAAAATGGC
TCATGATAATGGAATTAAAATAATAGTAGATGCAGCTCAGTTAGTTGCTCATAAGCCAATAAATATAGGGGGAACTGGAA
ATAATGATCACATAGATTTTCTAGTTTTCTCAGCTCATAAAATGTATGCTCCCTTTGGAACAGGGGTAATTATTGCATTA
AAAGAGCTTATAAAAGATAAAGATCCATTATTAAAAGGTGGAGGAGCAGTGGACTTAGTTTCAGATAATAAGGTCTTTTT
AGATAGTGAGCCAGAGCGTTTTGAAGCAGGAACCCCTAATATAATAGGAGTATGTTCACTTTTATCATCAATTAAAGTAA
TAAAATCTATAGGTTTTGACAAAATAGAATTATTAGAGGAAAACTTGAAAAAAACTTTGTTAGATGGCTTAAAAGGTATG
CCAGATATAATAACATATGGAGATTCTAATTATAAAAATAGAATAGGAGTAGTTGTCTTTAATGTTAAAGATATCCACCA
TGATGTAATATCAGAAAGGTTAGCTAACCTTAGGGGAATATCTATTAGAAATGGAACTTTTTGTGCTCATCCTTATGTTA
GAAGGCTTTTAAACCTTAAGGATGAAGAATTTTCAAAATATGCTTATAGCAATAAGCCTAGACCAGGTATGTTAAGAGTA
AGTTTAGGATTATATAATACTAAAGAAGAAATAGAGGAATTTTTAAATACCTTAGAAATAGTAAAAGAAAAAGATTTTAG
ACTATAA

Upstream 100 bases:

>100_bases
CAAATTAAATGTTTGCTTAGAAAGGATTTCATTAAATCCTTATGTTTTAAGAACCTAATTTAAACCTTTAGAATAATATA
TACCATTGGAGTGATGTGTT

Downstream 100 bases:

>100_bases
AATTTATTCTAAATAAATTCTTAAGTTTTCATATATAAGAATTTATTTAGAATTTTTTTATGTAAAATCACAGAAATAAA
AAGAAATTTTTGATATTATA

Product: aminotransferase, class V

Products: NA

Alternate protein names: Selenocysteine beta-lyase; SCL; Selenocysteine lyase; Selenocysteine reductase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MNNNFRELFIGVDEEITIYNGKKIVPINLDNAATTPALKEGLKCVSDMLHVYSSIGRGKGYKANFCNEFYENSRKKILEF
FNVKNTEDYTVIYVKNATEGLNLLAHSLGNKKDYIISTRMEHHANDLPWRENSNILYAEVDELGLLKKEKIEELIKKHKG
KVKYLTITGASNVTGYLNPINEIAKMAHDNGIKIIVDAAQLVAHKPINIGGTGNNDHIDFLVFSAHKMYAPFGTGVIIAL
KELIKDKDPLLKGGGAVDLVSDNKVFLDSEPERFEAGTPNIIGVCSLLSSIKVIKSIGFDKIELLEENLKKTLLDGLKGM
PDIITYGDSNYKNRIGVVVFNVKDIHHDVISERLANLRGISIRNGTFCAHPYVRRLLNLKDEEFSKYAYSNKPRPGMLRV
SLGLYNTKEEIEEFLNTLEIVKEKDFRL

Sequences:

>Translated_428_residues
MNNNFRELFIGVDEEITIYNGKKIVPINLDNAATTPALKEGLKCVSDMLHVYSSIGRGKGYKANFCNEFYENSRKKILEF
FNVKNTEDYTVIYVKNATEGLNLLAHSLGNKKDYIISTRMEHHANDLPWRENSNILYAEVDELGLLKKEKIEELIKKHKG
KVKYLTITGASNVTGYLNPINEIAKMAHDNGIKIIVDAAQLVAHKPINIGGTGNNDHIDFLVFSAHKMYAPFGTGVIIAL
KELIKDKDPLLKGGGAVDLVSDNKVFLDSEPERFEAGTPNIIGVCSLLSSIKVIKSIGFDKIELLEENLKKTLLDGLKGM
PDIITYGDSNYKNRIGVVVFNVKDIHHDVISERLANLRGISIRNGTFCAHPYVRRLLNLKDEEFSKYAYSNKPRPGMLRV
SLGLYNTKEEIEEFLNTLEIVKEKDFRL
>Mature_428_residues
MNNNFRELFIGVDEEITIYNGKKIVPINLDNAATTPALKEGLKCVSDMLHVYSSIGRGKGYKANFCNEFYENSRKKILEF
FNVKNTEDYTVIYVKNATEGLNLLAHSLGNKKDYIISTRMEHHANDLPWRENSNILYAEVDELGLLKKEKIEELIKKHKG
KVKYLTITGASNVTGYLNPINEIAKMAHDNGIKIIVDAAQLVAHKPINIGGTGNNDHIDFLVFSAHKMYAPFGTGVIIAL
KELIKDKDPLLKGGGAVDLVSDNKVFLDSEPERFEAGTPNIIGVCSLLSSIKVIKSIGFDKIELLEENLKKTLLDGLKGM
PDIITYGDSNYKNRIGVVVFNVKDIHHDVISERLANLRGISIRNGTFCAHPYVRRLLNLKDEEFSKYAYSNKPRPGMLRV
SLGLYNTKEEIEEFLNTLEIVKEKDFRL

Specific function: Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=406, Percent_Identity=22.4137931034483, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1787970, Length=402, Percent_Identity=33.3333333333333, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI1789175, Length=409, Percent_Identity=28.361858190709, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI48994898, Length=423, Percent_Identity=23.8770685579196, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193211090, Length=394, Percent_Identity=28.6802030456853, Blast_Score=141, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI25143064, Length=414, Percent_Identity=24.1545893719807, Blast_Score=78, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6319831, Length=415, Percent_Identity=25.7831325301205, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI20129463, Length=402, Percent_Identity=23.8805970149254, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7; =4.4.1.16 [H]

Molecular weight: Translated: 48166; Mature: 48166

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNNFRELFIGVDEEITIYNGKKIVPINLDNAATTPALKEGLKCVSDMLHVYSSIGRGKG
CCCCCEEEEEECCCEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
YKANFCNEFYENSRKKILEFFNVKNTEDYTVIYVKNATEGLNLLAHSLGNKKDYIISTRM
CCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCEEEEEHH
EHHANDLPWRENSNILYAEVDELGLLKKEKIEELIKKHKGKVKYLTITGASNVTGYLNPI
HHCCCCCCCCCCCCEEEEEHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHH
NEIAKMAHDNGIKIIVDAAQLVAHKPINIGGTGNNDHIDFLVFSAHKMYAPFGTGVIIAL
HHHHHHHCCCCCEEEEEHHHHHHCCCCCCCCCCCCCCEEEEEEECCHHCCCCCCHHHHHH
KELIKDKDPLLKGGGAVDLVSDNKVFLDSEPERFEAGTPNIIGVCSLLSSIKVIKSIGFD
HHHHCCCCCCCCCCCEEEEEECCEEEECCCCHHCCCCCCCHHHHHHHHHHHHHHHHCCCH
KIELLEENLKKTLLDGLKGMPDIITYGDSNYKNRIGVVVFNVKDIHHDVISERLANLRGI
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCCCE
SIRNGTFCAHPYVRRLLNLKDEEFSKYAYSNKPRPGMLRVSLGLYNTKEEIEEFLNTLEI
EECCCCEECCHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
VKEKDFRL
HHHCCCCC
>Mature Secondary Structure
MNNNFRELFIGVDEEITIYNGKKIVPINLDNAATTPALKEGLKCVSDMLHVYSSIGRGKG
CCCCCEEEEEECCCEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
YKANFCNEFYENSRKKILEFFNVKNTEDYTVIYVKNATEGLNLLAHSLGNKKDYIISTRM
CCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCEEEEEHH
EHHANDLPWRENSNILYAEVDELGLLKKEKIEELIKKHKGKVKYLTITGASNVTGYLNPI
HHCCCCCCCCCCCCEEEEEHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHH
NEIAKMAHDNGIKIIVDAAQLVAHKPINIGGTGNNDHIDFLVFSAHKMYAPFGTGVIIAL
HHHHHHHCCCCCEEEEEHHHHHHCCCCCCCCCCCCCCEEEEEEECCHHCCCCCCHHHHHH
KELIKDKDPLLKGGGAVDLVSDNKVFLDSEPERFEAGTPNIIGVCSLLSSIKVIKSIGFD
HHHHCCCCCCCCCCCEEEEEECCEEEECCCCHHCCCCCCCHHHHHHHHHHHHHHHHCCCH
KIELLEENLKKTLLDGLKGMPDIITYGDSNYKNRIGVVVFNVKDIHHDVISERLANLRGI
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCCCE
SIRNGTFCAHPYVRRLLNLKDEEFSKYAYSNKPRPGMLRVSLGLYNTKEEIEEFLNTLEI
EECCCCEECCHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
VKEKDFRL
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA