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The map label for this gene is clpB

Identifier: 18310410

GI number: 18310410

Start: 1681198

End: 1683798

Strand: Reverse

Name: clpB

Synonym: CPE1428

Alternate gene names: 18310410

Gene position: 1683798-1681198 (Counterclockwise)

Preceding gene: 18310413

Following gene: 18310409

Centisome position: 55.54

GC content: 30.14

Gene sequence:

>2601_bases
ATGAATGCAGATAAAATGACATTAAGAGTACAACAAAGCTTAAATGATGCTTATGAAATAGCAGTTAAATATAATAATCA
ACAATTAGATATAATTCACTTATTTTCAGCATTAGTAAATCAAAAAGATGGTTTAATTCCTAATATATTTGAAAAAATGG
GTGTTAATATAGATTCATTAAAAAGAGACATTCATGTTCAAATAGATAGAATGCCTAAGGTTTTAGGAGAAGCGGCACAA
TCATCAGGGGTTACTGCTACAAGAAGAATAAATGAAGTATTAATAAAGGCAGAAGAAATTTCAAAACAATTTGAAGATTC
ATATATAAGTGTTGAGCATGTAATGCTTGCAATGATAGATATAGATAAAAATGGAGCTGTAGGAGAAATCTTAAGAAAAA
ATAACATAACTAAAGATGGATTCCTAAAGGTTTTAAATGAAGTTAGAGGAAGTCAAAGAGTGGATTCACAAGATCCAGAA
GGAACTTATGAAGCTTTAGATAAATACGGTACTAATTTAATAGAACTTGTAAAACAACATAAATTAGATCCTGTTATAGG
AAGAGATGAAGAAATAAGAAGAGCTGTTAGAATTCTTTCAAGAAAAACTAAGAACAATCCAATACTAATAGGAGAACCTG
GAGTTGGTAAAACTGCTATAGTTGAAGGATTAGCAGAAAGAATTGTAAGAGGAGATGTGCCAGAAGGACTAAAGGATAAG
GTAATTATCTCATTAGATATGGGTGCATTAATAGCTGGTGCTAAATACAGAGGAGAATTTGAAGAAAGATTAAAAGCTGT
TTTAAAAGAAGTTCAAAGTTCAGAAGGAAAAATACTTTTATTCATAGATGAAATTCATACAATTGTAGGCGCTGGTAAAA
CAGATGGTGCAATGGATGCAGGAAACTTAATTAAACCAATGCTTGCAAGAGGAGAACTTCACTGCATAGGAGCCACAACT
TTTGACGAATATAGACAATATATAGAAAAGGATAAAGCTCTAGAGAGAAGATTCCAACCTGTAATAGTTGAAGAACCAAC
AGTTGAAGAAACTGTATCTATTTTAAGAGGATTAAAAGAAAGATTTGAAATTCACCATGGAATTAGAATCCATGACTCAG
CAATAGTAGCTGCTGCAAAACTTTCTCATAGATATATTCAAGATAGATATTTACCAGATAAGGCTATAGATTTAATAGAT
GAAGCTGGTGCTATGATAAGAAGTGAAATAGATTCTCTTCCAACTGAATTAGATATTATAAGAAGAAAGATCTTAATGCT
TGAAACTGAAAAGGAAGCTTTATCAAAAGAAAATGATGATGCATCTAAGGAAAGATTAGTTGCCTTAGAAAAAGAGCTTG
CAGAGCTTCAAGATAAAAATGATGAGATGACAATTAAATATGAAAAAGAAAAATCTCATATTTCAGCAGTTAGGGACTTA
AAGGCTGAATTAGATGAAGCAAGAGGATTAGCTGAAAAATATGAAAGAGAATATGATTTAAATAAAGTTGCAGAACTTAA
ATATGGAAAAATTCCAGAGCTTGAACGTAAAATAAAAGAACAAGAAGCAAGTATGGAAAAAGATAATGAAAATGCTTTAT
TAAAAGAAGAGGTTACTGAAAATGAAATTTCAGAAATAATCTCAAAATGGACTGGAATTCCTGTTACAAAACTAGTTGAA
AGTGAAAGAGAAAAACTTTTAAGACTAGAAGAAGAATTAAGAGAAAGAGTAATAGGTCAAGATGAGGCTACAACTGCAGT
TGCTAATGCTGTAATAAGAGCAAGAGCAGGTCTTAAAGATGAAAGAAAACCAATAGGATCATTTATATTCTTAGGACCTA
CTGGAGTTGGTAAAACAGAACTTGCAAAAACTTTAGCTAGAAATTTATTTGATAGTGAAGACAATATAGTAAGAATAGAT
ATGTCTGAATATATGGAAAAACATGCAGTATCTAGATTAATAGGACCTCCTCCAGGATATGTAGGATATGAAGAAGGGGG
ACAATTAACAGAGGCTGTTAGAAGAAACCCATATTCAGTAATATTATTTGATGAAATAGAAAAAGCACATGATGATGTAT
TTAACTTATTCCTTCAAATATTAGATGATGGTAGATTAACAGATAATAAAGGTAAAACTGTTGATTTCAAAAACACTATA
ATAATTATGACTTCTAATATAGGTAGTGGATACTTATTAGAAAATAAATCTGGTGAAGGTATAGAAGATGATATTAGAGA
AAATGTTATGAATGAAATGAAGTTAAGATTCAAACCAGAATTCTTAAACAGAGTAGATGATATCATAATGTTTAGACCTT
TAAGCAGTGAAGGAATTAAGAAAATAATAGATATCTTCTTAAGAGATGTTGAAAATAGATTAAGAGAAAGAAATATAACT
CTTGAAGTTACTGATAGAGCTAAGGAAATATTAGCTGAAGAAGGATATGATCCAGTATATGGAGCTAGACCATTAAAGAG
ATATATAAGTAATGTCTTAGAAACTGAAATAGCTAAGAAGATAATTGCAGGAGAAATTTATGATGGATCTGTTGCTTTAA
TAGATGGAGTAGATGGAAAAATTATAGTTTCTAGAAAATAA

Upstream 100 bases:

>100_bases
TTAATAAATTCTGAAAGTGAAAAATAGACTTTGACTTTCTTTGACTTTTATAGTATTATAATTACATGAGATACAAAAAA
GAGAATATTGAGGTGATAAA

Downstream 100 bases:

>100_bases
AATATAATAAATTTATAAGGACCATAGGTTTAATTAAATCTATGGTCCTTATTTTTATGAAATTTTAAATATATTTTTAA
TAAAATGATAACAAAAAACA

Product: clpB protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 866; Mature: 866

Protein sequence:

>866_residues
MNADKMTLRVQQSLNDAYEIAVKYNNQQLDIIHLFSALVNQKDGLIPNIFEKMGVNIDSLKRDIHVQIDRMPKVLGEAAQ
SSGVTATRRINEVLIKAEEISKQFEDSYISVEHVMLAMIDIDKNGAVGEILRKNNITKDGFLKVLNEVRGSQRVDSQDPE
GTYEALDKYGTNLIELVKQHKLDPVIGRDEEIRRAVRILSRKTKNNPILIGEPGVGKTAIVEGLAERIVRGDVPEGLKDK
VIISLDMGALIAGAKYRGEFEERLKAVLKEVQSSEGKILLFIDEIHTIVGAGKTDGAMDAGNLIKPMLARGELHCIGATT
FDEYRQYIEKDKALERRFQPVIVEEPTVEETVSILRGLKERFEIHHGIRIHDSAIVAAAKLSHRYIQDRYLPDKAIDLID
EAGAMIRSEIDSLPTELDIIRRKILMLETEKEALSKENDDASKERLVALEKELAELQDKNDEMTIKYEKEKSHISAVRDL
KAELDEARGLAEKYEREYDLNKVAELKYGKIPELERKIKEQEASMEKDNENALLKEEVTENEISEIISKWTGIPVTKLVE
SEREKLLRLEEELRERVIGQDEATTAVANAVIRARAGLKDERKPIGSFIFLGPTGVGKTELAKTLARNLFDSEDNIVRID
MSEYMEKHAVSRLIGPPPGYVGYEEGGQLTEAVRRNPYSVILFDEIEKAHDDVFNLFLQILDDGRLTDNKGKTVDFKNTI
IIMTSNIGSGYLLENKSGEGIEDDIRENVMNEMKLRFKPEFLNRVDDIIMFRPLSSEGIKKIIDIFLRDVENRLRERNIT
LEVTDRAKEILAEEGYDPVYGARPLKRYISNVLETEIAKKIIAGEIYDGSVALIDGVDGKIIVSRK

Sequences:

>Translated_866_residues
MNADKMTLRVQQSLNDAYEIAVKYNNQQLDIIHLFSALVNQKDGLIPNIFEKMGVNIDSLKRDIHVQIDRMPKVLGEAAQ
SSGVTATRRINEVLIKAEEISKQFEDSYISVEHVMLAMIDIDKNGAVGEILRKNNITKDGFLKVLNEVRGSQRVDSQDPE
GTYEALDKYGTNLIELVKQHKLDPVIGRDEEIRRAVRILSRKTKNNPILIGEPGVGKTAIVEGLAERIVRGDVPEGLKDK
VIISLDMGALIAGAKYRGEFEERLKAVLKEVQSSEGKILLFIDEIHTIVGAGKTDGAMDAGNLIKPMLARGELHCIGATT
FDEYRQYIEKDKALERRFQPVIVEEPTVEETVSILRGLKERFEIHHGIRIHDSAIVAAAKLSHRYIQDRYLPDKAIDLID
EAGAMIRSEIDSLPTELDIIRRKILMLETEKEALSKENDDASKERLVALEKELAELQDKNDEMTIKYEKEKSHISAVRDL
KAELDEARGLAEKYEREYDLNKVAELKYGKIPELERKIKEQEASMEKDNENALLKEEVTENEISEIISKWTGIPVTKLVE
SEREKLLRLEEELRERVIGQDEATTAVANAVIRARAGLKDERKPIGSFIFLGPTGVGKTELAKTLARNLFDSEDNIVRID
MSEYMEKHAVSRLIGPPPGYVGYEEGGQLTEAVRRNPYSVILFDEIEKAHDDVFNLFLQILDDGRLTDNKGKTVDFKNTI
IIMTSNIGSGYLLENKSGEGIEDDIRENVMNEMKLRFKPEFLNRVDDIIMFRPLSSEGIKKIIDIFLRDVENRLRERNIT
LEVTDRAKEILAEEGYDPVYGARPLKRYISNVLETEIAKKIIAGEIYDGSVALIDGVDGKIIVSRK
>Mature_866_residues
MNADKMTLRVQQSLNDAYEIAVKYNNQQLDIIHLFSALVNQKDGLIPNIFEKMGVNIDSLKRDIHVQIDRMPKVLGEAAQ
SSGVTATRRINEVLIKAEEISKQFEDSYISVEHVMLAMIDIDKNGAVGEILRKNNITKDGFLKVLNEVRGSQRVDSQDPE
GTYEALDKYGTNLIELVKQHKLDPVIGRDEEIRRAVRILSRKTKNNPILIGEPGVGKTAIVEGLAERIVRGDVPEGLKDK
VIISLDMGALIAGAKYRGEFEERLKAVLKEVQSSEGKILLFIDEIHTIVGAGKTDGAMDAGNLIKPMLARGELHCIGATT
FDEYRQYIEKDKALERRFQPVIVEEPTVEETVSILRGLKERFEIHHGIRIHDSAIVAAAKLSHRYIQDRYLPDKAIDLID
EAGAMIRSEIDSLPTELDIIRRKILMLETEKEALSKENDDASKERLVALEKELAELQDKNDEMTIKYEKEKSHISAVRDL
KAELDEARGLAEKYEREYDLNKVAELKYGKIPELERKIKEQEASMEKDNENALLKEEVTENEISEIISKWTGIPVTKLVE
SEREKLLRLEEELRERVIGQDEATTAVANAVIRARAGLKDERKPIGSFIFLGPTGVGKTELAKTLARNLFDSEDNIVRID
MSEYMEKHAVSRLIGPPPGYVGYEEGGQLTEAVRRNPYSVILFDEIEKAHDDVFNLFLQILDDGRLTDNKGKTVDFKNTI
IIMTSNIGSGYLLENKSGEGIEDDIRENVMNEMKLRFKPEFLNRVDDIIMFRPLSSEGIKKIIDIFLRDVENRLRERNIT
LEVTDRAKEILAEEGYDPVYGARPLKRYISNVLETEIAKKIIAGEIYDGSVALIDGVDGKIIVSRK

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family

Homologues:

Organism=Homo sapiens, GI13540606, Length=309, Percent_Identity=38.5113268608414, Blast_Score=206, Evalue=6e-53,
Organism=Escherichia coli, GI1788943, Length=852, Percent_Identity=53.7558685446009, Blast_Score=934, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=409, Percent_Identity=40.8312958435208, Blast_Score=298, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6320464, Length=711, Percent_Identity=53.0239099859353, Blast_Score=759, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=858, Percent_Identity=42.6573426573427, Blast_Score=671, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): CLPB_CLOPE (Q8XKG8)

Other databases:

- EMBL:   BA000016
- RefSeq:   NP_562344.1
- ProteinModelPortal:   Q8XKG8
- GeneID:   989738
- GenomeReviews:   BA000016_GR
- KEGG:   cpe:CPE1428
- NMPDR:   fig|195102.1.peg.1491
- HOGENOM:   HBG413133
- OMA:   NSLARMI
- PhylomeDB:   Q8XKG8
- ProtClustDB:   CLSK882651
- BioCyc:   CPER195102:CPE1428-MONOMER
- GO:   GO:0005737
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- Gene3D:   G3DSA:1.10.1780.10
- PRINTS:   PR00300
- SMART:   SM00382
- TIGRFAMs:   TIGR03346

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small

EC number: NA

Molecular weight: Translated: 97941; Mature: 97941

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00870 CLPAB_1; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNADKMTLRVQQSLNDAYEIAVKYNNQQLDIIHLFSALVNQKDGLIPNIFEKMGVNIDSL
CCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHH
KRDIHVQIDRMPKVLGEAAQSSGVTATRRINEVLIKAEEISKQFEDSYISVEHVMLAMID
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHEE
IDKNGAVGEILRKNNITKDGFLKVLNEVRGSQRVDSQDPEGTYEALDKYGTNLIELVKQH
ECCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHH
KLDPVIGRDEEIRRAVRILSRKTKNNPILIGEPGVGKTAIVEGLAERIVRGDVPEGLKDK
CCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCC
VIISLDMGALIAGAKYRGEFEERLKAVLKEVQSSEGKILLFIDEIHTIVGAGKTDGAMDA
EEEEECCHHHHHCCHHCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCCCCCC
GNLIKPMLARGELHCIGATTFDEYRQYIEKDKALERRFQPVIVEEPTVEETVSILRGLKE
HHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHH
RFEIHHGIRIHDSAIVAAAKLSHRYIQDRYLPDKAIDLIDEAGAMIRSEIDSLPTELDII
HHHHHCCEEEECHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
RRKILMLETEKEALSKENDDASKERLVALEKELAELQDKNDEMTIKYEKEKSHISAVRDL
HHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHH
KAELDEARGLAEKYEREYDLNKVAELKYGKIPELERKIKEQEASMEKDNENALLKEEVTE
HHHHHHHHCHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHH
NEISEIISKWTGIPVTKLVESEREKLLRLEEELRERVIGQDEATTAVANAVIRARAGLKD
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCC
ERKPIGSFIFLGPTGVGKTELAKTLARNLFDSEDNIVRIDMSEYMEKHAVSRLIGPPPGY
CCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHCCCCCCC
VGYEEGGQLTEAVRRNPYSVILFDEIEKAHDDVFNLFLQILDDGRLTDNKGKTVDFKNTI
CCCCCCCHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEECCEE
IIMTSNIGSGYLLENKSGEGIEDDIRENVMNEMKLRFKPEFLNRVDDIIMFRPLSSEGIK
EEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHEECCCCHHHHH
KIIDIFLRDVENRLRERNITLEVTDRAKEILAEEGYDPVYGARPLKRYISNVLETEIAKK
HHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
IIAGEIYDGSVALIDGVDGKIIVSRK
HHHCCCCCCCEEEEECCCCEEEEECC
>Mature Secondary Structure
MNADKMTLRVQQSLNDAYEIAVKYNNQQLDIIHLFSALVNQKDGLIPNIFEKMGVNIDSL
CCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHH
KRDIHVQIDRMPKVLGEAAQSSGVTATRRINEVLIKAEEISKQFEDSYISVEHVMLAMID
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHEE
IDKNGAVGEILRKNNITKDGFLKVLNEVRGSQRVDSQDPEGTYEALDKYGTNLIELVKQH
ECCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHH
KLDPVIGRDEEIRRAVRILSRKTKNNPILIGEPGVGKTAIVEGLAERIVRGDVPEGLKDK
CCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCC
VIISLDMGALIAGAKYRGEFEERLKAVLKEVQSSEGKILLFIDEIHTIVGAGKTDGAMDA
EEEEECCHHHHHCCHHCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCCCCCC
GNLIKPMLARGELHCIGATTFDEYRQYIEKDKALERRFQPVIVEEPTVEETVSILRGLKE
HHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHH
RFEIHHGIRIHDSAIVAAAKLSHRYIQDRYLPDKAIDLIDEAGAMIRSEIDSLPTELDII
HHHHHCCEEEECHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
RRKILMLETEKEALSKENDDASKERLVALEKELAELQDKNDEMTIKYEKEKSHISAVRDL
HHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHH
KAELDEARGLAEKYEREYDLNKVAELKYGKIPELERKIKEQEASMEKDNENALLKEEVTE
HHHHHHHHCHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHH
NEISEIISKWTGIPVTKLVESEREKLLRLEEELRERVIGQDEATTAVANAVIRARAGLKD
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCC
ERKPIGSFIFLGPTGVGKTELAKTLARNLFDSEDNIVRIDMSEYMEKHAVSRLIGPPPGY
CCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHCCCCCCC
VGYEEGGQLTEAVRRNPYSVILFDEIEKAHDDVFNLFLQILDDGRLTDNKGKTVDFKNTI
CCCCCCCHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCEECCCCCEEEECCEE
IIMTSNIGSGYLLENKSGEGIEDDIRENVMNEMKLRFKPEFLNRVDDIIMFRPLSSEGIK
EEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHEECCCCHHHHH
KIIDIFLRDVENRLRERNITLEVTDRAKEILAEEGYDPVYGARPLKRYISNVLETEIAKK
HHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
IIAGEIYDGSVALIDGVDGKIIVSRK
HHHCCCCCCCEEEEECCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11792842