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The map label for this gene is mprF [H]

Identifier: 18310230

GI number: 18310230

Start: 1455868

End: 1456806

Strand: Reverse

Name: mprF [H]

Synonym: CPE1248

Alternate gene names: 18310230

Gene position: 1456806-1455868 (Counterclockwise)

Preceding gene: 18310231

Following gene: 18310229

Centisome position: 48.06

GC content: 27.9

Gene sequence:

>939_bases
TTGAAAATTAAAGTAAATAATAAAGTTAAGCTTTTTTTAAAGATAACTTTTATAGCAGTAGTATTAGTTTTAGTGGCCTT
TGGATTTAAAAATATGTTTAAGGAATTTAATATGACCTATTTTAATATGTATAGAGATAAATTGCATTTTTTTAAGCTAA
CTCTAATTGCCATAGCTGGTATTATTGCATATATGCCTTTATCTATTTATGATTTTATTTTGAAAAAGAATGTTGGAATA
GATATTAAGAATATAAAATTATATAAATATTCTTGGATAGCAAGTTCAATTGCAAGTTTACTTGGATTTGGAGGGGCTAC
ATCCTTAGCTTTTAAGCAATATTTTTATGGAAGTCATGTTAAGGATAAAAAGAAGCTATTAAGAGAAATTGGAAAGATCA
TATTTTTAAACTTAACTGGATTATCTGTATTATGTATAATCTATATTCTCTTAGAATTTAAAGATATACAAAATTTAGGG
CTTATAAAATATGTGGTATATGGAGTTTCTGCCTATGCTCCTTTGGTTATTATAAATTCACTATATAATTATAAGAAGAA
AAAGGACGAAGAGGGATTCACCTTAAAGGTTGTAGGAATATCCTTTGTGGAATGGACCTTAAATATGCTCCTTATATATT
TAATATTAGCTATTACAGGGGCTCATATAAAACTAACAGAATATTTTTATGTCTATGTGAGAGCTACAGCAGTTGGAATA
GTTAGCATGGTTCCTGGAGGACTTGGCACCTTTGACTTAACCTTTATAGATGGCTTTAAAGCCTTAGGTGTGCCTATAGA
GCAAACCTTTTTAGTAATAATACTTTATAGGATAAGTTATTTCATATTGCCAGCAGCAATAGGGGGAATTCTATATATTC
ATGAGTTTGGAATGAATTTCAAAGCCTTAATAAAAAGTAGAAAAAATAATGAGGATTAA

Upstream 100 bases:

>100_bases
TTTAAAAATTTTTTTAAATCGCTTTTAATTTTGAATTTTATTTAAATTAATGTAAAATAATATTAATGATGTGTTAATAA
ATGCAAAGGAGAGAAATGAA

Downstream 100 bases:

>100_bases
GTTTGAAAAACATTAAGGGACTGTATCAAAATAACTTTTTATAAAACTTACAAACATATTCCGAGAATTACTAGATTTTA
AGTGAAAGTCCAAATTTTAA

Product: hypothetical protein

Products: NA

Alternate protein names: Lysylphosphatidylglycerol synthase; LPG synthase; Multiple peptide resistance factor [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MKIKVNNKVKLFLKITFIAVVLVLVAFGFKNMFKEFNMTYFNMYRDKLHFFKLTLIAIAGIIAYMPLSIYDFILKKNVGI
DIKNIKLYKYSWIASSIASLLGFGGATSLAFKQYFYGSHVKDKKKLLREIGKIIFLNLTGLSVLCIIYILLEFKDIQNLG
LIKYVVYGVSAYAPLVIINSLYNYKKKKDEEGFTLKVVGISFVEWTLNMLLIYLILAITGAHIKLTEYFYVYVRATAVGI
VSMVPGGLGTFDLTFIDGFKALGVPIEQTFLVIILYRISYFILPAAIGGILYIHEFGMNFKALIKSRKNNED

Sequences:

>Translated_312_residues
MKIKVNNKVKLFLKITFIAVVLVLVAFGFKNMFKEFNMTYFNMYRDKLHFFKLTLIAIAGIIAYMPLSIYDFILKKNVGI
DIKNIKLYKYSWIASSIASLLGFGGATSLAFKQYFYGSHVKDKKKLLREIGKIIFLNLTGLSVLCIIYILLEFKDIQNLG
LIKYVVYGVSAYAPLVIINSLYNYKKKKDEEGFTLKVVGISFVEWTLNMLLIYLILAITGAHIKLTEYFYVYVRATAVGI
VSMVPGGLGTFDLTFIDGFKALGVPIEQTFLVIILYRISYFILPAAIGGILYIHEFGMNFKALIKSRKNNED
>Mature_312_residues
MKIKVNNKVKLFLKITFIAVVLVLVAFGFKNMFKEFNMTYFNMYRDKLHFFKLTLIAIAGIIAYMPLSIYDFILKKNVGI
DIKNIKLYKYSWIASSIASLLGFGGATSLAFKQYFYGSHVKDKKKLLREIGKIIFLNLTGLSVLCIIYILLEFKDIQNLG
LIKYVVYGVSAYAPLVIINSLYNYKKKKDEEGFTLKVVGISFVEWTLNMLLIYLILAITGAHIKLTEYFYVYVRATAVGI
VSMVPGGLGTFDLTFIDGFKALGVPIEQTFLVIILYRISYFILPAAIGGILYIHEFGMNFKALIKSRKNNED

Specific function: Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes

COG id: COG0392

COG function: function code S; Predicted integral membrane protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LPG synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016181
- InterPro:   IPR022791 [H]

Pfam domain/function: PF03706 UPF0104 [H]

EC number: =2.3.2.3 [H]

Molecular weight: Translated: 35518; Mature: 35518

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKVNNKVKLFLKITFIAVVLVLVAFGFKNMFKEFNMTYFNMYRDKLHFFKLTLIAIAG
CEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
IIAYMPLSIYDFILKKNVGIDIKNIKLYKYSWIASSIASLLGFGGATSLAFKQYFYGSHV
HHHHHHHHHHHHHHHCCCCCEEEEEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
KDKKKLLREIGKIIFLNLTGLSVLCIIYILLEFKDIQNLGLIKYVVYGVSAYAPLVIINS
HHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LYNYKKKKDEEGFTLKVVGISFVEWTLNMLLIYLILAITGAHIKLTEYFYVYVRATAVGI
HHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHEEHHHHHHHHH
VSMVPGGLGTFDLTFIDGFKALGVPIEQTFLVIILYRISYFILPAAIGGILYIHEFGMNF
HHHCCCCCCCEEEHEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
KALIKSRKNNED
HHHHHHCCCCCC
>Mature Secondary Structure
MKIKVNNKVKLFLKITFIAVVLVLVAFGFKNMFKEFNMTYFNMYRDKLHFFKLTLIAIAG
CEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
IIAYMPLSIYDFILKKNVGIDIKNIKLYKYSWIASSIASLLGFGGATSLAFKQYFYGSHV
HHHHHHHHHHHHHHHCCCCCEEEEEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
KDKKKLLREIGKIIFLNLTGLSVLCIIYILLEFKDIQNLGLIKYVVYGVSAYAPLVIINS
HHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LYNYKKKKDEEGFTLKVVGISFVEWTLNMLLIYLILAITGAHIKLTEYFYVYVRATAVGI
HHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHEEHHHHHHHHH
VSMVPGGLGTFDLTFIDGFKALGVPIEQTFLVIILYRISYFILPAAIGGILYIHEFGMNF
HHHCCCCCCCEEEHEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
KALIKSRKNNED
HHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11342591; 12496209 [H]