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The map label for this gene is lysP [H]

Identifier: 18310148

GI number: 18310148

Start: 1364467

End: 1365936

Strand: Reverse

Name: lysP [H]

Synonym: CPE1166

Alternate gene names: 18310148

Gene position: 1365936-1364467 (Counterclockwise)

Preceding gene: 18310150

Following gene: 18310146

Centisome position: 45.06

GC content: 33.2

Gene sequence:

>1470_bases
ATGAGTCAAGAACAAAATACTAATCTAAAAAGAGGCTTGAAATCAAGACATCTTAGCATGATTGCCATGGGTGGTGCCAT
AGGAACTGGTATTTTCTTAGCCATGGGAGATACACTTCATCAAGCCGGTGTAGGAGGAGCTTTTGTAGCTTACGGAATCA
TAGGAGTAATGGTATATTTCTTGTGTACAAGCTTAGGGGAGATGGCAACATATATGCCAGAAACAGGTTCCTTTGGAGCT
TATGCAACAAAATTTGTTGATCCTGCTTTAGGATTTGCTCTAGGATGGAATTACTGGTATAACTGGGCTATAACAATAGC
AGCAGAAATGGTTGCAGGTTCTTTATTAATGAAGTTTTGGTTTCCTAATATTCCAGCAATAGTTTGGAGCGCATTATTCT
TAGTAATTATATTAACTCTTAATTTATTATCTGCCAAAGCTTATGGAGAATCAGAGTTTTGGTTTGCAGCTGTAAAAGTT
GCTACTGTTATAATATTCTTAATCGTAGGAGTTCTTATGATTTTTGGAATATTAGGTGGAGATAATGTAGGATTCAAAAA
CTTCTATGAAAATGGAGGGCCATTTATTGGAGGAGCAAAATCAATTTTCATGATCTTTTTAATAGCTGGTTTCTCATTTC
AAGGAACTGAATTAGTAGGGGTTGCTGCTGGAGAAAGTGAAGATCCTGAAAAAAATGTACCTAAGGCTGTTAATACAATA
TTTTGGAGAATCTTATTATTTTATTTAGGAACAATTTTAGTAATAGGTGCTTTAGTGCCAAATGCTCAAGCAGGAGTAGA
AACAAGTGCATTTACAATAGTATTTGAAAAATTAGGATTAGCTGGAGCCGCTTCTATTATGAATGCTATAATACTTACAT
CCGTTTTATCAGCTGGTAACTCTGGTATGTATGCATCGAGTAGAATGCTTTATGCTATGGCTAAAAATGGAATGGCACCT
AAGATTTTTGAAAAAACTAATTCTAGAGGAGTACCAGTTAATGCTATTATAATAACAACAATAATTGCAAGTTTATGTTT
CTTAACAGGTATTTATGCCGAAAATACAGTTTATGTATGGCTTGTAGCAGCCTCAGGATTATCAGGATTTATAGCTTGGC
TTGGAATCGCAATATGTCATTATAGATTTAGAAAAGCTTATGTAGCTCAAGGTAAAGATATGAGTAGATTAGTTTATAAA
GCTAAATTATTCCCACTAGGGCCTATAATAGCTTTAATATTATGTGGAATAATAGTTTTAGGTCAAGGATATGCATACTT
AGATGTTAGAAATGGAGTAGACTGGGGTGGATTAATTTCATCTTATATTGGATTACCTCTATTCTTTGGATTATTTGCAT
ATTATAAAATTAAATATAAAACTAAAATAATAGACTTAAAAGATGTTGACTTAAGTGTAGAGCATATAGATACTGATGAG
AGTATAGAAGATGAAGTATTTTCTTACTAA

Upstream 100 bases:

>100_bases
AACCCTTAAGCATGAAACACGCTTAAGGGTTTCTTTTGTTAGCGAAAACTTAGTTATCACTTATGGCTTAATTATTAAAA
CCATAAGGAGGACTAAAAAA

Downstream 100 bases:

>100_bases
AAAAAGAGGTGGTTTTTTCACCTCTTTTTTATTTTAAAATTAATAAATTTGTTTTATTACATAATTTTGATCTGTTAAAG
CTTTTTTTATTTCCTCTATG

Product: lysine specific permease

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MSQEQNTNLKRGLKSRHLSMIAMGGAIGTGIFLAMGDTLHQAGVGGAFVAYGIIGVMVYFLCTSLGEMATYMPETGSFGA
YATKFVDPALGFALGWNYWYNWAITIAAEMVAGSLLMKFWFPNIPAIVWSALFLVIILTLNLLSAKAYGESEFWFAAVKV
ATVIIFLIVGVLMIFGILGGDNVGFKNFYENGGPFIGGAKSIFMIFLIAGFSFQGTELVGVAAGESEDPEKNVPKAVNTI
FWRILLFYLGTILVIGALVPNAQAGVETSAFTIVFEKLGLAGAASIMNAIILTSVLSAGNSGMYASSRMLYAMAKNGMAP
KIFEKTNSRGVPVNAIIITTIIASLCFLTGIYAENTVYVWLVAASGLSGFIAWLGIAICHYRFRKAYVAQGKDMSRLVYK
AKLFPLGPIIALILCGIIVLGQGYAYLDVRNGVDWGGLISSYIGLPLFFGLFAYYKIKYKTKIIDLKDVDLSVEHIDTDE
SIEDEVFSY

Sequences:

>Translated_489_residues
MSQEQNTNLKRGLKSRHLSMIAMGGAIGTGIFLAMGDTLHQAGVGGAFVAYGIIGVMVYFLCTSLGEMATYMPETGSFGA
YATKFVDPALGFALGWNYWYNWAITIAAEMVAGSLLMKFWFPNIPAIVWSALFLVIILTLNLLSAKAYGESEFWFAAVKV
ATVIIFLIVGVLMIFGILGGDNVGFKNFYENGGPFIGGAKSIFMIFLIAGFSFQGTELVGVAAGESEDPEKNVPKAVNTI
FWRILLFYLGTILVIGALVPNAQAGVETSAFTIVFEKLGLAGAASIMNAIILTSVLSAGNSGMYASSRMLYAMAKNGMAP
KIFEKTNSRGVPVNAIIITTIIASLCFLTGIYAENTVYVWLVAASGLSGFIAWLGIAICHYRFRKAYVAQGKDMSRLVYK
AKLFPLGPIIALILCGIIVLGQGYAYLDVRNGVDWGGLISSYIGLPLFFGLFAYYKIKYKTKIIDLKDVDLSVEHIDTDE
SIEDEVFSY
>Mature_488_residues
SQEQNTNLKRGLKSRHLSMIAMGGAIGTGIFLAMGDTLHQAGVGGAFVAYGIIGVMVYFLCTSLGEMATYMPETGSFGAY
ATKFVDPALGFALGWNYWYNWAITIAAEMVAGSLLMKFWFPNIPAIVWSALFLVIILTLNLLSAKAYGESEFWFAAVKVA
TVIIFLIVGVLMIFGILGGDNVGFKNFYENGGPFIGGAKSIFMIFLIAGFSFQGTELVGVAAGESEDPEKNVPKAVNTIF
WRILLFYLGTILVIGALVPNAQAGVETSAFTIVFEKLGLAGAASIMNAIILTSVLSAGNSGMYASSRMLYAMAKNGMAPK
IFEKTNSRGVPVNAIIITTIIASLCFLTGIYAENTVYVWLVAASGLSGFIAWLGIAICHYRFRKAYVAQGKDMSRLVYKA
KLFPLGPIIALILCGIIVLGQGYAYLDVRNGVDWGGLISSYIGLPLFFGLFAYYKIKYKTKIIDLKDVDLSVEHIDTDES
IEDEVFSY

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=483, Percent_Identity=53.416149068323, Blast_Score=526, Evalue=1e-150,
Organism=Escherichia coli, GI87081708, Length=441, Percent_Identity=39.4557823129252, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI1786789, Length=419, Percent_Identity=37.4701670644391, Blast_Score=309, Evalue=3e-85,
Organism=Escherichia coli, GI1786302, Length=411, Percent_Identity=38.9294403892944, Blast_Score=299, Evalue=2e-82,
Organism=Escherichia coli, GI48994972, Length=458, Percent_Identity=35.589519650655, Blast_Score=279, Evalue=3e-76,
Organism=Escherichia coli, GI1790653, Length=423, Percent_Identity=35.9338061465721, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI1786602, Length=385, Percent_Identity=37.9220779220779, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1789017, Length=398, Percent_Identity=36.1809045226131, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI87081915, Length=387, Percent_Identity=35.9173126614987, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI87081869, Length=420, Percent_Identity=22.8571428571429, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI2367353, Length=365, Percent_Identity=24.6575342465753, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17540018, Length=352, Percent_Identity=22.7272727272727, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=509, Percent_Identity=37.524557956778, Blast_Score=328, Evalue=1e-90,
Organism=Saccharomyces cerevisiae, GI6324061, Length=504, Percent_Identity=36.3095238095238, Blast_Score=313, Evalue=6e-86,
Organism=Saccharomyces cerevisiae, GI6324990, Length=506, Percent_Identity=34.9802371541502, Blast_Score=291, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6322892, Length=494, Percent_Identity=36.0323886639676, Blast_Score=287, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6324924, Length=518, Percent_Identity=33.3976833976834, Blast_Score=277, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6324059, Length=502, Percent_Identity=33.2669322709163, Blast_Score=276, Evalue=5e-75,
Organism=Saccharomyces cerevisiae, GI6321629, Length=493, Percent_Identity=31.237322515213, Blast_Score=268, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6324553, Length=502, Percent_Identity=32.6693227091633, Blast_Score=268, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6320717, Length=512, Percent_Identity=30.078125, Blast_Score=260, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6319824, Length=505, Percent_Identity=30.4950495049505, Blast_Score=254, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6321053, Length=494, Percent_Identity=31.7813765182186, Blast_Score=247, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6320251, Length=506, Percent_Identity=30.6324110671937, Blast_Score=240, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6319543, Length=510, Percent_Identity=30.9803921568627, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6322967, Length=497, Percent_Identity=30.9859154929577, Blast_Score=235, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6319542, Length=502, Percent_Identity=29.4820717131474, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6319608, Length=514, Percent_Identity=29.5719844357977, Blast_Score=221, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6324981, Length=498, Percent_Identity=30.3212851405622, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6320364, Length=557, Percent_Identity=25.3141831238779, Blast_Score=162, Evalue=9e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52896; Mature: 52765

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQEQNTNLKRGLKSRHLSMIAMGGAIGTGIFLAMGDTLHQAGVGGAFVAYGIIGVMVYF
CCCCCCCHHHHHHHHHHHHHEEECCHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHH
LCTSLGEMATYMPETGSFGAYATKFVDPALGFALGWNYWYNWAITIAAEMVAGSLLMKFW
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
FPNIPAIVWSALFLVIILTLNLLSAKAYGESEFWFAAVKVATVIIFLIVGVLMIFGILGG
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DNVGFKNFYENGGPFIGGAKSIFMIFLIAGFSFQGTELVGVAAGESEDPEKNVPKAVNTI
CCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHH
FWRILLFYLGTILVIGALVPNAQAGVETSAFTIVFEKLGLAGAASIMNAIILTSVLSAGN
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC
SGMYASSRMLYAMAKNGMAPKIFEKTNSRGVPVNAIIITTIIASLCFLTGIYAENTVYVW
CCCCHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEE
LVAASGLSGFIAWLGIAICHYRFRKAYVAQGKDMSRLVYKAKLFPLGPIIALILCGIIVL
EEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHH
GQGYAYLDVRNGVDWGGLISSYIGLPLFFGLFAYYKIKYKTKIIDLKDVDLSVEHIDTDE
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEECCCEEEEECCCCC
SIEDEVFSY
CHHHHHHCC
>Mature Secondary Structure 
SQEQNTNLKRGLKSRHLSMIAMGGAIGTGIFLAMGDTLHQAGVGGAFVAYGIIGVMVYF
CCCCCCHHHHHHHHHHHHHEEECCHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHH
LCTSLGEMATYMPETGSFGAYATKFVDPALGFALGWNYWYNWAITIAAEMVAGSLLMKFW
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
FPNIPAIVWSALFLVIILTLNLLSAKAYGESEFWFAAVKVATVIIFLIVGVLMIFGILGG
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DNVGFKNFYENGGPFIGGAKSIFMIFLIAGFSFQGTELVGVAAGESEDPEKNVPKAVNTI
CCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHH
FWRILLFYLGTILVIGALVPNAQAGVETSAFTIVFEKLGLAGAASIMNAIILTSVLSAGN
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC
SGMYASSRMLYAMAKNGMAPKIFEKTNSRGVPVNAIIITTIIASLCFLTGIYAENTVYVW
CCCCHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEE
LVAASGLSGFIAWLGIAICHYRFRKAYVAQGKDMSRLVYKAKLFPLGPIIALILCGIIVL
EEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHH
GQGYAYLDVRNGVDWGGLISSYIGLPLFFGLFAYYKIKYKTKIIDLKDVDLSVEHIDTDE
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEECCCEEEEECCCCC
SIEDEVFSY
CHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]